Details of the Target

General Information of Target

Target ID LDTP13746
Target Name Serine/arginine repetitive matrix protein 2 (SRRM2)
Gene Name SRRM2
Gene ID 23524
Synonyms
KIAA0324; SRL300; SRM300; Serine/arginine repetitive matrix protein 2; 300 kDa nuclear matrix antigen; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa; SR-related nuclear matrix protein of 300 kDa; Ser/Arg-related nuclear matrix protein of 300 kDa; Splicing coactivator subunit SRm300; Tax-responsive enhancer element-binding protein 803; TaxREB803
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKKVKEEHKPQLT
QWFPFSGITELVNNVLQPQQKQQNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDA
PTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGA
WFYNSGSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGL
TRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRS
PSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEY
QSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMD
RPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLR
RTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQ
ISLSSSEEELASTPEYTSCDDVEIESESVSEKGDSQKGKRKTSEQAVLSDSNTRSERQKE
MMYFGGHSLEEDLEWSEPQIKDSGVDTCSSTTLNEEHSHSDKHPVTWQPSKDGDRLIGRI
LLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVL
EWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQ
KMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRP
RNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQAR
VREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRR
LQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRV
DVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCE
AADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHP
RTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWM
TRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGD
IQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLE
PLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPP
SSLVDPTLAPLTRRASQSSLESSTGPSYSRS
Target Bioclass
Other
Family
CWC21 family
Subcellular location
Nucleus
Function Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Uniprot ID
Q9UQ35
Ensemble ID
ENST00000301740.13
HGNC ID
HGNC:16639

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.T2316I DBIA    Probe Info 
COLO792 SNV: p.P1133S DBIA    Probe Info 
HCC15 SNV: p.N2255I DBIA    Probe Info 
HCT15 SNV: p.L124W DBIA    Probe Info 
HEC1 SNV: p.G148C; p.R1788Q DBIA    Probe Info 
HEC1B SNV: p.G148C; p.R1788Q .
HT115 SNV: p.S1674P DBIA    Probe Info 
IGR37 SNV: p.R1692L DBIA    Probe Info 
IGR39 SNV: p.R1692L DBIA    Probe Info 
IGROV1 SNV: p.R2423Q DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.G14D DBIA    Probe Info 
JURKAT SNV: p.V959M; p.R1979H Compound 10    Probe Info 
KARPAS422 SNV: p.C785F DBIA    Probe Info 
KMCH1 SNV: p.A254V DBIA    Probe Info 
KMS11 SNV: p.P1464S DBIA    Probe Info 
L428 SNV: p.S2394R DBIA    Probe Info 
LS180 SNV: p.S2613R DBIA    Probe Info 
LS513 SNV: p.S421I DBIA    Probe Info 
MCC13 SNV: p.R1744G DBIA    Probe Info 
MDAMB231 SNV: p.S1281F .
MDAMB453 SNV: p.R670L DBIA    Probe Info 
MEWO SNV: p.P2120L DBIA    Probe Info 
MFE319 SNV: p.R219G DBIA    Probe Info 
NALM6 SNV: p.R52Q DBIA    Probe Info 
NCIH1792 SNV: p.S1902Y DBIA    Probe Info 
OCUG1 SNV: p.P1278R .
RKO SNV: p.Q512H DBIA    Probe Info 
SNU1 SNV: p.P1278R DBIA    Probe Info 
SNU245 SNV: p.S2713N DBIA    Probe Info 
TE1 SNV: p.T2367S DBIA    Probe Info 
YSCCC SNV: p.E862Q; p.E1623Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.23  LDD0402  [1]
P1
 Probe Info  		1.72  LDD0448  [2]
P2
 Probe Info  		1.67  LDD0449  [2]
P3
 Probe Info  		1.60  LDD0450  [2]
A-EBA
 Probe Info  		2.93  LDD0215  [3]
7-N3
 Probe Info  		1.22  LDD0281  [4]
W1
 Probe Info  		20.64  LDD0235  [5]
TH211
 Probe Info  		Y967(20.00)  LDD0260  [6]
C-Sul
 Probe Info  		13.89  LDD0066  [7]
ONAyne
 Probe Info  		K51(5.26)  LDD0274  [8]
STPyne
 Probe Info  		K101(5.22); K1261(7.50); K2680(5.53); K285(6.23)  LDD0277  [8]
Probe 1
 Probe Info  		Y18(26.40); Y2390(18.33)  LDD3495  [9]
BTD
 Probe Info  		C2130(2.54); C2116(1.79); C956(1.17); C785(1.08)  LDD1700  [10]
AZ-9
 Probe Info  		10.00  LDD2154  [11]
AHL-Pu-1
 Probe Info  		C1036(2.03)  LDD0168  [12]
HHS-475
 Probe Info  		Y1049(0.44); Y145(0.52); Y1145(0.78); Y2323(1.29)  LDD0264  [13]
HHS-465
 Probe Info  		Y2323(6.44); Y2390(5.52)  LDD2237  [14]
DBIA
 Probe Info  		C956(1.03); C785(0.99); C1029(0.97); C1036(0.97)  LDD0078  [15]
5E-2FA
 Probe Info  		H122(0.00); H60(0.00); H2345(0.00)  LDD2235  [16]
ATP probe
 Probe Info  		K1186(0.00); K2602(0.00); K285(0.00); K1022(0.00)  LDD0199  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C2116(0.00); C872(0.00); C1480(0.00); C785(0.00)  LDD0038  [18]
IA-alkyne
 Probe Info  		C2116(0.00); C872(0.00)  LDD0032  [19]
Lodoacetamide azide
 Probe Info  		C2116(0.00); C872(0.00); C785(0.00); C956(0.00)  LDD0037  [18]
JW-RF-010
 Probe Info  		C956(0.00); C70(0.00)  LDD0026  [20]
NAIA_4
 Probe Info  		C872(0.00); C1016(0.00)  LDD2226  [21]
TFBX
 Probe Info  		C1036(0.00); C956(0.00); C1016(0.00); C1029(0.00)  LDD0027  [20]
WYneN
 Probe Info  		C956(0.00); C872(0.00)  LDD0021  [22]
WYneO
 Probe Info  		C872(0.00); C1016(0.00); C956(0.00)  LDD0022  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [23]
Compound 10
 Probe Info  		C1029(0.00); C1036(0.00); C2116(0.00); C872(0.00)  LDD2216  [24]
Compound 11
 Probe Info  		C1029(0.00); C1036(0.00); C2116(0.00); C872(0.00)  LDD2213  [24]
ENE
 Probe Info  		C1036(0.00); C872(0.00)  LDD0006  [22]
IPM
 Probe Info  		C1509(0.00); C785(0.00); C872(0.00); C1036(0.00)  LDD0005  [22]
NHS
 Probe Info  		N.A.  LDD0010  [22]
SF
 Probe Info  		Y2323(0.00); Y1145(0.00); Y2390(0.00); Y2693(0.00)  LDD0028  [25]
