Details of the Target

General Information of Target

Target ID LDTP06145
Target Name Protein disulfide-isomerase A5 (PDIA5)
Gene Name PDIA5
Gene ID 10954
Synonyms
PDIR; Protein disulfide-isomerase A5; EC 5.3.4.1; Protein disulfide isomerase-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEVAA
ENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHT
EYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAP
WCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLF
QYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMF
HAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKN
GEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVM
FYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYH
YGKFAEKYDSDRTELGFTNYIRALREGDHERLGKKKEEL
Target Bioclass
Enzyme
Family
Protein disulfide isomerase family
Subcellular location
Endoplasmic reticulum lumen
Uniprot ID
Q14554
Ensemble ID
ENST00000316218.12
HGNC ID
HGNC:24811

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDST8 SNV: p.H119Y DBIA    Probe Info 
NCIH1793 SNV: p.A469V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		6.71  LDD0348  [1]
HRP
 Probe Info  		4.74  LDD0347  [1]
W1
 Probe Info  		10.15  LDD0235  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K363(0.15); K40(10.00); K431(9.73)  LDD0277  [4]
IPM
 Probe Info  		C231(0.00); C465(0.00); C182(0.00); C185(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y364(10.87)  LDD3495  [5]
DA-P3
 Probe Info  		4.35  LDD0179  [1]
HHS-475
 Probe Info  		Y211(0.87)  LDD0264  [6]
DBIA
 Probe Info  		C426(7.02)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K448(0.00); K160(0.00)  LDD0199  [9]
m-APA
 Probe Info  		N.A.  LDD2231  [8]
IA-alkyne
 Probe Info  		C465(0.00); C231(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C465(0.00); C231(0.00)  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Crotonaldehyde
 Probe Info  		C81(0.00); C231(0.00)  LDD0219  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		7.46  LDD1725  [15]
C158
 Probe Info  		9.38  LDD1838  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C231(1.02)  LDD0812  [7]
 LDCM0215  AC10 HEK-293T C231(1.11)  LDD0813  [7]
 LDCM0216  AC100 HCT 116 C451(0.55); C456(0.55)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C451(0.42); C456(0.42)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C451(0.47); C456(0.47)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C451(0.29); C456(0.29)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C451(0.36); C456(0.36)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C451(0.37); C456(0.37)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C451(0.35); C456(0.35)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C451(0.29); C456(0.29)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C451(0.59); C456(0.59)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C451(0.59); C456(0.59)  LDD0542  [7]
 LDCM0226  AC11 HEK-293T C231(1.10)  LDD0824  [7]
 LDCM0227  AC110 HCT 116 C451(0.55); C456(0.55)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C451(0.51); C456(0.51)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C451(0.37); C456(0.37)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C426(0.76)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C426(0.73)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C426(0.81)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C426(0.70)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C426(0.61)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C426(0.62)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C426(0.67)  LDD0553  [7]
 LDCM0237  AC12 HEK-293T C231(1.09)  LDD0835  [7]
 LDCM0238  AC120 HCT 116 C426(1.64)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C426(0.76)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C426(0.60)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C426(0.75)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C426(0.57)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C426(0.88)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C426(0.64)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C426(0.53)  LDD0562  [7]
 LDCM0246  AC128 HEK-293T C231(1.10)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C231(1.49)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C231(1.54)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C231(1.07)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C231(1.23)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C231(1.50)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C231(1.33)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C231(1.49)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C231(1.49)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C231(1.91)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C231(2.27)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C231(1.82)  LDD0856  [7]
 LDCM0259  AC14 HEK-293T C231(1.20)  LDD0857  [7]
 LDCM0260  AC140 HEK-293T C231(1.58)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C231(1.98)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C231(1.67)  LDD0860  [7]
 LDCM0270  AC15 HEK-293T C231(1.25)  LDD0868  [7]
 LDCM0276  AC17 HEK-293T C231(1.11)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C231(1.04)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C231(1.03)  LDD0876  [7]
 LDCM0279  AC2 HEK-293T C231(1.09)  LDD0877  [7]
 LDCM0280  AC20 HEK-293T C231(1.16)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C231(1.03)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C231(1.19)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C231(1.46)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C231(1.02)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C231(0.90); C451(1.11); C426(1.09); C182(1.02)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C231(0.90); C451(1.11); C426(0.93); C305(1.00)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C231(0.97); C451(1.02); C426(1.04); C182(0.96)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C231(0.98); C451(1.01); C426(1.03); C305(0.96)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C465(1.13); C231(0.93); C451(1.11); C426(0.92)  LDD1528  [16]
