Details of the Target

General Information of Target

Target ID LDTP07345
Target Name Cell division cycle-associated protein 2 (CDCA2)
Gene Name CDCA2
Gene ID 157313
Synonyms
Cell division cycle-associated protein 2; Recruits PP1 onto mitotic chromatin at anaphase protein; Repo-Man
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTV
TVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKS
PLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLT
RKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETS
VDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVS
SDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSL
ISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTP
VCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETL
SGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRR
KSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVP
EMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFC
SYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEE
RVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCN
RLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGR
SLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDL
ENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENS
QGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGE
RKQ
Target Bioclass
Other
Subcellular location
Nucleus
Function
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
Uniprot ID
Q69YH5
Ensemble ID
ENST00000330560.8
HGNC ID
HGNC:14623

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.E887D .
HEC1 SNV: p.C347Y DBIA    Probe Info 
HEC1B SNV: p.C347Y .
IPC298 SNV: p.N902D DBIA    Probe Info 
JURKAT SNV: p.C315Y Compound 10    Probe Info 
KATOIII SNV: p.S943F .
NALM6 SNV: p.V221A DBIA    Probe Info 
NCIH358 SNV: p.G972V DBIA    Probe Info 
REH SNV: p.D642G .
SW1271 SNV: p.R891Ter .
U937 SNV: p.K160E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		8.65  LDD0348  [1]
HRP
 Probe Info  		6.77  LDD0347  [1]
STPyne
 Probe Info  		K575(10.00)  LDD0277  [2]
BTD
 Probe Info  		C315(0.86)  LDD1700  [3]
DA-P3
 Probe Info  		14.98  LDD0179  [1]
AHL-Pu-1
 Probe Info  		C835(5.02); C792(2.36); C750(2.50); C532(3.16)  LDD0168  [4]
Acrolein
 Probe Info  		N.A.  LDD0223  [5]
DBIA
 Probe Info  		C315(1.35); C790(1.13); C792(1.13); C660(0.96)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C422(0.00); C979(0.00); C315(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		C46(0.00); C188(0.00); C280(0.00); C422(0.00)  LDD2226  [9]
NAIA_5
 Probe Info  		C714(0.00); C422(0.00); C315(0.00)  LDD2224  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
Compound 10
 Probe Info  		C280(0.00); C315(0.00); C979(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		C315(0.00); C979(0.00)  LDD2213  [11]
IPM
 Probe Info  		C280(0.00); C979(0.00); C422(0.00); C315(0.00)  LDD0147  [8]
VSF
 Probe Info  		C188(0.00); C315(0.00)  LDD0007  [10]
Phosphinate-6
 Probe Info  		C532(0.00); C522(0.00); C164(0.00); C188(0.00)  LDD0018  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		14.30  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		7.21  LDD1945  [14]
C286
 Probe Info  		8.22  LDD1956  [14]
C287
 Probe Info  		9.13  LDD1957  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C315(0.82)  LDD2142  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C315(1.20)  LDD2152  [3]
 LDCM0025  4SU-RNA HEK-293T C835(5.02); C792(2.36); C750(2.50); C532(3.16)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C835(3.79); C750(2.53); C532(2.44); C522(5.77)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C790(0.73); C164(1.04); C188(0.78); C315(1.12)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C315(0.49); C422(0.67); C824(0.49); C835(0.88)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C790(0.84); C792(0.84); C164(0.73); C188(1.37)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C790(0.86); C792(0.86); C164(0.96); C188(1.29)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C790(0.88); C792(0.88); C164(0.80); C188(1.19)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C790(1.22); C792(1.22); C164(0.86); C188(1.53)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C790(1.04); C792(1.04); C164(0.81); C188(1.01)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C790(1.11); C792(1.11); C164(0.89); C188(1.46)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C790(1.03); C792(1.03); C164(0.97); C188(1.50)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C790(0.98); C792(0.98); C164(0.70); C188(1.23)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C790(0.75); C792(0.75); C164(0.82); C188(1.24)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C790(0.72); C792(0.72); C164(0.84); C188(1.03)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C315(0.68); C422(0.64); C824(0.45); C835(0.86)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C790(0.78); C792(0.78); C164(0.88); C188(1.32)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C790(0.77); C792(0.77); C164(0.98); C188(1.26)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C790(0.89); C792(0.89); C164(1.02); C188(1.40)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C790(0.72); C792(0.72); C188(0.88); C280(0.95)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C790(1.05); C792(1.05); C188(1.05); C280(1.10)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C790(1.18); C792(1.18); C188(1.05); C280(1.70)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C790(1.13); C792(1.13); C188(0.94); C280(1.51)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C790(1.00); C792(1.00); C188(0.91); C280(1.04)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