Details of the Target

General Information of Target

Target ID LDTP01815
Target Name Complement C3 (C3)
Gene Name C3
Gene ID 718
Synonyms
CPAMD1; Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c; C3bc; Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein; ASP; C3adesArg; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVH
DFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKV
VLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSL
SSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTE
KFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEV
VLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKT
PKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPL
SITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMD
RAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGA
SGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDK
GVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAEL
QCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEAC
KKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKE
PPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVV
RNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVI
VPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKE
DIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTP
TVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTA
YVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKD
MALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMG
RLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQR
YYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLR
SEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDA
KNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDG
KLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDE
YIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSY
IIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN
Target Type
Successful
Target Bioclass
Other
Subcellular location
Secreted
Function
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.; Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.; [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation.; [Acylation stimulating protein]: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.
TTD ID
T26851
Uniprot ID
P01024
DrugMap ID
TTXA5VP
Ensemble ID
ENST00000245907.11
HGNC ID
HGNC:1318
ChEMBL ID
CHEMBL4917

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		27.01  LDD0235  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
YN-4
 Probe Info  		100.00  LDD0445  [2]
IPM
 Probe Info  		C662(0.00); C627(0.00); C559(0.00); C1513(0.00)  LDD0241  [1]
OPA-S-S-alkyne
 Probe Info  		K1546(4.18); K1535(5.81); K1051(6.25); K692(7.71)  LDD3494  [3]
BTD
 Probe Info  		C873(0.74)  LDD2120  [4]
DBIA
 Probe Info  		C693(0.95)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C693(0.95)  LDD0531  [5]
 LDCM0215  AC10 PaTu 8988t C694(1.78); C693(1.40)  LDD1094  [5]
 LDCM0216  AC100 HEK-293T C694(1.07)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C694(1.22)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C694(0.98)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C694(1.56)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C694(1.38)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C694(0.95)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C694(0.96)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C694(1.08)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C694(0.71)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C694(0.94)  LDD0823  [5]
 LDCM0226  AC11 PaTu 8988t C694(1.46); C693(1.17)  LDD1105  [5]
 LDCM0227  AC110 HEK-293T C694(1.21)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C694(1.27)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C694(1.33)  LDD0827  [5]
 LDCM0230  AC113 HCT 116 C693(1.05)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C693(1.10)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C693(1.15)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C693(0.97)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C693(0.93)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C693(1.07)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C693(0.97)  LDD0553  [5]
 LDCM0237  AC12 PaTu 8988t C694(1.15); C693(1.11)  LDD1116  [5]
 LDCM0238  AC120 HCT 116 C693(1.00)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C693(0.97)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C693(1.24)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C693(1.02)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C693(1.02)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C693(1.00)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C693(1.02)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C693(1.03)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C694(1.66); C693(1.47)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C694(1.68); C693(1.07)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C694(1.47); C693(0.85)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C694(1.44); C693(1.30)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C694(1.05); C693(1.03)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C694(1.02); C693(1.13)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C694(1.48); C693(1.42)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C694(1.22); C693(1.42)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C694(0.78); C693(1.43)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C694(0.82); C693(1.42)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C694(1.03); C693(0.84)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C694(0.98); C693(1.17)  LDD1137  [5]
