Details of the Target

General Information of Target

Target ID LDTP01252
Target Name Cold shock domain-containing protein E1 (CSDE1)
Gene Name CSDE1
Gene ID 7812
Synonyms
D1S155E; KIAA0885; NRU; UNR; Cold shock domain-containing protein E1; N-ras upstream gene protein; Protein UNR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNL
QDLKVGDDVEFEVSSDRRTGKPIAVKLVKIKQEILPEERMNGQVVCAVPHNLESKSPAAP
GQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLK
KKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKE
VATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPFG
DKDTKSKVTLLEGDHVRFNISTDRRDKLERATNIEVLSNTFQFTNEAREMGVIAAMRDGF
GFIKCVDRDVRMFFHFSEILDGNQLHIADEVEFTVVPDMLSAQRNHAIRIKKLPKGTVSF
HSHSDHRFLGTVEKEATFSNPKTTSPNKGKEKEAEDGIIAYDDCGVKLTIAFQAKDVEGS
TSPQIGDKVEFSISDKQRPGQQVATCVRLLGRNSNSKRLLGYVATLKDNFGFIETANHDK
EIFFHYSEFSGDVDSLELGDMVEYSLSKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGK
VIRPLRSVDPTQTEYQGMIEIVEEGDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVLG
QNAQTMAYNITPLRRATVECVKDQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFS
VILNQRTGKCSACNVWRVCEGPKAVAAPRPDRLVNRLKNITLDDASAPRLMVLRQPRGPD
NSMGFGAERKIRQAGVID
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
RNA-binding protein involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Required for efficient formation of stress granules.; (Microbial infection) Required for internal initiation of translation of human rhinovirus RNA.
Uniprot ID
O75534
Ensemble ID
ENST00000261443.9
HGNC ID
HGNC:29905

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 Deletion: p.N345RfsTer3 DBIA    Probe Info 
DU145 SNV: p.L49P DBIA    Probe Info 
HT115 SNV: p.R404K DBIA    Probe Info 
LS180 SNV: p.C53Ter DBIA    Probe Info 
MCC13 Substitution: p.P633L DBIA    Probe Info 
MCC26 SNV: p.G361S DBIA    Probe Info 
MFE319 SNV: p.R769H DBIA    Probe Info 
NCIH1299 SNV: p.T309I m-APA    Probe Info 
NCIH196 SNV: p.K239N DBIA    Probe Info 
RD SNV: p.Q497P DBIA    Probe Info 
RKO SNV: p.L510Ter DBIA    Probe Info 
SBC5 SNV: p.V637F DBIA    Probe Info 
SNGM SNV: p.K527E DBIA    Probe Info 
SW1783 SNV: p.R508Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.55  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
W1
 Probe Info  		11.75  LDD0235  [4]
TH211
 Probe Info  		Y37(8.00)  LDD0257  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
STPyne
 Probe Info  		K166(2.38); K180(8.23); K239(1.67); K277(10.00)  LDD0277  [7]
BTD
 Probe Info  		C739(5.60)  LDD1699  [8]
ONAyne
 Probe Info  		K758(0.00); K81(0.00)  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K307(1.59)  LDD3494  [9]
Probe 1
 Probe Info  		Y597(9.31); Y690(30.29)  LDD3495  [10]
AHL-Pu-1
 Probe Info  		C53(11.44)  LDD0168  [11]
DBIA
 Probe Info  		C680(1,106.74); C733(433.79); C645(36.86)  LDD0209  [12]
HHS-482
 Probe Info  		Y37(1.12)  LDD0285  [13]
HHS-475
 Probe Info  		Y37(0.78)  LDD0264  [14]
5E-2FA
 Probe Info  		H212(0.00); H167(0.00); H52(0.00); H9(0.00)  LDD2235  [15]
AMP probe
 Probe Info  		K81(0.00); K729(0.00); K166(0.00)  LDD0200  [16]
ATP probe
 Probe Info  		K81(0.00); K729(0.00); K166(0.00); K91(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C680(0.00); C464(0.00); C53(0.00); C42(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C730(0.00); C464(0.00); C680(0.00); C53(0.00)  LDD0032  [18]
IPIAA_L
 Probe Info  		C464(0.00); C42(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C680(0.00); C464(0.00); C53(0.00); C42(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [20]
JW-RF-010
 Probe Info  		C506(0.00); C42(0.00)  LDD0026  [21]
NAIA_4
 Probe Info  		C42(0.00); C680(0.00)  LDD2226  [22]
TFBX
 Probe Info  		C739(0.00); C42(0.00); C680(0.00)  LDD0027  [21]
WYneN
 Probe Info  		C680(0.00); C739(0.00)  LDD0021  [23]
WYneO
 Probe Info  		N.A.  LDD0022  [23]
Compound 10
 Probe Info  		C42(0.00); C506(0.00)  LDD2216  [24]
Compound 11
 Probe Info  		N.A.  LDD2213  [24]
ENE
 Probe Info  		N.A.  LDD0006  [23]
IPM
 Probe Info  		C680(0.00); C506(0.00); C739(0.00)  LDD0005  [23]
PF-06672131
 Probe Info  		C645(0.00); C739(0.00)  LDD0152  [25]
SF
 Probe Info  		Y522(0.00); Y37(0.00)  LDD0028  [26]
VSF
 Probe Info  		C186(0.00); C739(0.00); C464(0.00)  LDD0007  [23]
Phosphinate-6
 Probe Info  		C730(0.00); C680(0.00); C739(0.00); C506(0.00)  LDD0018  [27]
1c-yne
 Probe Info  		K277(0.00); K581(0.00); K600(0.00); K682(0.00)  LDD0228  [28]
Acrolein
 Probe Info  		C464(0.00); C53(0.00); C506(0.00); C42(0.00)  LDD0217  [29]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [29]
