Details of the Target

General Information of Target

Target ID LDTP03221
Target Name Glycine dehydrogenase (decarboxylating), mitochondrial (GLDC)
Gene Name GLDC
Gene ID 2731
Synonyms
GCSP; Glycine dehydrogenase; decarboxylating), mitochondrial; EC 1.4.4.2; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase; aminomethyl-transferring)
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQSCARAWGLRLGRGVGGGRRLAGGSGPCWAPRSRDSSSGGGDSAAAGASRLLERLLPRH
DDFARRHIGPGDKDQREMLQTLGLASIDELIEKTVPANIRLKRPLKMEDPVCENEILATL
HAISSKNQIWRSYIGMGYYNCSVPQTILRNLLENSGWITQYTPYQPEVSQGRLESLLNYQ
TMVCDITGLDMANASLLDEGTAAAEALQLCYRHNKRRKFLVDPRCHPQTIAVVQTRAKYT
GVLTELKLPCEMDFSGKDVSGVLFQYPDTEGKVEDFTELVERAHQSGSLACCATDLLALC
ILRPPGEFGVDIALGSSQRFGVPLGYGGPHAAFFAVRESLVRMMPGRMVGVTRDATGKEV
YRLALQTREQHIRRDKATSNICTAQALLANMAAMFAIYHGSHGLEHIARRVHNATLILSE
GLKRAGHQLQHDLFFDTLKIQCGCSVKEVLGRAAQRQINFRLFEDGTLGISLDETVNEKD
LDDLLWIFGCESSAELVAESMGEECRGIPGSVFKRTSPFLTHQVFNSYHSETNIVRYMKK
LENKDISLVHSMIPLGSCTMKLNSSSELAPITWKEFANIHPFVPLDQAQGYQQLFRELEK
DLCELTGYDQVCFQPNSGAQGEYAGLATIRAYLNQKGEGHRTVCLIPKSAHGTNPASAHM
AGMKIQPVEVDKYGNIDAVHLKAMVDKHKENLAAIMITYPSTNGVFEENISDVCDLIHQH
GGQVYLDGANMNAQVGICRPGDFGSDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFL
PNHPVISLKRNEDACPVGTVSAAPWGSSSILPISWAYIKMMGGKGLKQATETAILNANYM
AKRLETHYRILFRGARGYVGHEFILDTRPFKKSANIEAVDVAKRLQDYGFHAPTMSWPVA
GTLMVEPTESEDKAELDRFCDAMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHW
DRPYSREVAAFPLPFVKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS
Target Bioclass
Enzyme
Family
GcvP family
Subcellular location
Mitochondrion
Function
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).
Uniprot ID
P23378
Ensemble ID
ENST00000321612.8
HGNC ID
HGNC:4313

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		18.14  LDD0235  [2]
AHL-Pu-1
 Probe Info  		C250(3.39)  LDD0168  [3]
DBIA
 Probe Info  		C444(1.07); C250(1.36); C1000(1.47); C1002(1.47)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
ENE
 Probe Info  		N.A.  LDD0006  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		C795(0.00); C112(0.00); C382(0.00)  LDD0018  [9]
1c-yne
 Probe Info  		N.A.  LDD0228  [10]
1d-yne
 Probe Info  		N.A.  LDD0357  [10]
HHS-465
 Probe Info  		N.A.  LDD2240  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C250(3.39)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C250(2.36)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C250(0.94); C757(1.02); C920(0.83); C558(1.13)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C442(1.18); C444(1.19)  LDD0813  [4]
 LDCM0216  AC100 PaTu 8988t C250(1.02)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C250(1.12)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C250(1.44)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C250(1.23)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C250(1.29)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C250(1.13)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C250(1.17)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C250(1.06)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C250(1.06)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C250(1.45)  LDD1104  [4]
 LDCM0226  AC11 HEK-293T C442(1.27); C444(1.41)  LDD0824  [4]
 LDCM0227  AC110 PaTu 8988t C250(1.24)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C250(1.52)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C250(1.13)  LDD1108  [4]
 LDCM0230  AC113 HEK-293T C1000(0.90)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C1000(0.84)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C1000(0.87)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C1000(1.08)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C1000(1.17)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C1000(1.14)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C1000(1.13)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C442(1.49); C444(1.29)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C1000(1.14)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C1000(1.13)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C1000(1.15)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C1000(1.32)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C1000(1.27)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C1000(1.20)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C1000(1.53)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C1000(1.71)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C442(1.05); C444(1.05)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C442(1.18); C444(1.18)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C442(1.10); C444(1.10)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C442(1.06); C444(1.06)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C442(1.35); C444(1.35)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C442(1.38); C444(1.38)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C442(1.28); C444(1.28)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C442(1.31); C444(1.31)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C442(1.05); C444(1.05)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C442(1.23); C444(1.23)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C442(1.05); C444(1.05)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C442(1.39); C444(1.39)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C442(1.50); C444(1.25)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C442(1.18); C444(1.18)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C442(1.27); C444(1.27)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C442(1.12); C444(1.12)  LDD0860  [4]
 LDCM0263  AC143 PaTu 8988t C1000(0.96); C1002(0.96)  LDD1142  [4]
