Details of the Target

General Information of Target

Target ID LDTP13272
Target Name Septin-9 (SEPTIN9)
Gene Name SEPTIN9
Gene ID 10801
Synonyms
KIAA0991; MSF; SEPT9; Septin-9; MLL septin-like fusion protein MSF-A; MLL septin-like fusion protein; Ovarian/Breast septin; Ov/Br septin; Septin D1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEYLSALNPSDLLRSVSNISSEFGRRVWTSAPPPQRPFRVCDHKRTIRKGLTAATRQELL
AKALETLLLNGVLTLVLEEDGTAVDSEDFFQLLEDDTCLMVLQSGQSWSPTRSGVLSYGL
GRERPKHSKDIARFTFDVYKQNPRDLFGSLNVKATFYGLYSMSCDFQGLGPKKVLRELLR
WTSTLLQGLGHMLLGISSTLRHAVEGAEQWQQKGRLHSY
Target Bioclass
Enzyme
Family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
Subcellular location
Cytoplasm, cytoskeleton
Function
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {, }.
Uniprot ID
Q9UHD8
Ensemble ID
ENST00000329047.13
HGNC ID
HGNC:7323
ChEMBL ID
CHEMBL4105891

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.I301V DBIA    Probe Info 
CCK81 SNV: p.K291T DBIA    Probe Info 
GB1 SNV: p.N70T DBIA    Probe Info 
HEC1 SNV: p.P157H DBIA    Probe Info 
JURKAT SNV: p.R399H Compound 10    Probe Info 
KASUMI1 SNV: p.K381N DBIA    Probe Info 
LNCaP clone FGC SNV: p.L27F DBIA    Probe Info 
MFE319 Deletion: p.L466del DBIA    Probe Info 
MOLT4 SNV: p.A292T; p.R335H IA-alkyne    Probe Info 
MONOMAC6 Substitution: p.Q118P DBIA    Probe Info 
NCIH446 SNV: p.N40T .
SUPT1 SNV: p.T359I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
W1
 Probe Info  		17.70  LDD0235  [3]
TH211
 Probe Info  		Y473(16.89); Y278(10.10)  LDD0257  [4]
TH216
 Probe Info  		Y387(20.00); Y473(20.00); Y390(10.80); Y560(7.21)  LDD0259  [4]
ONAyne
 Probe Info  		K141(6.99); K458(1.26); K490(1.44); K87(2.93)  LDD0274  [5]
STPyne
 Probe Info  		K141(7.72); K156(10.00); K226(10.00); K262(10.00)  LDD0277  [5]
BTD
 Probe Info  		C248(14.68)  LDD1699  [6]
Probe 1
 Probe Info  		Y387(33.86); Y390(33.17)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C248(3.59)  LDD0168  [8]
HHS-482
 Probe Info  		Y390(0.80); Y506(1.59); Y560(0.89)  LDD0285  [9]
HHS-475
 Probe Info  		Y278(1.07)  LDD0264  [10]
HHS-465
 Probe Info  		Y390(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C248(1.43); C375(1.13); C531(1.13); C531(1.00)  LDD0078  [12]
5E-2FA
 Probe Info  		H140(0.00); H504(0.00); H369(0.00); H162(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
1d-yne
 Probe Info  		N.A.  LDD0358  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C375(0.00); C248(0.00); C531(0.00); C410(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C375(0.00); C248(0.00); C531(0.00); C410(0.00)  LDD0036  [16]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [17]
IPIAA_L
 Probe Info  		C531(0.00); C375(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C375(0.00); C248(0.00); C410(0.00); C411(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
IPM
 Probe Info  		N.A.  LDD0025  [19]
NAIA_4
 Probe Info  		C248(0.00); C375(0.00); C531(0.00)  LDD2226  [20]
TFBX
 Probe Info  		N.A.  LDD0027  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [21]
WYneO
 Probe Info  		N.A.  LDD0022  [21]
DA-P3
 Probe Info  		N.A.  LDD0178  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
Compound 11
 Probe Info  		C375(0.00); C531(0.00)  LDD2213  [23]
ENE
 Probe Info  		N.A.  LDD0006  [21]
VSF
 Probe Info  		N.A.  LDD0007  [21]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
1c-yne
 Probe Info  		N.A.  LDD0228  [15]
Acrolein
 Probe Info  		C248(0.00); C375(0.00); H77(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [25]
Methacrolein
 Probe Info  		N.A.  LDD0218  [25]
AOyne
 Probe Info  		14.00  LDD0443  [26]
NAIA_5
 Probe Info  		C375(0.00); C410(0.00); C531(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		1.00  LDD0139  [27]
VE-P
 Probe Info  		N.A.  LDD0396  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C248(0.82)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C248(0.93)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C248(0.65)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C248(0.84)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C248(1.19)  LDD2117  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C248(0.74)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C248(3.59)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C248(4.27)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C248(0.81); C375(1.00); C410(0.79); C411(0.79)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C248(0.88); C375(0.87); C410(0.96); C411(0.96)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C248(0.92); C375(0.66); C411(1.74); C531(0.79)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C248(1.08); C375(0.66); C411(1.83); C531(0.85)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C248(1.01); C375(0.71); C411(1.27); C531(0.89)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C248(1.11); C375(0.68); C411(1.21); C531(0.82)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C248(1.08); C375(0.75); C411(1.45); C531(0.85)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C248(1.21); C375(0.63); C411(1.10); C531(0.83)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C248(1.03); C375(0.65); C411(1.64); C531(0.80)