VSF
 Probe Info  		C1029(0.00); C872(0.00); C1480(0.00); C1036(0.00)  LDD0007  [22]
Phosphinate-6
 Probe Info  		C1029(0.00); C1016(0.00); C872(0.00); C1509(0.00)  LDD0018  [26]
Acrolein
 Probe Info  		H2345(0.00); C872(0.00); C1480(0.00); C785(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		H2345(0.00); C956(0.00); H2176(0.00); C872(0.00)  LDD0219  [27]
Methacrolein
 Probe Info  		C1480(0.00); C872(0.00)  LDD0218  [27]
NAIA_5
 Probe Info  		C872(0.00); C891(0.00); C1016(0.00)  LDD2223  [21]
HHS-482
 Probe Info  		Y967(0.91)  LDD2239  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		8.68  LDD0475  [28]
FFF probe3
 Probe Info  		8.58  LDD0464  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C956(0.79); C1016(1.02)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C956(0.66)  LDD2095  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C2116(0.95); C785(1.15)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C956(0.91); C2116(1.01); C785(0.69); C2130(0.94)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C956(1.04); C2116(0.99); C2130(1.67); C1016(1.46)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C956(0.83); C1016(0.74)  LDD2103  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C2116(0.47)  LDD2132  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C785(0.78); C1016(0.74); C872(0.48)  LDD2131  [10]
 LDCM0025  4SU-RNA HEK-293T C1036(2.03)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C956(4.62); C872(2.22); C2116(2.16); C1509(2.37)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C1016(0.77); C872(1.33); C1029(0.94); C1036(0.93)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C1016(1.25); C872(0.98); C1029(1.21); C1036(1.19)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C1016(1.20); C872(1.07); C1029(1.04); C1036(0.99)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C1016(1.13); C872(1.13); C1029(1.00); C1036(0.96)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C1016(1.14); C872(0.94); C1029(1.02); C1036(1.03)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C1016(1.63); C872(1.65); C1029(1.33); C1036(1.36)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C1016(1.38); C872(1.23); C1029(1.15); C1036(1.11)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C1016(1.37); C872(1.68); C1029(1.29); C1036(1.28)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C1016(1.58); C872(1.21); C1029(1.33); C1036(1.30)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C1016(1.32); C872(1.05); C1029(1.20); C1036(0.96)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C1016(1.28); C872(1.71); C1029(1.05); C1036(1.00)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C1016(1.09); C872(1.87); C1029(0.91); C1036(0.86)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C1016(1.47); C872(1.29); C1029(1.58); C1036(1.41)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C1016(1.32); C872(1.69); C1029(1.06); C1036(1.00)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C1016(1.36); C872(1.48); C1029(1.08); C1036(1.02)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C1016(1.32); C872(0.90); C1029(1.16); C1036(1.05)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C1016(1.25); C872(1.05); C1029(1.12); C1036(1.21)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C1016(1.47); C872(1.43); C1029(1.30); C1036(1.34)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C1016(1.75); C872(1.52); C1029(1.47); C1036(1.52)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C1016(1.51); C872(1.65); C1029(1.67); C1036(1.73)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C1016(1.20); C872(1.46); C1029(1.29); C1036(1.29)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C1016(1.03); C872(1.25); C1029(1.13); C1036(1.12)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C1016(1.09); C872(1.34); C1029(1.23); C1036(1.27)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C1016(1.18); C872(0.78); C1029(1.13); C1036(1.01)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C1016(1.32); C872(1.26); C1029(1.52); C1036(1.53)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C1016(1.18); C872(0.96); C1029(1.17); C1036(1.23)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C1016(1.35); C872(1.23); C1029(1.19); C1036(1.24)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C1016(1.16); C872(0.94); C1029(1.11); C1036(1.08)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C1016(1.03); C872(1.01); C1029(1.17); C1036(1.20)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C1016(1.12); C872(1.32); C1029(1.14); C1036(1.13)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C1016(1.36); C872(1.56); C1029(1.51); C1036(1.62)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C1016(1.36); C872(1.64); C1029(1.47); C1036(1.60)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C1016(1.64); C872(0.26); C1029(1.13); C1036(1.11)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C1016(0.79); C872(0.30); C1029(0.79); C1036(0.77)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C1016(1.36); C872(0.28); C1029(1.02); C1036(0.94)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C1016(0.83); C872(0.29); C1029(0.88); C1036(0.89)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C1016(0.74); C872(0.33); C1029(0.67); C1036(0.64)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C1016(0.90); C872(0.32); C1029(0.74); C1036(0.74)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C1016(1.11); C872(0.39); C1029(0.96); C1036(0.97)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C1016(1.12); C872(0.37); C1029(0.82); C1036(0.81)