Details of the Target

General Information of Target

Target ID LDTP06385
Target Name Scaffold attachment factor B1 (SAFB)
Gene Name SAFB
Gene ID 6294
Synonyms
HAP; HET; SAFB1; Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMER
LKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSL
ENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQE
HAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQP
FAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQ
PGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFD
ACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRAT
DLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVE
KAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQD
DQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKR
SVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLE
RERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRD
DAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHY
PERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGG
MMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQ
SRGSRPSDARFTRRY
Target Bioclass
Other
Subcellular location
Nucleus
Function
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Thereby acts as a negative regulator of cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter.
Uniprot ID
Q15424
Ensemble ID
ENST00000292123.9
HGNC ID
HGNC:10520

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
W1
 Probe Info  		29.39  LDD0235  [3]
TH211
 Probe Info  		Y449(20.00)  LDD0260  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
P11
 Probe Info  		7.68  LDD0201  [6]
DBIA
 Probe Info  		C448(1.44)  LDD3310  [7]
BTD
 Probe Info  		C519(0.73)  LDD1700  [8]
AHL-Pu-1
 Probe Info  		C309(2.14)  LDD0168  [9]
HHS-475
 Probe Info  		Y449(0.84)  LDD0264  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C448(0.00); C225(0.00); C362(0.00); C463(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C448(0.00); C225(0.00)  LDD0032  [13]
IPIAA_L
 Probe Info  		C225(0.00); C362(0.00); C448(0.00)  LDD0031  [14]
Lodoacetamide azide
 Probe Info  		C448(0.00); C225(0.00); C362(0.00); C519(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		C225(0.00); C362(0.00)  LDD2226  [15]
WYneN
 Probe Info  		C362(0.00); C225(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C362(0.00); C225(0.00)  LDD0022  [16]
aHNE
 Probe Info  		N.A.  LDD0001  [16]
Compound 10
 Probe Info  		C225(0.00); C362(0.00)  LDD2216  [17]
Compound 11
 Probe Info  		C225(0.00); C362(0.00)  LDD2213  [17]
ENE
 Probe Info  		C519(0.00); C362(0.00); C225(0.00)  LDD0006  [16]
IPM
 Probe Info  		C362(0.00); C225(0.00)  LDD0005  [16]
NHS
 Probe Info  		K436(0.00); K805(0.00); K578(0.00); K83(0.00)  LDD0010  [16]
PF-06672131
 Probe Info  		N.A.  LDD0017  [18]
PPMS
 Probe Info  		N.A.  LDD0008  [16]
SF
 Probe Info  		Y736(0.00); Y780(0.00); Y723(0.00); K436(0.00)  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
TFBX
 Probe Info  		C448(0.00); C362(0.00); C463(0.00); C225(0.00)  LDD0148  [20]
VSF
 Probe Info  		C362(0.00); C309(0.00); C225(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		C404(0.00); C448(0.00); C362(0.00); C225(0.00)  LDD0018  [21]
Ox-W18
 Probe Info  		W637(0.00); W724(0.00)  LDD2175  [22]
