Details of the Target

General Information of Target

Target ID LDTP04126
Target Name F-actin-capping protein subunit alpha-2 (CAPZA2)
Gene Name CAPZA2
Gene ID 830
Synonyms
F-actin-capping protein subunit alpha-2; CapZ alpha-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLD
QFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESW
RTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFT
ITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQ
TAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
Target Bioclass
Other
Family
F-actin-capping protein alpha subunit family
Function
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Uniprot ID
P47755
Ensemble ID
ENST00000361183.8
HGNC ID
HGNC:1490

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A24V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
W1
 Probe Info  		26.38  LDD0235  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K97(5.88)  LDD0274  [5]
STPyne
 Probe Info  		K19(5.88); K97(8.19)  LDD0277  [5]
Probe 1
 Probe Info  		Y70(18.30)  LDD3495  [6]
BTD
 Probe Info  		C111(2.06)  LDD2127  [7]
AHL-Pu-1
 Probe Info  		C111(2.83)  LDD0168  [8]
DBIA
 Probe Info  		C141(0.86)  LDD0593  [9]
5E-2FA
 Probe Info  		H52(0.00); H23(0.00); H209(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C111(0.00); C141(0.00); C157(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
IPIAA_L
 Probe Info  		C111(0.00); C157(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C111(0.00); C141(0.00); C157(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
IPM
 Probe Info  		C111(0.00); C157(0.00)  LDD2156  [18]
SF
 Probe Info  		Y199(0.00); K278(0.00)  LDD0028  [19]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		N.A.  LDD0228  [21]
Acrolein
 Probe Info  		H23(0.00); C141(0.00); C111(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [22]
Methacrolein
 Probe Info  		C111(0.00); C141(0.00)  LDD0218  [22]
AOyne
 Probe Info  		14.70  LDD0443  [23]
NAIA_5
 Probe Info  		C141(0.00); C111(0.00); C95(0.00); C157(0.00)  LDD2223  [24]
HHS-465
 Probe Info  		N.A.  LDD2240  [25]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C111(2.83)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C111(3.63)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C111(1.07)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C111(1.17)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C111(1.01)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C111(0.96)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C111(1.18)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C111(1.00)  LDD1513  [27]
 LDCM0276  AC17 HCT 116 C141(0.86)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C141(1.57)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C141(1.19)  LDD0595  [9]
 LDCM0279  AC2 HEK-293T C111(1.26)  LDD1518  [27]
 LDCM0280  AC20 HCT 116 C141(1.03)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C141(1.33)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C141(1.00)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C141(1.35)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C141(0.86)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C141(1.12)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C141(0.66)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C141(0.74)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C141(0.71)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C141(0.55)  LDD0606  [9]
 LDCM0290  AC3 HEK-293T C111(0.95)  LDD1529  [27]
 LDCM0291  AC30 HCT 116 C141(0.52)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C141(0.59)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C141(0.45)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C141(0.82)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C141(1.10)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C141(1.33)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C141(0.84)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C141(1.32)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C141(0.76)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C141(0.95)  LDD0617  [9]
 LDCM0301  AC4 HEK-293T C111(0.93)  LDD1540  [27]
 LDCM0302  AC40 HCT 116 C141(1.15)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C141(0.84)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C141(0.81)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C141(0.50)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C141(1.70)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C141(1.70)  LDD0624  [9]
 LDCM0308  AC46 HEK-293T C111(1.08)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C111(0.95)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C111(0.96); C141(1.17)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C111(1.00)  LDD1550  [27]
 LDCM0312  AC5 HEK-293T C111(1.04)  LDD1551  [27]
 LDCM0313  AC50 HEK-293T C111(1.02)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C111(1.00)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C111(0.99)  LDD1554  [27]
 LDCM0316  AC53 HEK-293T C111(1.00)  LDD1555  [27]
 LDCM0317  AC54 HEK-293T C111(1.04)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C111(1.00)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C111(0.97); C141(1.08)  LDD1558  [27]
 LDCM0320  AC57 HCT 116 C141(0.96)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C141(0.81)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C141(1.22)  LDD0639  [9]
 LDCM0323  AC6 HEK-293T C111(1.09)  LDD1562  [27]
 LDCM0324  AC60 HCT 116 C141(1.24)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C141(1.03)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C141(1.27)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C141(1.58)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C141(1.20)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C141(0.75)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C141(0.78)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C141(1.04)  LDD0648  [9]
 LDCM0334  AC7 HEK-293T C111(0.97)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C111(1.11); C141(1.27)  LDD1569  [27]
 LDCM0248  AKOS034007472 HEK-293T C111(1.01)  LDD1511  [27]
 LDCM0356  AKOS034007680 HEK-293T C111(0.99)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C111(1.05); C141(1.17)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 11.84  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C157(0.00); H23(0.00); C111(0.00); C141(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C95(20.00); C95(0.95); C95(0.48); C111(0.47)  LDD2227  [24]
 LDCM0367  CL1 HEK-293T C111(0.96)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C111(0.89)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C111(0.90)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C111(1.02)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C111(0.91)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C111(1.24)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C111(0.93)  LDD1577  [27]
 LDCM0374  CL105 HCT 116 C141(1.43)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C141(2.49)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C141(1.66)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C141(1.46)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C141(1.17)  LDD0695  [9]
 LDCM0379  CL11 HEK-293T C111(0.92)  LDD1583  [27]
 LDCM0380  CL110 HCT 116 C141(1.09)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C141(0.86)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C141(0.76)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C141(0.56)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C141(0.70)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C141(0.71)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C141(0.85)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C141(0.70)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C141(0.50)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C141(0.72)  LDD0706  [9]
 LDCM0390  CL12 HEK-293T C111(0.94); C141(1.06)  LDD1594  [27]
 LDCM0391  CL120 HCT 116 C141(0.61)  LDD0708  [9]