 LDCM0290  AC3 HEK-293T C231(0.97)  LDD0888  [7]
 LDCM0291  AC30 HEK-293T C465(1.56); C231(0.97); C451(1.11); C426(0.95)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C465(0.89); C231(0.95); C451(1.07); C426(0.96)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C465(0.94); C231(1.01); C451(1.02); C426(1.03)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C231(0.93); C451(1.08); C426(0.88); C182(0.99)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C231(0.95); C451(1.13); C426(0.85); C305(1.17)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C231(1.04); C451(0.95); C426(1.05); C182(0.95)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C231(0.93); C451(1.16); C426(0.94); C305(1.25)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C465(1.25); C231(0.98); C451(1.21); C426(0.96)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C465(1.38); C231(1.10); C451(1.14); C426(0.85)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C465(1.00); C231(0.83); C451(1.02); C426(0.97)  LDD1539  [16]
 LDCM0301  AC4 HEK-293T C231(0.96)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C465(0.99); C231(0.96); C451(1.02); C426(1.09)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C231(0.94); C451(1.11); C426(0.98); C182(1.13)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C231(0.86); C451(1.10); C426(0.94); C305(1.12)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C231(0.92); C451(0.93); C426(1.04); C182(1.03)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C231(0.95); C451(1.06); C426(0.99); C305(1.02)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C465(0.81); C231(0.96); C451(1.13); C426(0.97)  LDD1546  [16]
 LDCM0308  AC46 HCT 116 C231(0.82)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C231(0.74)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C231(0.79)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C231(0.68)  LDD0628  [7]
 LDCM0312  AC5 HEK-293T C231(1.06)  LDD0910  [7]
 LDCM0313  AC50 HCT 116 C231(0.61)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C231(0.87)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C231(0.77)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C231(0.75)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C231(0.75)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C231(0.64)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C231(0.40)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C451(0.50); C456(0.50); C231(0.74)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C451(0.47); C456(0.47); C231(0.68)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C451(0.43); C456(0.43); C231(0.72)  LDD0639  [7]
 LDCM0323  AC6 HEK-293T C231(1.04)  LDD0921  [7]
 LDCM0324  AC60 HCT 116 C451(0.54); C456(0.54); C231(0.71)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C451(0.67); C456(0.67); C231(0.77)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C451(0.42); C456(0.42); C231(0.72)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C451(0.50); C456(0.50); C231(0.66)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C451(0.41); C456(0.41); C231(0.70)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C451(0.60); C456(0.60); C231(1.05)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C451(0.64); C456(0.64); C231(1.04)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C451(0.26); C456(0.26); C231(0.46)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C451(0.94); C456(0.94); C426(1.26)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C451(0.62); C456(0.62); C426(1.01)  LDD0650  [7]
 LDCM0334  AC7 HEK-293T C231(1.08)  LDD0932  [7]
 LDCM0335  AC70 HCT 116 C451(0.44); C456(0.44); C426(0.95)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C426(0.85); C451(0.85); C456(0.85)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C451(0.68); C456(0.68); C426(0.99)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C451(0.48); C456(0.48); C426(0.96)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C451(0.44); C456(0.44); C426(1.06)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C451(0.30); C456(0.30); C426(0.95)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C451(0.66); C456(0.66); C426(0.86)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C451(0.58); C456(0.58); C426(1.32)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C451(0.91); C456(0.91); C426(0.93)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C451(0.75); C456(0.75); C426(1.00)  LDD0661  [7]
 LDCM0345  AC8 HEK-293T C231(1.34)  LDD0943  [7]
 LDCM0346  AC80 HCT 116 C426(0.78); C451(0.85); C456(0.85)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C451(0.85); C456(0.85); C426(1.01)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C451(0.10); C456(0.10); C426(1.05)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C231(0.57); C426(1.87)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C231(0.60); C426(2.17)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C231(0.61); C426(1.44)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C231(0.68); C426(1.50)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C231(0.86); C426(1.48)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C231(0.67); C426(1.26)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C231(0.70); C426(1.42)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C426(0.86); C231(1.06)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C231(0.60); C426(1.37)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C231(0.63); C426(1.01)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C231(0.79); C426(1.49)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C231(0.75); C426(1.09)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C231(0.87); C426(1.23)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C231(0.61); C426(1.05)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C231(0.68); C426(1.24)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C451(0.10); C456(0.10)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C451(0.52); C456(0.52)  LDD0683  [7]