 LDCM0259  AC14 PaTu 8988t C694(1.62); C693(1.01)  LDD1138  [5]
 LDCM0260  AC140 PaTu 8988t C694(1.52); C693(0.74)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C694(1.23); C693(0.93)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C694(1.02); C693(0.81)  LDD1141  [5]
 LDCM0263  AC143 HCT 116 C693(0.90)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C693(0.63)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C693(0.87)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C693(0.90)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C693(0.91)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C693(0.92)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C693(0.81)  LDD0586  [5]
 LDCM0270  AC15 PaTu 8988t C694(1.60); C693(1.39)  LDD1149  [5]
 LDCM0271  AC150 HCT 116 C693(1.25)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C693(0.88)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C693(0.94)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C693(0.87)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C693(0.94)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C693(1.07)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C693(1.10)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C693(1.05)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C693(0.51)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C693(0.57)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C693(0.56)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C693(1.12)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C693(0.23)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C693(0.29)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C693(0.35)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C693(0.37)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C693(0.50)  LDD0601  [5]
 LDCM0285  AC25 HEK-293T C694(0.96)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C694(1.65)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C694(1.65)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C694(1.11)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C694(1.21)  LDD0887  [5]
 LDCM0290  AC3 HCT 116 C693(1.00)  LDD0607  [5]
 LDCM0291  AC30 HEK-293T C694(1.19)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C694(1.25)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C694(1.31)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C694(1.13)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C694(1.03)  LDD0893  [5]
 LDCM0296  AC35 PaTu 8988t C693(0.93)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C693(0.82)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C693(0.99)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C693(0.99)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C693(1.05)  LDD1179  [5]
 LDCM0301  AC4 HCT 116 C693(1.08)  LDD0618  [5]
 LDCM0302  AC40 PaTu 8988t C693(0.83)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C693(0.50)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C693(0.90)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C693(0.90)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C693(1.11)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C693(0.84)  LDD1186  [5]
 LDCM0308  AC46 HEK-293T C694(1.28)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C694(1.31)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C694(1.04)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C694(1.25)  LDD0909  [5]
 LDCM0312  AC5 HCT 116 C693(1.13)  LDD0629  [5]
 LDCM0313  AC50 HEK-293T C694(1.68)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C694(1.84)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C694(1.51)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C694(1.18)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C694(1.64)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C694(1.14)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C694(1.47)  LDD0917  [5]
 LDCM0320  AC57 PaTu 8988t C693(0.90)  LDD1199  [5]
 LDCM0321  AC58 PaTu 8988t C693(0.60)  LDD1200  [5]
 LDCM0322  AC59 PaTu 8988t C693(0.68)  LDD1201  [5]
 LDCM0323  AC6 PaTu 8988t C694(1.32); C693(0.98)  LDD1202  [5]
 LDCM0324  AC60 PaTu 8988t C693(0.73)  LDD1203  [5]
 LDCM0325  AC61 PaTu 8988t C693(0.81)  LDD1204  [5]
 LDCM0326  AC62 PaTu 8988t C693(0.72)  LDD1205  [5]
 LDCM0327  AC63 PaTu 8988t C693(0.83)  LDD1206  [5]
 LDCM0328  AC64 PaTu 8988t C693(0.78)  LDD1207  [5]
 LDCM0329  AC65 PaTu 8988t C693(0.59)  LDD1208  [5]
 LDCM0330  AC66 PaTu 8988t C693(0.86)  LDD1209  [5]
 LDCM0331  AC67 PaTu 8988t C693(0.97)  LDD1210  [5]
 LDCM0332  AC68 HCT 116 C693(1.22)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C693(1.39)  LDD0650  [5]
 LDCM0334  AC7 PaTu 8988t C694(0.78); C693(1.23)  LDD1213  [5]
 LDCM0335  AC70 HCT 116 C693(1.41)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C693(1.62)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C693(1.41)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C693(1.63)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C693(1.15)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C693(1.15)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C693(1.52)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C693(1.38)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C693(1.29)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C693(1.42)  LDD0661  [5]
 LDCM0345  AC8 PaTu 8988t C694(0.90); C693(1.03)  LDD1224  [5]
 LDCM0346  AC80 HCT 116 C693(1.37)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C693(1.64)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C693(1.20)  LDD0665  [5]
 LDCM0349  AC83 HEK-293T C694(0.88)  LDD0947  [5]
