Details of the Target

General Information of Target

Target ID LDTP07932
Target Name Probable ATP-dependent RNA helicase DDX46 (DDX46)
Gene Name DDX46
Gene ID 9879
Synonyms
KIAA0801; Probable ATP-dependent RNA helicase DDX46; EC 3.6.4.13; DEAD box protein 46; PRP5 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRS
RSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRS
KEKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAME
NIGELKKEIEEMKQGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVK
KFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSSEEEE
VDLQTALTGYQTKQRKLLEPVDHGKIEYEPFRKNFYVEVPELAKMSQEEVNVFRLEMEGI
TVKGKGCPKPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIMSGRDLIGIAKTGS
GKTIAFLLPMFRHIMDQRSLEEGEGPIAVIMTPTRELALQITKECKKFSKTLGLRVVCVY
GGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRRVTYVVLDEADRMFDMGFE
PQVMRIVDNVRPDRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQQVIVI
EEEKKFLKLLELLGHYQESGSVIIFVDKQEHADGLLKDLMRASYPCMSLHGGIDQYDRDS
IINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDYVHRAGRTGRAGNKGYAY
TFITEDQARYAGDIIKALELSGTAVPPDLEKLWSDFKDQQKAEGKIIKKSSGFSGKGFKF
DETEQALANERKKLQKAALGLQDSDDEDAAVDIDEQIESMFNSKKRVKDMAAPGTSSVPA
PTAGNAEKLEIAKRLALRINAQKNLGIESQDVMQQATNAILRGGTILAPTVSAKTIAEQL
AEKINAKLNYVPLEKQEEERQDGGQNESFKRYEEELEINDFPQTARWKVTSKEALQRISE
YSEAAITIRGTYFPPGKEPKEGERKIYLAIESANELAVQKAKAEITRLIKEELIRLQNSY
QPTNKGRYKVL
Target Bioclass
Enzyme
Family
DEAD box helicase family, DDX46/PRP5 subfamily
Subcellular location
Nucleus speckle
Function
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, DDX46 plays essential roles during assembly of pre-spliceosome and proofreading of the branch site.
Uniprot ID
Q7L014
Ensemble ID
ENST00000354283.8
HGNC ID
HGNC:18681

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 46 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.78  LDD0402  [1]
P1
 Probe Info  		1.59  LDD0448  [2]
P2
 Probe Info  		1.51  LDD0449  [2]
P3
 Probe Info  		1.52  LDD0450  [2]
P8
 Probe Info  		1.74  LDD0451  [2]
A-EBA
 Probe Info  		4.04  LDD0215  [3]
W1
 Probe Info  		11.62  LDD0235  [4]
TH211
 Probe Info  		Y328(20.00); Y718(7.10)  LDD0260  [5]
C-Sul
 Probe Info  		3.01  LDD0066  [6]
TH216
 Probe Info  		Y328(20.00)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
Probe 1
 Probe Info  		Y328(95.34); Y720(33.98); Y910(13.22); Y932(12.04)  LDD3495  [9]
BTD
 Probe Info  		C501(0.85)  LDD1700  [10]
Johansson_61
 Probe Info  		_(10.28)  LDD1487  [11]
AHL-Pu-1
 Probe Info  		C590(2.64)  LDD0172  [12]
HHS-475
 Probe Info  		Y1020(0.40); Y961(0.60); Y718(0.72)  LDD0264  [13]
HHS-465
 Probe Info  		Y910(7.82)  LDD2237  [14]
DBIA
 Probe Info  		C501(1.77)  LDD0080  [15]
ATP probe
 Probe Info  		K271(0.00); K272(0.00); K577(0.00); K1025(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C646(0.00); C501(0.00); C367(0.00); C696(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [18]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [19]
IPIAA_L
 Probe Info  		C478(0.00); C646(0.00); C590(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C646(0.00); C501(0.00); C696(0.00); C590(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [20]
IPM
 Probe Info  		N.A.  LDD0025  [21]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [21]
TFBX
 Probe Info  		C590(0.00); C501(0.00)  LDD0027  [21]
WYneN
 Probe Info  		N.A.  LDD0021  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [23]
Compound 10
 Probe Info  		N.A.  LDD2216  [24]
Compound 11
 Probe Info  		N.A.  LDD2213  [24]
NHS
 Probe Info  		K417(0.00); K1025(0.00); K186(0.00); K903(0.00)  LDD0010  [22]
PPMS
 Probe Info  		N.A.  LDD0008  [22]
SF
 Probe Info  		Y1020(0.00); Y961(0.00); Y910(0.00)  LDD0028  [25]
STPyne
 Probe Info  		N.A.  LDD0009  [22]
VSF
 Probe Info  		N.A.  LDD0007  [22]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
1c-yne
 Probe Info  		K577(0.00); K716(0.00); K333(0.00); K422(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		C590(0.00); C646(0.00); C501(0.00); H433(0.00)  LDD0217  [27]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [27]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [27]
Methacrolein
 Probe Info  		C646(0.00); C501(0.00); C590(0.00); C377(0.00)  LDD0218  [27]
NAIA_5
 Probe Info  		C501(0.00); C696(0.00); C590(0.00); C478(0.00)  LDD2223  [28]
HHS-482
 Probe Info  		Y1020(0.95)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		14.41  LDD0475  [29]
STS-1
 Probe Info  		N.A.  LDD0136  [30]
STS-2
 Probe Info  		N.A.  LDD0138  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C501(0.90)  LDD2112  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C377(0.95)  LDD2117  [10]
 LDCM0025  4SU-RNA HEK-293T C590(2.64)  LDD0172  [12]
