Details of the Target

General Information of Target

Target ID LDTP00606
Target Name Phosphomannomutase 2 (PMM2)
Gene Name PMM2
Gene ID 5373
Synonyms
Phosphomannomutase 2; PMM 2; EC 5.4.2.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDV
VEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFI
EFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISF
DVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRI
CELLFS
Target Bioclass
Enzyme
Family
Eukaryotic PMM family
Subcellular location
Cytoplasm
Function Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Uniprot ID
O15305
Ensemble ID
ENST00000268261.9
HGNC ID
HGNC:9115
ChEMBL ID
CHEMBL1741162

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HG3 SNV: p.W187Ter DBIA    Probe Info 
MFE319 SNV: p.K114E .
THP1 SNV: p.G176R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		10.23  LDD0235  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
IPM
 Probe Info  		N.A.  LDD0241  [2]
Probe 1
 Probe Info  		Y66(27.76); Y229(23.16)  LDD3495  [4]
BTD
 Probe Info  		C136(1.17)  LDD2099  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
DBIA
 Probe Info  		C136(1.32)  LDD0532  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C241(0.00); C103(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C241(0.00); C103(0.00); C136(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C103(0.00); C241(0.00); C136(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
AOyne
 Probe Info  		13.40  LDD0443  [13]
NAIA_5
 Probe Info  		C9(0.00); C103(0.00); C241(0.00); C136(0.00)  LDD2223  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C136(1.30)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C241(1.11)  LDD0812  [7]
 LDCM0215  AC10 HCT 116 C136(1.32)  LDD0532  [7]
 LDCM0216  AC100 HEK-293T C241(1.06)  LDD0814  [7]
 LDCM0217  AC101 HEK-293T C241(1.03)  LDD0815  [7]
 LDCM0218  AC102 HEK-293T C241(1.04)  LDD0816  [7]
 LDCM0219  AC103 HEK-293T C241(1.18)  LDD0817  [7]
 LDCM0220  AC104 HEK-293T C241(1.11)  LDD0818  [7]
 LDCM0221  AC105 HEK-293T C241(0.83)  LDD0819  [7]
 LDCM0222  AC106 HEK-293T C241(0.86)  LDD0820  [7]
 LDCM0223  AC107 HEK-293T C241(1.07)  LDD0821  [7]
 LDCM0224  AC108 HEK-293T C241(0.91)  LDD0822  [7]
 LDCM0225  AC109 HEK-293T C241(0.96)  LDD0823  [7]
 LDCM0226  AC11 HCT 116 C136(1.46)  LDD0543  [7]
 LDCM0227  AC110 HEK-293T C241(1.42)  LDD0825  [7]
 LDCM0228  AC111 HEK-293T C241(1.56)  LDD0826  [7]
 LDCM0229  AC112 HEK-293T C241(1.54)  LDD0827  [7]
 LDCM0230  AC113 HCT 116 C136(1.12)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C136(1.22)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C136(1.39)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C136(1.37)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C136(1.06)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C136(1.22)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C136(1.89)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C136(1.42)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C136(1.27)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C136(1.44)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C136(1.03)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C136(1.12)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C136(1.29)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C136(1.41)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C136(1.57)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C136(1.24)  LDD0562  [7]
 LDCM0246  AC128 PaTu 8988t C136(1.29)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C136(0.95)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C136(2.42)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C136(1.15)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C136(1.41)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C136(1.47)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C136(1.27)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C136(1.08)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C136(1.15)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C136(1.31)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C136(1.13)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C136(1.04)  LDD1137  [7]
 LDCM0259  AC14 HCT 116 C136(1.46)  LDD0576  [7]
 LDCM0260  AC140 PaTu 8988t C136(1.01)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C136(1.15)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C136(1.24)  LDD1141  [7]
 LDCM0263  AC143 HCT 116 C136(0.64); C241(0.95)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C241(0.38); C136(0.86)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C241(0.69); C136(0.93)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C241(0.48); C136(0.91)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C241(0.33); C136(0.94)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C241(0.13); C136(0.99)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C241(0.28); C136(0.82)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C136(1.10)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C136(0.85); C241(1.07)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C241(0.72); C136(0.98)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C241(0.29); C136(0.89)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C241(0.10); C136(0.81)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C136(0.96); C241(0.43)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C136(0.94); C241(0.74)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C136(1.07); C241(1.17)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C136(0.84); C241(0.89)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C136(0.81)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C136(1.17)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C136(1.18)  LDD0595  [7]
 LDCM0279  AC2 HEK-293T C241(1.19)  LDD0877  [7]
 LDCM0280  AC20 HCT 116 C136(0.95)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C136(0.77)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C136(0.88)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C136(1.24)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C136(1.13)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C136(0.67)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C136(0.53)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C136(0.96)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C136(0.89)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C136(0.50)  LDD0606  [7]
 LDCM0290  AC3 HEK-293T C241(1.35)  LDD0888  [7]
 LDCM0291  AC30 HCT 116 C136(0.51)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C136(1.09)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C136(0.55)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C136(1.38)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C136(0.95)  LDD0612  [7]
 LDCM0296  AC35 HEK-293T C241(0.94); C136(0.98)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C241(0.98); C136(0.96)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C241(0.99); C136(1.06)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C136(1.20)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C136(0.81)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C241(1.20)  LDD0899  [7]
