Details of the Target

General Information of Target

Target ID LDTP06902
Target Name mRNA export factor GLE1 (GLE1)
Gene Name GLE1
Gene ID 2733
Synonyms
GLE1L; mRNA export factor GLE1; hGLE1; GLE1 RNA export mediator; GLE1-like protein; Nucleoporin GLE1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM
QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL
QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ
HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE
GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES
SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH
KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM
DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL
AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE
GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH
GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAIT
SSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS
Target Bioclass
Transporter and channel
Family
GLE1 family
Subcellular location
Cytoplasm; Nucleus
Function Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).
Uniprot ID
Q53GS7
Ensemble ID
ENST00000309971.9
HGNC ID
HGNC:4315

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.A231V DBIA    Probe Info 
COLO792 SNV: p.S83L DBIA    Probe Info 
COLO800 SNV: p.R196K DBIA    Probe Info 
MFE319 SNV: p.A632V DBIA    Probe Info 
MOLT4 SNV: p.P536R IA-alkyne    Probe Info 
NALM6 SNV: p.T386A DBIA    Probe Info 
REH SNV: p.V492M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.15  LDD0402  [1]
DA-P2
 Probe Info  		8.00  LDD0348  [2]
HRP
 Probe Info  		7.18  LDD0347  [2]
STPyne
 Probe Info  		K204(5.76); K672(0.63)  LDD0277  [3]
Probe 1
 Probe Info  		Y302(8.88)  LDD3495  [4]
BTD
 Probe Info  		C333(2.43)  LDD2100  [5]
DA-P3
 Probe Info  		11.19  LDD0179  [2]
AHL-Pu-1
 Probe Info  		C39(2.28)  LDD0169  [6]
DBIA
 Probe Info  		C287(1.03)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [9]
TFBX
 Probe Info  		C528(0.00); C39(0.00)  LDD0027  [10]
WYneN
 Probe Info  		C528(0.00); C7(0.00)  LDD0021  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
Phosphinate-6
 Probe Info  		C528(0.00); C7(0.00); C131(0.00)  LDD0018  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C333(1.20)  LDD2117  [5]
 LDCM0025  4SU-RNA HEK-293T C39(5.52)  LDD0371  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C39(2.28)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C287(1.18); C528(1.02)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C287(1.16); C528(0.95)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C528(0.73)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C528(0.74)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C528(0.77)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C528(0.79)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C528(0.81)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C528(0.84)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C528(0.79)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C528(0.86)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C528(0.75)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C528(0.84)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C287(1.22); C528(0.93)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C528(0.78)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C528(0.75)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C528(0.77)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C287(0.94); C528(1.03)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C287(1.13); C528(0.97)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C287(1.18); C528(1.03)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C287(1.36); C528(0.88)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C287(1.19); C528(1.01)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C287(1.10); C528(1.02)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C287(1.13); C528(0.90)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C287(1.06); C528(0.98)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C287(1.15); C528(1.08)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C287(1.14); C528(1.01)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C287(1.13); C528(1.01)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C287(1.32); C528(1.10)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C287(1.04); C528(1.01)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C287(1.04); C528(1.09)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C287(1.35); C528(1.05)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C287(1.21); C528(1.08)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C287(1.57); C528(1.71)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C287(0.99); C528(1.57)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C287(1.20); C528(1.30)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C287(1.12); C528(1.28)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C287(1.51); C528(1.09)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C287(1.15); C528(1.19)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C287(1.27); C528(1.26)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C287(1.41); C528(1.26)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C287(1.18); C528(1.20)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C287(1.14); C528(1.28)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C287(1.31); C528(1.63)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C287(1.26); C528(1.11)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C287(1.29); C528(1.01)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C287(1.28); C528(1.35)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C287(1.39); C528(1.29)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C287(1.22); C528(1.22)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C287(1.03); C528(1.15)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C528(1.01); C287(1.01)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C528(1.04); C287(1.14)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C528(1.12); C287(1.19)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C528(1.05); C287(1.16)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C528(1.21); C287(1.51)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C528(1.09); C287(1.15)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C528(0.99); C287(1.21)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C528(1.03); C287(1.09)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C528(0.94); C287(1.04)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C287(1.09); C528(1.22)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C528(1.36); C287(1.63)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C287(1.15); C528(1.07)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C287(1.10); C528(1.11)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C287(0.88); C528(1.04)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C287(0.98); C528(1.07)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C287