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C248(1.21); C375(0.69); C411(3.23); C531(0.86)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C248(0.92); C375(0.72); C411(1.35); C531(0.72)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C248(0.79); C375(0.71); C411(1.69); C531(0.71)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C248(0.99); C375(0.92); C410(0.90); C411(0.90)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C248(1.00); C375(0.75); C411(1.03); C531(0.83)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C248(0.95); C375(0.62); C411(1.87); C531(0.67)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C248(1.14); C375(0.66); C411(1.47); C531(0.79)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C248(1.06); C375(0.98); C410(0.73); C411(0.90)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C248(1.10); C375(1.00); C410(0.49); C411(0.72)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C248(1.23); C375(0.94); C410(0.58); C411(0.82)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C248(1.36); C375(0.99); C410(0.49); C411(0.76)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C248(1.07); C375(1.03); C410(0.61); C411(0.72)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C248(1.01); C375(1.00); C410(0.54); C411(0.72)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C248(1.05); C375(0.98); C410(0.53); C411(0.74)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C248(0.88); C375(1.10); C410(0.99); C411(0.99)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C248(1.10); C375(1.07); C410(0.63); C411(0.85)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C248(0.93); C375(1.02); C410(0.52); C411(0.67)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C248(1.03); C375(0.97); C410(0.58); C411(0.79)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C248(0.94); C375(1.05); C410(0.85); C411(0.85)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C248(1.01); C375(1.00); C410(0.64); C411(0.81)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C248(1.07); C375(0.98); C410(1.05); C411(1.06)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C248(1.24); C375(1.01); C410(0.55); C411(0.82)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C248(1.26); C375(1.01); C410(0.62); C411(0.80)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C248(1.01); C375(1.00); C531(0.81)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C248(0.76); C375(0.88); C531(0.77)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C248(0.89); C375(0.89); C531(0.79)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C248(0.99); C375(0.84); C531(0.81)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C248(0.71); C375(0.78); C531(0.84)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C248(0.83); C375(0.86); C531(0.95)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C248(0.90); C375(0.87); C531(0.82)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C248(0.83); C375(0.79); C531(0.81)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C248(0.84); C375(0.91); C531(0.78)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C248(0.73); C375(0.89); C531(0.86)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C248(0.83); C375(0.84); C531(0.72)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C248(0.88); C375(0.84); C531(0.70)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C248(0.91); C375(0.93); C410(0.95); C411(0.95)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C248(0.90); C375(0.83); C531(0.78)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C248(0.89); C375(0.78); C531(0.78)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C248(0.70); C375(0.90); C531(0.67)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C248(1.09); C375(0.98); C531(1.06)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C375(0.90); C531(1.12); C248(1.56)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C375(0.92); C531(1.07); C248(1.20)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C375(0.93); C248(1.25); C531(1.26)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C375(0.91); C531(1.18); C248(1.54)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C375(1.04); C531(1.46); C248(1.71)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C375(0.96); C531(1.08); C248(1.58)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C531(0.85); C375(0.90); C410(0.96); C411(0.96)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C531(0.94); C375(0.97); C248(1.14)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C375(0.84); C531(1.11); C248(1.16)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C375(1.01); C531(1.17); C248(1.47)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C375(1.18); C531(1.28); C248(2.01)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C248(1.38); C375(0.99); C531(1.12)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C248(1.46); C375(0.99); C531(1.30)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C248(1.01); C375(1.07); C531(1.31)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C248(1.32); C375(1.02); C531(1.08)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C410(0.85); C375(0.89); C531(1.03); C411(1