 LDCM0302  AC40 HEK-293T C241(1.12); C136(0.95); C103(1.24)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C241(0.97); C136(0.91)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C241(0.94); C136(0.97)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C241(1.06); C136(1.09)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C241(1.08); C136(1.07)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C241(0.99); C136(1.01)  LDD1546  [15]
 LDCM0308  AC46 HCT 116 C136(0.51)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C136(0.96)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C136(0.48)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C136(0.45)  LDD0628  [7]
 LDCM0312  AC5 HEK-293T C241(1.08)  LDD0910  [7]
 LDCM0313  AC50 HCT 116 C136(0.42)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C136(0.51)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C136(0.44)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C136(0.87)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C136(0.64)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C136(1.08)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C136(0.55)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C241(0.82); C136(1.58)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C241(0.72); C136(1.00)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C241(0.52); C136(1.50)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C136(0.96)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C241(0.66); C136(1.35)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C241(0.59); C136(1.52)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C241(0.42); C136(1.56)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C241(0.59); C136(1.70)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C241(0.45); C136(1.39)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C241(0.68); C136(1.28)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C241(0.69); C136(1.28)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C241(0.14); C136(1.38)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C136(0.71); C241(0.90)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C241(0.70); C136(0.92)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C136(1.00)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C241(0.38); C136(0.66)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C136(0.94); C241(1.00)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C136(0.69); C241(0.86)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C241(0.23); C136(0.65)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C241(0.22); C136(0.81)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C241(0.15); C136(0.67)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C241(0.58); C136(0.94)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C241(0.63); C136(0.70)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C241(1.07); C136(1.12)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C136(0.76); C241(0.98)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C136(0.81)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C241(0.75); C136(1.05)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C241(0.70); C136(0.78)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C241(0.08); C136(0.86)  LDD0665  [7]
 LDCM0349  AC83 HEK-293T C241(1.54)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C241(1.77)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C241(1.51)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C241(1.43)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C241(1.71)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C241(1.32)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C241(1.43)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C241(1.23)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C241(1.43)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C241(1.28)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C241(1.51)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C241(1.24)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C241(1.52)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C241(1.27)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C241(1.52)  LDD0962  [7]
 LDCM0365  AC98 HEK-293T C241(1.06)  LDD0963  [7]
 LDCM0366  AC99 HEK-293T C241(0.95)  LDD0964  [7]
 LDCM0248  AKOS034007472 HCT 116 C136(1.20)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C136(1.27)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C136(0.81)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.77  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C241(20.00)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C241(0.95); C136(1.29)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C241(0.37); C136(0.68)  LDD0685  [7]
 LDCM0369  CL100 HEK-293T C241(1.25)  LDD0967  [7]
 LDCM0370  CL101 HCT 116 C136(0.93)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C136(1.35)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C136(1.30)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C136(0.84)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C136(0.99)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C136(1.66)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C136(0.97)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C136(1.52)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C136(1.08)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C241(0.33); C136(0.54)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C136(1.27)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C136(1.04)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C136(0.85)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C136(0.51)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C136(0.50)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C136(0.56)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C136(1.15)  LDD0703  [7]
 LDCM0387  CL117 HEK-293T C241(1.22); C136(1.05)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C241(0.99); C136(0.92)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C241(1.00); C136(1.13)  LDD1593  [15]
 LDCM0390  CL12 HCT 116 C241(0.33); C136(0.61)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C241(0.93); C136(0.99)  LDD1595  [15]
 LDCM0392  CL121 HCT 116 C136(0.71)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C136(0.85)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C136(0.82)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C136(0.58)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C136(1.40); C241(2.23)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C136(1.03); C241(1.34)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C136(1.53); C241(1.67)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C241(0.70); C136(1.04)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C241(0.47); C136(0.75)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C136(0.86); C241(1.01)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C241(0.19); C136(0.62)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C241(0.79)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C241(0.75); C136(0.93)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C241(0.52); C136(0.99)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C241(0.66); C136(1.06)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C136(1.30); C241(1.37)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C241(0.54); C136(0.58)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C241(0.37); C136(1.14)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C241(0.22); C136(1.01)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C241(0.60); C136(0.82)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C241(0.43); C136(0.81)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C136(0.88); C241(0.49)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C136(1.10); C241(0.69)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C136(1.08); C241(0.78)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C136(1.08); C241(0.56)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C136(1.04); C241(0.52)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C136(1.21); C241(1.17)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C136(1.30); C241(0.76)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C136(0.68)  LDD0737  [7]