(0.93); C528(1.06)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C287(1.02); C528(1.10)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C287(0.88); C528(0.91)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C528(0.96); C287(1.20)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C287(0.89); C528(1.09)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C287(0.92); C528(1.07)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C287(0.84); C528(1.03)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C287(0.82); C528(1.00)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C287(0.85); C528(1.03)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C528(0.71); C287(0.97)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C528(0.82); C287(1.10)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C528(0.88); C287(1.05)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C528(0.93); C287(1.00)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C528(0.79); C287(1.05)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C528(0.97); C287(1.18)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C528(0.77); C287(1.06)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C528(0.78); C287(1.05)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C528(0.84); C287(1.25)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C528(0.83); C287(1.15)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C528(1.05); C287(1.25)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C287(0.91); C528(1.16)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C287(0.95); C528(1.12)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C287(1.00); C528(1.04)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C287(0.99); C528(1.18)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C287(1.05); C528(1.11)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C528(1.11); C287(1.27)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C528(1.10); C287(1.10)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C528(1.06); C287(1.11)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C528(1.07); C287(1.12)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C528(0.96); C287(1.16)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C528(0.94); C287(1.12)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C528(0.97); C287(1.24)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C528(0.96); C287(1.05)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C528(1.02); C287(1.04)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C528(0.92); C287(1.19)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C528(0.95); C287(1.34)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C528(1.14); C287(1.27)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C528(0.97); C287(1.21)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C528(0.91); C287(0.97)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C528(0.91); C287(1.04)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C528(1.01); C287(1.16)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C528(1.03); C287(1.13)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C528(0.94); C287(1.23)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C528(1.00); C287(1.50)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C528(0.94)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C528(1.03)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C528(0.91)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C528(0.98); C287(1.20)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C528(0.91)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C528(0.76)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C528(0.91)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C528(0.89)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C528(0.97)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C528(0.84)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C528(0.86)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C528(0.91)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C287(0.98); C528(1.16)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C287(1.00); C528(1.27)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C528(0.99); C287(1.07)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C287(0.94); C528(1.14)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C287(0.97); C528(1.24)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C287(1.03); C528(1.18)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C287(1.19); C528(1.42)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C287(1.15); C528(1.51)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C287(1.33); C528(1.45)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C287(1.04); C528(1.21)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C287(0.99); C528(1.18)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C287(0.98); C528(1.08)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C287(1.08); C528(1.18)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C528(1.06); C287(1.12)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C287(1.00); C528(1.14)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C287(0.82); C528(1.15)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C287(1.22); C528(1.60)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C528(0.94); C287(1.27)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C528(0.99); C287(1.18)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C528(0.83); C287(0.93)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C528(0.73); C287(1.11)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C528(0.80); C287(0.96)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C528(0.77); C287(0.99)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C528(0.77); C287(1.12)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C528(0.69); C287(1.00)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C528(0.92); C287(1.22)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C528(0.87); C287(1.23)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C528(0.86); C287(0.93)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C287(0.98); C528(1.06)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C528(0.79); C287(1.02)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C528(0.98); C287(1.01)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C528(0.77); C287(1.06)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C528(0.97)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C528(0.78)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C333(0.82)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C287(1.02); C528(0.88)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C528(0.90); C287(1.31)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C528(1.09); C287(1.46)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.47  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C287(1.03)  LDD0078  [7]
 LDCM0087  Capsaicin HEK-293T 6.80  LDD0185  [2]
