Details of the Target

General Information of Target

Target ID LDTP02000
Target Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)
Gene Name HMGCR
Gene ID 3156
Synonyms
3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase; EC 1.1.1.34
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKFEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADTSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQTETESTLSLKNPITSPVVT
QKKVPDNCCRREPMLVRNNQKCDSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNS
SLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLSEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDEKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRAC
DSAEVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVKSHMIHNRSKINLQDLQGACTKKTA
Target Type
Successful
Target Bioclass
Enzyme
Family
HMG-CoA reductase family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs.
TTD ID
T53585
Uniprot ID
P04035
DrugMap ID
TTPADOQ
Ensemble ID
ENST00000287936.9
HGNC ID
HGNC:5006
ChEMBL ID
CHEMBL402

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A654V .
CCK81 SNV: p.N419Y DBIA    Probe Info 
HCT15 SNV: p.E152Ter .
HT115 SNV: p.A137T; p.E155Ter .
JURKAT SNV: p.S565N .
SW756 SNV: p.V22A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		12.82  LDD0348  [1]
HRP
 Probe Info  		8.42  LDD0347  [1]
IPM
 Probe Info  		C883(0.00); C382(0.00); C600(0.00); C448(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C620(1.45); C903(3.26)  LDD3360  [3]
DA-P3
 Probe Info  		10.62  LDD0179  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		9.71  LDD1728  [6]
C091
 Probe Info  		16.00  LDD1782  [6]
C092
 Probe Info  		22.63  LDD1783  [6]
C094
 Probe Info  		37.79  LDD1785  [6]
C100
 Probe Info  		5.39  LDD1789  [6]
C106
 Probe Info  		16.34  LDD1793  [6]
C107
 Probe Info  		6.45  LDD1794  [6]
C112
 Probe Info  		21.41  LDD1799  [6]
C134
 Probe Info  		30.06  LDD1816  [6]
C135
 Probe Info  		10.93  LDD1817  [6]
C141
 Probe Info  		10.13  LDD1823  [6]
C143
 Probe Info  		14.93  LDD1825  [6]
C153
 Probe Info  		19.70  LDD1834  [6]
C201
 Probe Info  		31.78  LDD1877  [6]
C206
 Probe Info  		16.45  LDD1881  [6]
C349
 Probe Info  		22.32  LDD2010  [6]
C350
 Probe Info  		56.49  LDD2011  [6]
C355
 Probe Info  		22.94  LDD2016  [6]
C356
 Probe Info  		8.94  LDD2017  [6]
C366
 Probe Info  		6.11  LDD2027  [6]
C403
 Probe Info  		16.80  LDD2061  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C600(0.74); C883(0.78); C561(1.29); C382(0.98)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C600(1.04); C883(1.00); C561(1.16); C382(1.16)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C600(0.94); C448(0.87); C883(0.96); C561(1.05)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C600(0.98); C883(1.01); C561(0.97); C382(0.98)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C600(0.81); C883(1.05); C382(1.19); C688(1.14)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C600(1.04); C883(1.04); C561(1.00); C382(1.02)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C600(1.08); C883(1.03); C561(0.94); C382(1.17)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C600(1.02); C883(1.02); C561(1.05); C382(1.10)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C600(0.95); C448(0.77); C883(1.20); C561(1.23)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C600(0.97); C883(0.98); C561(1.08); C382(1.23)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C600(0.88); C883(0.93); C561(1.09); C382(0.97)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C883(0.93); C561(0.79); C382(0.96)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C600(0.96); C883(1.06); C382(0.98); C688(1.34)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C600(0.94); C883(1.00); C561(1.11); C382(1.02)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C600(0.96); C883(1.07); C561(0.85); C382(0.93)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C600(1.08); C883(0.87); C561(0.98); C382(1.17)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C600(1.04); C883(0.96); C561(1.25); C382(1.17)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C600(0.98); C448(0.88); C883(0.97); C561(0.91)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C600(1.06); C883(0.91); C561(0.97); C382(1.08)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C883(0.96); C561(0.81); C382(1.02)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C600(1.04); C448(0.92); C883(0.97); C561(1.40)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C600(1.04); C883(0.97); C382(1.07); C688(1.09)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C600(1.02); C883(0.91); C561(1.21); C382(0.98)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C600(0.98); C883(0.92); C561(0.92); C382(1.11)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C600(1.02); C883(0.91); C561(1.