Details of the Target

General Information of Target

Target ID LDTP07002
Target Name Transport and Golgi organization protein 1 homolog (MIA3)
Gene Name MIA3
Gene ID 375056
Synonyms
KIAA0268; TANGO; Transport and Golgi organization protein 1 homolog; TANGO1; C219-reactive peptide; D320; Melanoma inhibitory activity protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAPGLLVWLLVLRLPWRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPD
CRFVNFKKGDPVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDET
DFVCFDGGRDDFHNYNVEELLGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPE
PVEANSEESDSVFSENTEDLQEQFTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKV
PESENNKTSNSSQVSNEQDKIDAYKLLKKEMTLDLKTKFGSTADALVSDDETTRLVTSLE
DDFDEELDTEYYAVGKEDEENQEDFDELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNE
EDKVQLTVPPGIKNDDKNILTTWGDTIFSIVTGGEETRDTMDLESSSSEEEKEDDDDALV
PDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDKEVNAEHHIKGKGRGVQESKRGLVQ
DKTELEDENQEGMTVHSSVHSNNLNSMPAAEKGKDTLKSAYDDTENDLKGAAIHISKGML
HEEKPGEQILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLMGDDHPNASRDSVEGDAL
VNGAKLHTLSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEVPILGRNLPWQQE
RDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGGPAFLSKV
EEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEESKQ
ETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPE
LGEVFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPE
DDSFHWTPHTSVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLK
SAQQESLPYNMEKVLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDD
IQDLIYFVRYKHSTAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPE
EPTHLDQRVIGDTHASEVSQKPNTEKDLDPGPVTTEDTPMDAIDANKQPETAAEEPASVT
PLENAILLIYSFMFYLTKSLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASFAIFLWRT
VLVVKDRVYQVTEQQISEKLKTIMKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSD
EAIKYKDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISENKKSIEKLKDVISM
NASEFSEVQIALNEAKLSEEKVKSECHRVQEENARLKKKKEQLQQEIEDWSKLHAELSEQ
IKSFEKSQKDLEVALTHKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVG
GDRNEKMKNQIKQMMDVSRTQTAISVVEEDLKLLQLKLRASVSTKCNLEDQVKKLEDDRN
SLQAAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAV
SAAEEVKTYKRRIEEMEDELQKTERSFKNQIATHEKKAHENWLKARAAERAIAEEKREAA
NLRHKLLELTQKMAMLQEEPVIVKPMPGKPNTQNPPRRGPLSQNGSFGPSPVSGGECSPP
LTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHPRWSAEASGKPSPSDPGSGTATMMNSS
SRGSSPTRVLDEGKVNMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGPRPL
PPPFGPGMRPPLGLREFAPGVPPGRRDLPLHPRGFLPGHAPFRPLGSLGPREYFIPGTRL
PPPTHGPQEYPPPPAVRDLLPSGSRDEPPPASQSTSQDCSQALKQSP
Target Bioclass
Transporter and channel
Family
MIA/OTOR family, Tango1 subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES.
Uniprot ID
Q5JRA6
Ensemble ID
ENST00000340535.11
HGNC ID
HGNC:24008

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.F1193L DBIA    Probe Info 
GB2 SNV: p.E139K DBIA    Probe Info 
HT SNV: p.N505I DBIA    Probe Info 
JHH4 SNV: p.G280V .
LN229 SNV: p.V1641M .
MEWO SNV: p.P1060S DBIA    Probe Info 
NCIH1793 SNV: p.G578C .
NCIH2172 SNV: p.L841V .
NCIH446 SNV: p.E187Ter .
OVK18 SNV: p.E701D DBIA    Probe Info 
PC3 SNV: p.L1085V .
