Details of the Target

General Information of Target

Target ID LDTP15840
Target Name Tetratricopeptide repeat protein 1 (TTC1)
Gene Name TTC1
Gene ID 7265
Synonyms
TPR1; Tetratricopeptide repeat protein 1; TPR repeat protein 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSVRGKAGKGLGKGGAKCHRKVLSDNIQGITKCTIRRLARHGGVKRILGLIYEETRRVFK
VFLENVIWYAVTNTEHAKRKTVTAMAVVYVLKRQGRTL
Target Bioclass
Other
Uniprot ID
Q99614
Ensemble ID
ENST00000231238.10
HGNC ID
HGNC:12391

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		6.15  LDD0348  [2]
HRP
 Probe Info  		4.78  LDD0347  [2]
TH211
 Probe Info  		Y280(12.40)  LDD0257  [3]
TH216
 Probe Info  		Y280(20.00)  LDD0259  [3]
Probe 1
 Probe Info  		Y139(11.21); Y188(4.30)  LDD3495  [4]
P12
 Probe Info  		9.38  LDD0202  [5]
BTD
 Probe Info  		C178(1.58)  LDD2099  [6]
AHL-Pu-1
 Probe Info  		C28(2.43)  LDD0168  [7]
HHS-482
 Probe Info  		Y188(1.08)  LDD0285  [8]
HHS-475
 Probe Info  		Y280(0.95)  LDD0264  [9]
HHS-465
 Probe Info  		Y188(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C62(0.99); C66(0.99); C149(0.92)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C8(0.00); C28(0.00); C146(0.00); C149(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C146(0.00); C149(0.00); C28(0.00); C8(0.00)  LDD0036  [14]
IPIAA_L
 Probe Info  		C178(0.00); C28(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C146(0.00); C149(0.00); C28(0.00); C178(0.00)  LDD0037  [14]
NAIA_5
 Probe Info  		C149(0.00); C8(0.00); C28(0.00)  LDD2224  [16]
WYneN
 Probe Info  		C149(0.00); C28(0.00)  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
DA-P3
 Probe Info  		N.A.  LDD0178  [2]
Compound 10
 Probe Info  		C28(0.00); C8(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		C28(0.00); C8(0.00)  LDD2213  [18]
ENE
 Probe Info  		C28(0.00); C149(0.00)  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		N.A.  LDD0010  [17]
SF
 Probe Info  		N.A.  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [20]
VSF
 Probe Info  		C28(0.00); C8(0.00); C149(0.00)  LDD0007  [17]
Phosphinate-6
 Probe Info  		C28(0.00); C149(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
1d-yne
 Probe Info  		N.A.  LDD0357  [22]
Acrolein
 Probe Info  		C28(0.00); C178(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		C28(0.00); C8(0.00)  LDD0218  [23]
W1
 Probe Info  		C28(0.00); C146(0.00)  LDD0236  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C228
 Probe Info  		15.78  LDD1901  [26]
FFF probe11
 Probe Info  		5.70  LDD0471  [27]
FFF probe2
 Probe Info  		5.29  LDD0463  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C178(1.03)  LDD2117  [6]
 LDCM0025  4SU-RNA HEK-293T C28(2.43)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C8(2.57); C28(3.03)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C149(0.84); C28(0.90); C62(1.19); C66(1.19)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C149(1.65); C28(1.39); C62(1.04); C66(1.04)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C149(1.15); C28(0.89); C62(1.05); C66(1.05)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C149(1.20); C28(0.92); C62(1.06); C66(1.06)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C149(1.14); C28(1.01); C62(0.90); C66(0.90)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C149(1.25); C28(1.05); C62(0.99); C66(0.99)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C149(1.01); C28(0.88); C62(0.96); C66(0.96)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C149(1.13); C28(1.01); C62(0.99); C66(0.99)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C149(1.25); C28(1.00); C62(1.19); C66(1.19)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C149(1.17); C28(0.89); C62(0.95); C66(0.95)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C149(1.20); C28(0.90); C62(1.67); C66(1.67)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C149(1.00); C28(0.98); C62(1.02); C66(1.02)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C149(1.76); C28(1.29); C62(1.06); C66(1.06)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C149(1.17); C28(1.09); C62(1.34); C66(1.34)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C149(1.33); C28(1.02); C62(1.25); C66(1.25)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C149(1.45); C28(1.10); C62(1.33); C66(1.33)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C149(0.97); C28(1.02); C62(0.82); C66(0.82)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C149(1.07); C28(1.01); C62(0.94); C66(0.94)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C149(1.15); C28(1.05); C62(1.27); C66(0.96)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C149(1.14); C28(0.94); C62(1.17); C66(1.05)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C149(1.02); C28(0.90); C62(1.13); C66(1.02)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C149(0.91); C28(0.89); C62(0.94); C66(0.94)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C149(1.02); C28(0.95); C62(1.07); C66(0.90)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C149(1.16); C28(1.11); C62(0.93); C66(0.93)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C149(1.20); C28(1.04); C62(1.04); C66(0.80)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C149(0.82); C28(0.74); C62(0.83); C66(0.72)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C149(0.82); C28(0.91); C62(1.07); C66(0.83)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C149(1.04); C28(0.87); C62(0.94); C66(0.76)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C149(0.97); C28(0.79); C62(0.95); C66(0.67)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C149(0.94); C28(0.76); C62(0.67); C66(0.63)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C149(0.78); C28(0.82); C62(1.08); C66(0.68