Methacrolein
 Probe Info  		C464(0.00); C506(0.00)  LDD0218  [29]
AOyne
 Probe Info  		10.70  LDD0443  [30]
NAIA_5
 Probe Info  		C680(0.00); C365(0.00); C657(0.00); C645(0.00)  LDD2223  [22]
HHS-465
 Probe Info  		Y37(0.00); K573(0.00)  LDD2240  [31]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.18  LDD0476  [32]
FFF probe3
 Probe Info  		6.03  LDD0464  [32]
STS-1
 Probe Info  		N.A.  LDD0136  [33]
STS-2
 Probe Info  		N.A.  LDD0138  [33]
VE-P
 Probe Info  		N.A.  LDD0396  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C42(0.23)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C739(0.52)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C739(0.81)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C739(1.14); C506(0.97)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C739(1.26); C506(1.17); C680(1.02)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C506(0.98)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C739(0.44); C506(0.43)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C739(0.40)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C53(11.44)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C680(2.41); C53(2.83); C464(2.40); C106(5.04)  LDD0169  [11]
 LDCM0561  Abegg_cp(-)-10 HeLa C42(3.18)  LDD0311  [21]
 LDCM0214  AC1 HCT 116 C106(0.78); C129(1.27); C186(1.32); C191(1.09)  LDD0531  [35]
 LDCM0215  AC10 HCT 116 C129(0.67); C186(1.07); C191(0.96); C42(1.08)  LDD0532  [35]
 LDCM0216  AC100 HCT 116 C106(0.92); C129(0.63); C186(0.43); C191(0.43)  LDD0533  [35]
 LDCM0217  AC101 HCT 116 C106(1.06); C129(0.55); C186(0.48); C191(0.48)  LDD0534  [35]
 LDCM0218  AC102 HCT 116 C106(0.99); C129(0.54); C186(0.46); C191(0.46)  LDD0535  [35]
 LDCM0219  AC103 HCT 116 C106(1.21); C129(0.33); C186(0.36); C191(0.36)  LDD0536  [35]
 LDCM0220  AC104 HCT 116 C106(1.16); C129(0.39); C186(0.53); C191(0.53)  LDD0537  [35]
 LDCM0221  AC105 HCT 116 C106(1.02); C129(0.35); C186(0.40); C191(0.40)  LDD0538  [35]
 LDCM0222  AC106 HCT 116 C106(1.04); C129(0.37); C186(0.42); C191(0.42)  LDD0539  [35]
 LDCM0223  AC107 HCT 116 C106(1.06); C129(0.30); C186(0.39); C191(0.41)  LDD0540  [35]
 LDCM0224  AC108 HCT 116 C106(0.93); C129(0.72); C186(0.59); C191(0.46)  LDD0541  [35]
 LDCM0225  AC109 HCT 116 C106(1.03); C129(0.61); C186(0.62); C191(0.55)  LDD0542  [35]
 LDCM0226  AC11 HCT 116 C129(0.67); C186(1.09); C191(0.91); C42(1.17)  LDD0543  [35]
 LDCM0227  AC110 HCT 116 C106(0.97); C129(0.58); C186(0.50); C191(0.48)  LDD0544  [35]
 LDCM0228  AC111 HCT 116 C106(1.27); C129(0.56); C186(0.52); C191(0.45)  LDD0545  [35]
 LDCM0229  AC112 HCT 116 C106(1.20); C129(0.38); C186(0.35); C191(0.38)  LDD0546  [35]
 LDCM0230  AC113 HCT 116 C129(1.24); C186(1.04); C191(1.00); C42(0.99)  LDD0547  [35]
 LDCM0231  AC114 HCT 116 C129(0.84); C186(0.91); C191(0.80); C42(1.01)  LDD0548  [35]
 LDCM0232  AC115 HCT 116 C129(0.90); C186(0.81); C191(0.75); C42(0.92)  LDD0549  [35]
 LDCM0233  AC116 HCT 116 C129(0.82); C186(0.83); C191(0.75); C42(0.94)  LDD0550  [35]
 LDCM0234  AC117 HCT 116 C129(0.80); C186(0.89); C191(0.79); C42(1.00)  LDD0551  [35]
 LDCM0235  AC118 HCT 116 C129(0.91); C186(0.96); C191(0.83); C42(0.95)  LDD0552  [35]
 LDCM0236  AC119 HCT 116 C129(0.90); C186(0.88); C191(0.83); C42(0.98)  LDD0553  [35]
 LDCM0237  AC12 HCT 116 C129(0.93); C186(1.13); C191(0.98); C42(1.08)  LDD0554  [35]
 LDCM0238  AC120 HCT 116 C129(0.91); C186(0.85); C191(0.83); C42(1.09)  LDD0555  [35]
 LDCM0239  AC121 HCT 116 C129(0.93); C186(0.95); C191(0.85); C42(0.97)  LDD0556  [35]
 LDCM0240  AC122 HCT 116 C129(0.89); C186(0.93); C191(0.87); C42(1.03)  LDD0557  [35]
 LDCM0241  AC123 HCT 116 C129(0.95); C186(1.03); C191(0.93); C42(1.10)  LDD0558  [35]
 LDCM0242  AC124 HCT 116 C129(0.92); C186(1.11); C191(0.88); C42(0.94)  LDD0559  [35]
 LDCM0243  AC125 HCT 116 C129(0.98); C186(0.93); C191(0.79); C42(0.96)  LDD0560  [35]
 LDCM0244  AC126 HCT 116 C129(0.89); C186(0.89); C191(0.78); C42(0.93)  LDD0561  [35]
 LDCM0245  AC127 HCT 116 C129(0.80); C186(0.96); C191(0.79); C42(0.92)  LDD0562  [35]
 LDCM0246  AC128 HCT 116 C129(0.61); C186(1.34); C191(1.10); C42(1.05)  LDD0563  [35]
 LDCM0247  AC129 HCT 116 C129(1.01); C186(1.54); C191(1.37); C42(1.42)  LDD0564  [35]
 LDCM0249  AC130 HCT 116 C129(0.74); C186(1.14); C191(1.06); C42(1.11)  LDD0566  [35]
 LDCM0250  AC131 HCT 116 C129(0.93); C186(1.32); C191(1.28); C42(0.93)  LDD0567  [35]