1c-yne
 Probe Info  		K356(0.00); K231(0.00); K527(0.00); K537(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		C362(0.00); C448(0.00); C225(0.00); H747(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		C362(0.00); H737(0.00); C225(0.00); H675(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C362(0.00); C225(0.00); C519(0.00)  LDD0218  [24]
AOyne
 Probe Info  		13.20  LDD0443  [25]
NAIA_5
 Probe Info  		C463(0.00); C448(0.00); C519(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		19.82  LDD0475  [26]
FFF probe2
 Probe Info  		6.99  LDD0463  [26]
FFF probe3
 Probe Info  		12.91  LDD0464  [26]
FFF probe4
 Probe Info  		13.28  LDD0466  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C519(0.70)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C519(0.97)  LDD2112  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C519(1.11); C463(1.40)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C519(1.98)  LDD2152  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C362(0.80); C225(0.74)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C362(0.89); C225(0.50)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C309(2.14)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C362(2.54)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C463(0.90); C448(0.97)  LDD1507  [27]
 LDCM0215  AC10 HEK-293T C463(0.93); C448(1.07)  LDD1508  [27]
 LDCM0226  AC11 HEK-293T C463(1.00); C448(1.06)  LDD1509  [27]
 LDCM0237  AC12 HEK-293T C463(0.89); C448(1.05)  LDD1510  [27]
 LDCM0259  AC14 HEK-293T C463(0.91); C448(1.03)  LDD1512  [27]
 LDCM0270  AC15 HEK-293T C463(0.91); C448(1.16)  LDD1513  [27]
 LDCM0276  AC17 HEK-293T C463(0.95); C448(1.01)  LDD1515  [27]
 LDCM0277  AC18 HEK-293T C463(0.98); C448(1.07)  LDD1516  [27]
 LDCM0278  AC19 HEK-293T C463(0.91); C448(0.94)  LDD1517  [27]
 LDCM0279  AC2 HEK-293T C463(0.99); C448(1.11)  LDD1518  [27]
 LDCM0280  AC20 HEK-293T C463(0.99); C448(1.04)  LDD1519  [27]
 LDCM0281  AC21 HEK-293T C463(1.08); C448(1.11)  LDD1520  [27]
 LDCM0282  AC22 HEK-293T C463(1.00); C448(1.13)  LDD1521  [27]
 LDCM0283  AC23 HEK-293T C463(0.88); C448(1.03)  LDD1522  [27]
 LDCM0284  AC24 HEK-293T C463(1.02); C448(1.05)  LDD1523  [27]
 LDCM0285  AC25 HEK-293T C463(0.88); C448(0.96)  LDD1524  [27]
 LDCM0286  AC26 HEK-293T C463(0.97); C448(1.07)  LDD1525  [27]
 LDCM0287  AC27 HEK-293T C463(1.02); C448(1.01)  LDD1526  [27]
 LDCM0288  AC28 HEK-293T C463(0.94); C448(1.14)  LDD1527  [27]
 LDCM0289  AC29 HEK-293T C463(1.00); C448(1.08)  LDD1528  [27]
 LDCM0290  AC3 HEK-293T C463(0.94); C448(0.91)  LDD1529  [27]
 LDCM0291  AC30 HEK-293T C463(0.99); C448(1.03)  LDD1530  [27]
 LDCM0292  AC31 HEK-293T C463(0.94); C448(1.09)  LDD1531  [27]
 LDCM0293  AC32 HEK-293T C463(0.99); C448(1.06)  LDD1532  [27]
 LDCM0294  AC33 HEK-293T C463(0.82); C448(0.99)  LDD1533  [27]
 LDCM0295  AC34 HEK-293T C463(0.95); C448(0.95)  LDD1534  [27]
 LDCM0296  AC35 HEK-293T C463(0.98); C448(0.97)  LDD1535  [27]
 LDCM0297  AC36 HEK-293T C463(0.91); C448(1.07)  LDD1536  [27]
 LDCM0298  AC37 HEK-293T C463(1.06); C448(1.08)  LDD1537  [27]
 LDCM0299  AC38 HEK-293T C463(0.98); C448(1.06)  LDD1538  [27]