.10)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C375(0.88); C531(0.99); C248(1.07); C410(1.44)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C531(0.86); C375(0.89); C410(1.02); C248(1.23)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C410(0.64); C411(0.64); C375(0.82); C248(0.82)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C375(0.92); C531(0.94); C248(1.19); C410(1.21)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C375(1.02); C531(1.07); C410(1.28); C411(1.29)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C531(0.93); C375(0.99); C410(1.12); C248(1.17)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C375(0.95); C248(1.07); C531(1.12); C411(1.18)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C375(0.94); C531(1.03); C248(1.17); C410(1.20)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C410(0.75); C411(0.75); C531(0.78); C375(0.87)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C410(0.69); C411(0.69); C375(0.77); C531(0.82)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C375(0.69); C410(0.82); C411(0.82); C531(0.82)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C410(0.75); C411(0.75); C375(0.77); C531(0.85)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C375(0.66); C531(0.78); C410(0.99); C411(0.99)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C410(0.64); C411(0.64); C248(0.79); C375(0.96)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C375(0.62); C531(0.78); C410(0.89); C411(0.89)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C375(0.69); C410(0.75); C411(0.75); C531(0.87)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C375(0.62); C410(0.64); C411(0.64); C531(0.80)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C375(0.74); C531(0.81); C410(0.85); C411(0.85)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C410(0.80); C411(0.80); C375(0.80); C531(0.92)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C531(0.86); C248(0.88); C375(1.24)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C531(0.73); C248(0.86); C375(0.91)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C531(0.74); C375(0.92); C248(0.92)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C531(0.84); C375(0.93); C248(0.94)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C531(0.67); C375(0.94); C248(0.97)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C410(0.82); C411(0.82); C248(0.87); C531(0.94)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C375(0.78); C531(0.86); C248(1.14)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C531(0.75); C375(0.84); C248(0.95)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C531(0.79); C375(0.82); C248(1.06)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C531(0.82); C375(0.87); C248(1.02)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C531(0.73); C375(0.92); C248(1.00)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C531(0.84); C375(0.92); C248(1.12)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C531(0.85); C375(0.90); C410(1.00); C411(1.00)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C410(0.74); C411(0.74); C531(0.95); C375(0.95)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C410(0.54); C411(0.54); C531(0.94); C248(0.95)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C375(0.92); C531(0.94); C410(1.25); C411(1.25)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C410(0.69); C411(0.69); C248(0.74); C375(0.91)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C375(0.88); C531(0.91); C410(1.08); C411(1.08)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C410(0.77); C411(0.77); C531(0.87); C248(1.02)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C410(0.87); C411(0.87); C531(0.88); C375(0.98)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C375(1.04); C531(1.04); C410(1.14); C411(1.14)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C531(0.90); C375(1.04); C410(1.20); C411(1.20)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C531(0.95); C375(0.98); C410(1.02); C411(1.02)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C531(0.88); C375(1.03); C410(1.30); C411(1.30)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C531(0.85); C410(0.91); C411(0.91); C375(0.91)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C375(0.78); C410(1.01); C411(1.01); C531(1.11)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C375(0.84); C410(0.87); C411(0.87); C531(1.03)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C531(0.76); C375(0.85); C410(0.94); C411(0.94)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C375(0.88); C248(0.98); C410(1.00); C411(1.00)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C410(0.78); C411(0.78); C531(0.81); C375(0.82)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C410(0.80); C411(0.80); C375(0.85); C531(1.05)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C410(0.88); C411(0.88); C531(0.89); C375(0.91)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C531(0.89); C375(0.95); C248(1.07); C410(1.10)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C248(0.80); C410(0.82); C411(0.82); C375(0.84)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