Details of the Target

General Information of Target

Target ID LDTP04439
Target Name Glypican-3 (GPC3)
Gene Name GPC3
Gene ID 2719
Synonyms
OCI5; Glypican-3; GTR2-2; Intestinal protein OCI-5; MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGS
DLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVR
HAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYT
QLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVI
NTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYI
LSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSA
YYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDT
LCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPK
GRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQ
QATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH
Target Type
Clinical trial
Target Bioclass
Other
Family
Glypican family
Subcellular location
Cell membrane
Function
Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression. Inhibits the dipeptidyl peptidase activity of DPP4. Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4. Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis. Required for coronary vascular development. Plays a role in regulating cell movements during gastrulation.
TTD ID
T25726
Uniprot ID
P51654
DrugMap ID
TTJTSX4
Ensemble ID
ENST00000370818.8
HGNC ID
HGNC:4451
ChEMBL ID
CHEMBL4630889

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.T326I .
ICC9 SNV: p.E298Ter .
LNCaP clone FGC SNV: p.P135T .
MEWO SNV: p.P176S .
NCIH23 SNV: p.V289L .
SJSA1 SNV: p.L157V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		25.90  LDD0235  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
YN-4
 Probe Info  		100.00  LDD0445  [2]
IPM
 Probe Info  		C65(0.00); C349(0.00); C72(0.00); C73(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C372(1.12); C65(2.47)  LDD3424  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
VSF
 Probe Info  		C73(0.00); C72(0.00)  LDD0007  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C349(1.11); C65(1.08); C73(1.03)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C349(1.06); C65(1.02); C73(1.04)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C349(0.94); C65(1.05); C73(1.02)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C349(1.02); C65(1.07); C73(1.01)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C349(0.99); C65(0.93); C73(1.03)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C349(0.97); C65(1.02); C73(1.02)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C349(1.02); C65(1.08); C73(1.07)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C349(1.06); C65(1.01); C73(1.02)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C349(1.45); C65(1.30); C73(1.13)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C349(1.03); C65(0.97); C73(1.05)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C349(1.09); C65(1.03); C73(1.00)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C349(0.98); C65(1.03); C73(1.03)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C349(0.98); C65(0.86); C73(1.00)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C349(0.97); C65(1.01); C73(0.98)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C349(1.00); C65(1.04); C73(1.04)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C349(1.06); C65(1.03); C73(1.05)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C349(0.98); C65(1.16); C73(1.04)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C349(1.02); C65(1.02); C73(1.00)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C349(0.96); C65(1.08); C73(1.05)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C349(1.03); C65(1.04); C73(1.08)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C349(0.99); C65(1.11); C73(1.00)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C349(0.95); C65(0.98); C73(1.02)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C349(0.99); C65(0.94); C73(1.03)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C349(0.97); C65(1.04); C73(0.99)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C349(1.10); C65(1.02); C73(1.07)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C349(1.05); C65(0.97); C73(1.08)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C349(0.94); C65(1.08); C73(1.04)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C349(1.11); C65(1.00); C73(1.02)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C349(0.97); C65(0.92); C73(1.00)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C349(0.99); C65(0.89); C73(0.95)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C349(0.91); C65(1.08); C73(1.05)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C349(1.13); C65(1.04); C73(0.97)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C349(0.99); C65(0.91); C73(1.04)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C349(1.02); C65(1.07); C73(1.07)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C349(1.09); C65(1.04); C73(1.05)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C349(0.96); C65(1.04); C73(1.02)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C349(1.01); C65(1.03); C73(0.99)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C349(1.04); C65(0.96); C73(1.16)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C349(0.97); C65(0.93); C73(0.98)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C349(1.04); C65(1.01); C73(1.00)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C349(1.00); C65(0.98); C73(0.99)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C349(1.02); C65(0.99); C73(1.04)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C349(0.92); C65(0.94); C73(1.04)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C349(1.03); C65(1.00); C73(1.00)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C349(0.99); C65(1.09); C73(1.01)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C349(0.97); C65(1.01); C73(0.97)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C349(0.90); C65(0.96); C73(1.02)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C349(1.01); C65(0.98); C73(0.99)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C349(0.94); C65(0.91); C73(1.00)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C349(0.94); C65(0.96); C73(1.01)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C349(1.06); C65(1.00); C73(1.08)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C349(1.01); C65(1.15); C73(0.99)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C349(1.05); C65(1.05); C73(1.01)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C349(1.07); C65(0.98); C73(1.00)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