)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C149(0.82); C28(0.79); C62(0.88); C66(0.88)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C149(0.84); C28(0.31); C62(0.96); C66(0.96)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C149(0.96); C28(0.33); C62(1.00); C66(1.00)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C149(1.08); C28(0.38); C62(1.18); C66(1.18)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C149(1.05); C28(0.41); C62(1.26); C66(1.26)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C149(1.26); C28(0.44); C62(1.50); C66(1.50)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C149(1.11); C28(0.39); C62(1.20); C66(1.20)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C149(1.20); C28(0.43); C62(1.26); C66(1.26)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C149(1.19); C28(0.45); C62(1.08); C66(1.08)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C149(1.32); C28(0.47); C62(1.38); C66(1.38)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C149(1.25); C28(0.40); C62(1.35); C66(1.35)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C149(1.57); C28(0.48); C62(1.31); C66(1.31)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C149(1.46); C28(0.51); C62(1.49); C66(1.49)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C149(1.42); C28(1.13); C62(1.14); C66(1.14)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C149(1.79); C28(0.54); C62(1.42); C66(1.42)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C149(1.78); C28(0.58); C62(1.75); C66(1.75)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C149(1.44); C28(0.41); C62(1.44); C66(1.44)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C149(0.89); C62(0.98); C66(0.98); C8(1.16)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C8(0.81); C66(1.01); C62(1.03); C149(1.04)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C8(0.74); C66(0.74); C62(0.77); C28(0.98)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C28(0.69); C62(0.83); C66(0.84); C8(0.95)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C62(0.83); C66(0.85); C28(0.88); C8(0.91)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C28(0.66); C62(0.70); C66(0.78); C8(0.81)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C28(0.55); C62(0.72); C66(0.75); C8(0.88)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C62(1.12); C66(1.12); C28(1.14); C149(1.48)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C62(0.76); C66(0.77); C8(0.93); C28(0.95)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C8(0.90); C149(1.00); C62(1.73); C66(1.76)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C62(0.73); C66(0.73); C28(0.94); C8(0.94)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C28(0.56); C8(0.70); C62(0.70); C66(0.76)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C149(0.98); C28(1.05); C62(0.92); C66(0.90)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C149(0.91); C28(1.18); C62(0.93); C66(0.95)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C149(0.91); C28(0.74); C62(0.86); C66(0.85)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C149(1.02); C28(1.27); C62(0.92); C66(0.89)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C28(0.69); C149(0.95); C8(1.04); C62(1.09)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C28(0.87); C149(1.00); C62(1.30); C66(1.30)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C28(0.78); C149(0.92); C8(1.07); C62(1.38)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C28(0.84); C62(1.06); C66(1.06); C149(1.33)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C28(0.72); C149(1.01); C8(1.14); C62(1.23)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C28(0.69); C149(0.87); C62(1.03); C66(1.03)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C28(0.84); C149(0.96); C62(1.05); C66(1.05)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C28(0.65); C62(0.98); C66(0.98); C8(1.00)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C28(0.57); C62(1.00); C66(1.00); C8(1.06)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C62(0.83); C66(0.83); C149(0.93); C28(1.02)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C149(1.10); C62(1.14); C66(1.14); C28(1.23)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C149(0.81); C62(1.13); C66(1.13); C28(1.42)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C149(1.05); C28(1.24); C62(1.83); C66(1.83)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C149(1.05); C62(1.35); C66(1.35); C28(1.49)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C28(0.85); C149(0.89); C62(1.13); C66(1.13)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C149(1.08); C62(1.23); C66(1.23); C28(1.40)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C149(0.95); C62(1.28); C66(1.28); C28(1.36)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C149(1.39); C62(1.48); C66(1.48); C28(2.09)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C62(1.09); C66(1.09); C149(1.09); C28(1.49)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C149(0.98); C62(1.08); C66(1.08); C28(1.42)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C28(0.70); C149(0.71); C62(0.95); C66(0.95)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C28(0.75); C62(1.06); C66(1.06); C149(1.07)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C149(0.68); C28(0.70); C62(0.93); C66(0.93)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C149(0.72); C62(0.76); C66(0.76); C28(0.86)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C149(0.80); C62(1.00); C66(1.00); C28(1.05)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C149(0.80); C28(0.95); C62(1.03); C66(1.03)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C149