05); C382(1.15)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C600(1.03); C883(1.00); C561(1.38); C382(1.16)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C600(1.00); C448(1.00); C883(1.00); C561(1.23)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C600(0.92); C883(0.85); C561(1.03); C382(1.15)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C883(0.92); C561(0.82); C382(0.93)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C600(0.84); C883(0.99); C382(1.00); C688(0.97)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C600(0.94); C883(1.06); C561(1.42); C382(0.93)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C600(1.00); C883(0.95); C561(1.04); C382(0.91)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C600(0.94); C883(1.05); C561(0.84); C382(0.95)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C600(1.19); C883(0.88); C561(1.00); C382(1.15)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C600(1.09); C883(1.02); C561(1.08); C382(1.05)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C600(0.98); C448(0.92); C883(1.07); C561(1.18)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C600(1.00); C883(0.92); C561(0.98); C382(0.94)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C883(1.01); C561(0.83); C382(1.07)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C600(0.80); C883(1.03); C382(1.07); C688(1.10)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C600(0.93); C883(1.04); C561(1.33); C382(1.06)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C600(0.97); C883(1.19); C561(0.83); C382(1.11)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C600(0.85); C883(0.97); C561(0.87); C382(1.22)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C883(0.96); C561(0.99); C382(0.97)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C600(0.96); C883(0.95); C561(1.17); C382(1.06)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C600(0.96); C448(0.95); C883(0.98); C561(1.04)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C600(0.95); C883(1.02); C561(0.95); C382(1.00)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C883(0.98); C561(0.85); C382(0.95)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C600(0.95); C883(1.06); C382(1.25); C688(1.19)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C600(1.03); C883(1.03); C561(1.08); C382(1.08)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C600(0.97); C883(1.28); C561(1.14); C382(1.09)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C600(1.14); C883(0.82); C561(1.11); C382(0.95)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C600(0.99); C883(0.95); C561(1.26); C382(1.10)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C600(0.97); C448(1.08); C883(1.04); C561(1.30)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C600(1.14); C883(1.04); C382(1.07); C688(1.20)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C600(0.96); C883(0.99); C561(1.17); C382(0.98)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C883(1.01); C561(0.86); C382(1.05)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C600(1.11); C883(0.98); C382(1.10); C688(1.15)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C600(1.08); C883(1.00); C561(0.97); C382(0.89)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C600(0.97); C883(1.12); C561(1.12); C382(1.05)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C600(0.95); C883(1.04); C561(1.08); C382(1.02)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C600(1.05); C883(1.03); C561(0.92); C382(1.09)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C883(0.97); C561(0.80); C382(1.04)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C600(0.96); C883(0.86); C561(1.22); C382(1.17)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C600(1.10); C883(1.10); C561(1.09); C382(1.15)  LDD1514  [7]
 LDCM0087  Capsaicin HEK-293T 18.63  LDD0185  [1]
 LDCM0632  CL-Sc Hep-G2 C883(20.00)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C600(0.94); C448(1.01); C883(0.99); C561(1.30)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C600(1.00); C883(1.33); C382(1.07); C688(1.55)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C600(0.99); C883(0.96); C561(0.90); C382(0.82)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C600(1.02); C448(1.05); C883(0.99); C561(1.04)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C600(1.06); C883(1.10); C561(0.94); C382(0.97)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C600(0.96); C883(0.99); C561(0.93); C382(1.10)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C600(1.09); C883(0.95); C561(0.81); C382(0.93)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C600(1.00); C448(1.06); C883(1.02); C561(1.17)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C600(0.87); C883(0.97); C561(1.16); C382(1.10)