 LDCM0392  CL121 HEK-293T C111(1.03)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C111(0.91)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C111(1.08)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C111(0.91)  LDD1599  [27]
 LDCM0396  CL125 HCT 116 C141(0.85)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C141(0.70)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C141(0.90)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C141(1.06)  LDD0716  [9]
 LDCM0400  CL13 HEK-293T C111(1.00)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C111(1.09)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C111(1.13)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C111(1.03)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C111(0.90)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C111(1.05)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C111(0.96)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C111(1.01)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C111(1.02)  LDD1612  [27]
 LDCM0409  CL21 HEK-293T C111(0.93)  LDD1613  [27]
 LDCM0410  CL22 HEK-293T C111(0.95)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C111(1.04)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C111(0.93); C141(1.04)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C111(1.03)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C111(0.95)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C111(1.08)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C111(0.96)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C111(1.05)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C111(1.27)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C111(0.91)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C111(0.82)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C111(1.05)  LDD1625  [27]
 LDCM0422  CL33 HEK-293T C111(0.90)  LDD1626  [27]
 LDCM0423  CL34 HEK-293T C111(0.94)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C111(1.10)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C111(0.96); C141(1.06)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C111(1.06)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C111(1.26)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C111(0.98)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C111(0.99)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C111(0.86)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C111(1.86)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C111(0.84)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C111(1.01)  LDD1638  [27]
 LDCM0435  CL45 HEK-293T C111(1.02)  LDD1639  [27]
 LDCM0436  CL46 HCT 116 C141(0.55)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C141(0.66)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C141(0.79)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C141(0.81)  LDD0756  [9]
 LDCM0440  CL5 HEK-293T C111(0.94)  LDD1644  [27]
 LDCM0441  CL50 HCT 116 C141(0.90)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C141(0.73)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C141(0.55)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C141(0.99)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C141(0.64)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C141(0.95)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C141(0.78)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C141(0.83)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C141(0.77)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C141(0.88)  LDD0767  [9]
 LDCM0451  CL6 HEK-293T C111(0.79)  LDD1654  [27]
 LDCM0452  CL60 HCT 116 C141(0.61)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C141(0.84)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C141(0.79)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C141(0.94)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C141(0.81)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C141(1.22)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C141(0.91)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C141(1.52)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C141(1.09)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C141(0.56)  LDD0778  [9]
 LDCM0462  CL7 HEK-293T C111(0.97)  LDD1665  [27]
 LDCM0463  CL70 HCT 116 C141(0.83)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C141(0.97)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C141(0.60)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C141(0.81)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C141(1.05)  LDD0784  [9]
 LDCM0469  CL76 HEK-293T C111(0.99)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C111(0.91)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C111(0.84)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C111(0.95)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C111(0.73)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C111(1.06)  LDD1677  [27]
 LDCM0475  CL81 HEK-293T C111(1.03)  LDD1678  [27]
 LDCM0476  CL82 HEK-293T C111(1.01)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C111(1.07)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C111(0.90); C141(1.11)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C111(1.08)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C111(1.01)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C111(1.12)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C111(0.94)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C111(1.00)  LDD1686  [27]
 LDCM0484  CL9 HEK-293T C111(1.02)  LDD1687  [27]
 LDCM0485  CL90 HEK-293T C111(0.98)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C111(0.96)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C111(0.93)  LDD1690  [27]
 LDCM0488  CL93 HEK-293T C111(1.00)  LDD1691  [27]
 LDCM0489  CL94 HEK-293T C111(0.94)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C111(0.76)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C111(0.91); C141(1.24)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C111(1.00)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C111(0.92)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C111(1.12)  LDD1697  [27]
 LDCM0495  E2913 HEK-293T C111(1.06)  LDD1698  [27]
 LDCM0625  F8 Ramos C111(1.22)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C111(0.93)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C111(0.92)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C111(0.63)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C111(0.92)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C111(0.73)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C111(1.31)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C111(0.97)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C111(0.98)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C111(1.08)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C111(1.49)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C111(1.12)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C111(1.05)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C111(0.88)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C141(0.76)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C111(0.77)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C111(0.85)  LDD2184  [28]
 LDCM0427  Fragment51 HEK-293T C111(1.00)  LDD1631  [27]
 LDCM0610  Fragment52 Ramos C111(1.11)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C111(1.19)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C111(0.83)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C111(1.01)  LDD2188  [28]
 LDCM0107  IAA HeLa H23(0.00); C157(0.00); C141(0.00); C111(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C111(1.02)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C111(1.03)  LDD1497  [27]
 LDCM0024  KB05 HMCB C157(1.83)  LDD3312  [29]
 LDCM0109  NEM HeLa N.A.  LDD0223  [22]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C111(2.06)  LDD2127  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C141(1.11)  LDD2136  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C141(0.68)  LDD2150  [7]
 LDCM0131  RA190 MM1.R C111(1.04)  LDD0304  [30]
 LDCM0112  W16 Hep-G2 C111(0.71)  LDD0239  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
26 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.