Details of the Target

General Information of Target

Target ID LDTP05239
Target Name Vigilin (HDLBP)
Gene Name HDLBP
Gene ID 3069
Synonyms
HBP; VGL; Vigilin; High density lipoprotein-binding protein; HDL-binding protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEP
AGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLA
KDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKT
ATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGP
YNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAV
EVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAK
ANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVA
QEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNL
IRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEV
IINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKG
GANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSI
PAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLA
EEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKE
DAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRS
GTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQIT
RDFSVQIKFPDREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKC
EAAKEALEALVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAI
TGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRL
EHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHA
RIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLAD
VVDSEALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPK
TLPWGPKR
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Uniprot ID
Q00341
Ensemble ID
ENST00000310931.10
HGNC ID
HGNC:4857
ChEMBL ID
CHEMBL4295796

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
W1
 Probe Info  		11.78  LDD0235  [3]
TH211
 Probe Info  		Y465(20.00); Y986(5.11)  LDD0257  [4]
TH216
 Probe Info  		Y465(12.43)  LDD0259  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K510(0.66); K494(2.15); K1066(6.11)  LDD3494  [7]
Probe 1
 Probe Info  		Y40(14.58); Y309(40.76); Y738(39.64); Y830(6.95)  LDD3495  [8]
BTD
 Probe Info  		C566(2.27); C855(1.37); C960(1.10); C636(1.07)  LDD1700  [9]
DA-P3
 Probe Info  		4.27  LDD0182  [10]
AHL-Pu-1
 Probe Info  		C948(2.17); C940(2.39)  LDD0168  [11]
HHS-475
 Probe Info  		Y437(0.93); Y986(0.94); Y582(3.65)  LDD0264  [12]
HHS-465
 Probe Info  		Y437(10.00); Y582(4.07); Y986(8.51)  LDD2237  [13]
DBIA
 Probe Info  		C940(1.02); C948(1.01)  LDD0078  [14]
5E-2FA
 Probe Info  		H81(0.00); H15(0.00); H114(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K1071(0.00); K714(0.00); K453(0.00); K991(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C636(0.00); C948(0.00); C940(0.00); C104(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C948(0.00); C940(0.00)  LDD0032  [18]
Lodoacetamide azide
 Probe Info  		C940(0.00); C855(0.00); C104(0.00); C948(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		K510(0.00); K466(0.00)  LDD0035  [19]
WYneO
 Probe Info  		C104(0.00); C636(0.00)  LDD0022  [20]
ENE
 Probe Info  		N.A.  LDD0006  [20]
IPM
 Probe Info  		N.A.  LDD0005  [20]
PF-06672131
 Probe Info  		N.A.  LDD0152  [21]
SF
 Probe Info  		K510(0.00); Y986(0.00); K494(0.00)  LDD0028  [22]
STPyne
 Probe Info  		K714(0.00); K494(0.00); K453(0.00)  LDD0009  [20]
TFBX
 Probe Info  		C855(0.00); C104(0.00); C636(0.00); C940(0.00)  LDD0148  [23]
VSF
 Probe Info  		C948(0.00); C940(0.00)  LDD0007  [20]
Phosphinate-6
 Probe Info  		C636(0.00); C855(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		K25(0.00); K274(0.00); K536(0.00); K590(0.00)  LDD0228  [25]
1d-yne
 Probe Info  		K908(0.00); K1240(0.00)  LDD0357  [25]
Acrolein
 Probe Info  		H665(0.00); H1136(0.00); C636(0.00); C104(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		C104(0.00); C636(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C104(0.00); C636(0.00); C940(0.00); C948(0.00)  LDD0218  [26]
NAIA_5
 Probe Info  		C636(0.00); C855(0.00); C960(0.00); C566(0.00)  LDD2223  [27]
HHS-482
 Probe Info  		Y437(0.78); Y582(2.09); Y89(0.90); Y986(0.81)  LDD2239  [13]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		12.68  LDD0475  [28]
FFF probe2
 Probe Info  		9.39  LDD0463  [28]
FFF probe3
 Probe Info  		12.41  LDD0464  [28]
STS-1
 Probe Info  		N.A.  LDD0136  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C566(0.74); C960(1.01)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C566(1.26); C636(1.00); C855(0.70)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C566(1.26); C636(1.04); C855(1.08); C960(0.89)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C566(1.04); C855(1.15); C960(1.02); C104(1.06)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C566(2.02); C636(1.29); C855(1.59); C960(1.45)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C566(0.57); C636(1.12); C960(0.53)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C566(0.63); C636(0.33); C855(0.68)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C566(0.70); C636(0.70); C855(0.81)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C948(2.17); C940(2.39)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C948(2.28); C940(2.58)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C636(1.24); C104(1.24); C683(0.83); C