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C600(1.00); C883(0.96); C561(1.28); C382(1.14)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C600(0.97); C883(0.91); C561(0.86); C382(1.04)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C600(1.09); C448(0.86); C883(0.95); C561(0.93)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C600(0.93); C883(1.06); C561(1.12); C382(1.26)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C600(0.99); C883(1.00); C561(0.44); C382(1.07)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C600(0.91); C883(0.99); C561(1.17); C382(1.03)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C600(1.03); C883(0.96); C561(0.89); C382(1.23)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C600(0.92); C448(1.15); C883(1.05); C561(0.97)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C600(0.97); C883(1.04); C561(1.11); C382(0.82)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C600(1.00); C883(0.99); C561(0.86); C382(1.17)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C600(1.02); C883(0.95); C561(0.96); C382(0.90)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C600(1.09); C448(0.96); C883(1.05); C561(0.97)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C600(1.13); C883(1.08); C561(1.10); C382(1.04)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C600(1.04); C883(0.93); C561(0.88); C382(1.17)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C600(1.04); C883(1.18); C561(1.20); C382(1.06)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C600(0.97); C883(0.97); C561(1.12); C382(0.87)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C600(0.95); C448(0.99); C883(1.04); C561(1.12)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C600(0.94); C883(1.03); C561(0.96); C382(0.98)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C600(0.88); C883(0.94); C561(0.96); C382(0.98)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C600(0.99); C883(0.94); C561(0.99); C382(1.01)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C600(0.97); C448(1.10); C883(1.00); C561(1.06)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C600(0.98); C883(1.10); C561(1.13); C382(0.86)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C600(0.98); C883(1.00); C561(1.18); C382(1.01)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C600(0.95); C883(0.98); C561(1.01); C382(0.76)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C600(0.89); C448(1.07); C883(1.20); C561(1.02)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C600(0.98); C883(1.10); C561(1.32); C382(0.88)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C600(0.97); C883(1.03); C561(1.15); C382(1.33)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C600(1.08); C883(0.96); C561(0.98); C382(1.02)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C600(1.45); C883(0.95); C561(1.04); C382(0.93)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C600(1.07); C883(0.97); C561(1.23); C382(0.88)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C600(1.08); C448(0.87); C883(1.09); C561(1.16)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C600(1.14); C883(1.05); C561(1.04); C382(0.85)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C600(1.11); C883(0.93); C561(1.06); C382(1.11)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C883(1.09); C561(1.11); C382(1.09)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C600(1.06); C883(1.21); C382(1.09); C688(1.32)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C600(0.96); C883(1.13); C561(1.17); C382(1.11)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C600(1.13); C883(1.23); C561(0.98); C382(1.08)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C600(0.97); C448(1.10); C883(1.00); C561(1.15)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C600(1.02); C883(1.11); C561(1.26); C382(0.87)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C600(1.03); C883(0.99); C561(1.13); C382(1.11)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C600(1.00); C883(0.92); C561(0.93); C382(0.99)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C600(1.21); C883(0.94); C561(0.86); C382(1.27)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C600(0.99); C883(1.00); C561(0.88); C382(1.05)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C600(1.12); C883(0.97); C561(1.08); C382(0.90)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C600(0.95); C448(1.27); C883(0.99); C561(1.00)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C600(1.04); C883(1.04); C561(1.12); C382(1.26)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C883(1.01); C561(0.77); C382(1.21)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C600(1.19); C883(1.04); C382(1.17); C688(1.32)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C600(1.24); C883(1.07); C561(1.05); C382(1.15)