Details of the Target

General Information of Target

Target ID LDTP09702
Target Name Nesprin-2 (SYNE2)
Gene Name SYNE2
Gene ID 23224
Synonyms
KIAA1011; NUA; Nesprin-2; KASH domain-containing protein 2; KASH2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; Protein NUANCE; Synaptic nuclear envelope protein 2; Syne-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASSPELPTEDEQGSWGIDDLHISLQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTD
IKKGHVLLDLLEVLSGQQLPRDKGSNTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGN
PSIILGLIWTIILHFHIEKLAQTLSCNYNQPSLDDVSVVDSSPASSPPAKKCSKVQARWQ
MSARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKD
NLREAFRIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGTGEEAQGKVK
DAMGWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEEKKSFLDVLSIKRDLDELD
KDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWLQEVEELMDEDLSASQDHSQAV
TLIQEKMTLFKSLMDRFEHHSNILLTFENKDENHLPLVPPNKLEEMKRRINNILEKKFIL
LLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESVELLLEDWHKFIEEKEFLARLDTSFQ
KCGEIYKNLAGECQNINKQYMMVKSDVCMYRKNIYNVKSTLQKVLACWATYVENLRLLRA
CFEETKKEEIKEVPFETLAQWNLEHATLNEAGNFLVEVSNDVVGSSISKELRRLNKRWRK
LVSKTQLEMNLPLMIKKQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQNIKAGE
KHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEESLKHLIAKGSMF
DELMARSEDMLQMDIQNISSQESFQHVLTTGLQAKIQEAKEKVQINVVKLIAALKNLTDV
SPDLDIRLKMEESQKELESYMMRAQQLLGQRESPGELISKHKEALIISNTKSLAKYLKAV
EELKNNVTEDIKMSLEEKSRDVCAKWESLHHELSLYVQQLKIDIEKGKLSDNILKLEKQI
NKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPSQKSQQEVKRLLK
DYEQKIERLLKCASEIHMTLQPTAGGTSKNEGTITTSENRGGDPHSEAPFAKSDNQPSTE
KAMEPTMKFSLASVLRPLQEESIMEKDYSASINSLLERYDTYRDILEHHLQNNKFRITSD
FSSEEDRSSSCLQAKLTDLQVIKNETDARWKEFEIISLKLENHVNDIKKPFVIKERDTLK
ERERELQMTLNTRMESLETALRLVLPVEKASLLLCGSDLPLHKMAIQGFHLIDADRIYQH
LRNIQDSIAKQIEICNRLEEPGNFVLKELHPFDLHAMQNIILKYKTQFEGMNHRVQRSED
TLKALEDFLASLRTAKLSAEPVTDLSASDTQVAQENTLTVKNKEGEIHLMKDKAKHLDKC
LKMLDMSFKDAERGDDTSCENLLDAFSIKLSETHGYGVQEEFTEENKLLEACIFKNNELL
KNIQDVQSQISKIGLKDPTVPAVKHRKKSLIRLDKVLDEYEEEKRHLQEMANSLPHFKDG
REKTVNQQCQNTVVLWENTKALVTECLEQCGRVLELLKQYQNFKSILTTLIQKEESVISL
QASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKTFEEPPFEKEA
NIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQLTEEDRE
RLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNKMEHVQKCLTGESNC
HALSGSTAELREDLDQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQKHSMILL
ENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKLLNDQCKNFNDWFSNIKVNLKE
CFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHVKELISWLVGQ
EFELEKMESICQARAKELEDSLQQLLRLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFC
QALARKREQFESVAQLNNSLKEYGFTEEEEIIMEATCLMDRYQTLLRQLSEIEEEDKLLP
TEDQSFNDLAHDVIHWIKEIKESLMVLNSSEGKMPLEERIQKIKEIILLKPEGDARIETI