 LDCM0214  AC1 HCT 116 C377(0.99); C478(1.00); C501(1.27); C590(1.25)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C377(1.05); C478(1.04); C501(1.28); C590(1.29)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C377(0.88); C478(0.60); C501(0.72); C590(0.96)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C377(0.75); C478(0.62); C501(0.77); C590(1.11)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C377(0.90); C478(0.65); C501(0.74); C590(0.99)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C377(0.84); C478(0.69); C501(0.76); C590(1.39)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C377(0.79); C478(0.66); C501(0.79); C590(1.16)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C377(0.87); C478(0.69); C501(0.75); C590(1.67)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C377(0.82); C478(0.69); C501(0.76); C590(1.47)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C377(0.84); C478(0.56); C501(0.69); C590(1.04)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C377(0.84); C478(0.71); C501(0.80); C590(0.74)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C377(0.89); C478(0.69); C501(0.81); C590(1.22)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C377(1.14); C478(1.01); C501(0.86); C590(1.19)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C377(0.83); C478(0.70); C501(0.75); C590(1.07)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C377(0.84); C478(0.63); C501(0.73); C590(1.07)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C377(0.86); C478(0.65); C501(0.72); C590(1.04)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C377(0.98); C478(0.93); C501(1.04); C590(1.00)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C377(0.96); C478(0.91); C501(1.21); C590(1.19)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C377(1.04); C478(0.92); C501(1.24); C590(1.17)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C377(1.03); C478(0.88); C501(1.05); C590(1.14)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C377(0.97); C478(0.91); C501(1.18); C590(1.11)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C377(0.97); C478(0.97); C501(1.21); C590(1.02)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C377(1.04); C478(0.92); C501(1.06); C590(1.13)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C377(1.12); C478(1.05); C501(0.94); C590(0.94)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C377(0.98); C478(0.92); C501(1.02); C590(0.92)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C377(1.05); C478(0.93); C501(1.23); C590(1.03)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C377(0.95); C478(0.91); C501(1.22); C590(1.00)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C377(1.03); C478(1.15); C501(1.19); C590(0.96)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C377(1.00); C478(0.85); C501(1.29); C590(0.98)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C377(0.99); C478(0.97); C501(1.21); C590(1.13)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C377(1.09); C478(0.97); C501(1.20); C590(1.31)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C377(1.03); C478(0.92); C501(1.25); C590(1.25)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C377(1.28); C478(1.42); C501(1.01); C590(1.39)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C377(1.02); C478(1.09); C501(1.38); C590(1.09)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C377(1.03); C478(1.20); C501(1.10); C590(1.24)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C377(1.07); C478(1.16); C501(1.11); C590(1.19)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C377(1.09); C478(1.26); C501(1.02); C590(1.08)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C377(1.05); C478(1.10); C501(1.13); C590(1.16)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C377(1.09); C478(1.06); C501(0.99); C590(1.30)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C377(1.13); C478(1.38); C501(1.19); C590(1.45)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C377(1.19); C478(1.09); C501(1.09); C590(1.01)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C377(1.12); C478(1.06); C501(1.01); C590(1.02)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C377(1.01); C478(1.18); C501(1.17); C590(1.03)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C377(1.16); C478(1.37); C501(0.98); C590(1.27)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C377(0.94); C478(1.10); C501(1.19); C590(1.20)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C377(1.19); C478(1.36); C501(1.28); C590(1.22)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C377(1.15); C478(1.22); C501(1.37); C590(1.30)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C377(0.97); C478(1.20); C501(0.99); C590(1.02)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C377(0.84); C478(0.88); C501(0.88); C646(0.91)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C377(0.83); C501(0.84); C646(0.93); C478(0.96)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C646(0.90); C478(0.98); C501(0.98); C377(1.00)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C646(0.72); C478(0.87); C377(0.96); C501(0.96)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C501(0.81); C478(0.92); C646(0.95); C377(0.96)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C501(0.82); C646(1.08); C377(1.25); C478(1.29)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C501(0.79); C377(0.97); C646(1.02); C478(1.05)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C478(1.08); C377(1.10); C590(1.23); C501(1.27)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C646(0.84); C478(0.87); C501(0.87); C377(0.93)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C646(0.79); C501(0.84); C377(0.84); C478(0.95)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C377(0.86); C646(0.89); C478(0.90); C501(1.01)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C501(0.93); C478(1.00); C646(1.11); C377(1.32)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