 LDCM0300  AC39 HEK-293T C463(0.92); C448(1.07)  LDD1539  [27]
 LDCM0301  AC4 HEK-293T C463(0.98); C448(1.03)  LDD1540  [27]
 LDCM0302  AC40 HEK-293T C463(0.92); C448(1.06)  LDD1541  [27]
 LDCM0303  AC41 HEK-293T C463(0.89); C448(1.02)  LDD1542  [27]
 LDCM0304  AC42 HEK-293T C463(0.88); C448(1.01)  LDD1543  [27]
 LDCM0305  AC43 HEK-293T C463(0.98); C448(1.02)  LDD1544  [27]
 LDCM0306  AC44 HEK-293T C463(0.87); C448(1.01)  LDD1545  [27]
 LDCM0307  AC45 HEK-293T C463(0.99); C448(1.10)  LDD1546  [27]
 LDCM0308  AC46 HEK-293T C463(0.90); C448(1.05)  LDD1547  [27]
 LDCM0309  AC47 HEK-293T C463(0.88); C448(1.12)  LDD1548  [27]
 LDCM0310  AC48 HEK-293T C463(0.92); C448(1.09)  LDD1549  [27]
 LDCM0311  AC49 HEK-293T C463(0.91); C448(1.11)  LDD1550  [27]
 LDCM0312  AC5 HEK-293T C463(1.09); C448(1.03)  LDD1551  [27]
 LDCM0313  AC50 HEK-293T C463(0.98); C448(1.04)  LDD1552  [27]
 LDCM0314  AC51 HEK-293T C463(0.94); C448(1.00)  LDD1553  [27]
 LDCM0315  AC52 HEK-293T C463(0.95); C448(1.02)  LDD1554  [27]
 LDCM0316  AC53 HEK-293T C463(1.02); C448(1.06)  LDD1555  [27]
 LDCM0317  AC54 HEK-293T C463(0.97); C448(1.05)  LDD1556  [27]
 LDCM0318  AC55 HEK-293T C463(0.91); C448(1.16)  LDD1557  [27]
 LDCM0319  AC56 HEK-293T C463(0.96); C448(1.08)  LDD1558  [27]
 LDCM0320  AC57 HEK-293T C463(0.81); C448(0.94)  LDD1559  [27]
 LDCM0321  AC58 HEK-293T C463(0.96); C448(0.99)  LDD1560  [27]
 LDCM0322  AC59 HEK-293T C463(0.97); C448(1.04)  LDD1561  [27]
 LDCM0323  AC6 HEK-293T C463(0.98); C448(0.99)  LDD1562  [27]
 LDCM0324  AC60 HEK-293T C463(0.91); C448(0.95)  LDD1563  [27]
 LDCM0325  AC61 HEK-293T C463(0.97); C448(0.98)  LDD1564  [27]
 LDCM0326  AC62 HEK-293T C463(0.91); C448(0.97)  LDD1565  [27]
 LDCM0327  AC63 HEK-293T C463(0.86); C448(0.98)  LDD1566  [27]
 LDCM0328  AC64 HEK-293T C463(0.91); C448(1.00)  LDD1567  [27]
 LDCM0334  AC7 HEK-293T C463(0.88); C448(1.05)  LDD1568  [27]
 LDCM0345  AC8 HEK-293T C463(0.99); C448(1.02)  LDD1569  [27]
 LDCM0248  AKOS034007472 HEK-293T C463(1.03); C448(1.09)  LDD1511  [27]
 LDCM0356  AKOS034007680 HEK-293T C463(0.89); C448(1.03)  LDD1570  [27]
 LDCM0275  AKOS034007705 HEK-293T C463(0.94); C448(1.15)  LDD1514  [27]
 LDCM0156  Aniline NCI-H1299 11.81  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C225(0.68); C519(0.29)  LDD2091  [8]
 LDCM0088  C45 HEK-293T 7.68  LDD0201  [6]
 LDCM0108  Chloroacetamide HeLa C225(0.00); C362(0.00); C448(0.00); H675(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C519(20.00); C519(1.05); C225(0.98); C519(0.82)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C463(0.82); C448(1.01)  LDD1571  [27]
 LDCM0368  CL10 HEK-293T C463(0.62); C448(0.87)  LDD1572  [27]
 LDCM0369  CL100 HEK-293T C463(0.92); C448(0.90)  LDD1573  [27]
 LDCM0370  CL101 HEK-293T C463(0.89); C448(1.00)  LDD1574  [27]
 LDCM0371  CL102 HEK-293T C463(0.85); C448(0.97)  LDD1575  [27]
 LDCM0372  CL103 HEK-293T C463(0.84); C448(1.11)  LDD1576  [27]
 LDCM0373  CL104 HEK-293T C463(0.93); C448(1.08)  LDD1577  [27]
 LDCM0374  CL105 HEK-293T C463(0.93); C448(0.97)  LDD1578  [27]
 LDCM0375  CL106 HEK-293T C463(0.94); C448(1.11)  LDD1579  [27]
 LDCM0376  CL107 HEK-293T C463(1.02); C448(1.15)  LDD1580  [27]