 LDCM0251  AC132 HCT 116 C129(1.19); C186(1.07); C191(1.09); C42(1.05)  LDD0568  [35]
 LDCM0252  AC133 HCT 116 C129(0.93); C186(1.20); C191(1.12); C42(1.34)  LDD0569  [35]
 LDCM0253  AC134 HCT 116 C129(0.74); C186(0.86); C191(0.94); C42(1.15)  LDD0570  [35]
 LDCM0254  AC135 HCT 116 C129(0.77); C186(0.98); C191(1.02); C42(1.03)  LDD0571  [35]
 LDCM0255  AC136 HCT 116 C129(0.96); C186(0.90); C191(0.98); C42(1.13)  LDD0572  [35]
 LDCM0256  AC137 HCT 116 C129(1.09); C186(0.90); C191(0.95); C42(1.16)  LDD0573  [35]
 LDCM0257  AC138 HCT 116 C129(0.87); C186(0.72); C191(0.87); C42(0.97)  LDD0574  [35]
 LDCM0258  AC139 HCT 116 C129(0.90); C186(0.85); C191(0.98); C42(1.03)  LDD0575  [35]
 LDCM0259  AC14 HCT 116 C129(0.93); C186(1.38); C191(1.20); C42(1.21)  LDD0576  [35]
 LDCM0260  AC140 HCT 116 C129(0.78); C186(0.76); C191(0.94); C42(0.96)  LDD0577  [35]
 LDCM0261  AC141 HCT 116 C129(0.84); C186(0.74); C191(0.95); C42(0.92)  LDD0578  [35]
 LDCM0262  AC142 HCT 116 C129(1.73); C186(1.17); C191(1.25); C42(1.22)  LDD0579  [35]
 LDCM0263  AC143 HCT 116 C129(0.80); C186(0.80); C191(0.90); C42(1.03)  LDD0580  [35]
 LDCM0264  AC144 HCT 116 C129(0.35); C186(0.66); C191(0.75); C42(0.89)  LDD0581  [35]
 LDCM0265  AC145 HCT 116 C129(0.51); C186(0.75); C191(0.77); C464(0.86)  LDD0582  [35]
 LDCM0266  AC146 HCT 116 C129(0.51); C186(0.69); C191(0.81); C733(1.03)  LDD0583  [35]
 LDCM0267  AC147 HCT 116 C129(0.34); C186(0.67); C191(0.70); C42(0.90)  LDD0584  [35]
 LDCM0268  AC148 HCT 116 C129(0.20); C186(0.55); C191(0.61); C42(0.85)  LDD0585  [35]
 LDCM0269  AC149 HCT 116 C129(0.33); C186(0.67); C733(0.71); C191(0.74)  LDD0586  [35]
 LDCM0270  AC15 HCT 116 C129(0.67); C733(1.00); C730(1.03); C506(1.06)  LDD0587  [35]
 LDCM0271  AC150 HCT 116 C129(0.66); C186(0.74); C191(0.78); C733(0.87)  LDD0588  [35]
 LDCM0272  AC151 HCT 116 C129(0.61); C186(0.70); C191(0.75); C733(0.85)  LDD0589  [35]
 LDCM0273  AC152 HCT 116 C129(0.29); C186(0.64); C191(0.75); C733(0.78)  LDD0590  [35]
 LDCM0274  AC153 HCT 116 C129(0.19); C186(0.63); C191(0.72); C733(0.77)  LDD0591  [35]
 LDCM0621  AC154 HCT 116 C129(0.41); C186(0.65); C191(0.73); C42(0.99)  LDD2158  [35]
 LDCM0622  AC155 HCT 116 C129(0.42); C186(0.67); C191(0.78); C42(0.93)  LDD2159  [35]
 LDCM0623  AC156 HCT 116 C129(0.70); C186(0.86); C191(0.97); C42(0.98)  LDD2160  [35]
 LDCM0624  AC157 HCT 116 C129(0.65); C186(0.90); C191(0.91); C42(0.93)  LDD2161  [35]
 LDCM0276  AC17 HCT 116 C129(0.65); C191(0.88); C186(0.93); C730(1.00)  LDD0593  [35]
 LDCM0277  AC18 HCT 116 C129(0.49); C186(0.61); C191(0.66); C42(0.96)  LDD0594  [35]
 LDCM0278  AC19 HCT 116 C129(0.64); C464(0.86); C186(0.91); C106(0.94)  LDD0595  [35]
 LDCM0279  AC2 HCT 116 C106(0.72); C657(0.74); C464(1.02); C191(1.06)  LDD0596  [35]
 LDCM0280  AC20 HCT 116 C129(0.65); C733(0.68); C191(0.72); C186(0.80)  LDD0597  [35]
 LDCM0281  AC21 HCT 116 C129(0.63); C186(0.72); C191(0.79); C733(0.79)  LDD0598  [35]
 LDCM0282  AC22 HCT 116 C733(0.74); C106(0.77); C191(0.81); C186(0.83)  LDD0599  [35]
 LDCM0283  AC23 HCT 116 C129(0.67); C191(0.68); C186(0.69); C464(0.80)  LDD0600  [35]
 LDCM0284  AC24 HCT 116 C129(0.67); C464(0.84); C106(0.91); C191(0.93)  LDD0601  [35]
 LDCM0285  AC25 HCT 116 C733(0.70); C506(0.75); C657(0.80); C730(0.83)  LDD0602  [35]
 LDCM0286  AC26 HCT 116 C733(0.49); C186(0.70); C191(0.72); C657(0.72)  LDD0603  [35]
 LDCM0287  AC27 HCT 116 C733(0.62); C186(0.69); C191(0.69); C730(0.82)  LDD0604  [35]
 LDCM0288  AC28 HCT 116 C733(0.52); C186(0.64); C191(0.65); C129(0.75)  LDD0605  [35]
 LDCM0289  AC29 HCT 116 C733(0.27); C186(0.56); C191(0.62); C730(0.65)  LDD0606  [35]
 LDCM0290  AC3 HCT 116 C657(0.71); C106(0.72); C464(1.07); C42(1.10)  LDD0607  [35]
 LDCM0291  AC30 HCT 116 C733(0.26); C186(0.57); C191(0.65); C129(0.74)  LDD0608  [35]
 LDCM0292  AC31 HCT 116 C733(0.45); C186(0.68); C730(0.70); C191(0.74)  LDD0609  [35]
 LDCM0293  AC32 HCT 116 C733(0.29); C186(0.50); C657(0.67); C129(0.68)  LDD0610  [35]
 LDCM0294  AC33 HCT 116 C733(0.69); C186(0.73); C129(0.75); C730(0.78)  LDD0611  [35]
 LDCM0295  AC34 HCT 116 C733(0.57); C186(0.64); C191(0.65); C129(0.68)  LDD0612  [35]
 LDCM0296  AC35 HCT 116 C464(0.77); C42(0.85); C733(0.86); C730(0.90)  LDD0613  [35]
 LDCM0297  AC36 HCT 116 C733(0.80); C42(0.85); C680(0.91); C730(0.92)  LDD0614  [35]
 LDCM0298  AC37 HCT 116 C506(0.76); C42(0.86); C680(0.91); C733(0.99)  LDD0615  [35]
 LDCM0299  AC38 HCT 116 C680(0.86); C42(0.87); C506(0.98); C733(1.00)  LDD0616  [35]