C377(1.07); C478(0.79); C501(0.85); C646(0.91)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C377(0.97); C478(0.86); C501(0.93); C646(0.73)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C377(0.90); C478(0.83); C501(0.93); C646(1.16)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C377(0.97); C478(0.87); C501(1.25); C646(0.96)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C478(0.97); C590(1.01); C501(1.13); C377(1.18)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C590(0.94); C646(0.98); C377(1.07); C478(1.09)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C478(0.97); C501(1.03); C377(1.06); C590(1.06)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C377(0.95); C478(1.05); C501(1.16); C590(1.31)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C646(0.81); C478(0.93); C501(0.96); C590(0.96)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C590(0.94); C478(0.96); C646(0.99); C377(1.03)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C646(0.92); C478(0.96); C590(1.03); C377(1.07)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C478(0.93); C590(0.93); C501(1.00); C377(1.05)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C646(0.98); C501(0.99); C478(1.00); C590(1.01)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C501(0.81); C377(1.01); C478(1.05); C590(1.17)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C501(0.90); C377(1.03); C478(1.11); C590(1.21)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C377(0.89); C478(0.92); C501(0.92); C590(1.40)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C377(0.97); C501(1.05); C590(1.23); C478(1.49)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C501(0.77); C377(0.92); C478(0.98); C590(1.30)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C478(1.00); C377(1.01); C501(1.22); C590(1.33)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C501(0.79); C377(0.91); C478(0.99); C590(1.24)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C377(0.95); C478(0.98); C501(1.06); C590(1.33)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C377(0.94); C478(0.95); C501(1.01); C590(1.50)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C501(0.80); C377(0.90); C478(0.97); C590(1.41)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C501(0.75); C377(0.90); C478(0.95); C590(1.38)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C590(0.70); C478(0.96); C377(0.97); C501(1.11)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C590(0.81); C478(0.91); C377(0.96); C501(0.96)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C377(0.98); C501(1.02); C478(1.05); C590(1.06)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C501(0.92); C478(0.93); C377(0.93); C590(0.95)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C646(0.89); C501(1.01); C478(1.07); C590(1.09)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C478(0.93); C377(1.08); C501(1.11); C590(1.43)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C501(0.92); C646(0.94); C377(1.03); C478(1.08)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C646(0.76); C501(0.88); C377(0.95); C590(0.98)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C377(0.91); C501(0.92); C646(1.00); C478(1.04)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C646(0.75); C501(0.95); C377(1.00); C478(1.03)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C501(1.01); C646(1.01); C377(1.05); C478(1.07)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C501(1.02); C478(1.13); C377(1.14); C646(1.18)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C478(0.92); C377(0.94); C501(1.08); C590(1.27)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C377(0.94); C478(0.97); C501(1.09); C590(1.31)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C478(0.97); C377(1.02); C501(1.27); C590(1.36)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C478(1.12); C377(1.14); C501(1.18); C590(1.56)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C478(0.99); C377(1.11); C501(1.40); C590(1.53)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C478(0.96); C377(1.02); C501(1.46); C590(1.69)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C377(0.95); C501(0.96); C478(0.99); C590(1.17)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C377(0.90); C501(0.98); C478(1.09); C590(1.28)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C377(0.89); C501(0.98); C478(0.99); C590(1.20)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C377(0.92); C478(1.03); C501(1.05); C590(1.28)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C501(0.97); C377(1.05); C478(1.12); C590(1.47)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C501(1.00); C478(1.08); C377(1.19); C590(1.57)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C478(1.02); C377(1.03); C501(1.13); C590(1.60)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C501(0.91); C478(1.00); C377(1.01); C590(1.64)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C377(0.93); C478(1.04); C501(1.07); C590(1.87)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C377(1.00); C478(1.01); C501(1.15); C590(1.40)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C377(0.81); C501(0.82); C478(0.97); C590(1.63)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C377(0.89); C501(0.95); C478(0.97); C590(1.66