(0.71); C28(0.98); C62(1.25); C66(1.25)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C28(0.75); C62(0.95); C66(0.95); C149(1.00)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C28(0.83); C149(0.89); C62(0.91); C66(0.91)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C62(0.94); C66(0.94); C149(0.96); C28(0.96)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C149(0.91); C62(0.98); C66(0.98); C28(0.99)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C149(0.84); C62(1.17); C66(1.17); C28(1.22)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C62(1.07); C66(1.07); C149(1.29)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C62(0.92); C66(0.92); C149(1.11)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C62(0.86); C66(0.86); C149(1.15)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C149(1.25); C62(1.28); C66(1.28)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C149(0.88); C28(0.91); C62(1.11); C66(1.11)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C149(1.22); C62(1.27); C66(1.27)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C62(0.75); C66(0.75); C149(1.46)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C62(0.98); C66(0.98); C149(1.26)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C62(0.98); C66(0.98); C149(1.11)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C62(0.93); C66(0.93); C149(1.16)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C149(1.03); C62(1.45); C66(1.45)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C149(1.26); C62(1.95); C66(1.95)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C28(1.01); C149(1.09); C62(1.18); C66(1.18)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C149(0.89); C28(1.04); C62(1.49); C66(1.49)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C149(1.25); C28(1.31); C8(1.47); C62(1.56)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C62(1.10); C66(1.10); C28(1.33); C149(1.34)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C149(1.10); C28(1.25); C62(1.39); C66(1.39)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C28(1.05); C62(1.23); C66(1.23); C8(1.29)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C149(1.03); C28(1.18); C8(1.43); C62(1.80)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C149(0.90); C62(1.25); C66(1.25); C8(1.33)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C28(1.30); C149(1.40); C62(1.44); C66(1.44)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C8(0.97); C28(1.12); C149(1.31); C62(1.59)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C8(0.98); C28(1.01); C62(1.40); C66(1.40)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C8(1.05); C149(1.25); C28(1.41); C62(2.03)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C62(0.79); C66(0.79); C28(0.84); C8(0.85)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C28(0.67); C8(0.84); C62(0.89); C66(0.89)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C62(0.83); C66(0.83); C28(1.02); C149(1.44)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C28(0.78); C8(0.92); C149(1.10); C62(1.58)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C28(0.69); C62(0.81); C66(0.81); C8(0.90)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C28(0.85); C62(0.86); C66(0.86); C8(1.04)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C28(0.84); C149(1.09); C62(1.18); C66(1.18)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C8(0.91); C28(0.91); C149(1.02); C62(1.10)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C28(0.77); C149(1.03); C8(1.11); C62(2.36)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C62(0.92); C66(0.92); C28(0.93); C149(0.98)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C28(0.85); C8(0.88); C149(1.16); C62(1.32)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C28(0.94); C8(0.98); C62(1.01); C66(1.01)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C28(0.80); C62(0.92); C66(0.92); C8(1.00)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C28(0.95); C62(1.01); C66(1.01); C149(1.42)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C62(0.95); C66(0.95); C28(0.98); C149(1.09)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C28(0.66); C8(0.72); C62(0.87); C66(0.87)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C28(0.83); C149(1.03); C8(1.26); C62(1.63)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C62(0.91); C66(0.91); C28(1.20); C8(1.32)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C62(0.84); C66(0.84); C149(1.17); C28(1.18)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C8(0.97); C62(1.06); C66(1.06); C149(1.18)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C62(0.82); C66(0.82); C149(1.06); C8(1.11)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C62(0.76); C66(0.76); C8(1.03); C149(1.03)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C62(0.90); C66(0.90); C28(0.95); C149(0.97)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C149(0.90); C62(1.04); C66(1.04); C28(1.16)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C149(0.65); C8(1.01); C28(1.01); C62(1.02)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C28(1.18); C149(1.21); C62(1.26); C66(1.26)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C149(0.62); C8(1.35); C62(1.36); C66(1.36)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C149(0.77); C62(0.93); C66(0.93); C8(1.21)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C8(0.97); C149(1.02); C62(1.44); C66(1.44)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C62(0.88); C66(0.88); C8(0.95); C28(1.06)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C149(0.70); C8(1.12); C28(1.26); C62(1.29)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C149(1.14); C8(1.19); C28(1.34); C62(1.46)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C28(1.13); C149(1.24); C62(1.31); C66(1.31)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C8(1.00); C28(1.06); C62(1.16); C66(1.16)  LDD0683  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C178(0.76)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C149(1.35); C28(1.08); C62(0.95); C66(0.95)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C62(0.98); C66(0.98); C28(1.19); C149(1.52)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C62(1.64); C66(1.64); C149(1.68); C28(1.68)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 13.98  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C62(0.99); C66(0.99); C149(0.92)  LDD0078  [11]