C410(0.67); C411(0.67); C375(0.81); C248(0.81)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C375(0.76); C248(0.85); C531(0.87); C410(1.11)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C410(0.88); C411(0.94); C531(0.97); C248(1.04)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C531(0.89); C411(0.96); C410(0.97); C375(1.12)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C531(0.82); C248(0.82); C375(0.84); C410(0.96)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C411(0.57); C410(0.60); C375(0.86); C531(0.92)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C411(0.93); C248(0.97); C410(0.98); C531(1.04)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C411(0.92); C410(0.93); C531(0.95); C375(1.06)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C411(0.82); C410(0.86); C375(0.94); C531(1.09)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C411(1.03); C410(1.10); C375(1.12); C531(1.19)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C410(0.87); C531(0.93); C411(0.97); C375(0.99)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C411(0.88); C410(0.90); C531(0.90); C375(1.10)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C410(0.74); C411(0.81); C531(0.90); C375(0.93)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C410(0.73); C411(0.82); C531(0.84); C375(0.98)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C410(0.78); C411(0.81); C531(1.00); C375(1.01)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C531(0.91); C375(0.91); C410(0.92); C411(0.92)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C411(0.98); C531(1.03); C410(1.10); C248(1.10)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C410(0.95); C411(0.95); C531(1.06); C248(1.20)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C411(0.86); C410(0.93); C375(1.13); C531(1.34)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C410(0.31); C411(0.31); C531(0.77); C375(0.93)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C410(0.48); C411(0.48); C531(0.82); C375(1.03)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C410(0.43); C411(0.43); C531(0.85); C375(0.94)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C410(0.49); C411(0.49); C531(0.65); C375(0.89)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C410(0.52); C411(0.52); C531(0.92); C375(1.05)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C410(0.42); C411(0.42); C531(0.71); C375(0.88)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C410(0.30); C411(0.30); C531(0.66); C375(0.89)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C410(0.42); C411(0.42); C531(0.78); C375(0.91)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C410(0.59); C411(0.59); C531(0.76); C375(0.99)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C410(0.35); C411(0.35); C531(0.83); C375(0.92)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C410(0.45); C411(0.45); C531(0.78); C375(0.90)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C410(0.56); C411(0.56); C375(1.11); C531(1.21)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C410(0.38); C411(0.38); C531(0.75); C375(1.15)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C410(0.74); C411(0.74); C531(0.79); C375(1.06)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C410(0.32); C411(0.32); C531(0.72); C375(0.91)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C375(0.64); C531(0.76); C411(0.90); C248(1.38)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C375(0.72); C531(0.81); C248(0.92); C411(1.02)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C248(0.46)  LDD2138  [6]
 LDCM0248  AKOS034007472 HCT 116 C248(0.83); C375(1.00); C410(0.83); C411(0.83)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C410(0.93); C411(0.93); C531(0.94); C248(0.95)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C531(0.80); C375(0.85); C410(0.89); C411(0.89)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 12.70  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C248(1.43); C375(1.13); C531(1.13); C531(1.00)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C248(0.54)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C248(1.26)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C248(0.00); C375(0.00); H77(0.00); H544(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C531(0.37)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C248(0.97); C531(0.98); C375(1.17)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C375(0.82); C531(1.06); C248(1.27)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C410(0.68); C411(0.68); C248(0.85); C531(0.87)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C375(0.80); C531(0.86); C410(0.87); C411(0.87)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C248(0.87); C375(0.92); C531(1.00); C410(1.05)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C248(0.95); C375(0.97); C410(1.02); C411(1.02)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C531(0.92); C248(0.93); C375(0.93); C410(1.03)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C375(0.89); C248(1.03); C531(1.04); C410(1.08)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C375(0.93); C531(1.05); C411(1.13); C410(1.21