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C600(1.09); C883(1.41); C561(1.02); C382(1.10)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C600(1.12); C448(1.06); C883(0.97); C561(0.85)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C600(0.98); C883(0.87); C561(1.05); C382(0.98)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C600(1.28); C883(0.98); C561(1.00); C382(1.08)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C600(0.99); C883(1.01); C561(0.93); C382(0.80)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C600(0.82); C883(0.85); C561(0.97); C382(1.04)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C600(1.11); C883(1.05); C561(0.93); C382(1.16)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C600(0.99); C448(0.97); C883(0.99); C561(1.00)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C600(1.05); C883(1.13); C561(0.87); C382(1.36)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C883(1.11); C561(0.82); C382(1.18)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C600(1.08); C883(1.18); C382(1.22); C688(1.42)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C600(1.36); C883(1.12); C561(1.27); C382(1.07)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C600(1.13); C883(1.45); C561(0.97); C382(1.10)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C600(0.94); C448(1.09); C883(1.06); C561(0.98)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C600(0.90); C883(0.79); C561(1.04); C382(1.06)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C600(1.07); C883(1.05); C561(1.12); C382(0.95)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C600(1.12); C883(0.97); C561(0.79); C382(1.23)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C600(1.04); C883(0.83); C561(1.01); C382(0.99)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C600(1.04); C883(0.94); C561(1.17); C382(1.15)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C600(1.00); C448(1.04); C883(1.00); C561(1.22)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C600(0.94); C883(1.00); C561(1.29); C382(1.18)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C883(1.19); C561(1.16); C382(1.40)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C600(1.04); C883(1.10); C382(1.35); C688(1.52)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C600(1.11); C883(1.10); C561(1.26); C382(1.19)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C600(1.07); C883(0.92); C561(1.16); C382(1.15)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C600(1.05); C883(1.44); C561(0.96); C382(1.33)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C600(1.01); C448(1.09); C883(0.98); C561(1.09)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C600(0.98); C883(1.06); C561(1.03); C382(1.01)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C600(0.99); C883(0.97); C561(0.97); C382(1.11)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C600(0.94); C883(1.01); C561(0.90); C382(1.40)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C600(1.05); C883(0.79); C561(1.15); C382(1.16)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C600(1.06); C883(1.04); C561(1.10); C382(1.18)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C600(0.96); C448(1.13); C883(1.02); C561(0.89)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C600(1.02); C883(0.97); C561(0.98); C382(1.10)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C883(1.01); C561(0.85); C382(1.22)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C600(1.11); C448(0.82); C883(1.05); C561(0.89)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C600(1.06); C883(1.23); C382(1.06); C688(1.39)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C600(0.91); C883(1.15); C561(0.98); C382(1.22)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C600(1.12); C883(1.09); C561(1.06); C382(1.02)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C600(0.89); C448(1.04); C883(0.92); C561(0.98)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C600(0.92); C883(1.09); C561(0.91); C382(1.21)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C600(0.97); C883(0.99); C561(0.93); C382(1.30)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C600(0.95); C883(1.09); C561(1.03); C382(1.08)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C600(1.01); C883(1.04); C561(1.14); C382(1.21)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C600(0.98); C448(1.19); C883(0.99); C561(1.04)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C600(0.84); C883(1.25); C561(1.44); C382(0.98)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C600(0.95); C883(1.00); C561(1.23); C382(0.99)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C883(1.02); C561(0.92); C382(1.15)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C600(0.92); C883(0.95); C382(1.26); C688(1.41)