855(1.09)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C636(1.26); C104(1.01); C855(1.09); C940(1.32)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C636(0.76); C104(0.77); C855(0.57); C940(1.14)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C636(0.75); C104(0.75); C855(0.59); C940(1.04)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C636(0.83); C104(0.64); C855(0.58); C940(1.05)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C636(0.81); C104(0.74); C855(0.52); C940(1.19)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C636(0.73); C104(0.63); C855(0.66); C940(1.08)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C636(0.73); C104(0.66); C855(0.60); C940(1.22)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C636(0.96); C104(0.65); C855(0.55); C940(1.30)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C636(0.69); C104(0.76); C855(0.53); C940(1.43)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C636(0.65); C104(0.76); C855(0.61); C940(1.01)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C636(0.71); C104(0.66); C855(0.57); C940(0.99)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C636(0.93); C104(1.04); C855(0.90); C940(1.24)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C636(0.69); C104(0.76); C855(0.51); C940(1.06)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C636(0.63); C104(0.77); C855(0.55); C940(1.13)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C636(0.78); C104(0.66); C855(0.52); C940(1.04)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C636(0.89); C104(0.85); C855(1.29); C940(1.03)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C636(0.81); C104(0.66); C855(1.28); C940(1.23)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C636(0.79); C104(0.61); C855(1.46); C940(1.30)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C636(0.90); C104(0.63); C855(1.24); C940(1.34)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C636(0.92); C104(0.68); C855(1.14); C940(1.23)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C636(0.86); C104(0.82); C855(1.32); C940(1.16)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C636(0.84); C104(0.72); C855(1.48); C940(1.29)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C636(1.18); C104(1.03); C855(1.05); C940(1.10)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C636(0.95); C104(0.88); C855(1.23); C940(1.14)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C636(0.85); C104(0.88); C855(1.31); C940(1.11)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C636(0.97); C104(0.88); C855(1.04); C940(1.19)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C636(0.86); C104(0.87); C855(1.00); C940(1.15)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C636(1.09); C104(0.87); C855(1.24); C940(1.04)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C636(0.88); C104(0.82); C855(1.01); C940(1.17)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C636(0.73); C104(0.66); C855(0.93); C940(1.27)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C636(0.94); C104(0.64); C855(0.97); C940(1.33)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C636(0.65); C104(1.22); C855(0.83); C940(1.15)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C636(0.75); C104(1.10); C855(0.92); C940(0.91)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C636(0.67); C104(1.01); C855(0.82); C940(1.10)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C636(0.64); C104(0.94); C855(0.97); C940(0.87)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C636(0.61); C104(1.14); C855(1.31); C940(0.95)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C636(0.60); C104(1.05); C855(1.15); C940(1.06)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C636(1.00); C104(1.00); C855(0.79); C940(1.13)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C636(0.81); C104(1.05); C855(0.90); C940(1.10)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C636(0.69); C104(1.10); C855(0.88); C940(1.06)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C636(0.59); C104(1.11); C855(1.08); C940(0.97)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C636(0.82); C104(1.07); C855(0.97); C940(1.13)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C636(0.78); C104(1.10); C855(0.90); C940(1.07)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C636(1.10); C104(1.01); C855(0.93); C940(1.20)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C636(0.71); C104(1.06); C855(0.94); C940(1.22)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C636(0.56); C104(1.00); C855(1.04); C940(1.17)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C636(0.71); C104(1.37); C855(1.26); C940(1.02)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C636(0.72); C104(0.66); C683(1.00); C940(1.04)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C104(0.53); C683(0.93); C636(1.08); C948(1.42)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C104(0.55); C683(0.94); C948(1.18); C940(1.26)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C104(0.70); C683(0.96); C940(1.21); C636(1.22)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C104(0.63); C636(0.75); C683(1.11); C948(1.41)