 LDCM0350  AC84 HEK-293T C694(0.95)  LDD0948  [5]
 LDCM0351  AC85 HEK-293T C694(0.92)  LDD0949  [5]
 LDCM0352  AC86 HEK-293T C694(0.96)  LDD0950  [5]
 LDCM0353  AC87 HEK-293T C694(0.79)  LDD0951  [5]
 LDCM0354  AC88 HEK-293T C694(0.89)  LDD0952  [5]
 LDCM0355  AC89 HEK-293T C694(0.81)  LDD0953  [5]
 LDCM0357  AC90 HEK-293T C694(0.89)  LDD0955  [5]
 LDCM0358  AC91 HEK-293T C694(0.81)  LDD0956  [5]
 LDCM0359  AC92 HEK-293T C694(0.94)  LDD0957  [5]
 LDCM0360  AC93 HEK-293T C694(1.37)  LDD0958  [5]
 LDCM0361  AC94 HEK-293T C694(1.23)  LDD0959  [5]
 LDCM0362  AC95 HEK-293T C694(0.85)  LDD0960  [5]
 LDCM0363  AC96 HEK-293T C694(0.86)  LDD0961  [5]
 LDCM0364  AC97 HEK-293T C694(1.21)  LDD0962  [5]
 LDCM0365  AC98 HEK-293T C694(1.14)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C694(3.67)  LDD0964  [5]
 LDCM0248  AKOS034007472 PaTu 8988t C694(2.18); C693(0.96)  LDD1127  [5]
 LDCM0356  AKOS034007680 PaTu 8988t C694(1.89); C693(1.87)  LDD1235  [5]
 LDCM0275  AKOS034007705 PaTu 8988t C694(1.47); C693(1.77)  LDD1154  [5]
 LDCM0367  CL1 HCT 116 C693(1.01)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C693(1.40)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C693(1.11)  LDD0686  [5]
 LDCM0370  CL101 PaTu 8988t C694(1.06); C693(1.74)  LDD1249  [5]
 LDCM0371  CL102 PaTu 8988t C694(0.83); C693(1.29)  LDD1250  [5]
 LDCM0372  CL103 PaTu 8988t C694(2.04); C693(1.21)  LDD1251  [5]
 LDCM0373  CL104 PaTu 8988t C694(1.18); C693(0.77)  LDD1252  [5]
 LDCM0374  CL105 HCT 116 C693(0.49)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C693(0.78)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C693(0.46)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C693(0.60)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C693(0.43)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C693(1.37)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C693(0.63)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C693(0.74)  LDD0698  [5]
 LDCM0382  CL112 HEK-293T C694(1.03)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C694(1.29)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C694(1.33)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C694(1.05)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C694(1.20)  LDD0984  [5]
 LDCM0387  CL117 PaTu 8988t C693(0.72)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C693(0.95)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C693(0.84)  LDD1268  [5]
 LDCM0390  CL12 HCT 116 C693(1.33)  LDD0707  [5]
 LDCM0391  CL120 PaTu 8988t C693(0.62)  LDD1270  [5]
 LDCM0392  CL121 HEK-293T C694(1.39)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C694(1.35)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C694(1.44)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C694(1.07)  LDD0993  [5]
 LDCM0396  CL125 PaTu 8988t C693(0.74)  LDD1275  [5]
 LDCM0397  CL126 PaTu 8988t C693(0.87)  LDD1276  [5]
 LDCM0398  CL127 PaTu 8988t C693(0.58)  LDD1277  [5]
 LDCM0399  CL128 PaTu 8988t C693(0.79)  LDD1278  [5]
 LDCM0400  CL13 HCT 116 C693(2.04)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C693(1.76)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C693(0.96)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C693(1.13)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C693(1.04)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C693(1.17)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C693(1.18)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C693(0.84)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C693(1.18)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C693(1.05)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C693(1.21)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C693(1.07)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C693(1.23)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C693(1.20)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C693(1.78)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C693(1.30)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C693(1.19)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C693(1.10)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C693(0.97)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C693(1.25)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C693(0.97)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C693(1.01)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C693(0.41)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C693(0.91)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C693(1.82)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C693(0.96)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C693(0.92)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C693(0.57)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C693(0.96)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C693(0.63)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C693(0.63)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C693(1.41)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C693(0.78)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C693(1.13)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C693(0.73)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C693(1.04)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C693(1.57)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C693(1.96)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C693(1.31)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C693(1.08)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C693(1.62)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C693(1.55)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