Details of the Target

General Information of Target

Target ID LDTP19744
Target Name Uncharacterized protein FAM241A (FAM241A)
Gene Name FAM241A
Gene ID 132720
Synonyms
C4orf32; Uncharacterized protein FAM241A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRSLKRAQLRSLLPRPPAVSHTQPWYRAAHPTTSPTAASRDVHPASGAVPGPWLVEGTA
VREGPQLQDAVPQRPTRPSKALWPAQMSAAPAIRLGQMVPGDTRGLWGPQGTLLTWTYRG
GQGGRWTRRAEGPREGTFAEQRPHFQSSGAQQESRLAMGPPPLGLGDAAGDGRGQTGQEK
GRAEGRQARKSACKCPRKGPNPGPWTRAAAWWGRLEGAKASAKGEQVRDPGGHLWEQGHV
SPCARFNQGHSCGSPKVSHTTWVS
Target Bioclass
Other
Family
FAM241 family
Subcellular location
Membrane
Uniprot ID
Q8N8J7
Ensemble ID
ENST00000309733.6
HGNC ID
HGNC:26813

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P2
 Probe Info  		6.21  LDD0348  [1]
HRP
 Probe Info  		4.07  LDD0347  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
NAIA_5
 Probe Info  		N.A.  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
ENE
 Probe Info  		N.A.  LDD0006  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C2(0.90)  LDD2227  [4]

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764