MKQAESSEAPLVQKTLTDISNQWDNTLHLASTYLSHQEKLLLEGEKYLQSKEDLRLMLIE
LKKKQEAGFALQHGLQEKKAQLKIYKKFLKKAQDLTSLLKELKSQGNYLLECTKNPSFSE
EPWLEIKHLHESLLQQLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNFSKEFVSFSDKPV
DQIAVEEKLQKLQELENRLSLQDGTLKKILALAKSVKQNTSSVGQKIIKDDIKSLQCKQK
DLENRLASAKQEMECCLNSILKSKRSTEKKGKFTLPGREKQATSDVQESTQESAAVEKLE
EDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQLEEIEK
LYTQLEAKKAAIKPLEQTECLNKTETGALVLHNIGYSAQHLDNLLQALITLKKNKESQYC
VLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKDSLGNLKIK
WENLSNHVTDMDKKLLESQIKQLEHGWEQVEQQIQKKYSQQVVEYDEFTTLMNKVQDTEI
SLQQQQQHLQLRLKSPEERAGNQSMIALTTDLQATKHGFSVLKGQAELQMKRIWGEKEKK
NLEDGINNLKKQWETLEPLHLEAENQIKKCDIRNKMKETILWAKNLLGELNPSIPLLPDD
ILSQIRKCKVTHDGILARQQSVESLAEEVKDKVPSLTTYEGSDLNNTLEDLRNQYQMLVL
KSTQRSQQLEFKLEERSNFFAIIRKFQLMVQESETLIIPRVETAATEAELKHHHVTLEAS
QKELQEIDSGISTHLQELTNIYEELNVFERLFLEDQLKNLKIRTNRIQRFIQNTCNEVEH
KIKFCRQFHEKTSALQEEADSIQRNELLLNQEVNKGVKEEIYNLKDRLTAIKCCILQVLK
LKKVFDYIGLNWDFSQLDQLQTQVFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDL
QIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKEI
LQIKLNAEENDKLYKVLQNMVLELSPKELDEKNCQDKLETSLHVLNQIKSQLQQPLLINL
EIKHIQNEKDNCEAFQEQVWAEMCSIKAVTAIEKQREENSSEASDVETKLREFEDLQMQL
NTSIDLRTNVLNDAYENLTRYKEAVTRAVESITSLEAIIIPYRVDVGNPEESLEMPLRKQ
EELESTVAHIQDLTEKLGMISSPEAKLQLQYTLQELVSKNSAMKEAFKAQETEAERYLEN
YKCYRKMEEDIYTNLSKMETVLGQSMSSLPLSYREALERLEQSKALVSNLISTKEELMKL
RQILRLLRLRCTENDGICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQEWKFVSEEIER
EAIILDNLQEELPEISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRIRSIQN
VPESSGAVETVPAFQEITSMKERCNKLLQKVQKNKELVQTEIQERHSFTKEIIALKNFFQ
QTTTSFQNMAFQDHPEKSEQFEELQSILKKGKLTFENIMEKLRIKYSEMYTIVPAEIESQ
VEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKSKNIEKAQEIQ
KKMWDELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQVSQRAECRTSQL
NKATVKMEEYSDLLKSTEAWIENTSHLLANPADYDSLRTLSHHASTVQMALEDSEQKHNL
LHSIFMDLEDLSIIFETDELTQSIQELSNQVTALQQKIMESLPQIQRMADDVVAIESEVK
SMEKRVSKIKTILLSKEIFDFSPEEHLKHGEVILENIRPMKKTIAEIVSYQVELRLPQTG
MKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVIKQTNEWDEEIENLKQILNNYSAQFS
LEHMSPDQADKLPQLQGEIERMEKQILSLNQRKEDLLVDLKATVLNLHQHLKQEQEGVER
DRLPAVTSEEGGVAERDASERKLNRRGSMSYLAAVEEEVEESSVKSDNGDEKAEPSPQSW
SSLWKHDKDMEEDRASSSSGTIVQEAYGKISTSDNSMAQILTPDSLNTEQGPECSLRPNQ
TEEGTTPPIEADTLDSSDAQGGLEPRVEKTRPEPTEVLHACKTQVAELELWLQQANVAVE
PETLNADMQQVLEQQLVGCQAMLTEIEHKVAFLLETCKDQGLGDNGATQHEAEALSLKLK
TVKCNLEKVQMMLQEKHSEDQHPTILKKSSEPEHQEALQPVNLSELESIVTERPQFSRQK
DFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDNDTTQESSASNQASSPENDVPDS
ILSPQGQNGDKWQYLHHELSSKIKLPLPQLVEPQVSTNMGILPSVTMYNFRYPTTEELKT
YTTQLEDLRQEASNLQTQENMTEEAYINLDKKLFELFLTLSQCLSSVEEMLEMPRLYRED
GSGQQVHYETLALELKKLYLALSDKKGDLLKAMTWPGENTNLLLECFDNLQVCLEHTQAA
AVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQSLNEISGQSVAEQLQKADAYTV
ELENAESRVAKLRDEGERLHLPYALLQEVYKLEDVLDSMWGMLRARYTELSSPFVTESQQ
DALLQGMVELVKIGKEKLAHGHLKQTKSKVALQAQIENHKVFFQKLVADMLLIQAYSAKI
LPSLLQNRETFWAEQVTEVKILEEKSRQCGMKLQSLLQKWEEFDENYASLEKDLEILIST
LPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPELEGQIAK
LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKEQSLNVSQD
LDTIRSNINNFFEFSKEVDEKSSLKTAVISIGNQLLHLKETDTATLRASLAQFEQKWTML
ITQLPDIQEKLHQLQMEKLPSRKAITEMISWMNNVEHQTSDEDSVHSPSSASQVKHLLQK
HKEFRMEMDYKQWIVDFVNQSLLQLSTCDVESKRYERTEFAEHLGEMNRQWHRVHGMLNR
KIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKPESVISVQKLLLDCQDIENQLA
IKSKALDELKQSYLTLESGAVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWK
IYDQLYDEVNMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDEAESSEGSWEKLQEV
IGKLKGLCPSVAEIIEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAHGEAAAR
LKQQEAKFQQLANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLDRLPQPA
ESSTHMLLPGPLHSLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEENL
DRLHQQEKENPDSFLNHVLALTAQSPDIEHLNEVSLKLPLSDVAVKTLQNMNRQWIRATA
TALERCSELQGIGLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPELLEQQKTYKMLEAE
VSINQTIADSYVTQSLQLLDTTEIENRPEFITEFSKLTDRWQNAVQGVRQRKGDVDGLVR
QWQDFTTSVENLFRFLTDTSHLLSAVKGQERFSLYQTRSLIHELKNKEIHFQRRRTTCAL
TLEAGEKLLLTTDLKTKESVGRRISQLQDSWKDMEPQLAEMIKQFQSTVETWDQCEKKIK
ELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLASWTQNLKELQTMKADLTRHVL
VEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEKNKELCAWLVQMENKV
LQTADISIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASNKSRAAEIDDKLNKIN
DRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELSKPVVYDVCDDQEIQ
KRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTTRSLDRRWRNI
CAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAKEELKRFE
AFQRQIHERLTQLELINKQYRRLARENRTDTASRLKQMVHEGNQRWDNLQRRVTAVLRRL
RHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSESDADDKMRQLNGFQQEITLNTNKI
DQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEA
SENETDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGCETPVSVDSIPLEWD
HTGDVGGSSSHEEDEEGPYYSALSGKSISDGHSWHVPDSPSCPEHHYKQMEGDRNVPPVP
PASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQSGAFDRWEMIQA
QELHNKLKIKQNLQQLNSDISAITTWLKKTEAELEMLKMAKPPSDIQEIELRVKRLQEIL
KAFDTYKALVVSVNVSSKEFLQTESPESTELQSRLRQLSLLWEAAQGAVDSWRGGLRQSL
MQCQDFHQLSQNLLLWLASAKNRRQKAHVTDPKADPRALLECRRELMQLEKELVERQPQV
DMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSF
DEVDSGDQPPATSVPAPRAKQFRAVRTTEGEEETESRVPGSTRPQRSFLSRVVRAALPLQ
LLLLLLLLLACLLPSSEEDYSCTQANNFARSFYPMLRYTNGPPPT
Target Bioclass
Other
Family
Nesprin family
Subcellular location
Nucleus outer membrane; Cell junction, focal adhesion
Function
Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2.