)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C375(0.89); C411(0.91); C531(0.96); C410(1.04)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C410(0.73); C411(0.74); C375(0.93); C531(1.02)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C375(0.89); C531(0.96); C411(1.16); C248(1.27)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C375(1.05); C248(1.14); C531(1.39)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C531(0.84); C375(0.86); C410(1.01); C411(1.09)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C375(0.82); C531(1.05); C410(1.08); C248(1.13)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C410(0.66); C411(0.66); C375(0.79); C531(0.89)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C375(0.69); C410(0.80); C411(0.80); C531(0.94)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C375(0.74); C410(0.79); C411(0.79); C531(1.07)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C410(0.70); C411(0.70); C375(0.72); C531(0.82)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C410(0.62); C411(0.62); C531(0.78); C375(0.79)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C531(0.81); C375(0.87); C248(1.42)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C531(0.88); C248(0.89); C375(0.90)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C531(0.76); C375(0.93); C248(1.08)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C375(0.96); C531(1.09); C248(1.79)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C531(0.67); C248(0.95); C375(0.97)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C375(0.80); C531(1.01); C248(1.53); C410(2.80)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C410(0.87); C411(0.87); C375(0.93); C531(0.99)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C375(0.97); C531(1.00); C410(1.10); C411(1.10)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C531(0.88); C375(0.96); C410(1.09); C411(1.09)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C410(0.74); C411(0.74); C375(0.81); C248(0.83)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C248(0.82); C410(0.86); C411(0.86); C375(0.91)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C410(0.59); C411(0.59); C375(0.83); C248(0.90)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C375(0.89); C410(0.95); C411(0.95); C531(0.98)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C375(0.97); C248(1.11); C531(1.18)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C375(0.90); C531(1.19); C248(1.22)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C375(1.01); C248(1.15); C531(1.37)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C531(0.90); C375(1.09); C248(1.15)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C375(0.97); C531(1.06); C248(1.09)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C375(0.85); C531(0.86); C248(1.63)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C531(0.88); C375(0.91); C248(1.30)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C375(0.97); C248(1.01); C531(1.05)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C531(0.74); C375(0.97); C248(1.50)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C375(0.95); C531(1.36); C248(1.80)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C375(0.94); C531(0.94); C248(2.24)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C531(0.86); C375(0.96); C248(1.39)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C375(0.88); C531(0.89); C248(1.78)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C248(1.63); C375(1.03); C531(0.87)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C248(1.33); C375(1.08); C531(0.93)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C248(1.33); C375(0.98); C531(0.84)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C248(1.91); C375(1.01); C531(0.95)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C248(1.73); C375(0.85); C531(0.92)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C248(1.01); C375(0.97); C531(1.05)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C248(1.16); C375(0.93); C531(0.92)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C248(1.13); C375(0.93); C410(1.36); C411(1.36)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C248(1.06); C375(0.92); C410(1.39); C411(1.39)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C248(1.20); C375(0.94); C410(1.77); C411(1.77)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C248(1.44); C375(0.80); C410(1.59); C411(1.59)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C248(1.79); C375(0.82); C410(2.01); C411(2.01)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C248(1.39); C375(0.83); C410(1.57); C411(1.57)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C248(1.61); C375(0.88); C410(1.63); C411(1.63)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C248(1.49); C375(0.88); C410(1.42); C411(1.42)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C248(1.22); C375(1.06); C531(1.13)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C248(1.44); C375(0.90); C410(1.27); C411(1.27)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C248(1.39); C375(0.91); C410(1.27); C411(1.27)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