 LDCM0377  CL108 HEK-293T C463(1.01); C448(1.11)  LDD1581  [27]
 LDCM0378  CL109 HEK-293T C463(0.96); C448(0.99)  LDD1582  [27]
 LDCM0379  CL11 HEK-293T C463(0.87); C448(1.00)  LDD1583  [27]
 LDCM0380  CL110 HEK-293T C463(0.85); C448(0.98)  LDD1584  [27]
 LDCM0381  CL111 HEK-293T C463(0.94); C448(1.03)  LDD1585  [27]
 LDCM0382  CL112 HEK-293T C463(0.95); C448(1.07)  LDD1586  [27]
 LDCM0383  CL113 HEK-293T C463(0.91); C448(1.01)  LDD1587  [27]
 LDCM0384  CL114 HEK-293T C463(0.84); C448(0.95)  LDD1588  [27]
 LDCM0385  CL115 HEK-293T C463(0.96); C448(1.00)  LDD1589  [27]
 LDCM0386  CL116 HEK-293T C463(0.92); C448(0.99)  LDD1590  [27]
 LDCM0387  CL117 HEK-293T C463(0.90); C448(1.03)  LDD1591  [27]
 LDCM0388  CL118 HEK-293T C463(0.96); C448(1.13)  LDD1592  [27]
 LDCM0389  CL119 HEK-293T C463(0.95); C448(0.97)  LDD1593  [27]
 LDCM0390  CL12 HEK-293T C463(0.80); C448(1.01)  LDD1594  [27]
 LDCM0391  CL120 HEK-293T C463(0.95); C448(1.02)  LDD1595  [27]
 LDCM0392  CL121 HEK-293T C463(0.88); C448(0.98)  LDD1596  [27]
 LDCM0393  CL122 HEK-293T C463(0.95); C448(1.09)  LDD1597  [27]
 LDCM0394  CL123 HEK-293T C463(0.83); C448(0.90)  LDD1598  [27]
 LDCM0395  CL124 HEK-293T C463(0.95); C448(1.09)  LDD1599  [27]
 LDCM0396  CL125 HEK-293T C463(0.89); C448(1.01)  LDD1600  [27]
 LDCM0397  CL126 HEK-293T C463(0.94); C448(0.98)  LDD1601  [27]
 LDCM0398  CL127 HEK-293T C463(0.87); C448(0.95)  LDD1602  [27]
 LDCM0399  CL128 HEK-293T C463(0.92); C448(0.99)  LDD1603  [27]
 LDCM0400  CL13 HEK-293T C463(0.80); C448(1.04)  LDD1604  [27]
 LDCM0401  CL14 HEK-293T C463(0.92); C448(1.09)  LDD1605  [27]
 LDCM0402  CL15 HEK-293T C463(0.81); C448(0.94)  LDD1606  [27]
 LDCM0403  CL16 HEK-293T C463(0.90); C448(1.05)  LDD1607  [27]
 LDCM0404  CL17 HEK-293T C463(0.67); C448(0.95)  LDD1608  [27]
 LDCM0405  CL18 HEK-293T C463(0.91); C448(1.06)  LDD1609  [27]
 LDCM0406  CL19 HEK-293T C463(0.88); C448(1.03)  LDD1610  [27]
 LDCM0407  CL2 HEK-293T C463(0.89); C448(1.07)  LDD1611  [27]
 LDCM0408  CL20 HEK-293T C463(0.82); C448(1.04)  LDD1612  [27]
 LDCM0409  CL21 HEK-293T C463(0.84); C448(0.98)  LDD1613  [27]
 LDCM0410  CL22 HEK-293T C463(0.86); C448(1.07)  LDD1614  [27]
 LDCM0411  CL23 HEK-293T C463(0.89); C448(1.15)  LDD1615  [27]
 LDCM0412  CL24 HEK-293T C463(0.82); C448(1.08)  LDD1616  [27]
 LDCM0413  CL25 HEK-293T C463(0.89); C448(0.95)  LDD1617  [27]
 LDCM0414  CL26 HEK-293T C463(1.01); C448(1.11)  LDD1618  [27]
 LDCM0415  CL27 HEK-293T C463(0.92); C448(1.10)  LDD1619  [27]
 LDCM0416  CL28 HEK-293T C463(1.01); C448(1.11)  LDD1620  [27]
 LDCM0417  CL29 HEK-293T C463(0.94); C448(1.10)  LDD1621  [27]
 LDCM0418  CL3 HEK-293T C463(0.90); C448(0.94)  LDD1622  [27]
 LDCM0419  CL30 HEK-293T C463(1.06); C448(1.09)  LDD1623  [27]
 LDCM0420  CL31 HEK-293T C463(0.93); C448(1.04)  LDD1624  [27]
 LDCM0421  CL32 HEK-293T C463(0.94); C448(1.06)  LDD1625  [27]
 LDCM0422  CL33 HEK-293T C463(0.85); C448(0.88)  LDD1626  [27]
 LDCM0423  CL34 HEK-293T C463(0.92); C448(1.03)  LDD1627  [27]
 LDCM0424  CL35 HEK-293T C463(0.90); C448(1.14)  LDD1628  [27]
 LDCM0425  CL36 HEK-293T C463(0.88); C448(1.03)  LDD1629  [27]
 LDCM0426  CL37 HEK-293T C463(0.92); C448(1.05)  LDD1630  [27]
 LDCM0428  CL39 HEK-293T C463(0.87); C448(0.98)  LDD1632  [27]