C790(0.91); C792(0.91); C188(1.08); C280(1.04)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C790(1.06); C792(1.06); C188(1.03); C280(1.31)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C315(0.61); C422(0.61); C824(0.33); C835(1.07)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C790(1.00); C792(1.00); C188(1.20); C280(1.34)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C790(0.84); C792(0.84); C188(1.03); C280(1.06)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C790(1.14); C792(1.14); C188(1.17); C280(1.26)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C790(0.82); C792(0.82); C188(2.18); C280(1.00)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C790(0.94); C792(0.94); C188(1.07); C280(1.21)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C790(1.01); C792(1.01); C188(1.10); C280(1.19)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C790(1.11); C792(1.11); C188(1.14); C280(1.44)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C790(1.04); C792(1.04); C188(1.14); C280(1.40)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C790(0.98); C792(0.98); C188(0.61); C280(1.03)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C790(0.73); C792(0.73); C188(0.56); C280(0.59)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C790(0.84); C792(0.84); C188(0.71); C280(0.84)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C790(0.83); C792(0.83); C188(0.70); C280(0.92)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C790(0.57); C792(0.57); C188(0.72); C280(0.79)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C790(0.68); C792(0.68); C188(0.71); C280(0.83)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C790(0.79); C792(0.79); C188(0.98); C280(0.95)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C790(0.63); C792(0.63); C188(0.85); C280(0.84)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C790(0.69); C792(0.69); C188(0.91); C280(0.75)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C790(0.68); C792(0.68); C188(0.74); C280(0.66)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C790(0.60); C792(0.60); C188(0.97); C280(0.66)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C790(0.69); C792(0.69); C188(1.01); C280(0.85)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C315(0.44); C422(0.69); C824(0.35); C835(0.62)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C790(0.67); C792(0.67); C188(1.04); C280(0.86)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C790(0.60); C792(0.60); C188(1.05); C280(0.80)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C790(0.56); C792(0.56); C188(0.77); C280(0.72)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C790(0.94); C792(0.94); C164(1.03); C188(0.93)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C188(0.72); C824(0.83); C164(0.92); C835(1.15)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C188(0.67); C824(0.74); C164(0.82); C792(0.97)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C188(0.90); C164(0.96); C792(1.01); C790(1.05)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C188(0.73); C164(0.83); C824(1.05); C792(1.16)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C188(0.77); C164(0.87); C660(1.10); C790(1.38)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C188(0.61); C164(0.98); C660(1.04); C835(1.22)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C824(0.28); C315(0.51); C422(0.90); C835(1.04)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C824(0.76); C164(0.85); C660(0.96); C790(0.97)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C164(0.94); C824(0.98); C790(1.06); C792(1.25)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C164(0.84); C790(1.22); C660(1.22); C188(1.24)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C188(0.70); C164(0.97); C660(1.34); C790(1.78)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C790(1.36); C792(1.44); C164(0.85); C188(1.06)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C790(1.37); C792(1.52); C164(0.94); C188(0.94)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C790(1.13); C792(1.16); C164(0.92); C188(0.85)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C790(1.28); C792(1.38); C164(0.88); C188(1.02)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C835(0.35); C824(0.43); C979(0.47); C790(0.58)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C835(0.37); C824(0.56); C790(0.58); C792(0.58)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C835(0.25); C824(0.43); C979(0.55); C790(0.66)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C422(0.61); C979(0.88); C790(0.92); C188(0.92)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C835(0.29); C824(0.43); C979(0.57); C790(0.58)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C835(0.27); C824(0.43); C979(0.56); C188(0.65)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C835(0.25); C824(0.46); C979(0.46); C790(0.74)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C835(0.30); C824(0.36); C979(0.55); C790(0.57)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C835(0.27); C824(0.40); C979(0.53); C790(0.58)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C280(0.89); C315(1.07); C660(1.15)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C280(1.01); C315(1.29); C660(1.31)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C280(1.03); C315(1.12); C660(1.31)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C280(1.03); C315(1.18); C660(1.53)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C315(1.06); C280(1.35); C660(1.42)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C422(0.56); C979(0.74); C790(0.