SKOV3 SNV: p.P83T DBIA    Probe Info 
TOV21G Deletion: p.N168TfsTer15 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DA-P2
 Probe Info  		5.66  LDD0348  [2]
HRP
 Probe Info  		4.63  LDD0347  [2]
TG42
 Probe Info  		4.92  LDD0326  [3]
TH211
 Probe Info  		Y108(20.00)  LDD0260  [4]
FBP2
 Probe Info  		2.38  LDD0323  [5]
Probe 1
 Probe Info  		Y73(7.42); Y1237(23.21); Y1543(7.44)  LDD3495  [6]
P12
 Probe Info  		13.36  LDD0202  [7]
BTD
 Probe Info  		C1486(1.14)  LDD1700  [8]
DA-P3
 Probe Info  		5.52  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C1417(10.03)  LDD0168  [9]
DBIA
 Probe Info  		C124(1.07)  LDD0078  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
IA-alkyne
 Probe Info  		C1346(0.00); C61(0.00)  LDD0162  [12]
Lodoacetamide azide
 Probe Info  		C1513(0.00); C1486(0.00)  LDD0037  [13]
IPM
 Probe Info  		C1513(0.00); C1899(0.00); C1486(0.00)  LDD0147  [14]
NHS
 Probe Info  		N.A.  LDD0010  [15]
PPMS
 Probe Info  		N.A.  LDD0008  [15]
SF
 Probe Info  		N.A.  LDD0028  [16]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
TFBX
 Probe Info  		C1486(0.00); C1513(0.00); C1346(0.00)  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		C1899(0.00); C1346(0.00); C1486(0.00)  LDD0018  [17]
1c-yne
 Probe Info  		N.A.  LDD0228  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
Methacrolein
 Probe Info  		N.A.  LDD0218  [19]
W1
 Probe Info  		N.A.  LDD0236  [20]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C201
 Probe Info  		27.47  LDD1877  [21]
C349
 Probe Info  		8.75  LDD2010  [21]
FFF probe11
 Probe Info  		15.08  LDD0472  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe2
 Probe Info  		13.56  LDD0463  [22]
OEA-DA
 Probe Info  		8.18  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1486(0.69)  LDD2112  [8]
 LDCM0025  4SU-RNA HEK-293T C1417(10.03)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C1417(2.32)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C1408(1.06); C1417(1.06); C1486(0.96)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C1899(1.57)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C1899(0.94)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C1899(0.97)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C1899(0.83)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C1899(1.20)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C1899(1.11)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C1899(1.17)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C1899(1.11)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C1899(0.98)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C1899(1.29)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C1899(1.17)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C1899(1.28)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C1899(0.82)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C1899(0.97)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C1899(0.83)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C1486(0.88); C61(1.07)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C1486(0.80); C61(0.89)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C1486(0.83); C61(1.02)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C1486(0.82); C61(1.15)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C1486(0.81); C61(1.08)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C1486(0.87); C61(1.00)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C1486(0.77); C61(1.12)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C1899(0.95)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C1486(0.84); C61(0.86)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C1486(0.73); C61(0.95)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C1486(0.78); C61(1.11)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C1486(0.84); C61(0.81)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C1486(0.79); C61(0.88)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C1486(0.81); C61(0.91)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C1486(0.83); C61(1.10)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C1486(0.86); C61(1.01)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C1408(1.65); C1417(1.65); C1486(0.71); C1899(1.14)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C1408(1.09); C1417(1.09); C1486(0.80); C1899(0.74)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C1408(1.35); C1417(1.35); C1486(0.79); C1899(1.40)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C1408(1.10); C1417(1.10); C1486(0.78); C1899(0.73)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C1408(0.99); C1417(0.99); C1486(0.79); C1899(0.90)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C1408(1.86); C1417(1.86); C1486(0.81); C1899(0.90)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C1408(1.44); C1417(1.44); C1486(0.71); C1899(0.89)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C1408(1.12); C1417(1.12); C1486(0.89); C1899(0.83)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C1408(1.04); C1417(1.04); C1486(0.79); C1899(1.01)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C1408(1.32); C1417(1.32); C1486(0.81); C1899(1.00)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C1408(1.63); C1417(1.63); C1486(0.82); C1899(0.80)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C1408(1.14); C1417(1.14); C1486(0.89); C1899(0.93)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C1899(1.30)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C1408(1.12); C1417(1.12); C1486(0.86); C1899(1.09)