 LDCM0264  AC144 PaTu 8988t C1000(0.74); C1002(0.74)  LDD1143  [4]
 LDCM0265  AC145 PaTu 8988t C1000(0.89); C1002(0.89)  LDD1144  [4]
 LDCM0266  AC146 PaTu 8988t C1000(1.00); C1002(1.00)  LDD1145  [4]
 LDCM0267  AC147 PaTu 8988t C1000(0.98); C1002(0.98)  LDD1146  [4]
 LDCM0268  AC148 PaTu 8988t C1000(0.88); C1002(0.88)  LDD1147  [4]
 LDCM0269  AC149 PaTu 8988t C1000(0.96); C1002(0.96)  LDD1148  [4]
 LDCM0270  AC15 HEK-293T C442(1.13); C444(1.12)  LDD0868  [4]
 LDCM0271  AC150 PaTu 8988t C1000(0.96); C1002(0.96)  LDD1150  [4]
 LDCM0272  AC151 PaTu 8988t C1000(1.26); C1002(1.26)  LDD1151  [4]
 LDCM0273  AC152 PaTu 8988t C1000(1.01); C1002(1.01)  LDD1152  [4]
 LDCM0274  AC153 PaTu 8988t C1000(0.78); C1002(0.78)  LDD1153  [4]
 LDCM0621  AC154 PaTu 8988t C1000(0.93); C1002(0.93)  LDD2166  [4]
 LDCM0622  AC155 PaTu 8988t C1000(0.72); C1002(0.72)  LDD2167  [4]
 LDCM0623  AC156 PaTu 8988t C1000(0.83); C1002(0.83)  LDD2168  [4]
 LDCM0624  AC157 PaTu 8988t C1000(0.81); C1002(0.81)  LDD2169  [4]
 LDCM0276  AC17 HEK-293T C1000(1.33)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C1000(1.18)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C1000(1.11)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C250(1.01); C757(1.11); C920(1.00); C558(1.02)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C1000(1.30)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C1000(1.31)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C1000(1.29)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C1000(1.50)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C1000(1.20)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C1002(1.01); C442(0.75); C444(0.75)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C1002(0.99); C442(0.86); C444(0.86)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C1002(1.11); C442(0.91); C444(0.91)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C1002(0.65); C442(0.77); C444(0.77)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C1002(1.07); C442(0.85); C444(0.85)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C250(1.02); C757(1.02); C920(1.00); C558(1.06)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C1002(1.04); C442(0.74); C444(0.74)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C1002(1.05); C442(0.67); C444(0.67)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C1002(1.04); C442(0.76); C444(0.76)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C1002(1.14); C442(0.82); C444(0.82)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C1002(1.04); C442(0.67); C444(0.67)  LDD0893  [4]
 LDCM0296  AC35 HEK-293T C1000(0.91)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C1000(1.13)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C1000(1.00)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C1000(1.14)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C1000(1.10)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C250(0.96); C757(1.06); C920(1.12); C558(1.04)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C1000(1.36)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C1000(1.06)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C1000(1.21)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C1000(1.27)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C1000(1.08)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C1000(1.23)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C250(1.13)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C250(1.25)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C250(1.04)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C250(1.09)  LDD0909  [4]
 LDCM0312  AC5 HEK-293T C250(1.00); C757(0.95); C920(1.10); C558(1.06)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C250(1.20)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C250(1.43)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C250(1.17)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C250(1.04)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C250(1.39)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C250(1.26)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C250(1.28)  LDD0917  [4]
 LDCM0320  AC57 HEK-293T C1000(1.05); C444(0.87)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C1000(0.97); C444(1.02)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C1000(0.97); C444(0.85)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C442(0.93); C444(0.90)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C1000(0.94); C444(1.47)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C1000(1.09); C444(1.19)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C1000(0.97); C444(1.13)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C1000(1.16); C444(1.06)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C1000(0.95); C444(1.24)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C1000(0.97); C444(1.22)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C1000(0.95); C444(0.93)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C1000(1.11); C444(0.98)  LDD0929  [4]
 LDCM0334  AC7 HEK-293T C442(1.11); C444(1.02)  LDD0932  [4]
 LDCM0345  AC8 HEK-293T C442(1.15); C444(1.04)  LDD0943  [4]
 LDCM0349  AC83 PaTu 8988t C1000(0.86); C1002(0.86)  LDD1228  [4]
 LDCM0350  AC84 PaTu 8988t C1000(0.91); C1002(0.91)  LDD1229  [4]
 LDCM0351  AC85 PaTu 8988t C1000(1.05); C1002(1.05)  LDD1230  [4]
 LDCM0352  AC86 PaTu 8988t C1000(1.17); C1002(1.17)  LDD1231  [4]
 LDCM0353  AC87 PaTu 8988t C1000(1.26); C1002(1.26)  LDD1232  [4]
 LDCM0354  AC88 PaTu 8988t C1000(1.23); C1002(1.23)  LDD1233  [4]
 LDCM0355  AC89 PaTu 8988t C1000(1.01); C1002(1.01)  LDD1234  [4]