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C104(0.62); C636(0.85); C683(1.07); C940(1.95)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C104(0.59); C636(0.99); C683(1.12); C940(1.37)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C104(1.00); C948(1.14); C855(1.15); C636(1.19)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C104(0.64); C683(0.87); C948(1.16); C940(1.18)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C104(0.64); C683(1.00); C948(1.17); C940(1.23)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C104(0.51); C636(0.56); C683(0.95); C948(1.10)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C104(0.76); C683(1.04); C636(1.32); C948(2.06)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C636(1.25); C104(0.50); C683(1.16); C940(1.23)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C636(1.11); C104(0.57); C683(1.00); C940(1.31)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C636(1.09); C104(0.68); C683(1.05); C940(1.04)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C636(1.17); C104(0.62); C683(0.97); C940(0.96)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C104(0.77); C636(0.90); C683(0.92); C940(1.00)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C104(0.64); C948(0.77); C855(0.82); C636(0.87)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C636(0.72); C104(0.76); C683(0.87); C855(1.00)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C683(0.92); C104(1.05); C636(1.07); C940(1.07)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C683(0.66); C104(0.77); C855(0.95); C636(0.97)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C636(0.67); C104(0.74); C948(0.91); C855(0.92)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C636(0.85); C683(0.85); C104(0.89); C940(0.97)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C683(0.69); C104(0.80); C855(1.03); C636(1.04)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C683(0.76); C636(0.91); C104(0.94); C940(0.98)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C855(0.86); C104(0.92); C940(0.92); C948(1.07)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C104(0.81); C855(0.83); C940(1.05); C683(1.17)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C104(0.73); C940(0.98); C855(1.03); C683(1.20)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C104(0.76); C855(0.95); C948(1.02); C940(1.02)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C104(0.78); C855(0.89); C683(1.10); C940(1.28)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C683(0.80); C636(0.89); C940(0.98); C104(1.07)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C104(0.78); C855(0.89); C683(1.25); C940(1.28)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C104(0.76); C855(0.92); C940(1.01); C683(1.10)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C104(0.72); C855(0.84); C940(1.15); C683(1.24)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C104(0.74); C855(0.91); C940(1.03); C683(1.29)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C104(0.70); C855(0.82); C948(1.20); C683(1.23)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C948(0.68); C940(0.85); C855(0.89); C683(0.96)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C855(0.84); C940(0.98); C636(1.00); C948(1.02)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C855(0.87); C940(0.93); C683(0.97); C948(1.07)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C855(0.95); C940(1.01); C948(1.03); C104(1.03)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C636(0.88); C855(0.91); C940(0.99); C948(0.99)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C683(0.75); C636(0.78); C104(0.99); C940(1.17)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C855(0.94); C940(0.96); C104(1.03); C636(1.04)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C855(0.85); C683(1.06); C940(1.08); C948(1.10)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C855(0.82); C940(0.99); C948(1.05); C104(1.09)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C855(0.79); C104(1.12); C940(1.17); C683(1.29)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C855(0.79); C940(0.99); C104(1.10); C683(1.12)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C855(0.81); C940(1.03); C683(1.06); C104(1.12)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C683(0.91); C104(1.00); C948(1.12); C940(1.20)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C683(0.91); C104(1.02); C940(1.07); C948(1.26)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C683(0.97); C940(1.17); C855(1.18); C104(1.22)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C683(0.96); C855(0.98); C104(1.00); C948(1.22)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C636(0.63); C683(0.81); C104(0.97); C940(1.19)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C683(0.97); C104(0.98); C855(0.98); C948(1.45)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C855(0.96); C940(0.97); C683(1.00); C948(1.13)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C683(0.83); C104(0.89); C940(1.18); C855(1.18)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C104(1.02); C683(1.04); C855(1.11); C940(1.11)