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C1408(0.97); C1417(0.97); C1486(0.90); C1899(0.98)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C1408(1.13); C1417(1.13); C1486(0.84); C1899(0.78)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C1408(0.99); C1417(0.99)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C1408(1.29); C1417(1.29)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C1408(1.11); C1417(1.11)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C1408(1.41); C1417(1.41)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C1408(1.29); C1417(1.29)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C1408(1.88); C1417(1.88)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C1408(1.47); C1417(1.47)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C1899(1.25)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C1408(0.92); C1417(0.92)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C1408(1.30); C1417(1.30)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C1408(1.54); C1417(1.54)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C1408(2.14); C1417(2.14)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C1408(1.33); C1417(1.33)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C1408(1.26); C1417(1.26)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C1408(0.98); C1417(0.98)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C1408(1.10); C1417(1.10)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C1486(1.04); C61(1.13); C1899(1.16)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C1486(0.85); C61(1.01); C1899(1.22)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C1486(0.86); C61(1.07); C1899(1.35)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C1408(0.95); C1417(0.95); C1486(1.10)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C61(0.85); C1486(1.08); C1899(1.14)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C1486(0.84); C61(1.10); C1899(1.55)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C1486(0.98); C61(1.06); C1899(1.24)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C1486(0.84); C61(0.92); C1899(1.33)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C61(0.88); C1486(1.06); C1899(1.11)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C1486(1.05); C1899(1.08)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C1486(1.12); C1899(1.32)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C1486(1.21); C1899(1.73)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C1486(1.25); C1899(1.36)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C1899(1.24); C1486(1.72)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C1486(0.87); C1408(1.02); C1417(1.02)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C1899(1.47); C1486(1.97)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C1899(1.23); C1486(1.29)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C1899(1.70); C1486(1.73)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C1486(1.08); C1899(1.48)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C1486(1.12); C1899(1.64)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C1899(0.63); C1486(0.91)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C1899(0.66); C1486(1.04)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C1899(0.78); C1486(1.11)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C1899(0.77); C1486(1.21)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C1899(0.96); C1486(1.08)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C1486(1.01); C1408(1.13); C1417(1.13)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C1899(1.02); C1486(1.04)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C1899(0.87); C1486(1.14)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C1899(1.22); C1486(1.27)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C1899(0.94); C1486(1.16)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C1899(0.98); C1486(1.15)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C1899(1.09); C1486(1.12)  LDD0624  [10]
 LDCM0308  AC46 HEK-293T C124(0.83); C1408(0.98); C1417(0.85); C1486(0.85)  LDD0906  [10]
 LDCM0309  AC47 HEK-293T C124(0.76); C1408(0.88); C1417(1.02); C1486(0.86)  LDD0907  [10]
 LDCM0310  AC48 HEK-293T C124(0.85); C1408(0.91); C1417(1.06); C1486(0.86)  LDD0908  [10]
 LDCM0311  AC49 HEK-293T C124(0.92); C1408(1.21); C1417(1.01); C1486(1.01)  LDD0909  [10]
 LDCM0312  AC5 HCT 116 C1408(0.90); C1417(0.90); C1486(1.00)  LDD0629  [10]
 LDCM0313  AC50 HEK-293T C124(0.82); C1408(0.98); C1417(0.90); C1486(0.76)  LDD0911  [10]
 LDCM0314  AC51 HEK-293T C124(0.74); C1408(1.06); C1417(1.10); C1486(0.75)  LDD0912  [10]
 LDCM0315  AC52 HEK-293T C124(0.73); C1408(1.45); C1417(1.18); C1486(0.82)  LDD0913  [10]
 LDCM0316  AC53 HEK-293T C124(0.67); C1408(0.96); C1417(1.05); C1486(0.82)  LDD0914  [10]
 LDCM0317  AC54 HEK-293T C124(0.80); C1408(1.10); C1417(1.07); C1486(0.93)  LDD0915  [10]
 LDCM0318  AC55 HEK-293T C124(0.91); C1408(1.18); C1417(1.05); C1486(0.87)  LDD0916  [10]
 LDCM0319  AC56 HEK-293T C124(0.88); C1408(1.12); C1417(1.14); C1486(0.81)  LDD0917  [10]