 LDCM0357  AC90 PaTu 8988t C1000(0.68); C1002(0.68)  LDD1236  [4]
 LDCM0358  AC91 PaTu 8988t C1000(0.92); C1002(0.92)  LDD1237  [4]
 LDCM0359  AC92 PaTu 8988t C1000(0.82); C1002(0.82)  LDD1238  [4]
 LDCM0360  AC93 PaTu 8988t C1000(1.08); C1002(1.08)  LDD1239  [4]
 LDCM0361  AC94 PaTu 8988t C1000(0.76); C1002(0.76)  LDD1240  [4]
 LDCM0362  AC95 PaTu 8988t C1000(0.98); C1002(0.98)  LDD1241  [4]
 LDCM0363  AC96 PaTu 8988t C1000(0.81); C1002(0.81)  LDD1242  [4]
 LDCM0364  AC97 PaTu 8988t C1000(0.92); C1002(0.92)  LDD1243  [4]
 LDCM0365  AC98 PaTu 8988t C250(1.27)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C250(1.17)  LDD1245  [4]
 LDCM0248  AKOS034007472 HEK-293T C442(1.02); C444(1.20)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C442(1.50); C444(1.19)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C442(1.35); C444(1.27)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0367  CL1 HEK-293T C1002(0.96); C250(1.09)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C1002(1.09); C250(0.91)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C250(0.98); C757(1.01); C920(1.10); C558(1.24)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C442(0.98); C444(0.91)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C442(0.93); C444(0.98)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C442(1.13); C444(1.07)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C442(1.08); C444(1.03)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C1000(1.12)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C1000(1.14)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C1000(1.13)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C1000(1.14)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C1000(1.18)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C1002(1.15); C250(1.00)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C1000(1.19)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C1000(1.22)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C1002(1.03); C442(0.77); C444(0.77)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C1002(0.93); C442(0.74); C444(0.74)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C1002(1.07); C442(0.54); C444(0.54)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C1002(1.02); C442(0.77); C444(0.77)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C1002(1.21); C442(0.73); C444(0.73)  LDD0984  [4]
 LDCM0387  CL117 HEK-293T C1000(0.99)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C1000(0.94)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C1000(1.13)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C1002(0.88); C250(0.84)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C1000(1.19)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C250(1.16)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C250(1.15)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C250(1.12)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C250(1.11)  LDD0993  [4]
 LDCM0396  CL125 HEK-293T C1000(0.98); C444(0.91)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C1000(0.94); C444(1.06)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C1000(1.05); C444(1.16)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C1000(1.01); C444(1.01)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C1002(0.88); C250(0.77)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C1002(0.96); C250(0.88)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C1002(1.02); C250(1.03)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C1000(0.92); C250(0.96)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C1000(0.94); C250(0.96)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C1000(1.03); C250(1.09)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C1000(1.00); C250(1.23)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C1002(0.81); C250(0.75)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C1000(1.10); C250(1.10)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C1000(1.16); C250(1.25)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C1000(1.03); C250(1.12)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C1000(0.93); C250(1.23)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C1000(0.92); C250(0.96)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C1000(1.14); C250(1.07)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C1000(1.04); C250(0.88)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C1000(0.96); C250(1.15)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C1000(0.91); C250(1.14)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C1000(0.90); C250(1.08)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C1002(0.84); C250(0.66)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C1000(1.17); C250(1.24)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C1000(1.16)  LDD1018  [4]
 LDCM0421  CL32 HEK-293T C1000(1.31)  LDD1019  [4]
 LDCM0422  CL33 HEK-293T C1000(1.48)  LDD1020  [4]
 LDCM0423  CL34 HEK-293T C1000(1.21)  LDD1021  [4]
 LDCM0424  CL35 HEK-293T C1000(1.36)  LDD1022  [4]
 LDCM0425  CL36 HEK-293T C1000(1.19)  LDD1023  [4]
 LDCM0426  CL37 HEK-293T C1000(1.26)  LDD1024  [4]
 LDCM0428  CL39 HEK-293T C1000(1.62)  LDD1026  [4]
 LDCM0429  CL4 HEK-293T C1002(0.91); C250(0.79)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C1000(1.26)  LDD1028  [4]
 LDCM0431  CL41 HEK-293T C1000(1.60)  LDD1029  [4]
 LDCM0432  CL42 HEK-293T C1000(1.56)  LDD1030  [4]
 LDCM0433  CL43 HEK-293T C1000(1.60)  LDD1031  [4]
 LDCM0434  CL44 HEK-293T C1000(1.23)  LDD1032  [4]
 LDCM0435  CL45 HEK-293T C1000(1.49)  LDD1033  [4]
