Details of the Target

General Information of Target

Target ID LDTP12591
Target Name Kinesin light chain 4 (KLC4)
Gene Name KLC4
Gene ID 89953
Synonyms
KNSL8; Kinesin light chain 4; KLC 4; Kinesin-like protein 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKRKPSNVSEKEKHQKPKRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTS
NNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSL
KASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYD
TDSLKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEEEAAPKKIKANRRSNS
KKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAE
NFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNSDNGKEDLESENLS
DMVHKIIITEPSD
Target Bioclass
Other
Family
Kinesin light chain family
Subcellular location
Cytoplasm, cytoskeleton
Function
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Uniprot ID
Q9NSK0
Ensemble ID
ENST00000259708.7
HGNC ID
HGNC:21624

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.L4R; p.P523H .
JURKAT SNV: p.R37C Compound 10    Probe Info 
KMCH1 SNV: p.G511W DBIA    Probe Info 
MCC13 SNV: p.P180S .
MDAMB453 SNV: p.R308K DBIA    Probe Info 
MOLT4 SNV: p.A365V IA-alkyne    Probe Info 
SW620 SNV: p.A92S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.10  LDD0402  [1]
W1
 Probe Info  		17.36  LDD0235  [2]
IPM
 Probe Info  		C489(0.00); C318(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y205(12.90); Y367(6.35)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C489(2.35)  LDD0169  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
DBIA
 Probe Info  		C318(80.11)  LDD0209  [6]
HHS-475
 Probe Info  		Y395(0.14); Y305(0.57); Y205(0.92)  LDD0264  [7]
HHS-465
 Probe Info  		Y305(9.14)  LDD2237  [8]
Acrolein
 Probe Info  		N.A.  LDD0222  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C318(0.00); C113(0.00); C489(0.00); C388(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C318(0.00); C489(0.00); C113(0.00)  LDD0037  [11]
BTD
 Probe Info  		N.A.  LDD0004  [13]
NAIA_4
 Probe Info  		C234(0.00); C53(0.00); C318(0.00); C388(0.00)  LDD2226  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		C113(0.00); C388(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
PPMS
 Probe Info  		N.A.  LDD0008  [13]
SF
 Probe Info  		K307(0.00); Y305(0.00)  LDD0028  [16]
TFBX
 Probe Info  		C489(0.00); C234(0.00); C388(0.00)  LDD0148  [17]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		C53(0.00); C113(0.00)  LDD0018  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C318(0.00); C489(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		40.79  LDD1884  [20]
C275
 Probe Info  		5.98  LDD1945  [20]
C278
 Probe Info  		79.89  LDD1948  [20]
C280
 Probe Info  		10.85  LDD1950  [20]
C282
 Probe Info  		18.38  LDD1952  [20]
C284
 Probe Info  		38.59  LDD1954  [20]
C339
 Probe Info  		5.43  LDD2002  [20]
C350
 Probe Info  		24.59  LDD2011  [20]
C362
 Probe Info  		26.54  LDD2023  [20]
C391
 Probe Info  		19.29  LDD2050  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C234(1.25); C347(0.86)  LDD2117  [21]
 LDCM0026  4SU-RNA+native RNA HEK-293T C489(2.35)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C113(0.94); C489(0.95); C53(0.90); C347(0.99)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C113(1.00); C489(1.03); C53(1.00); C318(1.03)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C113(0.91); C489(1.22); C318(1.01); C347(1.14)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C113(0.96); C489(0.94); C53(0.91); C318(1.00)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C113(0.97); C489(1.00); C53(1.07); C318(0.98)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C113(0.95); C489(0.95); C53(0.96); C318(1.06)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C113(1.02); C489(0.92); C53(0.91); C347(1.00)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C113(0.99); C489(1.14); C53(0.97); C318(1.01)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C113(0.98); C489(1.37); C318(0.93); C347(1.16)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C113(0.97); C489(0.87); C53(0.97); C318(1.01)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C113(1.04); C489(1.09); C53(0.94); C318(0.96)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C113(0.94); C489(1.02); C53(1.08); C318(1.05)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C113(0.94); C489(1.22); C53(1.12); C318(0.99)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C113(1.02); C489(1.04); C53(0.91); C318(1.05)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C113(1.00); C489(0.90); C318(0.95); C347(1.01)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C113(0.98); C489(0.94); C53(0.91); C347(0.93)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C113(1.02); C489(0.99); C53(0.91); C318(0.99)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C113(0.92); C489(1.13); C318(1.06); C347(0.84)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C113(1.01); C489(1.03); C53(0.91); C318(0.95)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C113(0.94); C489(1.03); C53(1.10); C318(1.04)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C113(0.87); C489(1.35); C318(0.99); C347(1.09)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C113(0.94); C489(1.10); C53(1.00); C318(1.02)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C113(0.98); C489(0.94); C53(0.93); C318(1.02)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C113(1.01); C489(0.94); C318(1.00); C347(0.91)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C113(0.98); C489(1.12); C53(1.10); C347(0.99)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C113(0.99); C489(1.04); C53(0.93); C318(1.02)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C113(0.92); C489(1.06); C318(1.00); C347(0.91)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C113(0.96); C489(0.98); C53(1.02); C318(1.09)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C113(1.01); C489(1.14); C53(1.14); C318(0.97)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