 LDCM0320  AC57 HCT 116 C1486(0.43)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C1486(0.69)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C1486(0.61)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C1899(1.57)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C1486(0.48)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C1486(0.59)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C1486(0.74)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C1486(0.50)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C1486(0.42)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C1486(0.61)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C1486(0.62)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C1486(0.57)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C1486(0.80); C1899(1.09)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C1486(0.75); C1899(1.54)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C1899(1.12)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C1486(0.90); C1899(1.40)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C1899(1.15); C1486(1.15)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C1486(0.98); C1899(1.60)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C1486(0.91); C1899(2.54)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C1486(0.80); C1899(1.92)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C1486(1.01); C1899(2.57)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C1486(0.96); C1899(1.48)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C1486(0.87); C1899(1.14)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C1486(0.78); C1899(1.52)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C1486(1.19); C1899(1.37)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C1899(1.25)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C1486(1.04); C1899(1.50)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C1486(0.88); C1899(1.17)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C1486(1.06); C1899(2.63)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C1899(1.84)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C1899(1.51)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C1899(1.26)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C1899(1.44)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C1899(1.08)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C1899(1.33)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C1899(1.47)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C1899(1.13)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C1899(2.34)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C1899(2.02)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C1899(1.16)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C1899(1.09)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C1899(1.49)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C1899(1.54)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C1899(1.66)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C1899(1.55)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C1899(0.77)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C1899(1.15)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C1899(1.60)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C1899(2.02)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C124(1.07)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C1486(0.57)  LDD2091  [8]
 LDCM0088  C45 HEK-293T 13.36  LDD0202  [7]
 LDCM0087  Capsaicin HEK-293T 100.66  LDD0185  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [19]
 LDCM0367  CL1 HCT 116 C1408(0.82); C1417(0.82); C1486(0.97)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C1486(0.91); C1408(1.24); C1417(1.24)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C1486(1.16); C1408(1.25); C1417(1.25)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C1899(1.26)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C1899(1.08)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C1899(1.44)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C1899(1.04)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C1486(0.88); C61(1.11); C1899(1.77)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C1486(0.87); C61(1.12); C1899(1.80)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C1486(0.90); C61(1.17); C1899(1.75)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C1486(1.02); C61(1.16); C1899(1.55)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C1486(0.94); C61(1.23); C1899(1.56)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C1486(0.85); C1408(1.76); C1417(1.76)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C1486(0.84); C61(1.27); C1899(1.71)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C1486(0.79); C61(1.15); C1899(1.47)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C1899(1.03); C1486(1.13)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C1899(1.17); C1486(1.36)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C1899(1.16); C1486(1.32)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C1899(1.20); C1486(1.51)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C1899(1.19); C1486(1.25)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C1486(0.94); C1899(1.63)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C1899(1.03); C1486(1.17)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C1899(1.08); C1486(1.09)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C1486(1.00); C1408(1.54); C1417(1.54)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C1899(0.90); C1486(1.24)  LDD0708  [10]
 LDCM0392  CL121 HEK-293T C124(0.81); C1408(1.26); C1417(1.10); C1486(0.84)  LDD0990  [10]
 LDCM0393  CL122 HEK-293T C124(0.93); C1408(1.04); C1417(0.97); C1486(0.85)  LDD0991  [10]
 LDCM0394  CL123 HEK-293T C124(0.75); C1408(0.75); C1417(0.83); C1486(0.75)  LDD0992  [10]
 LDCM0395  CL124 HEK-293T C124(0.79); C1408(1.13); C1417(1.00); C1486(0.88)  LDD0993  [10]