 LDCM0248  AKOS034007472 HEK-293T C231(1.13)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C231(1.38)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C231(1.30)  LDD0873  [7]
 LDCM0020  ARS-1620 HCC44 C231(1.03); C465(1.17)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa C231(0.00); C465(0.00); H348(0.00); C451(0.00)  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C451(0.56); C456(0.56)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C451(0.49); C456(0.49)  LDD0685  [7]
 LDCM0369  CL100 HEK-293T C231(1.15)  LDD0967  [7]
 LDCM0370  CL101 HEK-293T C231(1.18)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C231(1.37)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C231(1.46)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C231(1.28)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C231(0.92)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C231(1.00)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C231(1.07)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C231(0.93)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C231(0.95)  LDD0976  [7]
 LDCM0379  CL11 HCT 116 C451(0.45); C456(0.45)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C231(0.94)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C231(0.92)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C231(1.02); C451(1.05); C426(1.06); C305(0.99)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C465(0.92); C231(1.04); C451(0.92); C426(0.94)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C465(1.18); C231(0.83); C451(1.08); C426(1.21)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C465(1.40); C231(0.97); C451(1.10); C426(1.43)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C231(1.07); C451(1.01); C426(1.13); C305(1.16)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C465(1.24); C231(0.97); C451(0.98); C426(1.15)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C465(1.34); C231(0.94); C451(1.05); C426(1.15)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C465(1.34); C231(0.95); C451(1.04); C426(1.00)  LDD1593  [16]
 LDCM0390  CL12 HCT 116 C451(0.72); C456(0.72)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C231(1.07); C451(1.04); C426(1.20); C305(1.07)  LDD1595  [16]
 LDCM0392  CL121 HCT 116 C231(0.71)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C231(0.51)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C231(0.24)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C231(0.60)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C451(0.84); C456(0.84); C231(1.02)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C451(0.59); C456(0.59); C231(0.60)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C451(0.63); C456(0.63); C231(0.81)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C451(0.55); C456(0.55); C231(0.83)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C451(0.59); C456(0.59)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C451(0.63); C456(0.63)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C451(0.59); C456(0.59)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C231(0.71); C451(0.89); C456(0.89)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C231(0.34); C451(0.89); C456(0.89); C426(1.83)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C231(0.67); C426(0.80); C451(1.04); C456(1.04)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C231(0.76); C451(0.83); C456(0.83); C426(1.06)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C451(0.69); C456(0.69)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C231(0.78); C426(1.10); C451(1.27); C456(1.27)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C231(0.38); C451(0.53); C456(0.53); C426(10.27)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C231(0.24); C451(0.25); C456(0.25); C426(4.16)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C451(0.80); C456(0.80); C231(0.82); C426(1.24)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C231(0.75); C451(0.78); C456(0.78); C426(1.10)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C426(0.94); C231(0.30); C451(0.49); C456(0.49)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C426(1.01); C231(0.74); C451(0.79); C456(0.79)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C426(1.15); C231(0.67); C451(0.99); C456(0.99)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C426(5.86); C231(0.42); C451(0.89); C456(0.89)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C426(1.51); C231(0.67); C451(0.81); C456(0.81)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C451(0.61); C456(0.61)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C426(1.29); C231(0.80); C451(0.81); C456(0.81)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C426(0.98); C451(0.70); C456(0.70)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C451(1.59); C456(1.59)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C451(0.60); C456(0.60)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C451(0.36); C456(0.36)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C451(0.34); C456(0.34)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C451(0.61); C456(0.61)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C451(0.47); C456(0.47)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C451(0.36); C456(0.36)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