Uniprot ID
Q8WXH0
Ensemble ID
ENST00000341472.9
HGNC ID
HGNC:17084

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		23.42  LDD0348  [2]
HRP
 Probe Info  		21.98  LDD0347  [2]
TH211
 Probe Info  		Y5390(11.45)  LDD0260  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
OPA-S-S-alkyne
 Probe Info  		K1618(1.41)  LDD3494  [5]
Probe 1
 Probe Info  		Y1480(28.22); Y1638(13.28); Y3361(9.99); Y4678(5.01)  LDD3495  [6]
BTD
 Probe Info  		C2480(0.51)  LDD2089  [7]
DA-P3
 Probe Info  		27.21  LDD0185  [2]
AHL-Pu-1
 Probe Info  		C553(2.06); C3513(2.50); C2480(2.24)  LDD0168  [8]
DBIA
 Probe Info  		C90(198.84); C1844(21.06); C2520(39.68)  LDD0209  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C39(0.00); C2935(0.00); C1432(0.00); C5212(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C601(0.00); C39(0.00); C1235(0.00); C1032(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C2480(0.00); C601(0.00); C1235(0.00); C5586(0.00)  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		C553(0.00); C2994(0.00); C90(0.00); C2480(0.00)  LDD0005  [13]
NHS
 Probe Info  		N.A.  LDD0010  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
VSF
 Probe Info  		C2993(0.00); C5359(0.00); C553(0.00); C2480(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		C1380(0.00); C6161(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		C6739(0.00); C2257(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		8.40  LDD0443  [16]
NAIA_5
 Probe Info  		C1235(0.00); C5359(0.00); C5930(0.00); C3564(0.00)  LDD2223  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C2480(0.89)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1844(1.05)  LDD2117  [7]
 LDCM0025  4SU-RNA HEK-293T C553(2.06); C3513(2.50); C2480(2.24)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C5930(3.21); C553(2.05)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C90(0.97); C6739(0.93); C568(0.97); C1931(0.94)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C90(1.01); C6739(0.97); C568(1.02); C1931(1.07)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C90(1.02); C6739(0.99); C568(0.99); C1931(1.09)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C90(0.99); C6739(0.97); C568(0.99); C1861(1.02)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C90(1.05); C6739(1.20); C568(0.94); C1931(1.04)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C90(0.96); C6739(1.16); C568(1.00); C1931(1.01)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C90(0.99); C6739(0.94); C568(1.03); C1931(0.92)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C90(1.02); C6739(0.91); C568(1.09); C1931(0.97)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C90(0.97); C6739(0.91); C568(1.01); C1931(0.91)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C90(0.99); C6739(0.94); C568(1.01); C1931(0.94)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C90(1.01); C6739(1.24); C568(1.04); C1861(1.04)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C90(0.94); C6739(0.98); C568(1.02); C1931(0.95)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C90(0.92); C6739(1.00); C568(0.98); C1931(1.01)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C90(0.98); C6739(0.99); C568(0.97); C1931(0.97)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C90(0.94); C6739(1.03); C568(1.02); C1931(1.00)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C90(0.98); C6739(0.95); C568(1.06); C1931(0.96)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C90(1.06); C6739(0.98); C568(0.99); C1931(1.06)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C90(1.01); C6739(1.07); C568(0.98); C1931(0.90)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C90(0.99); C6739(0.93); C568(1.03); C1861(1.09)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C90(0.97); C6739(1.00); C568(1.04); C1931(0.98)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C90(1.03); C6739(1.02); C568(0.94); C1931(0.99)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C90(0.99); C6739(0.88); C568(0.90); C1931(1.00)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C90(0.93); C6739(1.01); C568(0.97); C1931(1.01)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C90(0.99); C6739(1.02); C568(1.05); C1931(1.00)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C90(1.02); C6739(0.96); C568(1.10); C1931(1.04)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C90(0.96); C6739(1.02); C568(0.99); C1931(0.94)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C90(0.95); C6739(1.06); C568(0.98); C1931(1.00)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C90(1.07); C6739(1.01); C568(0.93); C1861(0.82)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C90(1.02); C6739(0.95); C568(1.01); C1931(0.90)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C90(0.96); C6739(1.00); C568(0.94); C1931(1.11)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C90(0.99); C6739(1.15); C568(0.98); C1931(1.05)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C90(1.05); C6739(0.96); C568(0.95); C1861(0.87)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C90(0.99); C6739(0.95); C568(1.10); C1931(1.05)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C90(0.96); C6739(1.07); C568(1.06); C1931(1.00)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C90(1.02); C6739(0.90); C568(1.04); C1931(0.91)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C90(1.07); C6739(0.96); C568(1.02); C1931(1.12)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C90(0.94); C6739(1.04); C568(0.96); C1861(0.88)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C90(1.05); C6739(0.95); C568(0.96); C1931(0.94)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C90(1.04); C6739(0.88); C568(1.03); C1931(0.96)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C90(0.97); C6739(1.19); C568(1.00); C1931(0.85)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C90(1.03); C6739(1.03); C568(1.10); C1931(0.97)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C90(0.94); C6739(1.11); C568(1.04); C1931(0.99)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C90(1.03); C6739(0.97); C568(0.97); C1931(0.94)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C90(0.98); C6739(1.01); C568(1.06); C1931(0.95)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C90(1.02); C6739(0.94); C568(0.95); C1931(0.96)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C90(0.98); C6739(1.01); C568(0.98); C1861(0.91)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C90(1.00); C6739(1.03); C568(1.01); C1931(0.94)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C90(0.96); C6739(1.09); C568(0.92); C1931(0.99)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C90(0.96); C6739(1.19); C568(0.98); C1931(0.98)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C90(0.98); C6739(0.94); C568(1.04); C1931(0.99)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C90(1.00); C6739(1.00); C568(1.01); C1931(0.90)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C90(0.99); C6739(0.99); C568(1.02); C1931(1.02)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C90(1.01); C6739(0.90); C568(0.97); C1931(0.94)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C90(1.00); C6739(1.03); C568(0.93); C1931(1.07)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C90(1.01); C6739(1.08); C568(1.00); C1861(1.00)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C90(1.05); C6739(1.01); C568(1.05); C1931(0.94)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C90(0.98); C6739(1.11); C568(0.96); C1931(1.05)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C90(0.97); C6739(1.00); C568(1.07); C1931(1.02)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C90(1.00); C6739(0.96); C568(1.06); C1931(0.98)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C90(1.02); C6739(1.12); C568(0.96); C1931(1.02)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C90(1.02); C6739(0.96); C568(1.05); C1931(0.96)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C90(1.07); C6739(0.99); C568(1.01); C1931(0.96)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C90(1.03); C6739(0.97); C568(1.02); C1931(1.03)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C90(1.05); C6739(1.00); C568(1.04); C1931(0.96)  LDD1514  [18]
 LDCM0087  Capsaicin HEK-293T 27.21  LDD0185  [2]
 LDCM0108  Chloroacetamide HeLa C5212(0.00); C2257(0.00); C6702(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C1151(20.00); C39(2.56); C1980(1.50); C2935(1.11)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C90(1.02); C568(1.37); C1931(1.04); C1861(1.01)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C90(1.04); C6739(0.85); C568(3.05); C1931(0.79)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C90(0.90); C6739(1.00); C568(1.22); C1931(0.97)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C90(1.02); C568(1.09); C1931(0.97); C1861(1.10)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C90(1.02); C6739(0.91); C568(1.69); C1931(0.98)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C90(0.95); C6739(1.06); C568(1.12); C1931(1.00)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C90(0.92); C6739(1.02); C568(1.23); C1931(1.27)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C90(0.98); C568(1.16); C1931(0.98); C1861(0.96)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C90(1.01); C6739(0.93); C568(1.22); C1931(1.00)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C90(0.98); C6739(0.98); C568(0.95); C1931(1.00)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C90(0.89); C6739(1.06); C568(1.15); C1931(1.00)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C90(1.05); C568(1.24); C1931(0.93); C1861(1.05)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C90(0.97); C6739(1.02); C568(1.58); C1931(1.04)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C90(0.97); C6739(0.87); C568(2.03); C1931(1.00)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C90(1.01); C6739(0.96); C568(1.54); C1931(1.00)