 LDCM0396  CL125 HCT 116 C1486(0.52)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C1486(0.78)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C1486(0.62)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C1486(0.59)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C1486(0.97); C1408(1.19); C1417(1.19)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C1486(0.89); C1408(1.01); C1417(1.01)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C1486(0.89); C1408(1.39); C1417(1.39)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C1408(1.19); C1417(1.19)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C1408(0.98); C1417(0.98); C1486(1.12)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C1486(1.03); C1408(1.49); C1417(1.49)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C1486(1.04); C1408(1.28); C1417(1.28)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C1408(0.87); C1417(0.87); C1486(0.92)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C1486(1.06); C1408(1.79); C1417(1.79)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C1486(1.03); C1408(1.69); C1417(1.69)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C1486(0.89); C1408(2.66); C1417(2.66)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C1486(0.93); C1408(1.49); C1417(1.49)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C1486(1.04); C1408(1.84); C1417(1.84)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C1408(1.66); C1417(1.66); C1486(0.97)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C1408(1.42); C1417(1.42); C1486(1.05)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C1408(1.65); C1417(1.65); C1486(0.95)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C1408(1.79); C1417(1.79); C1486(1.08)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C1408(1.68); C1417(1.68); C1486(0.98)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C1408(1.07); C1417(1.07); C1486(0.89)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C1408(1.32); C1417(1.32); C1486(0.86)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C1486(0.96); C61(0.85)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C61(0.86)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C61(1.05)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C61(0.90)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C61(0.93)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C61(1.15)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C61(1.02)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C61(0.93)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C1408(1.09); C1417(1.09); C1486(0.95)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C61(0.72)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C61(0.95)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C61(0.90)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C61(1.07)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C61(0.94)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C61(0.88)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C1408(0.64); C1417(0.64); C1486(0.99); C61(1.05)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C1408(0.69); C1417(0.69); C1486(0.90); C61(1.08)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C1408(0.67); C1417(0.67); C1486(1.08); C61(1.09)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C1408(0.84); C1417(0.84); C1486(1.02); C61(0.92)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C1408(1.08); C1417(1.08); C1486(1.02)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C1408(0.82); C1417(0.82); C1486(1.02); C61(0.99)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C1408(1.00); C1417(1.00); C1486(1.01); C61(1.09)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C1408(0.79); C1417(0.79); C1486(1.03); C61(1.28)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C1408(0.79); C1417(0.79); C1486(0.99); C61(1.20)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C1408(0.74); C1417(0.74); C1486(1.01); C61(0.81)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C1408(0.78); C1417(0.78); C1486(0.97); C61(1.00)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C1408(0.76); C1417(0.76); C1486(0.86); C61(0.89)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C1408(0.80); C1417(0.80); C1486(1.06); C61(1.27)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C1408(0.70); C1417(0.70); C1486(1.08); C61(0.89)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C1408(0.96); C1417(0.96); C1486(1.12); C61(0.95)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C1408(1.01); C1417(1.01); C1486(1.06)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C1408(0.76); C1417(0.76); C1486(1.07); C61(1.05)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C1408(1.40); C1417(1.40); C1486(1.20)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C1408(1.27); C1417(1.27); C1486(1.14)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C1408(1.42); C1417(1.42); C1486(1.02)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C1408(1.47); C1417(1.47); C1486(1.12)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C1408(0.85); C1417(0.85); C1486(0.97)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C1408(1.44); C1417(1.44); C1486(1.12)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C1408(1.51); C1417(1.51); C1486(1.01)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C1408(1.30); C1417(1.30); C1486(0.93)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C1408(0.99); C1417(0.99); C1486(1.10)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C1408(1.22); C1417(1.22); C1486(1.16)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C1408(0.97); C1417(0.97); C1486(1.17)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C1408(1.07); C1417(1.07); C1486(1.05)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C1408(0.89); C1417(0.89); C1486(1.35)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C1408(1.19); C1417(1.19); C1486(1.08)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C1408(0.92); C1417(0.92); C1486(1.14)  LDD0784  [10]