 LDCM0421  CL32 PaTu 8988t C136(0.71); C241(0.59)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C136(0.48); C241(0.45)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C136(0.50); C241(0.47)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C136(0.48); C241(0.46)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C136(0.52); C241(0.31)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C136(0.39); C241(0.30)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C136(0.70); C241(0.57)  LDD1307  [7]
 LDCM0429  CL4 HCT 116 C136(1.02); C241(0.91)  LDD0746  [7]
 LDCM0430  CL40 PaTu 8988t C136(0.80); C241(0.74)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C136(0.42); C241(0.43)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C136(0.30); C241(0.27)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C136(0.16); C241(0.15)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C136(0.40); C241(0.42)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C136(0.56); C241(0.49)  LDD1314  [7]
 LDCM0436  CL46 PaTu 8988t C136(1.41)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C136(1.31)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C136(20.00)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C136(0.85)  LDD1318  [7]
 LDCM0440  CL5 HCT 116 C136(1.06); C241(0.91)  LDD0757  [7]
 LDCM0441  CL50 PaTu 8988t C136(0.75)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C136(1.42)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C136(1.08)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C136(1.97)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C136(1.05)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C136(0.74)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C136(0.16)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C136(0.34)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C136(0.92)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C136(0.28)  LDD1329  [7]
 LDCM0451  CL6 HCT 116 C136(0.99); C241(0.72)  LDD0768  [7]
 LDCM0452  CL60 PaTu 8988t C136(0.49)  LDD1331  [7]
 LDCM0453  CL61 PaTu 8988t C241(0.96)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C241(2.05)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C241(2.64)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C241(1.37)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C241(1.20)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C241(1.17)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C241(0.68)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C241(0.39)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C241(0.50)  LDD1340  [7]
 LDCM0462  CL7 HCT 116 C136(0.70); C241(0.44)  LDD0779  [7]
 LDCM0463  CL70 PaTu 8988t C241(0.65)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C241(2.28)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C241(2.94)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C241(0.58)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C241(1.00)  LDD1346  [7]
 LDCM0469  CL76 HCT 116 C241(0.82)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C241(0.84)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C241(0.83)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C241(0.49)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C136(0.58); C241(0.31)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C241(0.93)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C241(0.78)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C241(0.31)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C241(0.32)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C241(0.20)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C241(0.89)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C241(1.04)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C241(0.73)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C241(0.44)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C241(0.14)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C136(0.95); C241(0.74)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C241(1.23)  LDD0802  [7]
 LDCM0486  CL91 HEK-293T C241(0.92)  LDD1084  [7]
 LDCM0487  CL92 HEK-293T C241(1.04)  LDD1085  [7]
 LDCM0488  CL93 HEK-293T C241(0.94)  LDD1086  [7]
 LDCM0489  CL94 HEK-293T C241(1.35)  LDD1087  [7]
 LDCM0490  CL95 HEK-293T C241(1.09)  LDD1088  [7]
 LDCM0491  CL96 HEK-293T C241(1.07)  LDD1089  [7]
 LDCM0492  CL97 HEK-293T C241(1.07)  LDD1090  [7]
 LDCM0493  CL98 HEK-293T C241(1.11)  LDD1091  [7]
 LDCM0494  CL99 HEK-293T C241(1.16)  LDD1092  [7]
 LDCM0495  E2913 HEK-293T C241(0.98); C136(1.17)  LDD1698  [15]
 LDCM0625  F8 Ramos C136(1.10)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C136(0.50)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C136(20.00)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C136(0.52)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C136(0.77)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C136(0.72)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C136(0.52)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C136(0.77)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C136(0.36)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C136(0.85)  LDD2197  [16]
 LDCM0588  Fragment30 Ramos C136(1.08)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C136(0.74)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C136(0.53)  LDD2201  [16]
 LDCM0468  Fragment33 PaTu 8988t C241(1.09)  LDD1347  [7]
 LDCM0596  Fragment38 Ramos C136(0.67)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C136(0.60)  LDD2184  [16]
 LDCM0427  Fragment51 PaTu 8988t C136(0.29); C241(0.28)  LDD1306  [7]
 LDCM0610  Fragment52 Ramos C136(1.06)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C136(1.11)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C136(0.58)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C136(0.52)  LDD2188  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C136(0.96); C241(0.90)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C136(1.01); C241(0.86)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C136(1.95)  LDD3310  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C136(1.17)  LDD2099  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C136(0.91)  LDD2109  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C136(1.06)  LDD2125  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C136(1.01)  LDD2140  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) (ACY3) AspA/AstE family Q96HD9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840