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C90(0.92); C6739(0.98); C568(1.18); C1931(1.08)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C90(0.93); C568(0.96); C1931(1.02); C1861(0.96)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C90(0.98); C6739(0.91); C568(2.13); C1931(0.99)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C90(0.95); C6739(1.01); C568(1.03); C1931(1.04)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C90(0.86); C6739(1.09); C568(1.00); C1931(1.03)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C90(1.02); C568(0.98); C1931(0.97); C1861(0.97)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C90(1.02); C6739(1.02); C568(0.95); C1931(1.05)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C90(0.94); C6739(1.03); C568(0.99); C1931(1.12)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C90(1.08); C6739(0.97); C568(1.27); C1931(1.03)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C90(0.95); C6739(1.01); C568(1.08); C1931(1.08)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C90(1.00); C568(1.04); C1931(0.90); C1861(1.16)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C90(0.94); C6739(1.00); C568(1.25); C1931(0.99)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C90(0.93); C6739(0.93); C568(2.22); C1931(0.95)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C90(0.91); C6739(1.05); C568(1.38); C1931(1.20)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C90(1.02); C568(1.04); C1931(0.95); C1861(1.11)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C90(1.06); C6739(0.95); C568(1.21); C1931(0.95)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C90(0.98); C6739(1.05); C568(1.01); C1931(0.96)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C90(0.96); C6739(1.02); C568(1.00); C1931(0.85)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C90(0.98); C568(1.12); C1931(0.98); C1861(1.04)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C90(1.01); C6739(0.96); C568(0.96); C1931(1.06)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C90(0.97); C6739(0.97); C568(2.35); C1931(1.09)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C90(0.88); C6739(1.11); C568(1.02); C1931(1.04)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C90(0.95); C6739(0.97); C568(2.15); C1931(0.95)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C90(1.04); C6739(1.12); C568(1.05); C1931(1.04)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C90(1.05); C6739(1.07); C568(1.01); C1931(1.07)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C90(1.01); C6739(1.08); C568(0.97); C1931(1.04)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C90(1.21); C6739(1.04); C568(1.06); C1861(1.06)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C90(1.12); C6739(0.99); C568(2.32); C1931(0.94)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C90(1.07); C6739(1.29); C568(1.12); C1931(1.11)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C90(1.03); C6739(1.06); C568(1.12); C1931(1.04)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C90(1.03); C6739(1.04); C568(1.11); C1931(1.15)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C90(1.02); C568(1.47); C1931(0.94); C1861(1.17)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C90(0.97); C6739(1.01); C568(0.97); C1931(1.05)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C90(0.97); C6739(0.97); C568(1.04); C1931(1.06)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C90(0.96); C6739(1.01); C568(1.22); C1931(1.09)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C90(1.02); C6739(1.02); C568(1.08); C1931(1.12)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C90(0.94); C6739(1.05); C568(1.15); C1931(0.98)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C90(1.05); C6739(0.97); C568(0.99); C1931(1.03)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C90(1.03); C6739(1.14); C568(1.14); C1931(0.87)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C90(1.08); C6739(1.10); C568(1.16); C1861(1.16)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C90(1.13); C6739(0.94); C568(3.90); C1931(0.89)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C90(1.05); C6739(1.06); C568(1.58); C1931(1.04)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C90(1.09); C6739(1.05); C568(1.11); C1931(1.31)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C90(1.08); C6739(1.04); C568(1.45); C1931(1.05)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C90(1.00); C568(1.10); C1931(1.02); C1861(1.09)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C90(0.97); C6739(0.94); C568(1.46); C1931(0.97)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C90(0.93); C6739(1.07); C568(1.58); C1931(1.02)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C90(1.03); C6739(1.04); C568(1.01); C1931(1.14)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C90(0.98); C6739(0.90); C568(1.42); C1931(0.94)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C90(1.08); C6739(1.06); C568(1.02); C1931(1.04)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C90(1.07); C6739(1.17); C568(1.12); C1931(0.95)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C90(1.13); C6739(1.16); C568(1.13); C1861(1.15)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C90(1.09); C6739(1.00); C568(1.96); C1931(0.90)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C90(1.11); C6739(1.06); C568(1.19); C1931(1.01)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C90(1.07); C6739(1.00); C568(1.20); C1931(1.05)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C90(1.13); C6739(1.02); C568(1.22); C1931(1.13)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C90(1.03); C568(1.02); C1931(1.01); C1861(1.10)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C90(0.92); C6739(1.14); C568(0.97); C1931(0.96)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C90(1.07); C6739(0.97); C568(1.47); C1931(1.02)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C90(0.91); C6739(1.07); C568(1.08); C1931(1.05)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C90(0.97); C6739(1.01); C568(2.08); C1931(1.07)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C90(1.04); C6739(0.99); C568(2.78); C1931(0.96)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C90(1.03); C6739(1.36); C568(1.07); C1931(0.94)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C90(1.06); C6739(1.23); C568(1.08); C1861(0.99)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C90(1.02); C6739(0.88); C568(2.58); C1931(0.93)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C90(1.06); C6739(1.06); C568(1.85); C1931(1.00)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C90(1.08); C6739(1.17); C568(1.27); C1931(0.99)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C90(1.03); C6739(1.08); C568(2.40); C1931(1.07)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C90(1.11); C6739(1.03); C568(1.33); C1931(1.15)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C90(1.03); C568(0.95); C1931(0.91); C1861(0.98)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C90(1.10); C6739(1.01); C568(0.97); C1931(0.97)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C90(1.04); C6739(1.07); C568(0.99); C1931(1.19)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C90(0.91); C6739(0.96); C568(2.03); C1931(0.88)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C90(0.95); C6739(1.06); C568(0.98); C1931(0.97)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C90(1.06); C6739(1.02); C568(1.21); C1931(1.05)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C90(1.04); C6739(1.07); C568(1.01); C1931(1.20)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C90(1.02); C6739(1.11); C568(1.22); C1861(1.01)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C90(1.06); C6739(1.02); C568(1.68); C1931(1.06)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C90(1.11); C6739(0.96); C568(1.10); C1931(0.99)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C90(1.11); C6739(1.34); C568(1.05); C1931(1.04)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C90(1.04); C6739(1.16); C568(1.16); C1931(0.91)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C90(1.10); C6739(0.97); C568(1.08); C1931(1.11)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C90(1.03); C568(1.20); C1931(0.98); C1861(1.10)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C90(1.05); C6739(1.05); C568(0.88); C1931(1.01)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C90(0.97); C6739(1.08); C568(1.05); C1931(1.03)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C90(0.93); C6739(0.94); C568(1.71); C1931(0.88)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C90(1.00); C6739(1.01); C568(1.04); C1931(1.05)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C90(1.04); C6739(1.11); C568(1.05); C1931(1.00)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C90(1.34); C6739(0.72); C568(2.96); C1861(1.39)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C90(1.07); C6739(0.93); C568(1.02); C1861(1.25)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C90(1.10); C6739(1.10); C568(1.06); C1931(1.05)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C90(1.03); C6739(1.16); C568(1.05); C1931(1.04)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C90(1.00); C6739(1.08); C568(1.48); C1931(1.13)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C90(1.12); C6739(1.02); C568(1.63); C1931(1.06)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C90(1.05); C568(0.98); C1931(0.96); C1861(1.02)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C90(1.04); C6739(1.05); C568(1.07); C1931(1.07)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C90(0.94); C6739(0.98); C568(1.11); C1931(0.90)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C90(0.95); C6739(1.12); C568(1.03); C1931(1.17)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C90(1.01); C6739(1.11); C568(1.08); C1931(0.88)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