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C1016(1.14); C872(0.47); C1029(0.89); C1036(0.85)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C1016(1.00); C872(0.33); C1029(0.85); C1036(0.80)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C1016(0.99); C872(0.37); C1029(0.88); C1036(0.84)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C1016(0.83); C872(0.39); C1029(0.83); C1036(0.81)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C1016(1.13); C872(0.87); C1029(1.15); C1036(1.02)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C1016(1.06); C872(0.44); C1029(0.86); C1036(0.83)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C1016(0.99); C872(0.52); C1029(0.88); C1036(0.87)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C1016(0.74); C872(0.37); C1029(0.63); C1036(0.63)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C1016(1.25); C872(1.09); C1036(1.13); C1029(1.14)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C1029(1.57); C1036(1.61); C1016(1.71); C872(2.21)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C872(1.04); C1036(1.17); C1029(1.22); C1016(1.48)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C872(1.21); C1029(1.28); C1036(1.29); C1016(1.68)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C1036(1.55); C1029(1.55); C872(1.60); C1016(1.91)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C1029(2.01); C1036(2.11); C872(2.73); C1016(2.85)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C1029(1.65); C1036(1.69); C1016(1.79); C872(1.95)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C872(0.87); C1036(1.25); C1029(1.31); C1016(1.39)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C872(1.14); C1036(1.18); C1029(1.19); C1016(1.53)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C1029(1.23); C1036(1.26); C1016(1.32); C872(1.40)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C1029(1.58); C1036(1.66); C872(1.95); C1016(1.99)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C1029(2.62); C1036(2.73); C872(4.28); C1016(4.30)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C1016(1.88); C872(2.36); C1029(1.47); C1036(1.47)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C1016(2.18); C872(2.14); C1029(1.66); C1036(1.81)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C1016(1.54); C872(1.47); C1029(1.16); C1036(1.18)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C1016(1.33); C872(1.55); C1029(1.41); C1036(1.50)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C872(0.97); C1029(1.04); C1036(1.05); C1016(1.07)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C872(1.22); C1029(1.24); C1016(1.33); C1036(1.35)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C872(1.08); C1029(1.09); C1016(1.25); C1036(1.31)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C1036(0.95); C1029(1.00); C1016(1.07); C872(1.39)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C872(0.82); C1029(1.04); C1036(1.15); C1016(1.17)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C872(0.94); C1029(1.27); C1036(1.50); C1016(1.50)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C872(0.76); C1029(1.04); C1036(1.14); C1016(1.34)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C872(0.94); C1029(1.19); C1036(1.37); C1016(1.50)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C872(0.79); C1029(0.95); C1016(0.97); C1036(1.06)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C872(1.10); C1029(1.22); C1036(1.25); C1016(1.47)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C1029(1.21); C1036(1.22); C872(1.37); C1016(1.56)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C1029(1.28); C872(1.28); C1036(1.31); C1016(1.69)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C872(1.37); C1036(1.61); C1029(1.62); C1016(1.79)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C872(1.32); C1036(1.44); C1029(1.52); C1016(2.34)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C1036(0.84); C1029(0.91); C1016(0.92); C872(1.29)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C1036(1.28); C1029(1.33); C872(1.35); C1016(2.56)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C1016(1.29); C1029(1.40); C1036(1.40); C872(1.65)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C1036(1.71); C1029(1.73); C872(1.80); C1016(1.83)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C872(1.50); C1029(1.65); C1036(1.70); C1016(2.16)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C872(1.53); C1029(1.94); C1036(2.05); C1016(2.42)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C1029(0.90); C872(0.91); C1016(0.94); C1036(1.04)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C1029(0.88); C872(0.96); C1016(1.03); C1036(1.05)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C1029(0.81); C1036(1.10); C1016(1.11); C872(1.20)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C872(0.94); C1016(1.05); C1036(1.06); C1029(1.08)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C1036(1.13); C1029(1.17); C1016(1.48); C872(1.97)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C1016(0.75); C1036(0.86); C1029(0.93); C872(1.25)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C1029(0.92); C1036(1.14); C872(1.15); C1016(1.19)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C1029(0.99); C872(1.17); C1036(1.18); C1016(1.35)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C1029(0.95); C1036(1.12); C1016(1.22); C872(1.24)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C1029(0.95); C1036(1.12); C1016(1.29); C872(1.31)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C1029(0.85); C1036(1.09); C872(1.10); C1016(1.31)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C