C349(1.19); C65(0.99); C73(0.99)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C349(1.00); C65(0.99); C73(1.06)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C349(1.03); C65(0.95); C73(1.00)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C349(0.97); C65(1.02); C73(1.03)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C349(1.00); C65(1.03); C73(1.03)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C349(1.01); C65(0.95); C73(1.00)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C349(0.98); C65(1.02); C73(1.00)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C349(1.03); C65(1.02); C73(1.06)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C349(1.01); C65(1.01); C73(1.05)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C349(0.91); C65(1.00); C73(0.99)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C349(1.03); C65(1.06); C73(0.93)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C349(1.78); C65(0.97); C73(1.46)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C349(1.15); C65(0.99); C73(0.92)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C349(1.07); C65(0.95); C73(1.03)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C349(1.19); C65(0.93); C73(1.14)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C349(0.96); C65(1.02); C73(1.05)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C349(1.03); C65(0.95); C73(0.94)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C349(1.07); C65(1.08); C73(1.01)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C349(1.06); C65(0.90); C73(1.09)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C349(0.95); C65(1.02); C73(1.00)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C349(1.02); C65(0.78); C73(0.99)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C349(1.10); C65(0.92); C73(1.01)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C349(1.01); C65(0.93); C73(1.02)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C349(1.17); C65(0.92); C73(1.09)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C349(1.08); C65(1.04); C73(1.10)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C349(1.12); C65(1.02); C73(1.02)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C349(1.04); C65(1.03); C73(1.02)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C349(1.37); C65(1.09); C73(1.08)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C349(1.01); C65(0.99); C73(1.09)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C349(1.00); C65(0.98); C73(0.97)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C349(1.07); C65(1.04); C73(0.97)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C349(1.12); C65(1.31); C73(1.03)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C349(0.88); C65(0.95); C73(1.02)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C349(0.93); C65(1.07); C73(1.04)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C349(1.09); C65(0.95); C73(0.95)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C349(1.05); C65(0.95); C73(0.99)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C349(1.11); C65(1.05); C73(0.99)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C349(1.21); C65(0.97); C73(1.01)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C349(1.09); C65(0.96); C73(0.95)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C349(1.07); C65(1.04); C73(1.00)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C349(1.15); C65(1.07); C73(1.12)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C349(1.05); C65(1.02); C73(1.06)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C349(1.03); C65(1.15); C73(0.95)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C349(1.17); C65(1.18); C73(1.04)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C349(1.05); C65(1.02); C73(1.03)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C349(1.34); C65(1.02); C73(1.03)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C349(0.95); C65(1.02); C73(1.06)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C349(1.16); C65(1.00); C73(1.13)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C349(0.99); C65(1.03); C73(1.02)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C349(0.90); C65(1.16); C73(1.01)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C349(1.13); C65(1.14); C73(0.99)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C349(0.94); C65(1.07); C73(1.04)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C349(1.14); C65(1.05); C73(1.12)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C349(0.95); C65(0.85); C73(1.25)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C349(0.94); C65(1.01); C73(0.96)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C349(0.90); C65(1.00); C73(1.04)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C349(1.06); C65(0.85); C73(1.08)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C349(0.99); C65(1.03); C73(1.01)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C349(0.96); C65(0.92); C73(0.98)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C349(1.02); C65(0.97); C73(0.99)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C349(0.98); C65(1.19); C73(1.06)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C349(0.87); C65(0.98); C73(0.96)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C349(0.98); C65(1.05); C73(1.03)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C349(1.05); C65(1.05); C73(1.09)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C349(0.95); C65(0.96); C73(1.00)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C349(1.48); C65(1.02); C73(1.42)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C349(0.95); C65(0.99); C73(1.07)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C349(0.96); C65(1.04); C73(1.06)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C349(1.01); C65(1.15); C73(1.09)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C349(1.05); C65(0.93); C73(0.97)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C349(1.06); C65(1.05); C73(1.14)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C349(0.96); C65(0.86); C73(1.04)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C349(0.97); C65(1.00); C73(1.00)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C349(0.99); C65(1.09); C73(1.10)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C349(0.99); C65(1.00); C73(1.12)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C349(1.04); C65(1.06); C73(1.03)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C349(1.07); C65(0.97); C73(1.04)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C349(1.35); C65(1.03); C