)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C377(0.80); C501(0.91); C478(1.08); C590(2.05)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C501(0.75); C377(0.87); C478(0.92); C590(1.44)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C501(0.80); C377(0.86); C478(1.08); C590(2.12)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C377(0.96); C501(1.02); C478(1.12); C590(2.28)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C501(0.93); C377(1.00); C478(1.10); C590(2.02)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C377(0.84); C501(0.89); C478(1.13); C590(2.40)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C478(0.97); C377(1.05); C501(1.18); C590(1.27)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C478(0.99); C377(1.00); C501(1.11); C590(1.41)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C478(1.04); C377(1.04); C501(1.05); C590(1.14)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C478(0.85); C377(1.06); C501(1.26); C590(1.33)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C478(0.92); C501(1.15); C377(1.16); C590(1.42)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C478(0.91); C377(1.06); C501(1.18); C590(1.18)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C501(1.01); C478(1.07); C377(1.20); C590(1.96)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C478(1.10); C377(1.24); C501(1.27); C590(1.84)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C501(1.10); C478(1.22); C377(1.37); C590(2.33)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C478(0.99); C377(1.10); C501(1.30); C590(1.50)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C478(0.95); C377(0.98); C501(0.99); C590(1.89)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C478(0.91); C377(0.93); C501(1.15); C590(1.44)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C478(0.98); C377(1.04); C501(1.12); C590(1.26)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C377(0.98); C501(0.99); C590(1.08); C478(1.08)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C478(0.94); C377(1.20); C501(1.29); C590(1.34)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C478(0.90); C590(0.96); C377(1.19); C501(1.24)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C501(1.10); C478(1.19); C377(1.66); C590(2.55)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C646(0.72); C501(0.75); C478(0.76); C377(0.87)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C478(0.75); C501(0.84); C590(0.89); C377(0.92)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C478(0.68); C501(0.85); C377(0.87); C590(1.06)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C478(0.72); C377(0.85); C590(0.93); C646(0.93)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C478(0.71); C646(0.90); C501(0.93); C590(0.93)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C478(0.82); C646(0.87); C590(0.94); C501(0.96)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C646(0.66); C478(0.78); C501(0.80); C377(0.89)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C646(0.70); C501(0.81); C478(0.95); C377(0.97)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C646(0.80); C478(0.90); C501(0.94); C377(1.01)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C646(0.74); C478(0.78); C501(0.81); C590(0.96)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C478(0.69); C646(0.83); C501(0.87); C377(0.96)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C478(0.71); C646(1.02); C501(1.14); C377(1.29)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C478(0.80); C501(0.87); C646(0.92); C377(0.93)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C646(0.76); C478(0.84); C590(0.94); C501(1.02)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C501(0.81); C478(0.81); C377(0.86); C646(0.98)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C646(0.52); C478(0.72); C501(0.90); C377(0.97)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C646(0.55); C478(0.69); C377(0.81); C590(0.81)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C501(0.38)  LDD2138  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C501(0.86)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C377(1.22); C478(1.03); C501(1.17); C590(1.10)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C478(1.05); C377(1.06); C590(1.07); C501(1.14)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C377(1.06); C478(1.20); C501(1.29); C590(1.68)  LDD0592  [15]
 LDCM0498  BS-3668 MDA-MB-231 C501(0.57)  LDD2091  [10]
 LDCM0108  Chloroacetamide HeLa C646(0.00); C501(0.00); H433(0.00); C377(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C377(20.00); C478(2.61); C696(1.72)  LDD2227  [28]