C113(0.94); C489(1.18); C53(0.94); C318(0.99)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C113(0.99); C489(0.93); C53(1.00); C318(1.08)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C113(0.96); C489(0.96); C53(0.97); C318(0.91)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C113(0.95); C489(1.02); C318(0.94); C347(1.26)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C113(0.98); C489(1.14); C53(0.96); C347(0.96)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C113(1.00); C489(1.07); C53(1.01); C318(1.02)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C113(0.99); C489(1.11); C318(1.03); C347(1.06)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C113(0.99); C489(1.03); C53(1.03); C318(1.04)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C113(0.97); C489(0.99); C53(1.29); C318(1.08)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C113(0.97); C489(1.22); C53(1.09); C318(1.01)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C113(0.92); C489(1.01); C53(1.01); C318(1.08)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C113(0.93); C489(0.98); C318(0.93); C347(1.20)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C113(1.02); C489(1.05); C53(0.97); C347(0.95)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C113(0.93); C489(0.98); C53(1.15); C318(0.92)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C113(1.01); C489(1.14); C53(0.94); C318(0.97)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C113(0.92); C489(1.22); C318(0.97); C347(1.25)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C113(0.98); C489(1.00); C53(0.95); C318(1.02)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C113(0.96); C489(0.96); C53(1.08); C318(1.00)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C113(0.92); C489(1.05); C53(0.95); C318(0.97)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C113(1.01); C489(0.99); C53(0.83); C318(1.08)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C113(0.96); C489(0.97); C318(1.01); C347(1.01)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C113(0.99); C489(1.05); C53(0.82); C347(0.95)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C113(1.04); C489(1.17); C53(0.97); C318(1.07)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C113(0.90); C489(1.10); C318(1.03); C347(0.91)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C113(0.99); C489(1.09); C53(1.00); C318(0.93)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C113(0.97); C489(0.95); C53(1.02); C318(0.99)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C113(0.98); C489(0.98); C53(1.09); C318(1.09)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C113(0.98); C489(1.03); C53(0.91); C318(0.99)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C113(0.97); C489(0.95); C53(0.90); C318(1.07)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C113(0.96); C489(0.99); C318(0.99); C347(1.09)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C113(0.93); C489(1.01); C53(1.03); C318(1.00)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C113(0.96); C489(1.03); C318(0.94); C347(0.91)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C113(0.95); C489(0.94); C53(1.17); C318(1.07)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C113(0.98); C489(1.06); C53(1.01); C347(0.99)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C113(0.93); C489(0.97); C318(0.99); C347(1.10)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 12.39  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C113(0.87); C489(0.91); C53(0.99); C318(1.13)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C113(0.76); C489(0.94); C53(1.08); C318(1.18)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C113(0.92); C489(1.02); C318(1.02)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C113(0.98); C489(1.10); C53(1.01); C318(1.03)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C113(1.04); C489(0.95); C53(0.95); C318(1.01)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C113(0.96); C489(1.02); C53(1.01); C318(0.96)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C113(0.95); C489(0.99); C318(1.14)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C113(0.96); C489(1.00); C53(0.93); C318(1.05)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C113(0.96); C489(1.07); C53(0.99); C318(1.07)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C113(0.95); C489(1.01); C53(1.02); C318(1.00)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C113(1.02); C489(0.96); C318(1.00)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C113(0.97); C489(0.99); C53(1.06); C318(0.95)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C113(0.99); C489(0.88); C53(0.93); C318(0.99)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C113(1.05); C489(0.98); C53(0.95); C318(1.10)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C113(0.97); C489(0.89); C53(1.04); C318(0.99)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C113(1.02); C489(1.33); C318(1.05)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C113(0.99); C489(1.06); C53(1.07); C318(1.02)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C113(0.90); C489(1.00); C53(0.98); C318(1.01)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C113(0.99); C489(0.98); C53(0.82); C318(0.99)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C113(0.94); C489(1.09); C318(1.07)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C113(0.99); C489(1.04); C53(1.03); C318(1.06)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C113(1.18); C489(1.04); C53(0.97); C318(1.06)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C113(1.00); C489(1.03); C53(1.04); C318(1.04)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C113(0.96); C489(0.96); C318(0.91); C347(0.99)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C113(0.93); C489(0.94); C318(1.04)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C113(0.99); C489(1.08); C53(0.93); C318(1.07)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