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C683(0.98); C104(1.01); C948(1.08); C855(1.13)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C683(0.93); C855(1.05); C104(1.11); C940(1.27)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C683(1.09); C855(1.09); C104(1.30); C940(1.49)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C855(0.83); C636(0.96); C104(1.02); C948(1.21)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C855(0.86); C636(1.07); C104(1.20); C948(1.31)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C636(0.88); C855(1.05); C104(1.17); C948(1.31)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C104(0.85); C636(0.96); C855(1.06); C940(1.27)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C636(0.74); C855(0.81); C104(1.09); C948(1.27)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C855(0.88); C636(0.99); C104(1.23); C948(1.29)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C636(0.83); C855(1.18); C104(1.22); C940(1.61)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C855(0.83); C636(0.92); C948(1.15); C104(1.24)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C636(0.74); C855(0.88); C104(1.19); C948(1.33)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C636(0.96); C855(1.10); C948(1.54); C104(1.54)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C636(0.93); C855(0.96); C948(1.27); C104(1.46)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C636(0.85); C855(1.01); C104(1.38); C948(1.54)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C104(0.82); C636(0.86); C855(0.90); C948(0.98)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C104(0.89); C855(0.93); C948(1.03); C940(1.04)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C636(0.91); C104(0.95); C855(1.07); C948(1.14)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C104(0.86); C636(0.89); C855(0.90); C940(1.13)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C855(0.92); C104(0.93); C940(0.94); C948(0.96)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C104(0.90); C855(0.93); C948(1.08); C940(1.26)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C855(0.90); C104(1.15); C948(1.37); C940(1.38)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C855(0.97); C104(1.14); C636(1.22); C940(1.25)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C636(1.00); C855(1.04); C104(1.14); C948(1.51)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C104(0.83); C855(0.88); C636(1.15); C940(1.27)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C855(0.77); C104(1.09); C940(1.12); C636(1.14)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C636(0.93); C855(0.96); C104(0.98); C940(1.01)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C104(0.85); C855(0.88); C940(0.97); C636(1.00)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C948(0.95); C104(0.96); C855(1.07); C940(1.23)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C855(0.77); C104(0.93); C948(0.98); C636(1.04)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C948(0.83); C636(0.86); C940(0.95); C104(1.00)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C855(0.96); C636(1.06); C104(1.12); C948(1.40)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C855(0.74); C104(0.77); C948(1.48); C940(1.49)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C104(0.75); C855(0.76); C948(1.04); C940(1.42)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C855(0.79); C104(0.82); C948(1.03); C940(1.44)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C104(0.72); C855(0.90); C940(1.24); C948(1.31)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C104(0.94); C855(0.96); C948(1.12); C940(1.16)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C104(0.73); C855(0.76); C948(1.11); C940(1.30)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C104(0.69); C855(0.72); C948(1.28); C940(1.35)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C855(0.89); C104(1.06); C940(1.15); C948(1.33)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C104(0.77); C855(0.79); C940(1.55); C948(1.58)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C855(0.69); C104(0.71); C940(1.47); C948(1.47)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C855(0.68); C104(0.71); C948(0.93); C940(1.25)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C104(0.73); C855(0.74); C948(0.88); C940(1.16)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C855(0.66); C104(0.86); C948(1.16); C940(1.18)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C855(0.65); C104(0.70); C940(1.31); C948(1.35)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C855(0.60); C104(0.67); C948(1.15); C940(1.42)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C855(0.60); C104(0.76); C636(0.96); C948(1.25)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C855(0.62); C636(0.83); C948(0.85); C104(0.85)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C566(0.30)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C566(0.82); C636(0.74); C960(1.00)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C636(1.20); C104(1.17); C855(1.01); C940(1.09)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C855(0.91); C104(1.05); C636(1.13); C940(1.14)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C855(0.94); C104(0.95); C636(1.29); C948(1.68)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C940(1.02); C948(1.01)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C566(0.50); C960(0.35); C940(0.57)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C683(0.00); H81(0.00); H1136(0.00); H665(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C104(3.85); C948(3.02); C948(1.10); C948(0.75)  LDD2227  [27]