 LDCM0367  CL1 HCT 116 C501(0.93); C590(1.00); C377(1.01); C478(1.01)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C377(0.85); C501(0.94); C478(0.97); C646(1.11)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C478(0.96); C501(0.97); C377(1.00); C590(1.22)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C377(0.96); C478(1.03); C590(1.33); C501(1.45)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C377(0.98); C478(1.08); C590(1.11); C501(1.21)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C478(1.02); C590(1.04); C377(1.09); C501(1.36)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C377(0.99); C478(1.04); C590(1.11); C501(1.22)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C478(1.01); C590(1.05); C646(1.10); C377(1.13)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C478(1.05); C590(1.11); C377(1.16); C646(1.18)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C646(0.95); C478(1.02); C377(1.03); C501(1.13)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C590(1.11); C478(1.13); C501(1.15); C377(1.16)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C646(0.82); C377(0.92); C478(0.96); C590(1.06)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C646(0.87); C501(1.00); C377(1.04); C478(1.09)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C478(0.97); C377(1.02); C501(1.13); C590(1.15)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C478(0.97); C377(0.98); C590(1.03); C501(1.20)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C501(0.85); C590(0.97); C377(0.97); C478(1.02)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C501(0.77); C377(0.90); C478(0.96); C590(1.26)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C501(0.78); C377(0.92); C478(1.06); C590(1.14)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C501(0.75); C377(0.85); C478(1.05); C590(1.31)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C501(0.86); C478(0.88); C377(0.91); C590(1.31)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C646(1.09); C501(1.12); C377(1.35); C478(1.37)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C646(0.79); C501(0.88); C377(0.94); C590(0.99)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C646(0.63); C590(0.94); C501(0.97); C377(1.00)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C377(1.00); C646(1.01); C478(1.09); C501(1.11)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C646(0.66); C501(0.92); C377(0.96); C590(1.05)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C377(0.83); C501(0.95); C478(1.02); C590(1.14)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C478(0.93); C377(0.94); C590(1.21); C501(1.32)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C377(0.88); C478(0.94); C590(1.31); C501(1.33)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C478(0.93); C377(1.03); C501(1.13); C590(1.60)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C501(0.89); C377(0.97); C478(1.00); C590(1.08)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C501(0.90); C377(0.94); C478(1.00); C590(1.18)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C501(0.85); C377(0.89); C478(0.95); C590(1.18)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C377(1.00); C478(1.01); C501(1.13); C590(1.81)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C377(0.85); C478(0.95); C501(1.00); C646(1.02)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C377(0.81); C478(0.90); C501(0.99); C646(1.02)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C478(0.84); C377(0.88); C501(0.97); C590(0.97)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C377(0.81); C590(0.87); C501(0.91); C478(1.05)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C501(0.84); C590(0.91); C377(0.97); C646(0.97)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C377(0.90); C590(0.91); C501(0.91); C478(0.92)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C501(0.90); C377(0.98); C478(1.02); C590(1.03)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C590(0.89); C501(0.91); C478(0.92); C377(0.95)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C377(0.77); C501(0.86); C478(1.00); C646(1.05)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C377(0.91); C501(0.92); C478(1.03); C646(1.33)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C377(0.80); C646(0.81); C501(1.15); C478(1.32)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C377(0.79); C501(0.89); C478(0.98); C646(1.06)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C377(0.91); C501(0.93); C478(1.12); C590(1.13)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C377(0.96); C478(1.19); C501(0.82); C590(1.11)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C377(0.81); C478(0.94); C501(0.93); C590(1.03)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C377(0.88); C478(1.07); C501(0.89); C590(1.29)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C377(0.85); C478(1.03); C501(0.79); C590(1.16)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C377(0.81); C478(0.99); C501(0.92); C590(1.34)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C377(0.97); C478(1.00); C501(0.89); C590(1.00)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C377(1.00); C478(1.11); C501(1.00); C590(0.88)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C377(1.00); C478(0.95); C501(0.87); C590(1.11)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C377(1.06); C478(0.91); C501(1.07); C590(1.00)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C377(0.80); C478(0.76); C501(0.96); C590(1.24)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C377(1.19); C478(0.99); C501(0.87); C590(1.13)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C377(0.95); C478(0.82); C501(1.15); C590(1.03)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C377(1.20); C478(0.99); C501(0.96); C590(1.10)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C377(1.26); C478(0.96); C501(1.15); C590(0.83)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C377(1.10); C478