 LDCM0088  C45 HEK-293T 9.38  LDD0202  [5]
 LDCM0087  Capsaicin HEK-293T 5.03  LDD0185  [2]
 LDCM0108  Chloroacetamide HeLa C28(0.00); C178(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C28(20.00); C8(1.09)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C62(0.83); C66(0.83); C28(0.97); C149(1.02)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C149(0.97); C28(1.01); C62(1.61); C66(1.61)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C149(0.90); C28(0.90); C62(1.15); C66(1.15)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C28(1.03); C62(1.34); C66(1.34); C149(1.52)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C28(0.92); C62(1.00); C66(1.00); C149(1.68)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C62(0.94); C66(0.94); C28(1.18); C149(1.51)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C28(0.99); C62(1.01); C66(1.01); C149(1.76)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C28(0.68); C149(0.96); C62(1.16); C66(1.16)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C28(0.68); C149(0.91); C62(1.17); C66(1.17)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C28(0.95); C149(0.99); C62(1.22); C66(1.22)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C28(0.66); C149(0.89); C62(1.20); C66(1.20)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C28(0.85); C149(0.93); C62(1.19); C66(1.19)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C28(0.76); C149(0.79); C62(1.33); C66(1.33)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C28(0.65); C149(1.15); C62(1.20); C66(1.20)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C28(0.74); C8(1.03); C62(1.20); C66(1.20)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C62(0.77); C66(0.77); C28(1.07); C149(1.21)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C62(1.10); C66(1.10); C149(1.49); C28(1.77)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C149(0.94); C62(1.04); C66(1.04); C28(1.40)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C62(0.96); C66(0.96); C28(1.33); C149(1.77)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C62(1.03); C66(1.03); C149(1.29); C28(1.32)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C149(1.13); C62(1.69); C66(1.69); C28(1.84)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C149(0.89); C28(0.96); C62(1.10); C66(1.10)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C149(0.80); C28(1.07); C62(1.21); C66(1.21)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C149(0.88); C28(1.14); C62(1.68); C66(1.68)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C149(0.77); C28(0.88); C62(1.10); C66(1.10)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C149(1.25); C62(3.90); C66(3.90)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C62(0.92); C66(0.92); C149(1.39)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C149(0.96); C62(1.00); C66(1.00)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C62(1.16); C66(1.16); C149(1.19)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C8(0.95); C62(1.07); C66(1.07); C28(1.12)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C62(0.88); C66(0.88); C28(0.94); C8(1.00)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C62(1.05); C66(1.05); C8(1.08); C28(1.15)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C149(0.83); C28(1.09); C62(1.52); C66(1.52)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C62(0.86); C66(0.86); C28(0.87); C149(1.02)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C62(0.94); C66(0.94); C28(0.95); C149(1.02)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C28(0.71); C62(1.12); C66(1.12); C149(1.19)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C28(1.13); C62(1.23); C66(1.23); C149(1.36)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C28(1.01); C62(1.29); C66(1.29); C149(1.40)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C28(1.06); C62(1.29); C66(1.29); C149(2.08)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C28(1.13); C62(1.30); C66(1.30); C149(1.72)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C62(0.87); C66(0.87); C28(0.97); C149(1.13)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C28(1.22); C149(1.49); C62(1.77); C66(1.77)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C28(0.99); C149(1.16); C62(1.70); C66(1.70)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C28(0.91); C149(1.97); C62(2.61); C66(2.61)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C28(1.07); C149(1.27); C62(1.39); C66(1.39)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C149(1.34); C28(1.11); C62(1.82); C66(1.82)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C149(1.29); C28(1.07); C62(1.62); C66(1.62)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C149(1.58); C28(1.19); C62(1.28); C66(1.28)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C149(1.25); C28(1.13); C62(1.47); C66(1.47)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C149(1.48); C28(1.14); C62(1.37