 LDCM0367  CL1 HCT 116 C940(0.93); C948(0.94); C104(0.96); C855(1.19)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C104(1.02); C855(1.25); C948(1.34); C940(1.38)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C636(0.85); C683(0.86); C855(0.94); C104(1.04)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C104(0.93); C855(1.01); C636(1.09); C948(1.24)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C636(0.90); C855(0.95); C104(0.98); C940(1.06)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C855(1.03); C940(1.05); C636(1.07); C104(1.09)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C636(0.97); C104(0.98); C940(1.07); C948(1.10)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C104(0.69); C683(0.71); C855(0.89); C636(0.93)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C104(0.66); C855(0.86); C683(0.89); C948(1.28)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C104(0.63); C683(0.76); C855(0.89); C636(1.04)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C104(0.68); C855(0.86); C683(0.89); C948(1.10)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C104(0.66); C683(0.81); C636(0.84); C855(0.96)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C855(1.06); C104(1.09); C948(1.30); C940(1.40)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C104(0.61); C636(0.76); C683(0.90); C855(0.91)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C104(0.68); C636(0.71); C683(0.80); C948(1.02)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C948(0.88); C940(0.94); C104(0.95); C855(0.96)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C104(0.66); C855(0.79); C683(1.14); C940(1.16)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C855(0.69); C104(0.74); C683(1.07); C940(1.26)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C104(0.72); C855(0.78); C948(1.04); C940(1.15)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C104(0.81); C855(0.88); C940(1.11); C683(1.18)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C855(0.88); C940(1.07); C683(1.20); C636(1.32)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C636(0.88); C855(0.97); C940(0.99); C683(1.03)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C855(0.82); C940(1.04); C948(1.05); C683(1.06)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C104(1.09); C855(1.42); C940(1.47); C948(1.61)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C855(0.85); C940(1.06); C104(1.07); C683(1.07)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C683(1.00); C948(1.06); C104(1.06); C855(1.14)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C855(0.97); C683(1.03); C104(1.05); C940(1.19)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C683(0.90); C104(0.93); C948(1.16); C940(1.24)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C104(0.97); C683(1.00); C855(1.16); C940(1.31)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C855(0.96); C948(0.98); C636(1.06); C104(1.08)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C855(0.94); C636(1.00); C948(1.02); C104(1.22)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C636(0.96); C855(0.99); C104(1.12); C948(1.21)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C636(0.82); C104(1.16); C855(1.32); C948(1.35)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C940(1.23); C948(1.32); C104(1.34); C855(1.41)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C104(0.93); C940(1.06); C948(1.11); C855(1.23)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C104(1.06); C948(1.09); C855(1.16); C940(1.25)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C636(0.92); C948(1.07); C940(1.11); C104(1.15)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C104(0.98); C855(0.99); C948(1.00); C636(1.04)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C636(1.09); C855(1.11); C104(1.15); C940(1.16)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C636(0.94); C855(0.97); C104(1.03); C940(1.14)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C104(0.94); C940(0.99); C948(1.01); C855(1.02)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C855(1.03); C636(1.18); C104(1.21); C940(1.42)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C855(0.92); C636(0.93); C104(1.09); C948(1.37)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C636(1.07); C855(1.09); C104(1.18); C940(1.61)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C104(1.01); C855(1.04); C636(1.10); C948(1.27)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C855(1.09); C636(1.14); C104(1.23); C940(1.37)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C636(1.08); C104(1.17); C855(0.88); C940(1.32)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