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C600(1.15); C883(1.08); C561(1.22); C382(1.11)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C600(1.02); C883(1.25); C561(1.04); C382(0.98)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C600(0.83); C448(1.21); C883(0.96); C561(1.06)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C600(1.02); C883(1.00); C561(1.10); C382(0.87)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C600(0.91); C883(1.01); C561(1.25); C382(1.11)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C600(1.07); C883(0.99); C561(0.88); C382(0.93)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C600(0.96); C883(1.06); C561(0.98); C382(0.97)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C883(1.07); C561(0.98); C382(1.00)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C600(1.10); C883(1.21); C561(1.52); C382(1.16)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C600(1.06); C448(1.05); C883(0.95); C561(1.07)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C600(0.93); C883(0.97); C561(1.12); C382(0.95)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C883(1.09); C561(0.91); C382(1.26)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C600(0.96); C883(1.22); C382(1.13); C688(1.41)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C600(1.02); C883(1.29); C561(1.51); C382(1.09)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C600(1.06); C883(1.26); C561(1.13); C382(1.11)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C600(0.96); C448(1.02); C883(1.02); C561(1.25)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C600(1.08); C883(1.05); C561(1.30); C382(0.77)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C600(0.92); C883(1.05); C561(0.79); C382(0.97)  LDD1697  [7]
 LDCM0028  Dobutamine HEK-293T 4.90  LDD0180  [1]
 LDCM0027  Dopamine HEK-293T 10.62  LDD0179  [1]
 LDCM0495  E2913 HEK-293T C600(0.98); C883(1.00); C561(0.96); C382(1.07)  LDD1698  [7]
 LDCM0031  Epigallocatechin gallate HEK-293T 27.21  LDD0183  [1]
 LDCM0468  Fragment33 HEK-293T C600(0.94); C883(1.01); C561(1.21); C382(1.01)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C600(1.00); C883(1.04); C561(0.89); C382(0.68)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C382(0.97); C448(0.91); C883(0.97); C600(0.95)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C382(0.98); C448(0.86); C883(0.96); C600(0.94)  LDD1497  [7]
 LDCM0024  KB05 NCI-H3122 C620(1.45); C903(3.26)  LDD3360  [3]
 LDCM0030  Luteolin HEK-293T 26.62  LDD0182  [1]
 LDCM0032  Oleacein HEK-293T 6.02  LDD0184  [1]
 LDCM0029  Quercetin HEK-293T 16.72  LDD0181  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aspirin Small molecular drug D0GY5Z
Atorvastatin Small molecular drug D01QIN
Cannabidiol Small molecular drug DB09061
Cerivastatin Small molecular drug D03KIA
Fluvastatin Small molecular drug D08GHB
Lovastatin Small molecular drug D06WTZ
Nadh Small molecular drug DB00157
Pitavastatin Small molecular drug DB08860
Pitavastatin Calcium Small molecular drug D0G1WL
Pravastatin Small molecular drug D02RQU
Rosuvastatin Small molecular drug D0JE2E
Simvastatin Small molecular drug D0H0ND
Teriflunomide Small molecular drug D07QFP
Tocotrienol Small molecular drug D03VFL
Crestor/Trilipix . D04XGU
Ubidecarenone . DB09270
Phase 4
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Laropiprant Small molecular drug D0WL5V
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Premarin/Pravachol . D0G7IV
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Crilvastatin Small molecular drug D0CC8L
Xzk-monascus . D06BBV
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ncx-6560 . D0H0FX
Investigative
Click To Hide/Show 89 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(E)-5-octadecen-7,9-diynoic Acid Small molecular drug D0C8HK
(E)-octadecan-9-ynoic Acid Small molecular drug D0A6FX
(R)-mevalonate Small molecular drug D03GRA
(Z)-5-octadecen-7,9-diynoic Acid Small molecular drug D0NU6K
(Z)-7-octedecan-9-ynoic Acid Small molecular drug D0CU3I
1,4-dithiothreitol Small molecular drug D01GMJ
14-dithiothreitol Small molecular drug DB04447
2'-monophosphoadenosine 5'-diphosphoribose Small molecular drug D0J2FY
3-(1,3 Dodecadiynyl)-6-oxiranebutanoic Acid Small molecular drug D08SKU
3-hydroxy-3-methyl-glutaric Acid Small molecular drug D0IJ7H
5-ketodihydromevinolin Small molecular drug D0I0IM
6-hydroxy-7,9-octadecadiynoic Acid Small molecular drug D01YQX
7,9-octadecadiynoic Acid Small molecular drug D0C5LO
7,9-tetradecadiynoic Acid Small molecular drug D09EBV
9-octadecynoic Acid Small molecular drug D09QIA
Coenzyme A Small molecular drug D0W3NA
Dfgyvae Small molecular drug D09CSQ
F(4-fluoro)Vae Small molecular drug D0X1VL
Fpyvae Peptide Small molecular drug D01WQF
Gfpdgg Small molecular drug D03CYY
Gfpegg Small molecular drug D0C1RY
Gfptgg Small molecular drug D0S1LA