C90(1.07); C6739(1.06); C568(1.34); C1931(0.96)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C90(1.10); C6739(0.79); C568(3.45); C1931(0.78)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C90(1.08); C6739(1.18); C568(1.03); C1931(1.16)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C90(1.07); C6739(1.04); C568(1.59); C1861(0.80)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C90(1.03); C6739(0.97); C568(2.28); C1931(0.91)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C90(1.04); C6739(1.10); C568(1.15); C1931(1.16)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C90(1.06); C6739(1.03); C568(5.16); C1931(1.08)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C90(1.03); C6739(0.88); C568(1.58); C1931(1.01)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C90(0.95); C568(1.45); C1931(0.92); C1861(1.10)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C90(1.00); C6739(0.94); C568(1.28); C1931(1.04)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C90(0.94); C6739(1.01); C568(1.20); C1931(0.99)  LDD1697  [18]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C1032(9.88); C568(15.97)  LDD0513  [19]
 LDCM0495  E2913 HEK-293T C90(0.93); C6739(1.01); C568(1.22); C1931(0.89)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1151(3.24); C2480(3.21)  LDD1702  [7]
 LDCM0625  F8 Ramos C1151(1.19); C90(1.23); C553(0.58); C39(0.87)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C1151(1.39); C90(2.86); C1003(0.92); C39(2.26)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C1151(15.29); C90(0.82); C553(6.34); C39(0.02)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C1151(0.84); C90(4.90); C1003(1.06); C39(4.24)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C1151(1.03); C90(0.95); C1003(0.70); C39(0.91)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C1151(1.20); C39(2.45); C1235(1.77); C6161(0.83)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C1151(0.83)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C1151(1.01); C90(1.14); C1003(0.94); C553(0.97)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C1151(1.25); C90(1.12); C553(0.90); C39(0.82)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C1151(0.91); C90(0.85); C1003(1.00); C553(0.75)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C1151(0.66); C90(0.39); C1003(0.78); C553(0.70)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C1151(1.15); C90(1.17); C553(1.48); C39(0.82)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C1151(0.93); C90(1.33); C1003(1.03); C39(1.10)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C1151(1.44); C90(3.41); C1003(0.86); C39(3.78)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C90(0.93); C6739(1.01); C568(1.12); C1931(0.96)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C1151(0.87); C90(1.67); C1003(1.05); C39(1.08)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C1151(1.01); C90(1.93); C1003(0.62); C39(1.81)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C90(1.06); C6739(1.07); C568(0.99); C1931(1.09)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C1151(0.85); C90(1.57); C1003(1.39); C39(1.05)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C1151(1.44); C90(1.30); C553(0.69); C39(0.67)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C1151(1.16); C90(2.66); C39(2.30); C1235(1.15)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C1151(1.57); C90(1.31)  LDD2188  [20]
 LDCM0022  KB02 HEK-293T C6739(0.91); C568(0.59); C1931(0.87); C1861(0.85)  LDD1492  [18]
 LDCM0023  KB03 Jurkat C90(198.84); C1844(21.06); C2520(39.68)  LDD0209  [9]
 LDCM0024  KB05 COLO792 C1598(1.82)  LDD3310  [21]
 LDCM0109  NEM HeLa N.A.  LDD0230  [15]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C2480(0.51)  LDD2089  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C4324(1.16)  LDD2106  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2480(0.97)  LDD2109  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C4324(0.68)  LDD2114  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1598(1.64)  LDD2123  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1598(1.22)  LDD2127  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C4324(0.75)  LDD2129  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1598(1.42)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2480(0.79)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C4324(0.69)  LDD2141  [7]
 LDCM0170  Structure8 Ramos 20.00  LDD0433  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SUN domain-containing protein 1 (SUN1) . O94901
SUN domain-containing protein 2 (SUN2) . Q9UH99
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FH1/FH2 domain-containing protein 1 (FHOD1) Formin homology family Q9Y613
Prelamin-A/C (LMNA) Intermediate filament family P02545
DCC-interacting protein 13-alpha (APPL1) . Q9UKG1
Emerin (EMD) . P50402

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
22 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.