 LDCM0300  AC39 HCT 116 C42(0.83); C506(0.95); C186(0.95); C191(0.96)  LDD0617  [35]
 LDCM0301  AC4 HCT 116 C106(0.66); C657(0.74); C191(0.97); C464(0.98)  LDD0618  [35]
 LDCM0302  AC40 HCT 116 C733(0.71); C42(0.82); C186(0.86); C191(0.91)  LDD0619  [35]
 LDCM0303  AC41 HCT 116 C733(0.52); C730(0.72); C191(0.93); C186(0.96)  LDD0620  [35]
 LDCM0304  AC42 HCT 116 C733(0.72); C730(0.82); C186(0.87); C191(0.88)  LDD0621  [35]
 LDCM0305  AC43 HCT 116 C733(0.74); C730(0.93); C42(0.95); C186(0.97)  LDD0622  [35]
 LDCM0306  AC44 HCT 116 C733(0.55); C42(0.89); C506(0.90); C191(0.91)  LDD0623  [35]
 LDCM0307  AC45 HCT 116 C733(0.68); C129(0.85); C191(0.91); C42(0.91)  LDD0624  [35]
 LDCM0308  AC46 HCT 116 C733(0.36); C730(0.89); C186(0.89); C191(0.89)  LDD0625  [35]
 LDCM0309  AC47 HCT 116 C733(0.74); C191(0.84); C186(0.90); C42(0.98)  LDD0626  [35]
 LDCM0310  AC48 HCT 116 C733(0.35); C730(0.79); C680(0.99); C186(1.03)  LDD0627  [35]
 LDCM0311  AC49 HCT 116 C733(0.28); C129(0.54); C186(0.55); C191(0.72)  LDD0628  [35]
 LDCM0312  AC5 HCT 116 C657(0.67); C106(0.73); C191(1.02); C464(1.03)  LDD0629  [35]
 LDCM0313  AC50 HCT 116 C733(0.32); C129(0.55); C186(0.64); C191(0.71)  LDD0630  [35]
 LDCM0314  AC51 HCT 116 C733(0.35); C730(0.75); C42(0.96); C506(0.99)  LDD0631  [35]
 LDCM0315  AC52 HCT 116 C733(0.36); C191(0.80); C730(0.80); C186(0.84)  LDD0632  [35]
 LDCM0316  AC53 HCT 116 C733(0.68); C129(0.72); C730(0.80); C186(0.86)  LDD0633  [35]
 LDCM0317  AC54 HCT 116 C733(0.41); C129(0.67); C730(0.70); C186(0.71)  LDD0634  [35]
 LDCM0318  AC55 HCT 116 C129(0.51); C733(0.78); C191(0.83); C186(0.88)  LDD0635  [35]
 LDCM0319  AC56 HCT 116 C733(0.42); C129(0.47); C730(0.69); C186(0.70)  LDD0636  [35]
 LDCM0320  AC57 HCT 116 C129(0.48); C186(0.83); C730(0.84); C733(0.85)  LDD0637  [35]
 LDCM0321  AC58 HCT 116 C129(0.43); C186(0.75); C191(0.79); C464(0.80)  LDD0638  [35]
 LDCM0322  AC59 HCT 116 C129(0.35); C186(0.68); C191(0.70); C730(0.74)  LDD0639  [35]
 LDCM0323  AC6 HCT 116 C129(0.63); C191(0.92); C186(0.94); C733(1.00)  LDD0640  [35]
 LDCM0324  AC60 HCT 116 C129(0.53); C186(0.70); C191(0.75); C464(0.81)  LDD0641  [35]
 LDCM0325  AC61 HCT 116 C129(0.89); C186(0.90); C191(0.95); C464(0.96)  LDD0642  [35]
 LDCM0326  AC62 HCT 116 C129(0.32); C186(0.72); C191(0.76); C730(0.79)  LDD0643  [35]
 LDCM0327  AC63 HCT 116 C129(0.58); C186(0.74); C191(0.79); C464(0.91)  LDD0644  [35]
 LDCM0328  AC64 HCT 116 C129(0.39); C186(0.64); C191(0.67); C730(0.76)  LDD0645  [35]
 LDCM0329  AC65 HCT 116 C129(0.51); C186(0.76); C730(0.78); C191(0.81)  LDD0646  [35]
 LDCM0330  AC66 HCT 116 C129(0.56); C730(0.77); C733(0.82); C186(0.87)  LDD0647  [35]
 LDCM0331  AC67 HCT 116 C129(0.24); C186(0.53); C191(0.56); C730(0.72)  LDD0648  [35]
 LDCM0332  AC68 HCT 116 C129(0.76); C106(0.88); C464(0.91); C42(1.01)  LDD0649  [35]
 LDCM0333  AC69 HCT 116 C129(0.61); C464(0.84); C733(0.86); C730(0.95)  LDD0650  [35]
 LDCM0334  AC7 HCT 116 C129(0.93); C730(0.98); C733(1.00); C42(1.08)  LDD0651  [35]
 LDCM0335  AC70 HCT 116 C129(0.36); C106(0.66); C657(0.69); C42(0.85)  LDD0652  [35]
 LDCM0336  AC71 HCT 116 C106(0.79); C506(0.83); C464(0.83); C733(0.89)  LDD0653  [35]
 LDCM0337  AC72 HCT 116 C129(0.66); C106(0.76); C733(0.81); C730(0.89)  LDD0654  [35]
 LDCM0338  AC73 HCT 116 C129(0.33); C106(0.85); C464(0.86); C42(0.88)  LDD0655  [35]
 LDCM0339  AC74 HCT 116 C129(0.37); C464(0.83); C733(0.85); C106(0.88)  LDD0656  [35]
 LDCM0340  AC75 HCT 116 C129(0.31); C106(0.71); C42(0.84); C733(0.87)  LDD0657  [35]
 LDCM0341  AC76 HCT 116 C129(0.49); C106(0.72); C733(0.85); C730(0.92)  LDD0658  [35]
 LDCM0342  AC77 HCT 116 C129(0.47); C464(0.88); C733(0.94); C106(1.00)  LDD0659  [35]
 LDCM0343  AC78 HCT 116 C464(0.86); C106(0.97); C733(0.98); C129(1.02)  LDD0660  [35]
 LDCM0344  AC79 HCT 116 C733(0.77); C129(0.77); C106(0.81); C464(0.90)  LDD0661  [35]
 LDCM0345  AC8 HCT 116 C730(0.83); C733(0.84); C129(0.84); C464(0.91)  LDD0662  [35]
 LDCM0346  AC80 HCT 116 C129(0.56); C733(0.68); C730(0.82); C106(0.89)  LDD0663  [35]
 LDCM0347  AC81 HCT 116 C657(0.50); C733(0.70); C730(0.82); C106(0.87)  LDD0664  [35]
 LDCM0348  AC82 HCT 116 C129(0.28); C106(0.77); C42(0.91); C733(0.91)  LDD0665  [35]
 LDCM0349  AC83 HCT 116 C129(0.26); C733(0.57); C730(0.66); C191(0.86)  LDD0666  [35]
 LDCM0350  AC84 HCT 116 C129(0.27); C733(0.58); C730(0.69); C191(0.81)  LDD0667  [35]
 LDCM0351  AC85 HCT 116 C129(0.57); C733(0.66); C730(0.78); C191(0.82)  LDD0668  [35]