C248(1.96); C375(0.97); C410(1.48); C411(1.48)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C248(1.79); C375(0.92); C410(1.79); C411(1.79)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C248(1.56); C375(0.91); C410(1.55); C411(1.55)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C248(1.76); C375(0.88); C410(1.28); C411(1.28)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C248(1.07); C375(1.08); C410(0.43); C531(0.92)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C248(0.99); C375(1.12); C410(0.83); C531(1.01)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C248(1.02); C375(1.21); C410(0.58); C531(1.05)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C248(1.20); C375(1.02); C410(0.54); C531(0.89)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C248(1.04); C375(1.00); C531(1.23)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C248(1.04); C375(1.11); C410(0.65); C531(0.99)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C248(1.04); C375(1.07); C410(0.51); C531(0.99)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C248(1.13); C375(0.94); C410(0.46); C531(0.98)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C248(1.26); C375(0.99); C410(2.39); C531(1.20)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C248(1.18); C375(1.05); C410(0.62); C531(1.11)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C248(1.19); C375(1.17); C410(0.78); C531(0.85)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C248(1.08); C375(1.03); C410(1.10); C531(0.85)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C248(1.06); C375(1.09); C410(1.23); C531(0.89)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C248(1.10); C375(1.21); C410(0.77); C531(0.82)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C248(1.05); C375(1.01); C410(0.88); C531(1.06)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C248(1.06); C375(0.88); C531(1.03)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C248(1.15); C375(1.04); C410(0.49); C531(1.05)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C248(0.99); C375(0.91); C410(0.72); C531(0.88)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C248(1.23); C375(0.87); C410(0.62); C531(0.88)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C248(1.05); C375(0.81); C410(1.19); C531(0.93)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C248(1.10); C375(0.80); C410(0.75); C531(0.85)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C248(1.00); C375(0.93); C410(0.98); C531(1.01)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C248(1.39); C375(0.82); C410(0.81); C531(1.10)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C248(1.27); C375(0.94); C410(2.19); C531(1.20)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C248(1.10); C375(0.78); C410(2.91); C531(1.40)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C248(1.00); C375(0.82); C410(1.10); C531(0.92)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C248(1.14); C375(0.99); C531(1.23)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C248(1.16); C375(0.82); C410(1.00); C531(0.90)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C248(1.12); C375(0.79); C410(1.17); C531(0.90)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C248(1.05); C375(0.82); C410(1.15); C531(0.93)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C248(1.17); C375(0.83); C410(1.73); C531(1.16)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C248(1.17); C375(0.79); C410(1.63); C531(0.91)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C248(1.29); C375(0.90); C531(0.87)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C248(1.07); C375(0.95); C531(0.97)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C248(1.12); C375(0.96); C531(0.86)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C248(1.52); C375(0.81); C531(0.81)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C248(1.46); C375(1.00); C531(1.01)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C248(1.08); C375(1.09); C531(0.87)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C248(1.22); C375(0.94); C531(0.96)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C248(1.88); C375(0.93); C531(0.84)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C248(1.42); C375(0.90); C531(0.74)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C248(1.61); C375(0.85); C531(0.87)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C248(1.19); C375(0.90); C531(0.90)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C248(0.87); C375(1.03); C531(0.76)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C248(1.10); C375(1.02); C531(0.84)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C248(1.44); C375(0.94); C531(0.69)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C248(1.73); C375(1.13); C531(0.70)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C248(1.22); C375(0.96); C531(1.01)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C248(0.85); C375(1.13); C531(1.20)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C248(1.04); C375(0.87); C410(0.61); C411(0.61)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C248(0.97); C375(0.97); C410(0.65); C411(0.65)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C248(0.93); C375(1.01); C410(0.84); C411(0.84)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C248(1.15); C375(1.04); C410(0.71); C411(0.71)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C248(1.03); C375(0.80); C410(0.67); C411(0.67)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C248(1.02); C375(0.81); C410(0.69); C411(0.69)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C248(0.93); C375(0.76); C410(0.85); C411(0.85)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C248(0.91); C375(0.81); C410(0.69); C411(0.69)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C248(0.89); C375(0.87); C410(0.73); C411(0.73)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C248(1.35)  LDD2228  [20]