C636(1.02); C104(0.94); C855(0.87); C940(1.33)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C636(1.17); C104(1.26); C855(0.87); C940(1.21)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C636(1.03); C104(1.05); C855(0.81); C940(1.32)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C636(1.03); C104(1.15); C855(0.86); C940(1.25)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C104(0.96); C855(1.07); C940(1.08); C948(1.05)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C636(1.20); C104(1.01); C855(0.74); C940(1.08)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C636(1.03); C104(1.02); C855(0.84); C940(1.08)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C636(1.18); C104(0.87); C855(0.83); C940(1.09)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C636(1.14); C104(0.91); C855(0.89); C940(1.23)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C636(0.87); C104(0.94); C855(0.73); C940(1.21)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C636(1.05); C104(0.88); C855(0.78); C940(1.25)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C636(0.82); C104(0.92); C855(0.84); C940(1.20)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C636(0.98); C104(0.96); C855(0.80); C940(1.26)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C636(1.41); C104(0.86); C855(0.75); C940(1.41)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C104(0.88); C855(0.99); C940(1.07); C948(1.09)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C636(0.86); C104(0.87); C855(0.79); C940(1.22)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C636(1.92); C104(1.54); C855(0.74); C940(1.18)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C636(1.39); C104(0.86); C855(0.90); C940(1.57)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C636(0.85); C104(0.91); C855(0.69); C940(1.32)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C636(1.09); C104(0.94); C855(0.70); C940(1.14)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C636(1.18); C104(1.06); C855(0.84); C940(1.33)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C636(1.18); C104(1.12); C855(1.28); C940(1.00)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C636(1.12); C104(0.98); C855(1.23); C940(0.95)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C636(1.42); C104(1.27); C855(1.44); C940(0.91)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C636(1.28); C104(1.09); C855(1.06); C940(0.91)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C104(0.94); C855(1.05); C940(1.06); C948(1.11)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C636(1.35); C104(0.94); C855(1.17); C940(0.92)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C636(1.36); C104(1.20); C855(1.20); C940(1.05)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C636(0.87); C104(1.25); C855(1.26); C940(1.05)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C636(0.87); C104(0.85); C855(1.15); C940(0.95)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C636(1.10); C104(0.92); C855(1.18); C940(1.00)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C636(1.08); C104(1.06); C855(1.13); C940(0.99)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C636(1.21); C104(1.07); C855(1.09); C940(0.96)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C636(1.07); C104(0.94); C855(1.09); C940(0.97)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C636(1.25); C104(0.97); C855(0.88); C940(0.95)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C636(0.78); C104(1.09); C855(0.98); C940(0.96)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C104(1.02); C855(1.16); C940(1.15); C948(1.12)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C636(1.21); C104(1.22); C855(0.88); C940(1.00)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C636(0.98); C104(0.97); C855(1.02); C940(1.10)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C636(1.37); C104(1.06); C855(0.96); C940(1.08)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C636(1.13); C104(0.92); C855(0.86); C940(1.15)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C636(0.91); C104(0.88); C855(0.89); C940(1.07)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C636(1.04); C104(0.95); C855(0.88); C940(1.00)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C636(1.53); C104(0.96); C855(0.83); C940(1.40)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C636(1.67); C104(0.92); C855(0.86); C940(1.17)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C636(0.85); C104(0.94); C855(0.98); C940(1.15)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C636(1.45); C104(1.21); C855(1.04); C940(0.99)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C104(1.18); C855(1.31); C940(1.33); C948(1.32)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C636(1.17); C104(1.08); C855(1.03); C940(1.19)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C636(0.99); C104(0.93); C855(0.93); C940(1.07)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C636(1.00); C104(1.03); C855(1.01); C940(0.97)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C636(1.17); C104(0.92); C855(0.92); C940(1.18)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