 LDCM0352  AC86 HCT 116 C129(0.47); C733(0.71); C186(0.73); C191(0.78)  LDD0669  [35]
 LDCM0353  AC87 HCT 116 C733(0.81); C106(0.82); C730(0.86); C42(0.93)  LDD0670  [35]
 LDCM0354  AC88 HCT 116 C129(0.56); C730(0.70); C733(0.71); C106(0.87)  LDD0671  [35]
 LDCM0355  AC89 HCT 116 C129(0.31); C186(0.73); C733(0.73); C191(0.76)  LDD0672  [35]
 LDCM0357  AC90 HCT 116 C129(0.76); C106(0.77); C186(0.91); C191(0.95)  LDD0674  [35]
 LDCM0358  AC91 HCT 116 C129(0.24); C730(0.71); C733(0.75); C106(0.76)  LDD0675  [35]
 LDCM0359  AC92 HCT 116 C129(0.25); C191(0.71); C186(0.75); C106(0.78)  LDD0676  [35]
 LDCM0360  AC93 HCT 116 C129(0.54); C733(0.57); C730(0.61); C191(0.80)  LDD0677  [35]
 LDCM0361  AC94 HCT 116 C129(0.67); C733(0.70); C730(0.70); C106(0.79)  LDD0678  [35]
 LDCM0362  AC95 HCT 116 C106(0.73); C129(0.83); C42(0.85); C730(0.86)  LDD0679  [35]
 LDCM0363  AC96 HCT 116 C129(0.42); C730(0.81); C106(0.82); C191(0.85)  LDD0680  [35]
 LDCM0364  AC97 HCT 116 C129(0.32); C733(0.59); C730(0.62); C186(0.66)  LDD0681  [35]
 LDCM0365  AC98 HCT 116 C129(0.14); C186(0.29); C191(0.29); C42(0.62)  LDD0682  [35]
 LDCM0366  AC99 HCT 116 C186(0.47); C191(0.47); C129(0.65); C733(0.71)  LDD0683  [35]
 LDCM0545  Acetamide MDA-MB-231 C739(0.37); C506(0.31)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C739(0.74); C506(1.33)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C129(1.06); C186(1.31); C191(1.20); C42(1.06)  LDD0565  [35]
 LDCM0356  AKOS034007680 HCT 116 C129(0.80); C42(1.06); C730(1.06); C191(1.07)  LDD0673  [35]
 LDCM0275  AKOS034007705 HCT 116 C129(0.37); C733(0.91); C186(0.96); C191(0.98)  LDD0592  [35]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0498  BS-3668 MDA-MB-231 C739(0.54); C680(0.44)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa H421(0.00); C506(0.00); C464(0.00); C680(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C506(1.61); C680(1.61); C506(1.21); C680(1.21)  LDD2227  [22]
 LDCM0367  CL1 HCT 116 C42(0.78); C191(0.97); C506(0.99); C680(1.01)  LDD0684  [35]
 LDCM0368  CL10 HCT 116 C129(0.62); C42(0.90); C191(0.91); C186(0.97)  LDD0685  [35]
 LDCM0369  CL100 HCT 116 C657(0.64); C106(0.77); C191(0.87); C730(0.93)  LDD0686  [35]
 LDCM0370  CL101 HCT 116 C129(0.66); C733(0.95); C730(1.01); C42(1.10)  LDD0687  [35]
 LDCM0371  CL102 HCT 116 C129(0.89); C42(1.04); C680(1.15); C506(1.16)  LDD0688  [35]
 LDCM0372  CL103 HCT 116 C129(0.86); C42(1.01); C680(1.06); C506(1.06)  LDD0689  [35]
 LDCM0373  CL104 HCT 116 C129(0.89); C680(1.04); C42(1.07); C464(1.11)  LDD0690  [35]
 LDCM0374  CL105 HCT 116 C129(0.51); C186(0.60); C733(0.64); C191(0.72)  LDD0691  [35]
 LDCM0375  CL106 HCT 116 C129(0.41); C186(0.63); C191(0.75); C730(1.00)  LDD0692  [35]
 LDCM0376  CL107 HCT 116 C129(0.35); C186(0.55); C191(0.63); C464(0.86)  LDD0693  [35]
 LDCM0377  CL108 HCT 116 C129(0.32); C186(0.72); C191(0.75); C733(0.78)  LDD0694  [35]
 LDCM0378  CL109 HCT 116 C129(0.47); C186(0.70); C733(0.78); C464(0.85)  LDD0695  [35]
 LDCM0379  CL11 HCT 116 C129(0.53); C42(0.75); C191(0.84); C186(1.05)  LDD0696  [35]
 LDCM0380  CL110 HCT 116 C129(0.40); C186(0.76); C464(0.79); C191(0.81)  LDD0697  [35]
 LDCM0381  CL111 HCT 116 C129(0.60); C186(0.63); C191(0.78); C464(0.84)  LDD0698  [35]
 LDCM0382  CL112 HCT 116 C733(0.57); C730(0.74); C186(0.75); C191(0.78)  LDD0699  [35]
 LDCM0383  CL113 HCT 116 C733(0.26); C186(0.48); C730(0.58); C191(0.62)  LDD0700  [35]
 LDCM0384  CL114 HCT 116 C733(0.22); C186(0.53); C730(0.56); C191(0.70)  LDD0701  [35]
 LDCM0385  CL115 HCT 116 C733(0.32); C730(0.60); C186(0.60); C191(0.67)  LDD0702  [35]
 LDCM0386  CL116 HCT 116 C733(0.65); C186(0.72); C191(0.75); C464(0.84)  LDD0703  [35]
 LDCM0387  CL117 HCT 116 C733(0.64); C129(0.78); C186(0.80); C191(0.86)  LDD0704  [35]
 LDCM0388  CL118 HCT 116 C730(0.92); C186(0.99); C191(0.99); C42(1.00)  LDD0705  [35]
 LDCM0389  CL119 HCT 116 C730(0.90); C42(0.90); C733(0.91); C464(0.94)  LDD0706  [35]
 LDCM0390  CL12 HCT 116 C129(0.46); C191(0.89); C42(0.89); C680(1.13)  LDD0707  [35]
 LDCM0391  CL120 HCT 116 C730(0.83); C733(0.84); C42(0.90); C186(0.96)  LDD0708  [35]
 LDCM0392  CL121 HCT 116 C733(0.56); C42(0.85); C730(0.98); C186(1.10)  LDD0709  [35]
 LDCM0393  CL122 HCT 116 C733(0.58); C186(0.81); C129(0.85); C191(0.85)  LDD0710  [35]
 LDCM0394  CL123 HCT 116 C733(0.64); C129(0.67); C191(0.74); C186(0.76)  LDD0711  [35]
 LDCM0395  CL124 HCT 116 C733(0.42); C129(0.59); C191(0.67); C186(0.71)  LDD0712  [35]
 LDCM0396  CL125 HCT 116 C464(0.86); C42(0.99); C730(1.00); C186(1.01)  LDD0713  [35]