 LDCM0469  CL76 HEK-293T C1513(0.78); C1899(0.85); C61(1.22)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C1513(1.13); C1899(0.76); C61(1.20)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C1513(0.73); C1899(0.60); C61(1.70)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C1513(0.99); C1899(0.57); C61(1.39)  LDD1070  [10]
 LDCM0473  CL8 HCT 116 C1408(1.43); C1417(1.43); C1486(1.03)  LDD0790  [10]
 LDCM0474  CL80 HEK-293T C1513(0.72); C1899(0.72); C61(1.37)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C1513(1.03); C1899(0.67); C61(1.26)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C1513(0.99); C1899(0.80); C61(0.94)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C1513(0.94); C1899(0.99); C61(0.87)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C1513(1.18); C1899(0.58); C61(1.38)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C1513(0.79); C1899(0.72); C61(1.26)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C1513(0.70); C1899(0.55); C61(1.61)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C1513(1.29); C1899(0.66); C61(1.12)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C1513(1.01); C1899(0.76); C61(0.92)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C1513(0.86); C1899(0.68); C61(1.17)  LDD1081  [10]
 LDCM0484  CL9 HCT 116 C1408(1.08); C1417(1.08); C1486(1.15)  LDD0801  [10]
 LDCM0485  CL90 HEK-293T C1513(1.23); C1899(0.62); C61(0.84)  LDD1083  [10]
 LDCM0486  CL91 HCT 116 C1408(1.00); C1417(1.00); C1486(1.46)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C1408(0.77); C1417(0.77); C1486(1.19)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C1408(1.01); C1417(1.01); C1486(0.92)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C1408(1.11); C1417(1.11); C1486(0.78)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C1408(1.33); C1417(1.33); C1486(1.07)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C1408(1.24); C1417(1.24); C1486(1.54)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C1408(1.06); C1417(1.06); C1486(1.20)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C1408(1.02); C1417(1.02); C1486(1.16)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C1408(1.11); C1417(1.11); C1486(1.21)  LDD0811  [10]
 LDCM0028  Dobutamine HEK-293T 5.38  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 5.52  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C1513(0.97); C1899(1.21); C1486(0.98); C1408(0.94)  LDD1698  [24]
 LDCM0468  Fragment33 HCT 116 C1408(1.58); C1417(1.58); C1486(1.12)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C61(0.73)  LDD0744  [10]
 LDCM0107  IAA HeLa H613(0.00); H1374(0.00)  LDD0221  [19]
 LDCM0022  KB02 HCT 116 C1408(1.93); C1417(1.93); C38(2.51); C43(1.68)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C1408(2.69); C1417(2.69); C38(4.66); C43(2.00)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C1408(5.82); C1417(5.82); C38(5.52); C43(2.33)  LDD0082  [10]
 LDCM0030  Luteolin HEK-293T 8.91  LDD0182  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1486(0.59)  LDD2121  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1486(0.65)  LDD2089  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1486(0.89)  LDD2092  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1486(1.28)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1486(0.94)  LDD2096  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1486(0.65)  LDD2099  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1486(0.58)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1486(1.69)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1486(0.50)  LDD2106  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1486(0.47)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1486(0.60)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1486(0.76)  LDD2111  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1486(1.02)  LDD2116  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1486(0.87)  LDD2122  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1486(1.04)  LDD2124  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1486(1.02)  LDD2126  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1486(0.76)  LDD2129  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1486(0.64)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1486(1.02)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1486(0.72)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1486(1.14)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1486(0.64)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1486(0.65)  LDD2141  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1486(0.70)  LDD2146  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1486(0.41)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1486(0.99)  LDD2151  [8]
 LDCM0021  THZ1 HCT 116 C1408(0.98); C1417(0.98)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Collagen alpha-1(VII) chain (COL7A1) . Q02388
Cytoplasmic protein NCK2 (NCK2) . O43639
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402