(0.84); C501(1.15); C590(1.04)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C377(0.85); C478(0.92); C501(0.94); C590(1.00)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C377(1.03); C478(1.10); C501(0.73); C590(1.09)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C377(1.19); C478(0.98); C501(0.90); C590(0.98)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C377(1.56); C478(1.21); C501(1.12); C590(0.90)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C377(1.51); C478(0.93); C501(0.97); C590(1.30)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C377(1.11); C478(0.86); C501(0.97); C590(1.11)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C377(1.22); C478(0.97); C501(1.11); C590(1.02)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C377(0.90); C478(1.03); C501(0.95); C590(1.18)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C377(0.93); C478(1.03); C501(0.97); C590(1.12)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C377(0.91); C478(1.12); C501(1.14); C590(1.02)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C377(1.00); C478(1.09); C501(1.40); C590(1.05)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C377(0.94); C478(0.95); C501(0.96); C590(0.95)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C377(0.92); C478(1.07); C501(1.24); C590(1.02)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C377(0.99); C478(1.12); C501(1.18); C590(1.14)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C377(0.87); C478(1.00); C501(1.05); C590(1.22)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C377(0.88); C478(0.85); C501(0.86); C590(0.84)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C377(0.88); C478(1.09); C501(0.99); C590(1.02)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C377(0.97); C478(1.13); C501(0.94); C590(1.02)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C377(0.95); C478(1.05); C501(1.10); C590(1.00)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C377(0.90); C478(0.95); C501(1.10); C590(1.00)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C377(0.87); C478(1.02); C501(1.03); C590(1.07)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C377(1.00); C478(1.02); C501(1.12); C590(0.99)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C377(0.81); C478(0.91); C501(0.84); C590(1.03)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C377(0.92); C478(1.21); C501(1.33); C590(1.19)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C377(1.01); C478(0.97); C501(0.92); C590(1.14)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C377(0.93); C478(1.08); C501(0.88); C590(1.01)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C377(0.91); C478(1.04); C501(0.82); C590(1.01)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C377(1.01); C478(0.98); C501(0.92); C590(1.17)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C377(1.06); C478(1.03); C501(0.96); C590(1.02)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C377(0.98); C478(1.13); C501(1.02); C590(1.34)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C377(0.97); C478(1.00); C501(0.92); C590(0.91)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C377(0.94); C478(1.00); C501(0.83); C590(0.99)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C377(0.87); C478(0.97); C501(0.81); C590(1.04)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C377(0.98); C478(1.05); C501(1.16); C590(1.30)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C377(0.89); C478(1.01); C501(0.81); C590(1.05)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C377(0.92); C478(1.00); C501(0.80); C590(0.86)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C377(1.00); C478(1.03); C501(0.77); C590(1.19)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C377(0.92); C478(1.12); C501(0.80); C590(0.98)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C377(0.92); C478(1.02); C501(0.83); C590(1.06)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C377(0.99); C478(0.88); C501(1.37); C590(1.05)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C377(0.97); C478(1.07); C501(1.30); C590(0.92)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C377(1.01); C478(0.97); C501(1.21); C590(1.06)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C377(1.02); C478(1.04); C501(1.21); C590(1.12)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C377(1.00); C478(0.88); C501(0.88); C590(1.13)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C377(0.96); C478(1.01); C501(0.99); C590(1.01)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C377(1.11); C478(0.94); C501(1.43); C590(1.25)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C377(1.23); C478(1.09); C501(1.62); C590(1.34)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C377(1.19); C478(1.01); C501(1.24); C590(0.81)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C377(1.28); C478(1.29); C501(1.16); C590(0.90)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C377(0.96); C478(1.00); C501(1.11); C590(0.96)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C377(1.09); C478(1.13); C501(1.12); C590(0.92)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C377(1.12); C478(1.01); C501(1.30); C590(1.03)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C377(1.14); C478(1.08); C501(1.18); C590(0.95)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