 LDCM0397  CL126 HCT 116 C129(0.78); C186(0.85); C191(0.88); C464(0.91)  LDD0714  [35]
 LDCM0398  CL127 HCT 116 C129(0.75); C191(0.85); C186(0.90); C42(1.01)  LDD0715  [35]
 LDCM0399  CL128 HCT 116 C129(0.42); C186(0.81); C191(0.85); C730(0.88)  LDD0716  [35]
 LDCM0400  CL13 HCT 116 C129(0.79); C42(0.83); C191(1.06); C506(1.11)  LDD0717  [35]
 LDCM0401  CL14 HCT 116 C129(0.82); C42(0.88); C191(1.08); C680(1.10)  LDD0718  [35]
 LDCM0402  CL15 HCT 116 C129(0.70); C42(0.82); C506(1.02); C191(1.08)  LDD0719  [35]
 LDCM0403  CL16 HCT 116 C191(0.90); C186(0.91); C733(0.91); C730(0.93)  LDD0720  [35]
 LDCM0404  CL17 HCT 116 C42(0.87); C129(1.00); C106(1.00); C733(1.02)  LDD0721  [35]
 LDCM0405  CL18 HCT 116 C42(1.04); C106(1.10); C506(1.23); C730(1.26)  LDD0722  [35]
 LDCM0406  CL19 HCT 116 C129(0.77); C106(0.91); C42(0.94); C191(0.99)  LDD0723  [35]
 LDCM0407  CL2 HCT 116 C42(0.82); C191(0.95); C680(1.02); C129(1.08)  LDD0724  [35]
 LDCM0408  CL20 HCT 116 C129(0.57); C186(0.81); C191(0.84); C42(0.95)  LDD0725  [35]
 LDCM0409  CL21 HCT 116 C129(0.52); C42(0.87); C191(0.88); C733(0.90)  LDD0726  [35]
 LDCM0410  CL22 HCT 116 C129(0.38); C186(0.80); C191(0.87); C733(0.91)  LDD0727  [35]
 LDCM0411  CL23 HCT 116 C129(0.61); C733(0.85); C191(0.88); C186(0.88)  LDD0728  [35]
 LDCM0412  CL24 HCT 116 C129(0.54); C186(0.82); C191(0.85); C42(0.87)  LDD0729  [35]
 LDCM0413  CL25 HCT 116 C106(0.90); C129(0.57); C186(0.86); C191(0.86)  LDD0730  [35]
 LDCM0414  CL26 HCT 116 C106(1.19); C129(0.65); C186(0.85); C191(0.92)  LDD0731  [35]
 LDCM0415  CL27 HCT 116 C106(1.08); C129(0.77); C186(0.96); C191(0.95)  LDD0732  [35]
 LDCM0416  CL28 HCT 116 C106(1.03); C129(0.79); C186(0.85); C191(0.92)  LDD0733  [35]
 LDCM0417  CL29 HCT 116 C106(0.97); C129(0.74); C186(0.89); C191(0.91)  LDD0734  [35]
 LDCM0418  CL3 HCT 116 C129(0.95); C186(1.15); C191(0.93); C42(0.83)  LDD0735  [35]
 LDCM0419  CL30 HCT 116 C106(0.91); C129(1.03); C186(1.04); C191(1.03)  LDD0736  [35]
 LDCM0420  CL31 HCT 116 C106(0.91); C129(0.71); C186(0.87); C191(0.92)  LDD0737  [35]
 LDCM0421  CL32 HCT 116 C106(0.80); C129(1.02); C186(0.90); C191(0.95)  LDD0738  [35]
 LDCM0422  CL33 HCT 116 C106(0.80); C129(0.83); C186(1.05); C191(1.06)  LDD0739  [35]
 LDCM0423  CL34 HCT 116 C106(0.79); C129(0.52); C186(0.87); C191(1.12)  LDD0740  [35]
 LDCM0424  CL35 HCT 116 C106(1.19); C129(0.52); C186(0.95); C191(0.95)  LDD0741  [35]
 LDCM0425  CL36 HCT 116 C106(1.07); C129(0.55); C186(0.95); C191(0.94)  LDD0742  [35]
 LDCM0426  CL37 HCT 116 C106(1.13); C129(0.48); C186(0.85); C191(0.88)  LDD0743  [35]
 LDCM0428  CL39 HCT 116 C106(0.79); C129(0.52); C186(0.77); C191(0.80)  LDD0745  [35]
 LDCM0429  CL4 HCT 116 C129(0.87); C186(1.32); C191(1.07); C42(0.82)  LDD0746  [35]
 LDCM0430  CL40 HCT 116 C106(0.75); C129(0.59); C186(0.95); C191(0.88)  LDD0747  [35]
 LDCM0431  CL41 HCT 116 C106(0.81); C129(0.58); C186(0.89); C191(0.90)  LDD0748  [35]
 LDCM0432  CL42 HCT 116 C106(0.92); C129(0.44); C186(0.89); C191(0.85)  LDD0749  [35]
 LDCM0433  CL43 HCT 116 C106(0.59); C129(0.50); C186(0.93); C191(0.96)  LDD0750  [35]
 LDCM0434  CL44 HCT 116 C106(0.65); C129(0.67); C186(1.21); C191(1.09)  LDD0751  [35]
 LDCM0435  CL45 HCT 116 C106(0.62); C129(0.61); C186(1.07); C191(0.99)  LDD0752  [35]
 LDCM0436  CL46 HCT 116 C106(0.69); C186(1.05); C191(0.93); C42(0.98)  LDD0753  [35]
 LDCM0437  CL47 HCT 116 C106(1.01); C186(1.05); C191(0.89); C42(0.96)  LDD0754  [35]
 LDCM0438  CL48 HCT 116 C106(0.75); C186(0.98); C191(0.98); C42(0.97)  LDD0755  [35]
 LDCM0439  CL49 HCT 116 C106(0.65); C186(1.07); C191(0.86); C42(0.99)  LDD0756  [35]
 LDCM0440  CL5 HCT 116 C129(0.93); C186(1.46); C191(1.09); C42(0.97)  LDD0757  [35]
 LDCM0441  CL50 HCT 116 C106(0.71); C186(1.17); C191(1.01); C42(0.97)  LDD0758  [35]
 LDCM0442  CL51 HCT 116 C106(0.60); C186(1.07); C191(0.95); C42(0.88)  LDD0759  [35]
 LDCM0443  CL52 HCT 116 C106(0.74); C186(1.03); C191(0.93); C42(0.89)  LDD0760  [35]
 LDCM0444  CL53 HCT 116 C106(1.35); C186(1.09); C191(0.85); C42(0.93)  LDD0761  [35]
 LDCM0445  CL54 HCT 116 C106(0.81); C186(1.13); C191(0.93); C42(0.94)  LDD0762  [35]
 LDCM0446  CL55 HCT 116 C106(0.81); C186(1.02); C191(0.86); C42(0.88)  LDD0763  [35]
 LDCM0447  CL56 HCT 116 C106(0.90); C186(0.86); C191(0.81); C42(0.95)  LDD0764  [35]
 LDCM0448  CL57 HCT 116 C106(1.14); C186(1.11); C191(0.93); C42(1.01)  LDD0765  [35]
 LDCM0449  CL58 HCT 116 C106(0.78); C186(1.10); C191(1.24); C42(0.94)  LDD0766  [35]