 LDCM0632  CL-Sc Hep-G2 C39(20.00); C287(0.74)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C287(0.91); C528(0.96)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C528(0.91); C287(1.09)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C528(1.02); C287(1.19)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C528(0.88); C287(1.22)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C528(1.04); C287(1.21)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C528(0.89); C287(1.05)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C287(0.93); C528(0.98)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C528(1.01); C287(1.01)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C287(1.10); C528(1.23)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C287(1.01); C528(1.14)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C287(1.15); C528(1.15)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C287(0.94); C528(0.96)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C528(0.98); C287(1.27)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C528(0.94); C287(0.95)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C287(0.85); C528(1.01)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C528(0.90); C287(0.95)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C528(0.85); C287(1.12)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C528(0.69); C287(1.00)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C528(0.80); C287(0.96)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C528(0.91); C287(1.08)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C528(1.53); C287(1.54)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C528(1.04); C287(1.10)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C528(0.99); C287(1.10)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C528(0.99); C287(1.24)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C528(0.93); C287(1.05)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C528(0.57); C287(0.91)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C528(1.07); C287(1.14)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C528(0.91); C287(1.17)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C528(0.90); C287(1.23)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C528(0.94)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C528(1.05)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C528(0.82)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C528(1.05)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C528(1.00); C287(1.07)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C528(0.92); C287(1.00)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C528(1.02); C287(1.22)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C528(0.77); C287(1.12)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C528(1.08); C287(1.12)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C528(0.89); C287(1.25)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C528(0.91); C287(1.18)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C528(0.90); C287(1.01)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C528(0.88); C287(1.16)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C528(1.04); C287(1.43)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C528(1.15); C287(1.79)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C528(0.92); C287(1.12)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C528(0.82); C287(1.41)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C287(1.32); C528(0.78)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C287(1.07); C528(0.87)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C287(1.13); C528(0.78)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C287(1.17); C528(0.76)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C287(1.22); C528(0.77)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C287(1.02); C528(0.96)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C287(1.00); C528(0.73)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C287(0.97); C528(1.01)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C287(1.05); C528(1.01)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C287(0.99); C528(1.21)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C287(1.08); C528(1.04)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C287(0.99); C528(1.04)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C287(0.97); C528(1.08)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C287(1.11); C528(1.21)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C287(0.97); C528(1.05)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C287(0.98); C528(0.93)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C287(0.94); C528(1.05)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C287(1.11); C528(1.01)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C287(1.35); C528(1.52)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C287(1.12); C528(1.19)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C287(0.99); C528(1.02)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C287(1.13); C528(1.11)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C287(0.79); C528(0.80)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C287(0.87); C528(0.74)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C287(0.85); C528(0.91)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C287(0.83); C528(1.03)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C287(1.07); C528(0.97)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C287(0.78); C528(0.84)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C287(0.84); C528(0.84)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C287(0.83); C528(0.79)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C287(0.77); C528(0.96)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C287(0.78); C528(0.88)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C287(0.80); C528(0.84)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C287(0.92); C528(0.87)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C287(0.79); C528(0.98)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C287(0.85); C528(0.80)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C287(0.93); C528(0.89)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C287(1.10); C528(0.86)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C287(0.94); C528(0.87)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C287(1.02); C528(1.04)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C287(1.26); C528(0.99)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C287(1.20); C528(1.01)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C287(1.14); C528(1.03)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C287(1.19); C528(1.04)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C287(1.53); C528(1.06)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C287(1.27); C528(1.11)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C287(1.12); C528(1.04)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C287(1.03); C528(0.97)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C287(