1029(1.16); C1036(1.44); C872(1.53); C1016(1.88)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C1016(1.02); C1029(1.02); C1036(1.02)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C1029(1.03); C1036(1.03); C1016(1.41)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C1029(0.88); C1036(0.88); C1016(1.35)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C1029(1.51); C1036(1.51); C1016(2.45)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C1016(0.67); C1036(0.79); C1029(0.89); C872(1.22)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C1029(1.55); C1036(1.55); C1016(2.07)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C1029(0.89); C1036(0.89); C1016(0.94)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C1029(1.09); C1036(1.09); C1016(1.12)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C1029(1.48); C1036(1.48); C1016(1.65)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C1029(1.31); C1036(1.31); C1016(1.92)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C1029(1.68); C1036(1.68); C1016(2.13)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C1029(2.74); C1036(2.74); C1016(4.87)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C1036(1.26); C1029(1.31); C872(1.45); C1016(1.66)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C1036(1.19); C1029(1.29); C872(1.42); C1016(2.12)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C1036(1.06); C1029(1.14); C1016(1.52); C872(1.74)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C1029(1.10); C1036(1.12); C872(1.13); C1016(1.19)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C1036(0.98); C1029(1.08); C1016(1.34); C872(1.68)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C1036(0.91); C1029(0.95); C872(1.15); C1016(1.31)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C1036(1.45); C1029(1.46); C872(1.50); C1016(1.57)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C1036(1.03); C1029(1.14); C872(1.37); C1016(1.67)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C1036(1.10); C1029(1.24); C872(1.48); C1016(1.57)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C1036(0.65); C1029(0.73); C872(0.73); C1016(0.84)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C1036(0.62); C1029(0.71); C872(0.71); C1016(0.82)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C1036(0.78); C1029(0.89); C872(1.00); C1016(1.23)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C872(0.78); C1029(1.34); C1036(1.38); C1016(1.60)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C872(1.07); C1029(1.23); C1036(1.29); C1016(1.72)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C1029(0.84); C872(0.91); C1016(0.97); C1036(0.98)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C872(0.97); C1029(1.50); C1036(1.54); C1016(2.21)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C872(0.62); C1029(0.95); C1036(1.03); C1016(1.37)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C872(1.46); C1029(1.51); C1036(1.53); C1016(1.98)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C872(2.40); C1016(2.90); C1029(1.86); C1036(1.97)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C1029(1.44); C1036(1.53); C872(1.55); C1016(1.99)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C1036(2.31); C1029(2.33); C872(2.81); C1016(3.11)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C1029(1.33); C872(1.33); C1036(1.38); C1016(1.73)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C1029(1.70); C1036(1.70); C872(1.71); C1016(2.01)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C872(1.22); C1029(1.45); C1036(1.45); C1016(1.86)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C872(1.04); C1029(1.46); C1016(1.52); C1036(1.59)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C872(0.88); C1016(1.13); C1036(1.23); C1029(1.31)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C1036(1.37); C1029(1.39); C872(1.62); C1016(1.82)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C872(0.82); C1029(1.25); C1036(1.27); C1016(1.82)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C1036(2.27); C1029(2.32); C872(2.97); C1016(4.72)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C1029(2.10); C1036(2.26); C872(2.37); C1016(2.41)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C872(1.68); C1029(1.78); C1036(1.99); C1016(2.84)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C872(1.16); C1029(1.50); C1036(1.63); C1016(1.72)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C1029(1.40); C1016(1.45); C1036(1.47); C872(1.50)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C872(1.09); C1016(1.12); C1029(1.23); C1036(1.37)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C872(1.57); C1029(1.61); C1036(1.77); C1016(2.14)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C1029(1.72); C1036(1.89); C872(1.91); C1016(2.06)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C1016(1.19); C1029(1.20); C1036(1.24); C872(1.29)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C1029(2.29); C1036(2.49); C1016(2.52); C872(2.79)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C1029(2.23); C1016(2.43); C1036(2.50); C872(2.57)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C872(1.38); C1029(1.59); C1016(1.67); C1036(1.77)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C872(1.39); C1029(1.55); C1036(1.80); C1016(1.90)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C1029(1.36); C1036(1.39); C1016(1.41); C872(1.48)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C1016(1.80); C1029(2.03); C872(2.15); C1036(2.39)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C1029(2.16); C872(2.18); C1036(2.27); C1016(2.39)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C1029(1.70); C1036(1.76); C872(2.37); C1016(2.74)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C872(0.90); C1036(0.94); C1029(0.96); C1016(1.35)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C956(0.37); C2130(0.49); C1480(0.56); C1016(0.29)  