 LDCM0450  CL59 HCT 116 C106(0.74); C186(0.97); C191(0.89); C42(0.95)  LDD0767  [35]
 LDCM0451  CL6 HCT 116 C129(1.13); C186(1.46); C191(1.13); C42(0.79)  LDD0768  [35]
 LDCM0452  CL60 HCT 116 C106(0.68); C186(0.98); C191(0.84); C42(0.97)  LDD0769  [35]
 LDCM0453  CL61 HCT 116 C106(1.00); C129(0.91); C186(1.05); C191(0.94)  LDD0770  [35]
 LDCM0454  CL62 HCT 116 C106(0.91); C129(0.85); C186(0.97); C191(0.86)  LDD0771  [35]
 LDCM0455  CL63 HCT 116 C106(0.89); C129(1.33); C186(0.82); C191(0.85)  LDD0772  [35]
 LDCM0456  CL64 HCT 116 C106(0.93); C129(0.90); C186(0.95); C191(0.94)  LDD0773  [35]
 LDCM0457  CL65 HCT 116 C106(0.83); C129(0.88); C186(1.03); C191(0.97)  LDD0774  [35]
 LDCM0458  CL66 HCT 116 C106(0.93); C129(1.01); C186(0.92); C191(0.91)  LDD0775  [35]
 LDCM0459  CL67 HCT 116 C106(0.95); C129(0.92); C186(0.92); C191(0.94)  LDD0776  [35]
 LDCM0460  CL68 HCT 116 C106(0.89); C129(1.01); C186(1.10); C191(0.96)  LDD0777  [35]
 LDCM0461  CL69 HCT 116 C106(0.91); C129(1.12); C186(1.30); C191(1.11)  LDD0778  [35]
 LDCM0462  CL7 HCT 116 C129(0.66); C186(1.29); C191(1.04); C42(0.84)  LDD0779  [35]
 LDCM0463  CL70 HCT 116 C106(0.97); C129(0.82); C186(0.94); C191(0.96)  LDD0780  [35]
 LDCM0464  CL71 HCT 116 C106(0.98); C129(0.91); C186(0.78); C191(0.81)  LDD0781  [35]
 LDCM0465  CL72 HCT 116 C106(1.17); C129(0.81); C186(0.90); C191(0.86)  LDD0782  [35]
 LDCM0466  CL73 HCT 116 C106(0.90); C129(1.02); C186(0.97); C191(0.92)  LDD0783  [35]
 LDCM0467  CL74 HCT 116 C106(1.15); C129(0.82); C186(0.82); C191(0.94)  LDD0784  [35]
 LDCM0469  CL76 HCT 116 C106(0.93); C129(0.99); C186(0.98); C191(0.98)  LDD0786  [35]
 LDCM0470  CL77 HCT 116 C106(1.08); C129(0.79); C186(0.91); C191(0.91)  LDD0787  [35]
 LDCM0471  CL78 HCT 116 C106(1.04); C129(0.78); C186(0.85); C191(0.85)  LDD0788  [35]
 LDCM0472  CL79 HCT 116 C106(0.96); C129(0.64); C186(1.02); C191(1.02)  LDD0789  [35]
 LDCM0473  CL8 HCT 116 C129(0.45); C186(0.78); C191(0.74); C42(0.78)  LDD0790  [35]
 LDCM0474  CL80 HCT 116 C106(0.87); C129(1.10); C186(1.47); C191(1.47)  LDD0791  [35]
 LDCM0475  CL81 HCT 116 C106(0.94); C129(0.76); C186(1.12); C191(1.12)  LDD0792  [35]
 LDCM0476  CL82 HCT 116 C106(0.92); C129(0.64); C186(1.08); C191(1.08)  LDD0793  [35]
 LDCM0477  CL83 HCT 116 C106(0.86); C129(0.61); C186(0.99); C191(0.99)  LDD0794  [35]
 LDCM0478  CL84 HCT 116 C106(0.82); C129(0.51); C186(0.84); C191(0.84)  LDD0795  [35]
 LDCM0479  CL85 HCT 116 C106(0.88); C129(0.78); C186(0.87); C191(0.87)  LDD0796  [35]
 LDCM0480  CL86 HCT 116 C106(0.91); C129(0.86); C186(0.97); C191(0.97)  LDD0797  [35]
 LDCM0481  CL87 HCT 116 C106(0.92); C129(0.79); C186(1.04); C191(1.04)  LDD0798  [35]
 LDCM0482  CL88 HCT 116 C106(0.95); C129(0.66); C186(1.11); C191(1.11)  LDD0799  [35]
 LDCM0483  CL89 HCT 116 C106(0.75); C129(0.52); C186(0.85); C191(0.85)  LDD0800  [35]
 LDCM0484  CL9 HCT 116 C129(0.60); C186(0.99); C191(0.95); C42(0.81)  LDD0801  [35]
 LDCM0485  CL90 HCT 116 C106(0.99); C129(1.00); C186(1.15); C191(1.15)  LDD0802  [35]
 LDCM0486  CL91 HCT 116 C106(1.03); C129(0.90); C186(1.05); C191(1.04)  LDD0803  [35]
 LDCM0487  CL92 HCT 116 C106(0.82); C129(0.95); C186(1.23); C191(1.07)  LDD0804  [35]
 LDCM0488  CL93 HCT 116 C106(0.67); C129(1.09); C186(1.33); C191(1.10)  LDD0805  [35]
 LDCM0489  CL94 HCT 116 C106(0.86); C129(0.98); C186(1.42); C191(1.12)  LDD0806  [35]
 LDCM0490  CL95 HCT 116 C106(0.68); C129(1.09); C186(1.12); C191(1.02)  LDD0807  [35]
 LDCM0491  CL96 HCT 116 C106(0.71); C129(1.20); C186(1.23); C191(1.23)  LDD0808  [35]
 LDCM0492  CL97 HCT 116 C106(0.83); C129(1.14); C186(1.15); C191(1.14)  LDD0809  [35]
 LDCM0493  CL98 HCT 116 C106(0.84); C129(1.31); C186(0.87); C191(0.92)  LDD0810  [35]
 LDCM0494  CL99 HCT 116 C106(0.76); C129(1.33); C186(1.06); C191(1.00)  LDD0811  [35]
 LDCM0634  CY-0357 Hep-G2 C464(0.85); C464(0.31)  LDD2228  [22]
 LDCM0495  E2913 HEK-293T C506(1.29); C680(0.85); C464(0.96); C53(0.96)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C739(2.00); C680(2.00); C730(1.64); C42(1.33)  LDD1702  [8]