88); C188(0.91)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C315(1.00); C660(1.36); C280(1.42)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C280(1.00); C315(1.07); C660(1.16)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C660(1.18); C315(1.19); C280(1.20)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C280(0.97); C315(1.16); C660(1.55)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C280(1.03); C315(1.15); C660(1.46)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C422(0.82); C835(0.92); C315(1.04)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C315(1.02); C835(1.13); C422(1.16)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C835(1.00); C315(1.02); C422(1.56)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C315(1.03); C422(1.15); C835(1.40)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C422(0.82); C315(0.94); C835(1.44)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C422(0.47); C979(0.67); C188(0.69); C660(0.87)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C315(0.93); C835(1.11); C422(1.36)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C835(0.96); C315(1.03); C422(1.10)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C835(0.84); C422(1.04); C315(1.09)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C315(1.12); C835(1.14); C422(1.23)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C835(0.90); C315(1.06); C422(1.19)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C315(1.24); C422(1.51); C835(1.58)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C790(0.91); C792(0.91); C979(1.17)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C790(1.00); C792(1.00); C979(1.15)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C790(0.87); C792(0.87); C979(0.99)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C979(1.10); C790(3.48); C792(3.48)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C422(0.49); C979(0.63); C188(0.70); C660(0.81)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C979(0.89); C790(1.58); C792(1.58)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C790(0.84); C792(0.84); C979(0.88)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C979(0.92); C790(1.37); C792(1.37)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C790(1.18); C792(1.18); C979(1.27)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C979(0.83); C790(1.27); C792(1.27)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C979(1.29); C790(1.61); C792(1.61)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C979(1.12); C790(2.06); C792(2.06)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C315(0.76); C660(0.89); C164(0.89); C280(0.89)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C315(0.71); C280(0.86); C164(0.86); C660(0.87)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C315(0.86); C790(0.92); C792(0.92); C835(1.00)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C824(1.00); C422(1.03); C315(1.05); C835(1.22)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C835(0.84); C280(1.11); C164(1.17); C660(1.21)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C315(0.65); C164(0.81); C660(0.88); C280(0.90)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C660(0.84); C315(0.88); C164(0.90); C280(0.98)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C315(0.80); C164(1.00); C280(1.06); C835(1.15)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C835(0.95); C280(1.05); C660(1.06); C315(1.07)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C790(0.24); C792(0.24); C315(0.82); C660(0.92)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C790(0.21); C792(0.21); C315(0.69); C164(0.77)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C790(0.28); C792(0.28); C315(0.92); C164(0.93)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C315(0.72); C790(0.95); C792(0.95); C835(1.38)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C315(0.76); C790(0.90); C792(0.90); C835(1.39)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C835(0.70); C422(0.91); C824(1.18); C315(1.23)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C315(1.08); C835(1.53); C790(4.61); C792(4.61)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C790(0.69); C792(0.69); C315(0.73); C835(1.07)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C315(0.92); C790(1.05); C792(1.05); C835(1.65)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C315(0.92); C790(1.33); C792(1.33); C835(1.97)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C315(0.77); C790(1.07); C792(1.07); C835(1.56)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C315(0.85); C790(1.63); C792(1.63); C835(2.33)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C315(0.78); C790(1.04); C792(1.04); C835(1.46)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C315(0.63); C790(0.98); C792(0.98); C835(1.39)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C315(0.63); C790(0.89); C792(0.89); C835(1.54)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C315(0.76); C790(0.76); C792(0.76); C835(1.45)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C315(0.83); C422(0.86); C824(0.90); C835(1.21)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C315(0.84); C790(1.09); C792(1.09); C835(1.25)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C790(0.76); C792(0.76); C315(0.77); C835(1.20)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C315(0.78); C790(1.37); C792(1.37); C835(1.49)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C188(1.10); C979(1.25); C824(1.29); C280(1.34)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C188(0.95); C824(1.04); C979(1.17); C280(1.35)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C824(0.81); C188(0.92); C979(1.04); C790(1.08)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C824(0.75); C188(0.90); C979(1.02); C835(1.07)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C824(0.66); C188(0.86); C280(0.96); C979(0.97)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C824(0.74); C979(1.01); C188(1.05); C280(1.09)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C824(0.87); C188(0.94); C979(1.18); C280(1.23)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C280(0.88); C835(1.02); C824(1.05); C188(1.17)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C188(0.71); C824(0.88); C979(1.08); C835(1.40)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C824(0.79); C188(0.91); C979(1.13); C835(1.25)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C824(0.81); C188(0.83); C280(1.01); C979(1.11)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C824(0.45); C188(0.58); C979(0.78); C280(1.15)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C824(0.68); C188(0.96); C280(1.19); C979(1.20)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C824(0.44); C188(0.60); C979(0.71); C280(1.43)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C824(1.05); C188(1.11); C979(1.28); C280(1.29)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C164(0.88); C660(1.11); C835(1.20); C979(1.26)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C790(0.74); C792(0.74); C835(0.82); C164(0.86)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C315(0.41)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C315(0.68); C422(0.70); C824(0.34); C835(0.77)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C315(0.62); C422(0.69); C824(0.85); C835(1.16)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C824(0.29); C315(0.52); C422(0.63); C835(1.94)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C315(1.35); C790(1.13); C792(1.13); C660(0.96)  LDD0078  [6]
 LDCM0087  Capsaicin HEK-293T 13.04  LDD0185  [1]
 LDCM0632  CL-Sc Hep-G2 C422(0.33)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C824(0.76); C315(0.77); C660(0.77); C979(0.79)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C824(0.36); C315(0.49); C979(0.51); C660(0.65)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C422(0.59); C979(0.69); C188(0.94); C790(0.97)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C315(0.64); C422(0.82); C824(0.91); C835(1.39)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C315(0.62); C422(0.70); C824(0.75); C835(1.28)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C422(0.73); C824(0.74); C315(0.76); C835(1.28)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C315(0.51); C824(0.54); C422(0.80); C835(1.46)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C835(0.33); C979(0.54); C790(0.57); C792(0.57)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C835(0.25); C824(0.49); C188(0.51); C979(0.54)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C835(0.32); C824(0.49); C979(0.52); C790(0.57)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C835(0.33); C979(0.41); C824(0.52); C188(0.61)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C835(0.31); C824(0.45); C979(0.52); C188(0.66)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C824(0.35); C315(0.46); C979(0.46); C660(0.67)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C835(0.24); C979(0.35); C824(0.40); C188(0.57)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C835(0.23); C824(0.47); C979(0.48); C790(0.59)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C315(0.90); C280(0.92); C660(0.96)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C315(1.11); C280(1.12); C660(1.18)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C315(1.02); C280(1.06); C660(1.37)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C315(1.10); C280(1.14); C660(1.54)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C280(0.96); C315(1.04); C660(1.55)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C835(0.72); C422(1.09); C315(1.19)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C422(0.67); C835(0.92); C315(0.94)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C422(0.64); C835(1.07); C315(1.09)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C824(0.32); C979(0.47); C315(0.53); C660(0.55)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C422(0.87); C835(1.07); C315(1.11)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C979(1.09); C790(1.58); C792(1.58)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C790(0.82); C792(0.82); C979(1.03)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C790(0.94); C792(0.94); C979(0.97)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C979(0.97); C790(1.25); C792(1.25)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C164(0.84); C790(0.85); C792(0.85); C835(0.97)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C790(0.76); C792(0.76); C660(0.77); C164(0.77)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C164(0.82); C660(0.90); C790(0.90); C792(0.90)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C660(0.84); C164(0.85); C315(0.94); C280(0.96)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C824(0.35); C315(0.47); C979(0.57); C280(0.82)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C824(0.35); C315(0.48); C979(0.72); C835(0.87)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C824(0.29); C315(0.45); C835(0.67); C280(0.72)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C824(0.67); C422(0.78); C835(0.91); C660(1.02)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C790