C113(0.87); C489(1.08); C53(0.90); C318(1.05)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C113(0.85); C489(0.95); C53(1.00); C318(1.07)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C113(0.92); C489(1.02); C318(1.02)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C113(0.97); C489(0.95); C53(0.82); C318(1.03)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C113(0.91); C489(1.01); C53(0.89); C318(1.01)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C113(0.95); C489(0.97); C53(0.96); C318(1.02)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C113(0.96); C489(1.03); C318(1.00)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C113(0.94); C489(0.81); C53(1.07); C318(1.05)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C113(0.92); C489(1.09); C53(1.01); C318(0.97)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C113(0.97); C489(1.07); C53(1.09); C318(0.85)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C113(0.97); C489(0.92); C318(1.03)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C113(0.90); C489(0.84); C53(0.97); C347(0.91)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C113(1.07); C489(1.02); C53(0.96); C318(0.98)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C113(1.08); C489(1.15); C318(0.93); C347(1.08)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C113(0.95); C489(1.10); C53(1.03); C318(0.97)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C113(1.11); C489(1.01); C53(0.88); C318(1.08)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C113(0.74); C489(0.97); C53(1.07); C318(1.11)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C113(0.75); C489(0.92); C53(1.04); C318(1.13)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C113(0.97); C489(0.93); C53(0.92); C318(0.97)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C113(1.00); C489(0.94); C318(0.91); C347(0.86)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C113(0.85); C489(1.09); C53(0.89); C318(1.06)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C113(0.93); C489(1.09); C53(1.07); C318(1.01)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C113(1.03); C489(0.89); C53(1.15); C318(1.03)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C113(0.99); C489(0.94); C318(1.06)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C113(0.97); C489(1.08); C53(0.98); C347(1.03)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C113(0.98); C489(0.95); C53(1.03); C318(0.95)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C113(1.07); C489(0.87); C53(0.96); C318(1.07)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C113(1.09); C489(1.03); C318(0.98); C347(0.84)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C113(1.00); C489(0.96); C53(0.98); C318(1.06)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C113(0.76); C489(1.00); C53(0.87); C318(1.05)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C113(0.81); C489(1.13); C53(0.99); C318(1.03)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C113(1.02); C489(1.00); C53(0.90); C318(1.03)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C113(1.00); C489(1.00); C318(1.00); C347(0.79)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C113(0.92); C489(0.93); C53(1.03); C318(1.01)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C113(0.97); C489(0.83); C53(1.32); C318(1.02)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C113(1.02); C489(0.95); C318(1.08)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C113(0.93); C489(1.10); C318(1.03)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C113(1.05); C489(1.07); C53(0.93); C347(1.00)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C113(0.99); C489(1.10); C53(0.84); C318(1.03)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C113(1.06); C489(1.16); C318(1.11); C347(1.04)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C113(1.04); C489(1.05); C53(0.90); C318(1.08)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C113(0.84); C489(0.85); C53(1.05); C318(1.00)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C113(0.87); C489(1.07); C53(0.99); C318(1.11)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C113(1.03); C489(0.97); C53(0.80); C318(1.12)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C113(0.97); C489(0.92); C318(1.02); C347(0.83)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C113(0.89); C489(0.90); C53(0.88); C318(0.96)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C113(0.96); C489(1.03); C53(0.99); C347(0.92)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C113(0.98); C489(0.98); C53(0.98); C318(1.02)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C113(0.95); C489(1.06); C318(1.10)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C113(1.06); C489(0.94); C53(0.82); C347(0.99)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C113(0.94); C489(1.02); C53(0.89); C318(1.02)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C113(1.00); C489(1.13); C318(1.04); C347(1.46)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C113(1.00); C489(1.00); C53(0.94); C318(1.09)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C113(0.80); C489(1.16); C53(0.99); C318(1.10)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C113(0.83); C489(1.00); C53(0.98); C318(1.04)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C113(1.02); C489(0.96); C53(0.88); C318(1.09)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C113(1.08); C489(0.97); C53(0.97); C318(0.96)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C113(0.98); C489(1.03); C318(0.96); C347(0.93)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C113(0.96); C489(1.08); C53(0.94); C318(1.06)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C113(0.86); C489(1.03); C53(1.07); C318(0.98)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C113(0.95); C489(0.98); C53(1.07); C318(1.01)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C113(0.90); C489(1.16); C318(1.12)