C377(1.39); C478(1.46); C501(1.31); C590(1.02)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C377(0.89); C478(0.89); C501(0.97); C590(1.06)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C377(1.03); C478(0.91); C501(1.34); C590(1.07)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C377(0.93); C478(0.93); C501(1.04); C590(1.23)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C377(1.00); C478(0.87); C501(1.10); C590(1.05)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C377(1.13); C478(1.08); C501(1.16); C590(1.20)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C377(0.96); C478(0.81); C501(0.98); C590(1.23)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C377(0.97); C478(0.85); C501(1.09); C590(1.25)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C377(0.97); C478(0.87); C501(1.08); C590(1.34)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C377(0.87); C478(1.00); C501(1.00); C590(1.23)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C377(0.91); C478(0.96); C501(1.21); C590(1.43)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C377(1.02); C478(1.00); C501(1.19); C590(1.33)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C646(1.02); C501(1.07); C696(1.07); C377(1.32)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C646(4.23); C377(2.52); C367(2.14); C501(1.19)  LDD1702  [10]
 LDCM0468  Fragment33 HCT 116 C377(0.96); C478(1.02); C501(0.86); C590(1.03)  LDD0785  [15]
 LDCM0427  Fragment51 HCT 116 C377(2.29); C478(1.06); C501(1.11); C590(0.86)  LDD0744  [15]
 LDCM0615  Fragment63-R Jurkat _(10.28)  LDD1487  [11]
 LDCM0116  HHS-0101 DM93 Y1020(0.40); Y961(0.60); Y718(0.72)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y1020(0.47); Y718(0.60); Y961(0.99)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y718(0.44); Y961(0.64); Y1020(0.83)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y961(0.78); Y1020(0.94); Y718(1.07)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y1020(0.65); Y961(0.79); Y718(0.92)  LDD0268  [13]
 LDCM0107  IAA HeLa C646(0.00); H433(0.00); H323(0.00)  LDD0221  [27]
 LDCM0022  KB02 HCT 116 C501(1.77)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C501(2.80)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C501(2.35)  LDD0082  [15]
 LDCM0109  NEM HeLa N.A.  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C501(0.80)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C501(1.16); C646(1.23)  LDD2090  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C501(0.87); C377(1.02)  LDD2093  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C501(0.41)  LDD2096  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C501(1.46); C646(1.04); C377(1.07)  LDD2099  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C501(0.86)  LDD2101  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C501(0.67)  LDD2105  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C501(1.36); C646(0.98); C377(1.09)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C501(0.74)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C501(0.79); C646(1.15); C377(0.69)  LDD2109  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C501(1.47); C377(1.08)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C478(0.73)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C501(0.39)  LDD2115  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C646(0.87)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C501(1.99); C646(1.81); C377(1.32)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C501(0.95)  LDD2120  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C501(1.08); C646(1.20); C377(1.00); C478(1.08)  LDD2123  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C377(0.96); C478(1.13)  LDD2125  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C501(1.15); C377(1.00)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C501(0.82)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C501(1.70); C646(1.21); C377(0.93)  LDD2129  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C501(0.41)  LDD2133  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C501(0.47)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C646(1.23); C377(1.00)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C501(1.28); C646(1.08); C377(1.09); C478(0.84)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C501(0.96); C646(1.07); C377(0.95)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C501(0.85)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C501(0.98); C646(1.10); C377(0.89)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C501(0.36)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C501(0.81)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C501(1.88); C646(1.90)  LDD2144  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C501(1.08); C646(0.99); C377(1.05)  LDD2146  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C501(0.40)  LDD2148  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C501(0.70); C367(1.16)  LDD2149  [10]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C501(1.53)  LDD2153  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C590(0.56)  LDD2206  [32]
 LDCM0131  RA190 MM1.R C590(1.15)  LDD0304  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
33 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.