(0.61); C792(0.61); C422(0.73); C824(0.90)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C824(0.51); C422(0.70); C315(0.91); C790(0.93)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C824(0.58); C422(0.73); C790(0.84); C792(0.84)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C660(0.67); C979(0.83); C164(0.87); C280(0.92)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C824(0.39); C422(0.48); C790(0.74); C792(0.74)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C824(0.38); C422(0.47); C790(0.62); C792(0.62)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C824(0.25); C422(0.34); C790(0.52); C792(0.52)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C824(0.34); C422(0.47); C835(0.81); C315(0.91)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C824(0.27); C422(0.33); C790(0.65); C792(0.65)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C790(0.75); C792(0.75); C164(1.00); C315(1.06)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C790(0.93); C792(0.93); C164(1.17); C315(1.03)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C790(0.67); C792(0.67); C164(0.95); C315(0.96)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C790(0.77); C792(0.77); C164(0.99); C315(1.18)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C790(0.75); C792(0.75); C164(1.08); C315(1.11)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C790(1.04); C792(1.04); C164(1.01); C280(0.95)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C790(0.72); C792(0.72); C164(0.99); C315(1.23)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C280(0.87); C315(1.07); C422(0.87); C660(0.91)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C790(1.06); C792(1.06); C188(0.88); C280(1.12)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C790(1.04); C792(1.04); C188(0.99); C280(1.06)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C790(0.77); C792(0.77); C188(0.79); C280(1.09)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C790(0.83); C792(0.83); C188(0.78); C280(1.14)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C790(0.70); C792(0.70); C188(0.79); C280(0.94)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C790(0.67); C792(0.67); C188(0.72); C280(1.05)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C790(0.97); C792(0.97); C188(1.08); C280(1.09)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C790(1.04); C792(1.04); C164(0.78); C280(0.95)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C790(1.03); C792(1.03); C188(0.89); C280(1.12)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C790(0.92); C792(0.92); C188(1.09); C280(1.05)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C790(0.68); C792(0.68); C188(0.98); C280(0.93)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C790(1.00); C792(1.00); C188(0.82); C280(1.03)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C790(0.69); C792(0.69); C188(0.79); C280(1.01)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C790(0.67); C792(0.67); C188(0.82); C280(1.05)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C164(1.02); C280(0.78); C315(1.05); C660(0.96)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C164(0.85); C280(0.64); C315(0.99); C660(0.91)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C164(0.86); C280(0.67); C315(0.89); C660(0.77)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C164(0.83); C280(0.90); C315(0.98); C660(0.86)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C790(1.00); C792(1.00); C164(0.93); C280(0.91)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C164(0.86); C280(0.75); C315(0.91); C660(0.90)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C164(0.88); C280(0.84); C315(1.02); C660(0.80)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C164(1.14); C280(0.93); C315(0.94); C660(0.91)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C164(0.99); C280(0.78); C315(0.75); C660(0.89)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C164(0.98); C280(0.80); C315(0.76); C660(1.01)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C164(0.76); C280(0.75); C315(0.90); C660(0.84)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C164(0.82); C280(1.06); C315(0.86); C660(0.80)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C164(0.74); C280(0.72); C315(0.94); C660(0.90)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C164(0.91); C280(0.89); C315(0.83); C660(0.86)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C164(0.79); C280(1.08); C315(0.88); C660(1.02)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C790(1.05); C792(1.05); C164(1.17); C280(0.94)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C164(0.85); C280(0.85); C315(0.91); C660(0.87)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C280(1.05); C315(0.68); C660(1.15); C824(0.65)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C280(0.93); C315(0.91); C660(1.17); C824(1.21)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C280(0.90); C315(0.69); C660(1.10); C824(0.79)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C280(1.02); C315(0.71); C660(1.42); C824(0.50)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C280(0.83); C315(0.49); C660(0.96); C824(0.45)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C280(0.92); C315(0.56); C660(1.43); C824(0.45)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C280(0.98); C315(0.51); C660(1.60); C824(0.42)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C280(0.81); C315(0.42); C660(1.46); C824(0.42)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C280(0.93); C315(0.48); C660(1.32); C824(0.47)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