); C66(1.37)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C149(1.36); C28(1.19); C62(1.78); C66(1.78)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C149(0.97); C28(0.96); C62(1.14); C66(1.14)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C149(1.21); C28(0.98); C62(1.21); C66(1.21)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C149(1.18); C28(1.03); C62(1.03); C66(1.03)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C149(1.90); C28(1.16); C62(1.01); C66(1.01)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C149(1.46); C28(1.09); C62(0.96); C66(0.96)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C149(1.58); C28(1.03); C62(1.37); C66(1.37)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C149(1.97); C28(1.14); C62(1.51); C66(1.51)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C149(1.55); C28(1.04); C62(1.46); C66(1.46)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C149(1.30); C28(1.22); C62(1.79); C66(1.79)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C149(1.12); C28(1.17); C62(1.11); C66(1.11)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C149(1.13); C28(0.87); C62(0.92); C66(0.92)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C149(2.11); C28(0.92); C62(1.46); C66(1.46)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C149(1.56); C28(0.94); C62(1.10); C66(1.10)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C149(2.27); C28(0.98); C62(1.82); C66(1.82)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C149(1.39); C28(1.03); C62(1.36); C66(1.36)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C149(1.11); C28(1.00); C62(1.14); C66(1.14)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C149(1.11); C28(0.97); C62(1.39); C66(1.39)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C149(0.50); C62(0.93); C66(0.93)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C149(1.07); C62(0.94); C66(0.94)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C149(0.88); C62(0.94); C66(0.94)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C149(0.71); C62(1.06); C66(1.06)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C149(1.17); C28(0.84); C62(1.14); C66(1.14)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C149(0.66); C62(0.95); C66(0.95)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C149(0.50); C62(1.03); C66(1.03)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C149(0.71); C62(1.25); C66(1.25)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C149(0.72); C62(1.12); C66(1.12)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C149(0.49); C62(1.01); C66(1.01)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C149(0.71); C62(1.12); C66(1.12)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C149(1.19); C62(1.02); C66(1.02)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C149(0.89); C62(0.91); C66(0.91)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C149(1.00); C62(0.93); C66(0.93)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C149(0.75); C62(1.05); C66(1.05)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C149(1.13); C28(1.00); C62(1.34); C66(1.34)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C149(0.99); C62(0.80); C66(0.80)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C149(0.51); C28(0.85); C62(1.24); C66(1.24)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C149(0.36); C28(0.89); C62(1.04); C66(1.04)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C149(0.42); C28(0.96); C62(0.97); C66(0.97)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C149(0.44); C28(0.84); C62(1.27); C66(1.27)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C149(0.64); C28(1.06); C62(0.95); C66(0.95)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C149(0.54); C28(1.26); C62(1.27); C66(1.27)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C149(0.95); C28(0.99); C62(1.10); C66(1.10)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C149(0.81); C28(0.88); C62(1.15); C66(1.15)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C149(0.58); C28(0.98); C62(0.86); C66(0.86)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C149(0.86); C28(0.86); C62(1.18); C66(1.18)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C149(0.66); C28(1.77); C62(1.05); C66(1.05)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C149(0.52); C28(1.15); C62(1.13); C66(1.13)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C149(0.47); C28(1.18); C62(1.16); C66(1.16)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C149(0.42); C28(0.99); C62(1.15); C66(1.15)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C149(0.52); C28(2.03); C62(1.19); C66(1.19)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C149(1.02); C62(0.87); C66(0.87); C8(1.02)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C149(1.04); C62(0.77); C66(0.77); C8(1.02)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C149(0.95); C62(1.04); C66(1.04); C8(0.96)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C149(1.19); C62(1.32); C66(1.32); C8(1.01)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C149(0.97); C28(0.83); C62(1.18); C66(1.18)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C149(1.03); C62(0.87); C66(0.87); C8(1.06)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C149(0.90); C62(1.06); C66(1.06); C8(1.02)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C149(0.99); C62(1.19); C66(1.19); C8(0.86)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C149(1.00); C62(1.12); C66(1.12); C8(1.04)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C149(0.98); C62(1.55); C66(1.55); C8(1.12)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C149(1.11); C62(1.11); C66(1.11); C8(1.04)