C636(1.11); C104(0.91); C855(0.95); C940(1.18)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C636(1.03); C104(1.03); C855(0.90); C940(1.14)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C636(0.73); C104(1.35); C855(1.00); C940(1.02)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C636(0.62); C104(0.82); C855(0.97); C940(1.22)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C636(0.86); C104(0.77); C855(1.01); C940(1.39)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C104(1.08); C855(0.98); C940(1.56); C948(1.28)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C636(1.09); C104(1.31); C855(0.98); C940(1.04)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C636(0.83); C104(1.25); C855(0.98); C940(1.22)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C636(0.73); C104(0.96); C855(0.90); C940(1.57)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C636(0.72); C104(0.95); C855(0.99); C940(1.40)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C636(0.82); C104(1.07); C855(0.94); C940(1.60)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C636(1.15); C104(0.86); C855(0.75); C940(1.22)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C636(0.81); C104(1.09); C855(0.72); C940(1.03)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C636(1.02); C104(1.05); C855(0.79); C940(1.19)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C636(0.76); C104(1.17); C855(0.86); C940(1.41)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C636(0.84); C104(1.37); C855(0.89); C940(1.81)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C104(0.93); C855(1.11); C940(1.14); C948(1.15)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C636(0.70); C104(1.47); C855(0.65); C940(0.91)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C636(0.87); C104(0.89); C683(0.83); C855(0.97)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C636(1.08); C104(0.86); C683(0.69); C855(0.82)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C636(0.84); C104(0.97); C683(0.96); C855(1.11)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C636(0.74); C104(0.93); C683(0.84); C855(1.01)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C636(0.69); C104(0.83); C683(0.75); C855(0.97)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C636(1.24); C104(0.93); C683(1.08); C855(1.01)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C636(0.74); C104(0.92); C683(0.86); C855(1.02)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C636(0.98); C104(0.98); C683(0.70); C855(1.23)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C636(0.94); C104(1.04); C683(0.98); C855(1.15)  LDD0811  [14]
 LDCM0495  E2913 HEK-293T C636(1.13); C940(0.94); C948(0.99); C104(1.02)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C104(1.05)  LDD1702  [9]
 LDCM0031  Epigallocatechin gallate HEK-293T 7.82  LDD0183  [10]
 LDCM0625  F8 Ramos C104(0.72)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C104(0.91)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C104(0.81); C855(12.21)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C104(1.20)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C104(1.08)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C104(1.35); C855(0.91)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C104(1.11)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C104(1.37)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C104(1.62)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C104(1.26)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C104(0.59)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C104(1.14)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C104(1.27)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C104(1.01)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C636(0.98); C104(0.97); C855(0.95); C940(1.13)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C104(1.38)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C104(0.77)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C636(1.01); C104(0.69); C855(0.65); C940(1.42)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C104(1.17)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C104(1.31)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C104(0.84); C855(0.27)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C104(0.95)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y437(0.93); Y986(0.94); Y582(3.65)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y437(0.80); Y986(1.02); Y582(13.56)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y437(0.69); Y986(0.77); Y582(0.78)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y986(0.99); Y437(1.28); Y582(1.45)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y582(0.60); Y437(0.75); Y986(1.76)  LDD0268  [12]
 LDCM0107  IAA HeLa H81(0.00); H1136(0.00); H665(0.00); H398(0.00)  LDD0221  [26]
 LDCM0022  KB02 HCT 116 C636(1.57); C948(1.93)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C636(2.56); C948(1.96)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C636(1.90); C948(1.64)  LDD0082  [14]