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C113(0.96); C489(1.01); C53(0.90); C347(1.01)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C113(1.07); C489(1.06); C53(0.99); C318(1.04)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C113(1.03); C489(1.10); C318(1.02); C347(1.31)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C113(1.00); C489(1.07); C53(0.90); C318(1.06)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C113(0.87); C489(1.07); C53(1.18); C318(1.03)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C113(0.99); C489(1.05); C318(0.96); C347(0.88)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C113(0.87); C489(0.98); C53(1.02); C318(1.05)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C113(1.03); C489(0.88); C53(0.80); C318(1.04)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C113(1.00); C489(0.87); C318(0.96); C347(1.07)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C113(0.91); C489(0.95); C53(0.95); C318(0.97)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C113(0.92); C489(1.09); C53(0.99); C318(0.99)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C113(0.92); C489(1.03); C318(1.06)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C113(0.92); C489(0.99); C53(0.94); C347(0.99)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C113(0.97); C489(1.05); C53(0.90); C318(1.05)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C113(0.96); C489(1.25); C318(0.98); C347(1.00)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C113(0.99); C489(0.80); C53(0.73); C318(1.03)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C113(1.00); C489(1.03); C53(0.87); C318(0.94)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C113(0.86); C489(0.99); C53(1.03); C318(1.16)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C113(0.94); C489(0.96); C53(0.92); C318(1.03)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C113(0.97); C489(1.00); C53(0.86); C318(1.01)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C113(1.01); C489(0.96); C318(0.93); C347(1.04)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C113(0.91); C489(0.95); C53(0.91); C318(1.00)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C113(0.92); C489(1.00); C53(0.85); C318(1.02)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C113(0.96); C489(0.87); C53(0.99); C318(0.96)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C113(0.91); C489(1.00); C318(1.08)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C113(0.92); C489(1.07); C53(0.80); C347(1.04)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C113(0.82); C489(0.94); C53(1.09); C318(1.09)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C113(0.92); C489(1.14); C53(0.81); C318(1.10)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C113(0.93); C489(1.02); C318(1.08); C347(1.16)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C113(0.93); C489(1.06); C53(0.77); C318(1.06)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C113(0.90); C489(1.01); C53(0.93); C318(0.96)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C113(0.94); C489(1.07); C53(1.05); C318(1.10)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C113(0.97); C489(1.03); C53(0.81); C318(1.02)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C113(0.87); C489(1.02); C318(0.95); C347(1.34)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C113(0.98); C489(0.98); C53(1.01); C318(0.92)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C113(1.03); C489(0.96); C53(1.11); C318(0.98)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C113(0.93); C489(0.95); C53(0.92); C318(1.03)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C113(0.97); C489(0.96); C53(1.18); C318(1.08)  LDD1698  [22]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0576  Fragment14 Ramos C53(1.43)  LDD2193  [23]
 LDCM0468  Fragment33 HEK-293T C113(0.99); C489(0.90); C53(0.83); C318(0.94)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C113(0.96); C489(0.97); C53(1.09); C318(1.09)  LDD1631  [22]
 LDCM0569  Fragment7 Ramos C53(0.40)  LDD2186  [23]
 LDCM0116  HHS-0101 DM93 Y395(0.14); Y305(0.57); Y205(0.92)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y395(0.14); Y305(0.24); Y263(0.73); Y205(0.77)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y395(0.13); Y205(1.32); Y305(2.02)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y305(0.34); Y205(1.45)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y305(0.55); Y205(0.96)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C318(0.95); C113(0.94); C347(0.97); C489(1.14)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C318(80.11)  LDD0209  [6]
 LDCM0024  KB05 Hs 936.T C336(2.00)  LDD3313  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C234(0.83); C113(1.74)  LDD2090  [21]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C113(0.78)  LDD2092  [21]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C113(1.11)  LDD2094  [21]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C234(0.69)  LDD2098  [21]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C234(0.62)  LDD2122  [21]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C234(0.38)  LDD2126  [21]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C234(1.27)  LDD2129  [21]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C234(2.56)  LDD2144  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) AAA ATPase family Q9BW62
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Monocarboxylate transporter 9 (SLC16A9) Monocarboxylate porter (TC 2.A.1.13) family Q7RTY1
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
Homeobox protein MOX-2 (MEOX2) . P50222
Transcriptional adapter 2-alpha (TADA2A) . O75478
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha3-II (KRT33B) Intermediate filament family Q14525
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Nesprin-4 (SYNE4) Nesprin family Q8N205
SERTA domain-containing protein 1 (SERTAD1) . Q9UHV2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840