C693(1.67)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C693(1.27)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C693(1.09)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C693(1.01)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C693(1.33)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C693(1.45)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C693(1.43)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C693(1.31)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C693(1.23)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C693(1.73)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C693(1.26)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C693(1.18)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C693(1.16)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C693(1.17)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C693(1.39)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C693(1.35)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C693(1.44)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C693(1.20)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C693(1.12)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C693(2.13)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C693(1.15)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C693(1.46)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C693(1.26)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C693(1.33)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C693(1.18)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C693(1.38)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C693(1.03)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C693(0.72)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C693(1.03)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C693(1.05)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C693(0.91)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C693(1.01)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C693(1.13)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C693(1.09)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C693(1.44)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C693(1.70)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C693(2.74)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C693(1.10)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C693(1.00)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C693(1.15)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C693(1.21)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C693(1.08)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C693(0.82)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C693(0.71)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C693(1.08)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C693(0.92)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C693(0.94)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C693(0.95)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C693(1.04)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C693(1.01)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C693(0.84)  LDD0811  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C873(1.03)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C693(1.34)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C693(1.67)  LDD0744  [5]
 LDCM0022  KB02 42-MG-BA C559(1.87)  LDD2244  [7]
 LDCM0023  KB03 A101D C627(2.77); C662(2.94); C559(4.81)  LDD2667  [7]
 LDCM0024  KB05 G361 C627(2.15)  LDD3311  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C873(0.74)  LDD2120  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C873(0.81)  LDD2128  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C873(0.59)  LDD2143  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Complement factor B (CFB) Peptidase S1 family P00751
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Complement receptor type 2 (CR2) Receptors of complement activation (RCA) family P20023
Complement factor H (CFH) . P08603
Membrane cofactor protein (CD46) . P15529
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Human Immunoglobulin G BiotechDrug DB00028
Copper . DB09130
Pegcetacoplan . DB16694
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 3
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Apl-2 . D0P5LH
Imprime Pgg . D0P6MW
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amy-101 Peptide DSI31T
Pot-4 . D01SQI
Investigative
Click To Hide/Show 30 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cysteine Sulfenic Acid Small molecular drug D0V6UC
S-hydroxycysteine Small molecular drug DB01915
Ac-icv(1mew)Qdwgahrct-nh2 . D07VEA
Ac-icv(5fw)Qdwgahrct-nh2 . D0D3VF
Ac-icv(5mew)Qdwgahrct-nh2 . D0Y9TF
Ac-icvwqd(5fw)Gahrct-nh2 . D0T7CN
Ac-icvwqdwgahrct-nh2 . D01DQT
Ac-i[Cv(1nal)Qdwgahrc]T . D0N6LH
Ac-i[Cv(2igl)Qdwgahrc]T . D0DR3X
Ac-i[Cv(2igl)Qdwgahrc]T-nh2 . D0UK9D
Ac-i[Cv(2nal)Qdwgahrc]T . D05LJY
Ac-i[Cv(2nal)Qdwgahrc]T-nh2 . D0T6ST
Ac-i[Cv(Bpa)Qdwgahrc]T . D02AWT
Ac-i[Cv(Bpa)Qdwgahrc]T-nh2 . D0J3BV
Ac-i[Cv(Bta)Qdwgahrc]T . D00BCO
Ac-i[Cv(Bta)Qdwgahrc]T-nh2 . D01ZRJ
Ac-i[Cv(Dht)Qdwgahrc]T . D0PD8G
Ac-i[Cv(Yphs)Qdwgahrc]I-nh2 . D0T0PR
Ac-i[Cvfqdwghhrc]T-nh2 . D0R1MR
Ac-i[Cvhqdwghhrc]T-nh2 . D05AIB
Ac-i[Cvsqdwghhrc]T-nh2 . D0G4VH
Ac-i[Cvtqdwghhrc]T-nh2 . D0Q0HE
Ac-i[Cvvqdwgahrc]T-nh2 . D03SHO
Ac-i[Cvwqdwg(Abu)Hrc]T-nh2 . D02CSO
Ac-i[Cvwqdwgahrc]Dt . D0R2FS
Ac-i[Cvwqdwgahrc]T . D0B4JO
Ac-i[Cvwqdwghhrc]T-nh2 . D0O2BI
Ac-i[Cvwqdwgwhrc]T-nh2 . D00CYF
Ac-i[Cvyqdwgahrc]T-nh2 . D0V0RO
Mirococept . DB06492

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840