 LDCM0429  CL4 HEK-293T C463(0.80); C448(0.96)  LDD1633  [27]
 LDCM0430  CL40 HEK-293T C463(1.01); C448(1.10)  LDD1634  [27]
 LDCM0431  CL41 HEK-293T C463(0.86); C448(0.99)  LDD1635  [27]
 LDCM0432  CL42 HEK-293T C463(1.01); C448(1.05)  LDD1636  [27]
 LDCM0433  CL43 HEK-293T C463(0.98); C448(1.11)  LDD1637  [27]
 LDCM0434  CL44 HEK-293T C463(0.86); C448(0.99)  LDD1638  [27]
 LDCM0435  CL45 HEK-293T C463(0.82); C448(1.05)  LDD1639  [27]
 LDCM0436  CL46 HEK-293T C463(0.90); C448(1.03)  LDD1640  [27]
 LDCM0437  CL47 HEK-293T C463(0.82); C448(1.04)  LDD1641  [27]
 LDCM0438  CL48 HEK-293T C463(0.85); C448(1.07)  LDD1642  [27]
 LDCM0439  CL49 HEK-293T C463(0.88); C448(0.99)  LDD1643  [27]
 LDCM0440  CL5 HEK-293T C463(0.81); C448(0.98)  LDD1644  [27]
 LDCM0441  CL50 HEK-293T C463(0.92); C448(1.07)  LDD1645  [27]
 LDCM0443  CL52 HEK-293T C463(0.92); C448(0.97)  LDD1646  [27]
 LDCM0444  CL53 HEK-293T C463(0.77); C448(0.95)  LDD1647  [27]
 LDCM0445  CL54 HEK-293T C463(0.82); C448(1.04)  LDD1648  [27]
 LDCM0446  CL55 HEK-293T C463(0.95); C448(1.04)  LDD1649  [27]
 LDCM0447  CL56 HEK-293T C463(0.87); C448(0.98)  LDD1650  [27]
 LDCM0448  CL57 HEK-293T C463(0.89); C448(0.99)  LDD1651  [27]
 LDCM0449  CL58 HEK-293T C463(0.83); C448(1.06)  LDD1652  [27]
 LDCM0450  CL59 HEK-293T C463(0.86); C448(1.12)  LDD1653  [27]
 LDCM0451  CL6 HEK-293T C463(0.77); C448(0.93)  LDD1654  [27]
 LDCM0452  CL60 HEK-293T C463(0.85); C448(1.02)  LDD1655  [27]
 LDCM0453  CL61 HEK-293T C463(0.90); C448(1.03)  LDD1656  [27]
 LDCM0454  CL62 HEK-293T C463(0.93); C448(1.09)  LDD1657  [27]
 LDCM0455  CL63 HEK-293T C463(0.95); C448(0.99)  LDD1658  [27]
 LDCM0456  CL64 HEK-293T C463(0.82); C448(0.95)  LDD1659  [27]
 LDCM0457  CL65 HEK-293T C463(0.89); C448(1.05)  LDD1660  [27]
 LDCM0458  CL66 HEK-293T C463(0.94); C448(1.01)  LDD1661  [27]
 LDCM0459  CL67 HEK-293T C463(0.93); C448(1.01)  LDD1662  [27]
 LDCM0460  CL68 HEK-293T C463(0.89); C448(1.08)  LDD1663  [27]
 LDCM0461  CL69 HEK-293T C463(0.94); C448(1.05)  LDD1664  [27]
 LDCM0462  CL7 HEK-293T C463(0.90); C448(0.94)  LDD1665  [27]
 LDCM0463  CL70 HEK-293T C463(0.89); C448(1.05)  LDD1666  [27]
 LDCM0464  CL71 HEK-293T C463(0.84); C448(1.13)  LDD1667  [27]
 LDCM0465  CL72 HEK-293T C463(0.85); C448(1.12)  LDD1668  [27]
 LDCM0466  CL73 HEK-293T C463(0.90); C448(1.01)  LDD1669  [27]
 LDCM0467  CL74 HEK-293T C463(1.01); C448(1.07)  LDD1670  [27]
 LDCM0469  CL76 HEK-293T C463(0.97); C448(1.04)  LDD1672  [27]
 LDCM0470  CL77 HEK-293T C463(0.80); C448(0.91)  LDD1673  [27]
 LDCM0471  CL78 HEK-293T C463(0.97); C448(1.04)  LDD1674  [27]
 LDCM0472  CL79 HEK-293T C463(0.98); C448(1.05)  LDD1675  [27]
 LDCM0473  CL8 HEK-293T C463(0.61); C448(0.77)  LDD1676  [27]
 LDCM0474  CL80 HEK-293T C463(0.98); C448(1.10)  LDD1677  [27]
 LDCM0475  CL81 HEK-293T C463(1.04); C448(1.11)  LDD1678  [27]
 LDCM0476  CL82 HEK-293T C463(0.90); C448(1.08)  LDD1679  [27]
 LDCM0477  CL83 HEK-293T C463(0.87); C448(1.05)  LDD1680  [27]
 LDCM0478  CL84 HEK-293T C463(0.86); C448(0.97)  LDD1681  [27]
 LDCM0479  CL85 HEK-293T C463(0.87); C448(1.05)  LDD1682  [27]
 LDCM0480  CL86 HEK-293T C463(0.99); C448(1.00)  LDD1683  [27]