C451(0.66); C456(0.66)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C451(1.09); C456(1.09)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C451(0.65); C456(0.65)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C451(0.48); C456(0.48)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C451(0.38); C456(0.38)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C451(0.49); C456(0.49)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C451(0.53); C456(0.53)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C451(0.98); C456(0.98)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C451(0.94); C456(0.94)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C451(1.00); C456(1.00)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C451(0.98); C456(0.98)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C451(0.87); C456(0.87)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C451(0.92); C456(0.92)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C451(1.00); C456(1.00)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C451(1.25); C456(1.25)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C451(1.11); C456(1.11)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C451(0.80); C456(0.80)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C451(1.00); C456(1.00)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C451(0.84); C456(0.84)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C451(0.84); C456(0.84)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C451(1.09); C456(1.09)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C451(1.12); C456(1.12)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C451(0.74); C456(0.74)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C451(0.82); C456(0.82)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C231(0.97)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C231(1.16)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C231(1.13)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C231(1.03)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C231(1.27)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C231(1.18)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C231(1.25)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C231(1.15)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C231(1.06)  LDD1059  [7]
 LDCM0462  CL7 HCT 116 C451(0.82); C456(0.82)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C231(1.32)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C231(1.26)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C231(1.04)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C231(1.22)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C231(1.82)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C231(1.10); C451(0.98); C426(1.00); C305(1.04)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C231(0.78); C451(1.16); C426(1.28); C182(1.31)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C231(0.96); C451(1.12); C426(0.87); C305(0.92)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C231(1.05); C451(0.98); C426(0.91); C182(0.99)  LDD1675  [16]
 LDCM0473  CL8 HCT 116 C451(0.28); C456(0.28)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C231(1.03); C451(1.09); C426(0.92); C305(0.84)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C465(1.17); C231(0.92); C451(1.15); C426(0.76)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C465(1.32); C231(1.13); C451(1.12); C426(0.74)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C465(1.59); C231(1.02); C451(1.03); C426(0.85)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C465(1.60); C231(0.96); C451(1.09); C426(0.95)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C465(0.90); C231(1.01); C451(0.86); C426(1.14)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C465(1.10); C231(1.05); C451(1.09); C426(1.23)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C465(1.09); C231(0.78); C451(1.04); C426(3.29)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C231(1.09); C451(1.02); C426(0.99); C305(0.80)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C231(0.94); C451(1.16); C426(0.93); C182(1.05)  LDD1686  [16]
 LDCM0484  CL9 HCT 116 C451(0.61); C456(0.61)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C231(0.36); C451(0.84); C426(2.74); C305(6.77)  LDD1688  [16]
 LDCM0486  CL91 HEK-293T C231(0.79)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C231(0.87)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C231(0.92)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C231(1.11)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C231(1.19)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C231(0.94)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C231(0.84)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C231(0.99)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C231(0.93)  LDD1092  [7]
 LDCM0027  Dopamine HEK-293T 4.35  LDD0179  [1]
 LDCM0495  E2913 HEK-293T C465(1.07); C231(0.77); C451(1.01); C426(6.31)  LDD1698  [16]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.01  LDD0183  [1]
 LDCM0468  Fragment33 HEK-293T C231(1.42)  LDD1066  [7]
 LDCM0427  Fragment51 HCT 116 C451(0.37); C456(0.37)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y211(0.87)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y211(1.02)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y211(0.54)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y211(1.39)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y211(1.33)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HCT 116 C426(7.02)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C426(10.65)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C426(1.22)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0021  THZ1 HCT 116 C231(1.03); C465(1.17)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402