LDD2138  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C956(0.71); C785(0.93); C2130(0.69); C1016(0.68)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C1016(1.10); C872(1.11); C1029(1.11); C1036(1.07)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C1029(0.95); C1036(1.06); C1016(1.12); C872(1.14)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C872(0.99); C1036(1.63); C1029(1.74); C1016(1.92)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C956(1.03); C785(0.99); C1029(0.97); C1036(0.97)  LDD0078  [15]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [11]
 LDCM0498  BS-3668 MDA-MB-231 C956(0.37); C2116(0.66); C785(0.79); C2130(0.78)  LDD2091  [10]
 LDCM0108  Chloroacetamide HeLa C956(0.00); C1480(0.00); C785(0.00); H2345(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C785(20.00); C1016(20.00); C1480(4.74); C1016(0.74)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C1036(0.90); C1029(0.91); C1016(1.00); C872(1.11)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C872(1.27); C1016(1.74); C1036(1.87); C1029(1.89)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C1016(0.77); C1036(1.19); C1029(1.20); C872(1.53)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C872(0.75); C1016(1.02); C1036(1.20); C1029(1.25)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C872(0.71); C1016(1.01); C1029(1.07); C1036(1.10)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C872(0.76); C1016(0.76); C1036(1.02); C1029(1.11)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C872(0.76); C1016(1.04); C1036(1.04); C1029(1.10)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C872(1.27); C1029(1.27); C1036(1.31); C1016(1.47)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C872(1.05); C1029(1.34); C1036(1.51); C1016(1.71)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C1029(1.36); C1036(1.49); C872(1.62); C1016(1.85)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C1036(1.38); C1029(1.42); C872(1.58); C1016(1.68)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C872(1.22); C1029(1.34); C1016(1.40); C1036(1.53)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C872(1.26); C1016(1.71); C1029(1.76); C1036(1.77)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C872(1.11); C1029(1.64); C1016(1.79); C1036(1.90)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C1029(1.31); C1016(1.39); C872(1.40); C1036(1.47)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C1016(1.22); C872(1.38); C1029(1.39); C1036(1.44)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C1016(1.79); C1029(1.79); C872(1.86); C1036(1.89)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C872(1.46); C1029(1.71); C1036(1.71); C1016(2.12)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C872(1.42); C1029(1.67); C1036(1.71); C1016(2.16)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C1029(1.34); C1036(1.36); C872(1.53); C1016(2.23)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C1029(1.73); C1036(1.87); C1016(2.52); C872(2.84)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C1029(0.98); C1036(1.02); C872(1.12); C1016(1.13)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C1029(1.06); C1036(1.18); C872(1.29); C1016(1.34)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C872(1.31); C1016(1.71); C1029(2.20); C1036(2.22)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C1029(0.93); C1036(1.04); C1016(1.30); C872(1.31)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C1016(0.91); C1029(1.96); C1036(1.96)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C1029(0.96); C1036(0.96); C1016(1.29)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C1029(1.44); C1036(1.44); C1016(1.72)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C1029(1.59); C1036(1.59); C1016(1.97)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C1036(0.84); C1029(0.88); C1016(1.03); C872(1.07)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C1036(0.81); C1029(0.85); C872(0.98); C1016(1.32)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C1036(0.81); C1029(0.87); C872(1.08); C1016(1.29)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C1036(1.17); C1029(1.23); C1016(1.44); C872(1.56)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C1036(1.10); C1029(1.18); C872(1.38); C1016(1.45)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C1016(1.02); C1036(1.11); C1029(1.13); C872(1.44)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C872(0.95); C1036(1.23); C1016(1.24); C1029(1.33)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C872(1.04); C1029(1.14); C1016(1.15); C1036(1.19)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C1016(1.03); C872(1.09); C1029(1.09); C1036(1.19)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C1029(1.04); C1036(1.07); C872(1.11); C1016(1.64)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C872(1.06); C1016(1.32); C1029(1.33); C1036(1.38)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C1029(0.97); C1036(0.98); C1016(1.02); C872(1.07)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C872(1.26); C1016(1.50); C1029(1.63); C1036(1.66)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C872(1.29); C1016(1.74); C1029(2.03); C1036(2.10)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C872(0.88); C1029(2.64); C1036(2.77); C1016(3.04)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