 LDCM0481  CL87 HEK-293T C463(0.86); C448(1.01)  LDD1684  [27]
 LDCM0482  CL88 HEK-293T C463(0.91); C448(0.93)  LDD1685  [27]
 LDCM0483  CL89 HEK-293T C463(0.88); C448(1.00)  LDD1686  [27]
 LDCM0484  CL9 HEK-293T C463(0.92); C448(1.00)  LDD1687  [27]
 LDCM0485  CL90 HEK-293T C463(0.70); C448(0.81)  LDD1688  [27]
 LDCM0486  CL91 HEK-293T C463(1.00); C448(1.00)  LDD1689  [27]
 LDCM0487  CL92 HEK-293T C463(0.83); C448(0.96)  LDD1690  [27]
 LDCM0488  CL93 HEK-293T C463(0.90); C448(0.95)  LDD1691  [27]
 LDCM0489  CL94 HEK-293T C463(0.86); C448(0.98)  LDD1692  [27]
 LDCM0490  CL95 HEK-293T C463(0.66); C448(0.84)  LDD1693  [27]
 LDCM0491  CL96 HEK-293T C463(0.79); C448(0.92)  LDD1694  [27]
 LDCM0492  CL97 HEK-293T C463(0.87); C448(0.91)  LDD1695  [27]
 LDCM0493  CL98 HEK-293T C463(0.88); C448(0.98)  LDD1696  [27]
 LDCM0494  CL99 HEK-293T C463(0.90); C448(0.95)  LDD1697  [27]
 LDCM0495  E2913 HEK-293T C463(0.89); C448(1.02)  LDD1698  [27]
 LDCM0625  F8 Ramos C519(2.99); C225(0.86); C362(1.72)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C225(1.07); C362(1.31)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C519(0.60); C362(2.09); C448(1.30)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C519(0.44); C225(0.99); C362(0.95)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C519(0.23); C225(1.29)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C519(0.80); C225(0.68); C362(0.74); C448(6.38)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C519(0.51); C225(0.91); C362(1.27)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C519(0.30); C225(1.23); C362(0.81)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C225(1.73); C362(1.60)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C225(1.28); C362(1.73)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C519(1.63); C225(0.48)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C519(0.42); C225(1.16); C362(2.19)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C225(1.29)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C225(1.26); C362(1.19); C448(3.24)  LDD2201  [28]
 LDCM0468  Fragment33 HEK-293T C463(0.93); C448(1.01)  LDD1671  [27]
 LDCM0596  Fragment38 Ramos C225(1.03); C362(1.19)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C519(0.56); C225(1.05); C362(1.16)  LDD2184  [28]
 LDCM0427  Fragment51 HEK-293T C463(1.05); C448(1.05)  LDD1631  [27]
 LDCM0610  Fragment52 Ramos C225(1.21)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C519(0.43); C225(1.17); C362(3.73); C448(1.27)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C519(0.67); C225(0.86); C362(0.78)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C519(0.26); C225(0.89); C362(1.20); C448(1.64)  LDD2188  [28]
 LDCM0116  HHS-0101 DM93 Y449(0.84)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y449(1.09)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y449(1.47)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y449(1.58)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y449(0.91)  LDD0268  [10]
 LDCM0107  IAA HeLa H675(0.00); C225(0.00); H751(0.00); H747(0.00)  LDD0221  [24]
 LDCM0022  KB02 HEK-293T C463(0.97); C448(0.97)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C463(0.98); C448(1.02)  LDD1497  [27]