 LDCM0436  CL46 HEK-293T C1002(0.99); C250(0.99); C442(1.07); C444(1.07)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C1002(0.86); C250(0.86); C442(0.92); C444(0.92)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C1002(0.91); C250(0.91); C442(1.01); C444(1.01)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C1002(1.04); C250(1.04); C442(1.17); C444(1.17)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C1002(0.88); C250(0.81)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C1002(1.22); C250(1.22); C442(1.02); C444(1.02)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C1002(0.98); C250(0.98); C442(1.10); C444(1.10)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C1002(0.96); C250(0.96); C442(1.13); C444(1.13)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C1002(1.17); C250(1.17); C442(1.13); C444(1.13)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C1002(1.03); C250(1.03); C442(1.01); C444(1.01)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C1002(0.98); C250(0.98); C442(1.21); C444(1.21)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C1002(0.88); C250(0.88); C442(1.18); C444(1.18)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C1002(1.00); C250(1.00); C442(1.15); C444(1.15)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C1002(1.10); C250(1.10); C442(1.23); C444(1.23)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C1002(0.97); C250(0.97); C442(1.24); C444(1.24)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C1002(0.84); C250(0.79)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C1002(1.16); C250(1.16); C442(1.11); C444(1.11)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C1000(1.20); C1002(0.99); C250(0.99)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C1000(1.09); C1002(0.77); C250(0.77)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C1000(1.41); C1002(0.79); C250(0.79)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C1000(1.28); C1002(0.87); C250(0.87)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C1000(1.18); C1002(0.93); C250(0.93)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C1000(1.04); C1002(0.82); C250(0.82)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C1000(1.03); C1002(0.89); C250(0.89)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C1000(1.08); C1002(0.75); C250(0.75)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C1000(0.95); C1002(0.92); C250(0.92)  LDD1059  [4]
 LDCM0462  CL7 HEK-293T C1002(0.94); C250(0.87)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C1000(1.06); C1002(0.83); C250(0.83)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C1000(1.10); C1002(0.80); C250(0.80)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C1000(0.92); C1002(0.92); C250(0.92)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C1000(1.09); C1002(0.75); C250(0.75)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C1000(1.43); C1002(0.95); C250(0.95)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C1000(1.02)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C1000(1.00)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C1000(0.97)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C1000(0.99)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C1002(0.74); C250(2.13)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C1000(0.89)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C1000(0.83)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C1000(1.10)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C1000(1.19)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C1000(1.06)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C1000(0.87)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C1000(0.85)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C1000(0.98)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C1000(0.94)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C1000(1.10)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C1002(0.93); C250(1.18)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C1000(1.37)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C250(0.98); C757(0.99); C920(1.14); C558(0.85)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C250(0.93); C757(1.00); C920(1.26); C558(1.07)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C250(0.92); C757(1.13); C920(1.21); C558(1.22)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C250(1.02); C757(0.89); C920(1.42); C558(0.90)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C250(0.85); C757(0.90); C920(1.24); C558(1.78)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C250(0.94); C757(0.99); C920(1.22); C558(1.19)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C250(1.03); C757(1.01); C920(1.02); C558(1.07)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C250(0.95); C757(1.05); C920(1.06); C558(1.19)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C250(1.06); C757(0.89); C920(1.27); C558(1.02)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C250(0.96); C757(0.86); C920(1.12); C558(0.92)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C1000(1.38); C1002(0.92); C250(0.92)  LDD1066  [4]
 LDCM0427  Fragment51 HEK-293T C1000(1.19)  LDD1025  [4]
 LDCM0022  KB02 HCT 116 C444(1.07); C250(1.36); C1000(1.47); C1002(1.47)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C444(1.25); C250(0.96); C1000(0.99); C1002(0.99)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C444(1.26); C250(1.23); C1000(1.14); C1002(1.14)  LDD0082  [4]
 LDCM0131  RA190 MM1.R C612(1.23); C795(0.91)  LDD0304  [13]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glycine Small molecular drug DB00145
Pyridoxal Phosphate Small molecular drug DB00114

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.