C872(0.96); C1016(1.34); C1029(1.49); C1036(1.50)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C872(1.30); C1016(1.94); C1029(1.90); C1036(1.93)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C1016(1.70); C872(1.08); C1029(1.77); C1036(1.87)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C1016(1.41); C872(1.36); C1029(1.63); C1036(1.77)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C1016(1.38); C872(1.18); C1029(1.34); C1036(1.37)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C1016(1.58); C872(1.36); C1029(1.48); C1036(1.55)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C1016(1.68); C872(1.18); C1029(1.78); C1036(1.77)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C1016(1.03); C872(1.51); C1029(1.08); C1036(1.08)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C1016(1.15); C872(0.96); C1029(1.27); C1036(1.30)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C1016(1.22); C872(1.07); C1029(1.37); C1036(1.39)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C1016(1.32); C872(1.15); C1029(1.11); C1036(1.09)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C1016(1.34); C872(0.89); C1029(1.07); C1036(1.08)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C1016(1.64); C872(1.06); C1029(1.80); C1036(1.79)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C1016(1.58); C872(1.02); C1029(2.15); C1036(2.12)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C1016(1.53); C872(0.83); C1029(1.52); C1036(1.49)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C1016(1.97); C872(0.99); C1029(2.76); C1036(2.72)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C1016(2.02); C872(0.81); C1029(1.78); C1036(1.76)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C1016(0.93); C872(1.07); C1029(1.22); C1036(1.20)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C1016(1.60); C872(0.93); C1029(2.09); C1036(2.07)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C1016(1.45); C872(1.04); C1029(1.79); C1036(1.81)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C1016(2.86); C872(0.87); C1029(3.90); C1036(3.86)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C1016(1.73); C872(0.91); C1029(1.97); C1036(1.98)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C1016(1.83); C872(0.83); C1029(1.64); C1036(1.60)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C1016(2.38); C872(0.87); C1029(2.29); C1036(2.25)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C1016(0.94); C872(1.14); C1029(0.79); C1036(0.76)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C1016(0.81); C872(1.11); C1029(0.85); C1036(0.78)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C1016(0.82); C872(1.12); C1029(1.01); C1036(0.95)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C1016(1.20); C872(0.97); C1029(1.15); C1036(1.18)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C1016(1.10); C872(1.16); C1029(1.16); C1036(1.18)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C1016(0.92); C872(1.12); C1029(1.09); C1036(0.99)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C1016(1.08); C872(1.18); C1029(1.07); C1036(1.02)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C1016(1.05); C872(1.49); C1029(1.09); C1036(1.08)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C1016(1.01); C872(0.98); C1029(1.20); C1036(1.10)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C1016(0.82); C872(1.11); C1029(0.97); C1036(0.93)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C1016(0.88); C872(1.02); C1029(0.99); C1036(1.05)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C1016(1.24); C872(1.02); C1029(1.11); C1036(1.04)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C1016(1.10); C872(1.03); C1029(0.87); C1036(0.85)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C1016(0.94); C872(1.22); C1029(0.96); C1036(0.97)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C1016(1.13); C872(1.09); C1029(1.02); C1036(1.04)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C1016(1.06); C872(1.28); C1029(1.22); C1036(1.26)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C1016(0.98); C872(1.17); C1029(1.06); C1036(1.05)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C1016(1.16); C872(0.80); C1029(1.27); C1036(1.08)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C1016(1.28); C872(1.40); C1029(1.23); C1036(0.93)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C1016(1.03); C872(0.86); C1029(1.59); C1036(1.33)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C1016(1.14); C872(0.35); C1029(1.55); C1036(1.46)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C1016(1.15); C872(0.88); C1029(1.16); C1036(1.03)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C1016(1.12); C872(1.12); C1029(1.70); C1036(1.64)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C1016(1.21); C872(0.99); C1029(1.51); C1036(1.38)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C1016(1.05); C872(1.41); C1029(1.39); C1036(1.29)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C1016(1.12); C872(2.27); C1029(1.20); C1036(0.93)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C1016(1.62); C872(1.18); C1029(1.34); C1036(1.34)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C1016(1.22); C872(0.91); C1029(1.10); C1036(1.13)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C1016(1.40); C872(1.19); C1029(1.71); C1036(2.02)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C1016(1.41); C872(1.74); C1029(1.17); C1036(1.08)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C1016(1.18); C872(0.76); C1029(1.40); C1036(1.30)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C1016(1.14); C872(