C790(1.11); C792(1.11); C164(1.08); C280(0.88)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C280(0.85); C315(0.50); C660(1.27); C824(0.37)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C280(0.89); C315(0.57); C660(1.53); C824(0.41)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C280(1.10); C315(0.51); C660(1.09); C824(0.37)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C280(0.92); C315(0.51); C660(1.38); C824(0.32)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C280(0.88); C315(0.52); C660(1.37); C824(0.38)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C790(0.67); C792(0.53); C164(0.76); C188(1.01)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C790(0.88); C792(0.64); C164(0.72); C188(0.85)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C790(0.78); C792(0.53); C164(0.85); C188(1.02)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C790(0.87); C792(0.76); C164(0.71); C188(0.97)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C790(1.19); C792(1.19); C164(1.19); C280(1.17)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C790(0.88); C792(0.63); C164(0.78); C188(1.04)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C790(0.81); C792(0.43); C164(0.70); C188(0.85)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C790(0.63); C792(0.39); C164(0.70); C188(0.79)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C790(0.68); C792(0.53); C164(0.72); C188(1.03)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C790(0.69); C792(0.56); C164(0.71); C188(1.42)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C790(0.71); C792(0.61); C164(0.74); C188(1.03)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C790(0.76); C792(0.43); C164(0.75); C188(0.87)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C790(0.76); C792(0.53); C164(0.75); C188(0.90)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C790(0.76); C792(0.49); C164(0.72); C188(0.96)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C790(1.07); C792(0.64); C164(0.65); C188(1.10)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C790(0.99); C792(0.99); C164(0.92); C280(0.89)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C790(0.75); C792(0.47); C164(0.70); C188(0.91)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C790(0.75); C164(0.83); C188(0.92); C315(0.99)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C790(0.80); C164(0.84); C188(0.89); C315(0.69)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C790(0.74); C164(0.91); C188(0.64); C315(0.95)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C790(0.70); C164(1.15); C188(0.92); C315(0.85)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C790(0.66); C164(0.94); C188(1.35); C315(0.92)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C790(0.86); C164(0.98); C188(0.78); C315(0.97)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C790(0.93); C164(1.07); C188(0.83); C315(1.01)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C790(0.76); C164(1.04); C188(0.90); C315(0.95)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C790(0.69); C164(0.97); C188(0.81); C315(1.04)  LDD0811  [6]
 LDCM0028  Dobutamine HEK-293T 15.46  LDD0180  [1]
 LDCM0027  Dopamine HEK-293T 14.98  LDD0179  [1]
 LDCM0495  E2913 HEK-293T C280(0.95); C235(0.94); C660(1.16); C315(1.16)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C422(2.12); C824(1.28); C280(1.20); C315(0.35)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C280(0.98); C315(0.49); C660(1.63); C824(0.34)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C790(0.89); C792(0.89); C188(1.01); C280(0.99)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C790(5.45); C792(5.45); C315(2.12); C660(2.84)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C790(2.50); C792(2.50); C315(1.30); C660(1.38)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C790(3.92); C792(3.92); C315(2.67); C660(2.55)  LDD0082  [6]
 LDCM0030  Luteolin HEK-293T 8.27  LDD0182  [1]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C315(0.40)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C315(1.10)  LDD2090  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C824(0.70)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C315(1.00)  LDD2096  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C315(0.92)  LDD2099  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C315(1.38)  LDD2109  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C315(0.97); C422(0.67)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C315(1.63)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C315(1.06)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C422(0.71)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C422(1.16)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C315(1.03); C422(0.99)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C315(1.06)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C315(1.49); C422(2.51)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C315(1.31)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C315(0.86)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C315(0.61)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C315(0.60)  LDD2141  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C315(1.04)  LDD2146  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C315(0.33)  LDD2150  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C315(2.01)  LDD2153  [3]
 LDCM0029  Quercetin HEK-293T 9.96  LDD0181  [1]
 LDCM0021  THZ1 HCT 116 C280(1.17); C979(1.00); C790(1.01); C792(1.01)  LDD2173  [6]

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402