Glpdgg Peptide Small molecular drug D0X0GV
Glptgg Small molecular drug D0B2FM
Meglutol Small molecular drug DB04377
Nabiximols Small molecular drug DB14011
Nicotinamide-adenine-dinucleotide Small molecular drug D0R6JE
O-hydroxyatorvastatin Small molecular drug D03TKT
Pmid1527791c29 Small molecular drug D0W5FM
Pmid15686906c17 Small molecular drug D07QAX
Pmid15686906c29 Small molecular drug D0Q6WP
Pmid1656041c11dd Small molecular drug D06FRE
Pmid1656041c11ff Small molecular drug D0O2FD
Pmid1656041c11jj Small molecular drug D0T4PL
Pmid1656041c11nn Small molecular drug D0M9BZ
Pmid1656041c4ff Small molecular drug D00TIO
Pmid1656041c4rr Small molecular drug D0X0GG
Pmid1656041c74 Small molecular drug D0R8YV
Pmid17560788c29f Small molecular drug D0O8XW
Pmid17574411c41 Small molecular drug D00RHH
Pmid17574411c42 Small molecular drug D0G6PS
Pmid17574412c33 Small molecular drug D00UOI
Pmid18072721c50 Small molecular drug D0L6HX
Pmid18155906c16f Small molecular drug D0O7AS
Pmid18412317c13b Small molecular drug D02TIT
Pmid1875346c18 Small molecular drug D06HNA
Pmid1895299c1 Small molecular drug D01XMY
Pmid1895299c4p Small molecular drug D02OET
Pmid1895299c6v Small molecular drug D0M4YT
Pmid19502059c25d Small molecular drug D0N7RK
Pmid1992138c8b Small molecular drug D0G2QW
Pmid1992149c13 Small molecular drug D00VMO
Pmid1992149c9 Small molecular drug D02ITS
Pmid2153213c13b Small molecular drug D06BIF
Pmid2153213c13g Small molecular drug D09TKN
Pmid2153213c1a Small molecular drug D0R1FP
Pmid2153213c1e Small molecular drug D03EAN
Pmid2153213c1f Small molecular drug D0RA8F
Pmid2153213c2c Small molecular drug D02MEX
Pmid2153213c2d Small molecular drug D05GWF
Pmid2153213c2f Small molecular drug D0G4ZG
Pmid2231594c3j Small molecular drug D0MU7C
Pmid2231594c3k Small molecular drug D00ZJG
Pmid2231594c3q Small molecular drug D0UQ6A
Pmid2231594c3u Small molecular drug D02EQL
Pmid2296027c25 Small molecular drug D0J9DY
Pmid2296027c29 Small molecular drug D0ZQ3B
Pmid2296036c2g Small molecular drug D0O1OC
Pmid2296036c2t Small molecular drug D05UQC
Pmid2296036c4d Small molecular drug D0I9TR
Pmid2296036c4i Small molecular drug D01ZAL
Pmid2909732c7 Small molecular drug D0J8BD
Pmid7932551c9 Small molecular drug D0K1MB
Pmid8246233c28 Small molecular drug D0S1ER
Pmid8246233c35 Small molecular drug D0NJ5U
Pmid8246233c5ab Small molecular drug D00TBG
Pmid8246234c3h Small molecular drug D07VEB
Pmid8246237c18t Small molecular drug D0FD8Q
Pmid8426367c18 Small molecular drug D05YUT
Rawsonol Small molecular drug D0Y6DJ
Statin Small molecular drug D0W7VX
(S)-hmg-coa . DB03169
Bpl-001 . D02SRB
Brutieridin . D0Q2EH
Medical Cannabis . DB14009
Mt-001 . D03ZIK
Ncx-1067 . D04XQG
Nicotinamide Adenine Dinucleotide Phosphate . DB03461
Tak-475 . DB05317
Patented
Click To Hide/Show 24 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-cyclopropyl-4-substituted-phenoxy-quinoline Derivative 1 Small molecular drug D0LJ0M
Atorvastatin Lactole Derivative 1 Small molecular drug D09ZXW
Hexahydro Naphthalene Derivative 1 Small molecular drug D0L3BE
Hexahydro Naphthalene Derivative 2 Small molecular drug D0M9ZW
Hexahydro Naphthalene Derivative 3 Small molecular drug D05SOY
Lactol Derivative 1 Small molecular drug D0AY4N
Lactol Derivative 2 Small molecular drug D0CM4R
Pitavastatin Derivative 1 Small molecular drug D0G8JX
Pmid27537201-compound-figure11 Small molecular drug D0YX0O
Pmid27537201-compound-figure13b Small molecular drug D03HKN
Pmid27537201-compound-figure13c Small molecular drug D0EF9J
Pmid27537201-compound-figure15a Small molecular drug D00YVL
Pmid27537201-compound-figure15b Small molecular drug D0SH0L
Pmid27537201-compound-figure17 Small molecular drug D0S3BE
Poly-substituted Azoles Statin Lactone Derivative 1 Small molecular drug D0RW8J
Poly-substituted Azoles Statin Lactone Derivative 2 Small molecular drug D0AP6V
Poly-substituted Miazine Derivative 1 Small molecular drug D0CW2F
Pravastatin Derivative 1 Small molecular drug D0KU2T
Quinoline Derivative 1 Small molecular drug D0U2CK
Quinoline Derivative 16 Small molecular drug D0QW7F
Quinoline Derivative 17 Small molecular drug D04MFJ
Sterol Derivative 1 Small molecular drug D08FMC
Sterol Derivative 2 Small molecular drug D0YZ3U
Sterol Derivative 3 Small molecular drug D0O0OD
Discontinued
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bervastatin Small molecular drug D0L1LJ
Bmy-21950 Small molecular drug D04NCJ
Bmy-22089 Small molecular drug D0E2CO
Cp-83101 Small molecular drug D07QSA
Dalvastatin Small molecular drug D0Y9XD
Glenvastatin Small molecular drug D0U5NU
Mevastatin Small molecular drug D0J9GD
Pf-3052334 Small molecular drug D0MF7U
Sq-33600 Small molecular drug D0Y3OR
Sr12813 Small molecular drug D0C7RV
Gt-16-239 . D0YQ9G
Rbx10558 . D02GSA

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402