1.18); C1029(1.45); C1036(1.49)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C1016(1.12); C872(1.01); C1029(1.03); C1036(0.98)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C1016(1.11); C872(1.16); C1029(0.90); C1036(0.87)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C1016(1.31); C872(1.31); C1029(1.09); C1036(1.07)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C1016(1.32); C872(1.31); C1029(1.22); C1036(1.19)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C1016(1.45); C872(1.43); C1029(2.01); C1036(2.02)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C1016(1.33); C872(1.08); C1029(0.86); C1036(0.79)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C1016(1.51); C872(1.34); C1029(0.97); C1036(0.93)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C1016(2.56); C872(1.28); C1029(1.33); C1036(1.30)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C1016(1.85); C872(1.44); C1029(1.20); C1036(1.18)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C1016(1.72); C872(1.65); C1029(1.51); C1036(1.48)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C1016(1.31); C872(1.05); C1029(0.92); C1036(0.93)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C1016(1.21); C872(1.00); C1029(0.79); C1036(0.76)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C1016(1.24); C872(1.00); C1029(0.85); C1036(0.81)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C1016(1.40); C872(1.47); C1029(1.08); C1036(1.09)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C1016(2.72); C872(1.62); C1029(1.48); C1036(1.48)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C1016(1.28); C872(1.19); C1029(1.31); C1036(1.27)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C1016(1.20); C872(0.72); C1029(0.77); C1036(0.74)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C1016(1.21); C872(1.84); C1029(1.22); C1036(1.13)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C1016(1.46); C872(1.80); C1029(1.25); C1036(1.11)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C1016(0.76); C872(1.80); C1029(1.02); C1036(0.93)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C1016(0.76); C872(1.80); C1029(1.39); C1036(1.30)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C1016(0.89); C872(2.00); C1029(1.33); C1036(1.24)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C1016(0.96); C872(2.15); C1029(1.18); C1036(1.20)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C1016(0.96); C872(1.47); C1029(1.06); C1036(0.99)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C1016(1.09); C872(1.54); C1029(1.19); C1036(1.10)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C1016(1.00); C872(1.48); C1029(1.08); C1036(0.97)  LDD0811  [15]
 LDCM0634  CY-0357 Hep-G2 C956(1.01); C1016(0.45)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C891(0.98); C1480(0.82); C956(0.88); C1016(0.91)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1016(1.28); C872(1.22); C956(1.22); C785(1.08)  LDD1702  [10]
 LDCM0625  F8 Ramos C1016(1.20); C1480(1.52); C785(1.24); C956(1.14)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C1016(1.49); C1480(1.40); C785(1.97); C956(2.12)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C1016(0.61); C1480(0.07); C785(0.36); C956(0.34)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C1016(0.69); C1480(0.92); C785(1.05); C956(0.97)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C1016(0.77); C1480(1.17); C785(1.05); C956(0.99)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C1016(0.44); C1480(1.41); C785(0.80); C956(1.21)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C1016(0.54); C1480(0.99); C785(0.80); C956(0.95)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C1016(0.78); C1480(1.19); C785(1.03); C956(1.00)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C1016(1.07); C1480(2.01); C785(1.47); C956(1.44)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C1016(0.79); C1480(1.17); C785(1.11); C956(0.94)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C1016(0.88); C1480(0.55); C785(0.86); C956(0.86)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C1016(1.08); C1480(1.54); C785(1.67); C956(1.26)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C1016(1.06); C1480(1.59); C785(1.29); C956(1.23)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C1016(2.35); C1480(1.61); C785(3.20); C956(1.72)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C1016(1.09); C872(0.98); C1029(1.39); C1036(1.39)  LDD0785  [15]
 LDCM0596  Fragment38 Ramos C1016(0.79); C1480(1.14); C785(0.92); C956(0.91)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C1016(1.08); C1480(1.36); C785(1.32); C956(1.14)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C1016(3.34); C872(0.80); C1029(3.55); C1036(3.53)  LDD0744  [15]
 LDCM0610  Fragment52 Ramos C1016(1.10); C1480(1.95); C785(1.48); C956(1.37)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C1016(1.36); C1480(1.89); C785(1.83); C956(1.69)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C1016(0.92); C1480(1.43); C785(0.95); C956(1.51)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C1016(0.86); C1480(1.16); C785(1.16); C956(1.44)  LDD2188  [30]
 LDCM0116  HHS-0101 DM93 Y1049(0.44); Y145(0.52); Y1145(0.78); Y2323(1.29)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y1145(0.68); Y2390(1.39); Y2323(1.65); Y1049(2.82)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y145(0.23); Y1049(0.46); Y1145(0.96); Y2323(2.20)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y1145(0.81); Y1049(1.65); Y2323(1.97); Y2390(3.16)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y1145(0.62); Y145(0.84); Y1049(1.28); Y2323(1.31)  LDD0268  [13]