 LDCM0495  E2913 HEK-293T C248(0.98); C531(1.24); C375(0.92); C411(0.90)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C248(0.91)  LDD1702  [6]
 LDCM0625  F8 Ramos C375(0.97)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C375(1.57)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C375(0.16); 9.85  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C375(1.26)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C375(1.25)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C375(1.44); 1.99  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C375(1.21)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C375(1.08)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C375(1.37)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C375(1.12)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C375(1.80)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C375(1.62)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C375(1.70)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C375(1.19)  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C248(1.21); C375(0.76); C410(0.86); C531(0.94)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C375(1.12)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C375(0.91)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C248(2.06); C375(0.91); C410(1.69); C411(1.69)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C375(1.71)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C375(1.67)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C375(0.63)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C375(1.76)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y278(1.07)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y278(1.02)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y278(1.13)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y278(0.84)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y278(1.45)  LDD0268  [10]
 LDCM0107  IAA HeLa H544(0.00); H347(0.00); H369(0.00); H77(0.00)  LDD0221  [25]
 LDCM0123  JWB131 DM93 Y390(0.80); Y506(1.59); Y560(0.89)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y390(0.11); Y506(0.97); Y560(1.36)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y390(0.79); Y506(1.77); Y560(0.67)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y390(5.19); Y506(4.19); Y560(3.05)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y390(1.75); Y506(1.59); Y560(1.53)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y390(0.72); Y506(0.19); Y560(1.21)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y390(0.49); Y506(0.66); Y560(0.75)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y278(0.30); Y390(0.55); Y506(1.24); Y560(0.81)  LDD0292  [9]
 LDCM0022  KB02 HCT 116 C248(1.28)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C248(1.02)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C248(1.20)  LDD0082  [12]
 LDCM0030  Luteolin HEK-293T 5.71  LDD0182  [22]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C248(0.73)  LDD2121  [6]
 LDCM0109  NEM HeLa H77(0.00); H347(0.00); H544(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C248(0.81)  LDD2089  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C248(1.04)  LDD2099  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C248(1.29)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C248(0.98)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C248(1.04)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C248(1.23)  LDD2109  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C248(0.81)  LDD2114  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C248(1.07)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C248(0.92)  LDD2125  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C248(1.14)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C248(1.14)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C248(1.02)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C248(0.82)  LDD2140  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C248(0.46)  LDD2150  [6]
 LDCM0131  RA190 MM1.R C375(1.29); C531(1.11); C248(1.05)  LDD0304  [32]
 LDCM0021  THZ1 HCT 116 C410(1.12); C411(1.12); C248(0.94); C531(0.99)  LDD2173  [12]
 LDCM0113  W17 Hep-G2 C375(1.16)  LDD0240  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Septin-14 (SEPTIN14) Septin GTPase family Q6ZU15
Septin-6 (SEPTIN6) Septin GTPase family Q14141
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.