 LDCM0024  KB05 COLO792 C448(1.44)  LDD3310  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C519(0.70)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C225(0.82); C519(0.49)  LDD2121  [8]
 LDCM0109  NEM HeLa H280(0.00); H747(0.00); H737(0.00); H751(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C362(1.10); C225(0.62); C519(0.31)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C519(0.98)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C519(0.64)  LDD2092  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C519(1.13)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C362(0.57); C519(2.12)  LDD2096  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C519(0.86)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C519(0.68); C463(1.44)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C519(1.25); C463(0.36)  LDD2100  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C519(1.53); C463(0.47)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C519(0.99)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C463(0.46)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C463(1.06)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C519(0.91)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C519(0.95); C463(1.20)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C519(2.92); C463(0.79)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C463(1.32)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C519(1.08); C463(0.34)  LDD2114  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C519(1.09)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C519(1.48)  LDD2118  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C519(0.88); C463(0.31)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C519(1.02)  LDD2122  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C519(1.21)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C463(1.29)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C519(1.54)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C519(1.03); C463(0.95)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C519(0.64); C463(0.34)  LDD2128  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C519(0.28)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C519(1.02)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C519(1.06); C463(1.06)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C519(0.73)  LDD1700  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C519(2.44); C463(0.45)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C519(1.34); C463(0.30)  LDD2143  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C362(0.98)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C519(6.94)  LDD2147  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C519(0.27); C463(0.84)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C362(0.90); C519(2.59)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C362(1.71); C519(1.46)  LDD2153  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
RNA-binding protein FUS (FUS) RRM TET family P35637
Scaffold attachment factor B2 (SAFB2) . Q14151

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578