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C149(0.95); C62(0.80); C66(0.80); C8(1.11)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C149(0.91); C62(0.93); C66(0.93); C8(1.06)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C149(0.91); C62(1.21); C66(1.21); C8(1.05)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C149(1.20); C62(1.80); C66(1.80); C8(1.00)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C149(0.98); C28(0.95); C62(0.98); C66(0.98)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C149(0.86); C62(0.69); C66(0.69); C8(0.89)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C149(1.42); C28(1.05); C62(0.96); C66(0.96)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C149(1.08); C28(0.81); C62(0.85); C66(0.85)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C149(0.81); C28(0.84); C62(0.85); C66(0.85)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C149(0.96); C28(1.05); C62(1.06); C66(1.06)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C149(0.96); C28(0.97); C62(1.03); C66(1.03)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C149(1.08); C28(1.01); C62(1.23); C66(1.23)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C149(1.13); C28(0.87); C62(1.21); C66(1.21)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C149(0.97); C28(0.91); C62(1.18); C66(1.18)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C149(0.86); C28(0.85); C62(1.04); C66(1.04)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C28(0.92)  LDD2228  [16]
 LDCM0027  Dopamine HEK-293T 5.78  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C28(1.04); C8(1.19); C178(1.20); C149(0.84)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C149(1.05)  LDD1702  [6]
 LDCM0031  Epigallocatechin gallate HEK-293T 7.71  LDD0183  [2]
 LDCM0625  F8 Ramos C28(1.29)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C28(1.61)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C28(0.36)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C28(1.32)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C28(1.42)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C28(0.85)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C28(1.12)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C28(1.51)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C28(2.38)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C28(1.82)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C28(0.71)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C28(2.10)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C28(2.17)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C28(1.88)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C149(0.97); C28(0.74); C62(1.02); C66(1.02)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C28(1.37)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C28(0.94)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C149(1.34); C28(1.00); C62(1.92); C66(1.92)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C28(1.69)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C28(2.30)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C28(1.02)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C28(1.63)  LDD2188  [29]
 LDCM0116  HHS-0101 DM93 Y280(0.95)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y280(0.36)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y280(1.16)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y280(0.38)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y280(1.40)  LDD0268  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y188(1.08)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y188(1.81)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y188(1.18)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y188(4.39)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y188(3.23)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y188(0.10)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y188(1.15)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y188(1.16)  LDD0292  [8]
 LDCM0022  KB02 HCT 116 C62(1.91); C66(1.91); C8(1.31); C28(1.41)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C62(1.22); C66(1.22); C8(1.10); C28(1.07)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C62(1.83); C66(1.83); C8(1.44); C28(1.23)  LDD0082  [11]
 LDCM0030  Luteolin HEK-293T 6.53  LDD0182  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [23]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C178(1.58)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C178(0.94)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C178(1.11)  LDD2109  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C178(0.61)  LDD2115  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C178(0.94)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C178(1.02)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C178(0.92)  LDD2127  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C178(0.59)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C178(0.46)  LDD2134  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C178(0.97)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C178(1.06)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C178(1.13)  LDD2140  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C178(0.45)  LDD2148  [6]
 LDCM0029  Quercetin HEK-293T 4.88  LDD0181  [2]
 LDCM0131  RA190 MM1.R C149(1.27); C28(1.17)  LDD0304  [30]
 LDCM0021  THZ1 HCT 116 C149(1.29); C8(1.21); C62(1.12); C66(1.12)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH-cytochrome b5 reductase 1 (CYB5R1) Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHQ9
E3 ubiquitin-protein ligase NRDP1 (RNF41) . Q9H4P4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.