1.13); C528(1.01)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C287(1.21); C528(0.98)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C287(1.13); C528(0.95)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C287(1.06); C528(0.95)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C287(1.10); C528(1.06)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C287(1.10); C528(0.98)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C287(1.18); C528(1.11)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C287(1.05); C528(1.18)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C287(1.03); C528(0.96)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C287(1.16); C528(1.16)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C287(1.53); C528(1.19)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C287(1.12); C528(1.15)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C287(1.06); C528(1.09)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C287(1.45); C528(1.18)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C287(1.31); C528(1.13)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C287(1.66); C528(1.21)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C287(1.14); C528(1.08)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C287(1.12); C528(1.12)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C287(1.18); C528(0.98)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C287(1.34); C528(1.13)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C287(1.95); C528(1.24)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C287(1.01); C528(0.93)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C287(1.14); C528(1.17)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C287(1.10); C528(0.98)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C287(1.08); C528(1.07)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C287(1.09); C528(1.04)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C287(1.20); C528(0.99)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C287(1.21); C528(1.06)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C287(1.10); C528(0.95)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C287(1.10); C528(0.95)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C287(1.21); C528(0.99)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C287(1.25); C528(0.93)  LDD0811  [7]
 LDCM0027  Dopamine HEK-293T 11.19  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C528(1.69); C287(0.87); C400(0.84); C131(1.05)  LDD1698  [15]
 LDCM0625  F8 Ramos C131(1.04); C528(1.01); C287(0.21)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C528(1.03); C287(0.41)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C131(8.69); C528(1.26); C287(0.82)  LDD2190  [16]
 LDCM0575  Fragment13 Ramos C287(0.28)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C528(1.48)  LDD2193  [16]
 LDCM0580  Fragment21 Ramos C528(0.72); C287(0.62)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C131(1.02); C528(0.71); C287(0.49)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C131(2.10); C528(1.04); C287(0.30)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C131(0.73); C528(1.86); C287(0.64)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C131(1.69); C287(0.59)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C131(1.50); C287(0.49)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C528(1.20)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C287(1.21); C528(0.93)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C528(1.81); C287(0.80)  LDD2203  [16]
 LDCM0427  Fragment51 HCT 116 C287(1.25); C528(1.28)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C287(0.18)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C528(0.49); C287(0.21)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C528(2.59); C287(1.80)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C528(1.28)  LDD2188  [16]
 LDCM0022  KB02 HEK-293T C287(1.00); C400(1.17); C39(0.92)  LDD1492  [15]
 LDCM0023  KB03 Jurkat C528(4.81); C7(53.72)  LDD0209  [17]
 LDCM0024  KB05 COLO792 C131(2.57)  LDD3310  [18]
 LDCM0030  Luteolin HEK-293T 4.63  LDD0182  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C333(2.43)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C333(0.76)  LDD2101  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C333(0.60)  LDD2125  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C333(0.44)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C333(0.54)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C333(0.81)  LDD2135  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C333(1.09)  LDD2137  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C333(0.80)  LDD2146  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C23(2.40)  LDD2206  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) 3-beta-HSD family P26439
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Ubiquitin thioesterase OTUB1 (OTUB1) Peptidase C65 family Q96FW1
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
E3 ubiquitin-protein ligase RNF183 (RNF183) . Q96D59
E3 ubiquitin-protein ligase RNF34 (RNF34) . Q969K3
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
H(+)/Cl(-) exchange transporter 7 (CLCN7) Chloride channel (TC 2.A.49) family P51798
Gastrokine-1 (GKN1) Gastrokine family Q9NS71
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
Exocyst complex component 6 (EXOC6) SEC15 family Q8TAG9
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Transcription factor NF-E2 45 kDa subunit (NFE2) BZIP family Q16621
Zinc finger protein 57 (ZNF57) Krueppel C2H2-type zinc-finger protein family Q68EA5
Zinc finger protein with KRAB and SCAN domains 5 (ZKSCAN5) Krueppel C2H2-type zinc-finger protein family Q9Y2L8
LIM/homeobox protein Lhx8 (LHX8) . Q68G74
Zinc finger protein 366 (ZNF366) . Q8N895
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX3 (BEX3) BEX family Q00994
Cyclin-C (CCNC) Cyclin family P24863
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Protein FAM3B (FAM3B) FAM3 family P58499
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Mitochondrial import inner membrane translocase subunit Tim8 A (TIMM8A) Small Tim family O60220
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824
Syntaxin-11 (STX11) Syntaxin family O75558
Translin-associated protein X (TSNAX) Translin family Q99598
Fanconi anemia group G protein (FANCG) . O15287
Huntingtin-interacting protein M (H2AP) . O75409
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Lung adenoma susceptibility protein 2 (LAS2) . Q8IYD9
Melanoma-associated antigen B18 (MAGEB18) . Q96M61
Melanoma-associated antigen C2 (MAGEC2) . Q9UBF1
Nebulette (NEBL) . O76041
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) . Q9Y239
Outer dynein arm-docking complex subunit 3 (ODAD3) . A5D8V7
Regulator of G-protein signaling 17 (RGS17) . Q9UGC6
Required for excision 1-B domain-containing protein (REX1BD) . Q96EN9
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698
Superkiller complex protein 8 (SKIC8) . Q9GZS3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.