 LDCM0030  Luteolin HEK-293T 4.27  LDD0182  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C566(0.66); C636(1.07); C960(0.73)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C636(0.29); C855(0.79)  LDD2121  [9]
 LDCM0109  NEM HeLa H81(0.00); H376(0.00); H665(0.00); H210(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C566(0.76); C636(0.46); C855(1.15); C960(0.40)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C566(0.82); C636(0.80); C855(1.27); C960(1.11)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C566(0.72); C636(0.97); C855(1.08); C960(0.96)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C566(0.61); C636(0.65); C855(1.07); C960(0.84)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C566(1.11); C636(1.04); C855(2.23); C960(0.92)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C566(0.52); C855(0.28); C960(0.82)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C566(1.00); C636(0.92); C960(1.09)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C566(0.49); C636(1.04); C855(0.96); C960(0.71)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C566(0.99); C636(0.77); C960(0.93)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C566(0.57); C960(1.00); C940(0.54)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C566(0.65); C636(0.98); C960(1.02)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C566(0.63); C960(1.07); C940(0.81)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C566(1.00); C636(1.29)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C566(0.39); C940(0.52)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C566(1.01); C636(0.98); C855(1.40); C960(0.85)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C566(0.79); C855(1.25); C960(0.80)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C566(0.45); C855(0.81); C960(0.56); C104(0.66)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C566(0.83)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C566(1.05); C636(0.85); C855(1.60); C960(0.94)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C566(0.65); C960(1.01)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C566(0.53); C636(0.53); C960(0.79); C104(0.84)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C566(0.63); C855(0.57); C960(0.97)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C566(0.67); C855(0.56); C960(1.04); C940(1.06)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C566(2.53); C636(1.85); C855(1.71); C960(2.02)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C566(1.00); C940(0.85)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C566(0.47); C855(0.42); C960(0.87)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C566(0.88); C855(0.57); C960(0.57)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C566(0.50); C855(0.46); C960(0.96)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C566(0.64); C636(0.75); C855(0.85); C960(0.76)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C566(0.62); C855(0.60); C960(1.01)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C566(1.03); C636(1.07); C855(1.14); C960(0.95)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C566(1.05); C940(0.61)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C566(0.70); C636(0.73); C855(0.93); C948(1.18)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C566(0.42); C636(0.59)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C566(0.46); C636(0.46); C960(0.42)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C566(0.76); C636(0.70); C855(1.17); C960(0.51)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C636(1.06); C855(1.05); C960(0.99); C104(1.43)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C566(1.09); C636(0.96); C855(0.80); C960(1.03)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C566(2.27); C855(1.37); C960(1.10); C636(1.07)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C566(0.78); C636(0.84); C855(1.14); C960(0.65)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C566(0.68); C960(0.69); C940(0.84)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C566(1.41); C960(1.48); C940(0.94)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C566(4.39); C636(2.41); C960(3.01)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C566(5.81)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C566(0.77); C636(0.90); C855(0.81); C104(1.06)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C566(0.38); C636(0.58); C960(0.71)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C566(0.64); C855(0.48); C960(0.99)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C566(0.38); C636(0.35); C855(0.52); C960(0.43)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C566(0.59); C855(0.64); C960(1.16)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C566(1.02); C855(2.70); C960(1.09)  LDD2153  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C104(0.35)  LDD2207  [32]
 LDCM0021  THZ1 HCT 116 C636(1.34); C948(1.36); C940(1.13); C855(1.22)  LDD2173  [14]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional repressor CTCF (CTCF) CTCF zinc-finger protein family P49711
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA repair protein RAD51 homolog 1 (RAD51) RecA family Q06609

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.