73(1.29)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C349(1.03); C65(1.02); C73(1.12)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C349(1.04); C65(1.04); C73(1.11)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C349(1.01); C65(1.11); C73(1.07)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C349(1.05); C65(0.96); C73(0.96)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C349(0.99); C65(1.05); C73(1.04)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C349(1.09); C65(1.04); C73(1.01)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C349(0.97); C65(0.93); C73(0.95)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C349(1.18); C65(0.90); C73(1.10)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C349(1.24); C65(0.96); C73(1.16)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C349(0.94); C65(1.12); C73(1.02)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C349(1.00); C65(1.13); C73(1.11)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C349(1.37); C65(1.16); C73(1.25)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C349(1.05); C65(1.01); C73(1.13)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C349(1.03); C65(1.13); C73(1.09)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C349(1.15); C65(0.97); C73(1.04)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C349(1.05); C65(1.02); C73(1.16)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C349(1.05); C65(0.95); C73(0.98)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C349(1.05); C65(0.98); C73(0.99)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C349(0.83); C65(0.91); C73(1.08)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C349(1.17); C65(0.82); C73(0.99)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C349(1.01); C65(0.95); C73(1.02)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C349(1.04); C65(1.02); C73(1.09)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C349(1.03); C65(1.13); C73(1.05)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C349(0.96); C65(0.96); C73(1.04)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C349(0.96); C65(0.96); C73(1.12)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C349(0.94); C65(1.16); C73(1.01)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C349(0.92); C65(0.97); C73(1.06)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C349(1.02); C65(1.04); C73(1.11)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C349(1.01); C65(0.92); C73(1.11)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C349(1.13); C65(0.96); C73(1.00)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C349(1.07); C65(1.02); C73(1.08)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C349(0.97); C65(1.00); C73(1.00)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C349(1.18); C65(1.08); C73(1.16)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C349(0.96); C65(0.94); C73(1.04)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C349(1.00); C65(1.07); C73(1.02)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C349(2.58); C65(0.96); C73(1.20)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C349(0.96); C65(1.01); C73(1.05)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C349(0.93); C65(1.03); C73(1.15)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C349(0.94); C65(0.94); C73(1.13)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C349(1.06); C65(1.04); C73(1.11)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C349(1.05); C65(0.99); C73(1.12)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C349(1.05); C65(1.02); C73(0.99)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C349(1.20); C65(1.16); C73(0.99)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C349(1.21); C65(1.05); C73(1.06)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C349(1.01); C65(0.96); C73(0.93)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C349(1.02); C65(1.13); C73(1.05)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C349(0.89); C65(1.10); C73(1.09)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C349(1.70); C65(0.84); C73(1.36)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C349(1.07); C65(1.06); C73(1.09)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C349(0.98); C65(0.94); C73(1.05)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C349(0.98); C65(1.02); C73(1.17)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C349(0.98); C65(0.92); C73(1.16)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C349(2.11); C65(0.94); C73(1.32)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C349(1.12); C65(0.93); C73(1.13)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C349(1.12); C65(1.00); C73(1.09)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C349(1.06); C65(1.02); C73(1.07)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C349(1.09); C65(1.01); C73(1.14)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C349(1.25); C65(1.12); C73(1.13)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C349(0.93); C65(1.07); C73(1.08)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C349(0.97); C65(1.07); C73(0.98)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C349(0.89); C65(1.08); C73(0.94)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C349(0.90); C65(1.10); C73(1.00)  LDD1497  [7]
 LDCM0024  KB05 SK-HEP1 C372(1.12); C65(2.47)  LDD3424  [3]
 LDCM0110  W12 Hep-G2 K394(0.54); Q393(0.56); C73(8.64)  LDD0237  [1]
 LDCM0111  W14 Hep-G2 K394(0.51); C73(7.82)  LDD0238  [1]
 LDCM0112  W16 Hep-G2 Q393(0.65); C73(0.74)  LDD0239  [1]
 LDCM0113  W17 Hep-G2 K394(0.57); Q393(0.58); C73(5.48)  LDD0240  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Rg7686 Antibody D02ONR
Car-t Cells Targeting Glypican-3 (Gpc3) CAR T Cell Therapy D0WN2Y
Car-t Cells Targeting Gpc3 CAR T Cell Therapy D0J2IN
Gpc3-cart Cells CAR T Cell Therapy D04CKC
Retroviral Vector-transduced Autologous T Cells To Express Anti-gpc3 Cars CAR T Cell Therapy D0N0OV
Tai-gpc3-cart Cells CAR T Cell Therapy D0FY5E
Gpc-3298306 Vaccine D05HZJ
Codrituzumab . D0P0BY
Phase 1
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-gpc3 Car T CAR T Cell Therapy D0IQ4V
Car-gpc3 T Cells CAR T Cell Therapy D0H4UP
Gap T Cells CAR T Cell Therapy D0GD9E
Glycar T Cells CAR T Cell Therapy D0MA2E
Gpc3 Targeting Car-t Cells CAR T Cell Therapy D08UNC
Tak-102 CAR T Cell Therapy D2MZF8
Ery974 . D0IK5R
Clinical trial
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Car-gpc3 T Cell CAR T Cell Therapy D09RPP
Car-gpc3 T Cells CAR T Cell Therapy D0P1BM

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402