 LDCM0107  IAA HeLa H2345(0.00); H1255(0.00); H122(0.00)  LDD0221  [27]
 LDCM0022  KB02 HCT 116 C1029(4.34); C1036(1.76); C872(2.05); C785(2.27)  LDD0080  [15]
 LDCM0023  KB03 HCT 116 C1029(1.51); C1036(0.88); C872(1.52); C785(1.34)  LDD0081  [15]
 LDCM0024  KB05 HCT 116 C1029(2.39); C1036(2.10); C872(1.81); C785(1.60)  LDD0082  [15]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C956(0.95); C785(0.99)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C956(0.58); C2116(0.76); C785(0.36); C1480(0.55)  LDD2121  [10]
 LDCM0109  NEM HeLa H122(0.00); H1255(0.00); H2345(0.00); H60(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C956(0.58); C785(0.47); C1016(0.43)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C956(1.44); C785(1.24); C2130(0.81)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C956(1.16); C2130(1.52); C1016(0.70)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C956(1.01); C785(0.79); C2130(1.44); C1016(1.02)  LDD2093  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C956(1.62); C2130(1.22); C1016(1.14)  LDD2094  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C785(0.21); C1016(0.94)  LDD2096  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C956(0.68); C1016(0.69)  LDD2097  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C956(0.70); C2130(0.98); C1016(0.65)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C956(0.68); C2116(0.93); C785(0.50); C2130(0.96)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C956(0.83); C1016(1.03)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C956(1.09); C785(1.23); C2130(0.95); C1016(0.92)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C2130(0.88)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C956(1.52); C1016(1.32)  LDD2105  [10]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C956(0.84); C1016(0.86)  LDD2106  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C956(0.91); C2116(1.05); C872(1.43)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C956(0.59); C2130(0.33); C1036(1.04)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C956(1.04); C2116(1.08); C785(0.74); C2130(1.13)  LDD2109  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C956(0.81); C2116(0.98); C785(0.92); C1016(0.75)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1016(0.89)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C956(0.79); C2130(0.61)  LDD2115  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1016(1.15)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C785(0.32); C1480(0.50); C1016(1.25)  LDD2118  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C2116(0.65); C785(0.87); C1016(1.10)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C785(0.22); C1016(1.22)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C956(0.60); C2116(1.01); C785(0.53); C2130(0.83)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1016(1.39)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C956(0.70); C2116(0.83); C785(0.75); C2130(0.94)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C785(0.30); C1016(1.18)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C956(0.93); C2116(0.92); C785(0.86); C2130(1.04)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C785(0.99); C2130(1.13); C1016(0.78); C1036(0.59)  LDD2128  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C956(0.70); C2116(1.37)  LDD2129  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C956(0.75); C1016(0.59)  LDD2133  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C956(0.48); C785(0.82); C2130(0.41); C1016(0.43)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C956(0.78); C2116(1.26); C785(0.76); C2130(1.42)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C956(1.03); C785(0.80)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C956(1.00); C2116(0.96); C785(0.80)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C2130(2.54); C2116(1.79); C956(1.17); C785(1.08)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C956(1.06); C2116(0.90); C785(1.02); C2130(1.05)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C956(0.57); C2116(0.30); C785(0.30); C1016(0.84)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C785(1.23); C1016(1.08)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C956(1.79); C2116(1.75); C785(3.49); C2130(2.23)  LDD2144  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1016(6.58)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C956(0.83); C2116(0.95); C2130(0.93); C1016(0.94)  LDD2146  [10]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C2116(0.84); C1016(1.86)  LDD2147  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C956(0.81); C2130(0.46)  LDD2148  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1016(1.28)  LDD2149  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C956(0.31); C2116(0.41); C785(0.61); C2130(0.72)  LDD2150  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C2130(1.60); C1016(2.11)  LDD2151  [10]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C2130(1.02); C1036(2.28)  LDD2153  [10]
 LDCM0021  THZ1 HCT 116 C1029(1.18); C1016(1.08); C1036(1.07); C956(0.90)  LDD2173  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NUAK family SNF1-like kinase 1 (NUAK1) CAMK Ser/Thr protein kinase family O60285

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases. ACS Chem Biol. 2021 Aug 20;16(8):1401-1412. doi: 10.1021/acschembio.1c00192. Epub 2021 Jul 19.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
17 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
18 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
19 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578