 LDCM0625  F8 Ramos C680(1.07); C42(0.66); C53(1.14); C645(1.51)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C680(1.00); C42(0.71); C53(0.58); C645(0.54)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C680(1.30); C42(0.08); C53(0.77); C645(1.38)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C680(1.26); C42(0.81); C53(0.85); 1.24  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C680(1.13); C42(0.66); C53(0.76); C645(0.87)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C680(0.82); C42(0.62); C53(0.82); 0.55  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C680(1.01); C42(0.69); C53(0.75); 1.99  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C680(1.09); C42(1.02); C53(1.02); 1.58  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C680(0.91); C42(0.64); C53(0.47); 0.69  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C680(1.07); C42(0.68); C53(0.82); 1.84  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C680(0.67); C42(0.89); C53(0.88); 1.07  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C680(1.45); C42(0.67); C53(0.91); 1.81  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C680(0.99); C42(0.87); C53(0.74); C645(0.82)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C680(1.11); C42(0.74); C53(0.76); 0.93  LDD2201  [37]
 LDCM0468  Fragment33 HCT 116 C106(0.92); C129(1.02); C186(1.08); C191(0.98)  LDD0785  [35]
 LDCM0596  Fragment38 Ramos C680(0.99); C42(0.44); C53(0.70); 2.82  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C680(0.94); C42(1.08); C53(0.95); C645(0.83)  LDD2184  [37]
 LDCM0427  Fragment51 HCT 116 C106(1.02); C129(0.38); C186(0.92); C191(1.03)  LDD0744  [35]
 LDCM0610  Fragment52 Ramos C680(1.35); C42(0.43); C53(1.07); C645(1.36)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C680(1.71); C42(0.46); C53(0.89); C645(0.66)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C680(1.31); C42(0.95); C53(0.48); 0.97  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C680(0.88); C42(0.78); C53(0.66); 2.06  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y37(0.78)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y37(0.95)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y37(0.81)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y37(0.88)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y37(1.04)  LDD0268  [14]
 LDCM0107  IAA HeLa H421(0.00); H212(0.00); C42(0.00); H423(0.00)  LDD0221  [29]
 LDCM0123  JWB131 DM93 Y37(1.12)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y37(1.25)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y37(1.40)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y37(4.05)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y37(2.25)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y37(1.63)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y37(1.07)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y37(1.49)  LDD0292  [13]
 LDCM0022  KB02 HEK-293T C506(1.04); C680(0.92); C191(0.96); C464(0.94)  LDD1492  [36]
 LDCM0023  KB03 Jurkat C680(1,106.74); C733(433.79); C645(36.86)  LDD0209  [12]
 LDCM0024  KB05 COLO792 C703(1.56); C88(1.32); C552(1.52); C785(2.19)  LDD3310  [38]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C739(0.93); C506(1.27)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C739(0.52)  LDD2121  [8]
 LDCM0109  NEM HeLa H421(0.00); H423(0.00); H212(0.00); H167(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C739(0.67)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C506(1.20)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C739(0.87); C506(0.88)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C739(0.92); C506(0.88)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C739(0.96); C506(1.44)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C506(0.66)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C739(0.89)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C739(0.97); C506(0.42)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C739(0.95); C506(0.89); C680(1.43); C365(1.06)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C42(0.94)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C739(0.72); C506(0.81)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C506(1.01); C464(1.16)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C739(1.58)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C739(0.87); C506(0.96)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C739(0.72); C506(0.61)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C739(0.88); C506(1.03); C680(0.78)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C739(0.95); C42(1.00)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C739(0.49); C506(0.69)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C506(0.81)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C506(0.84)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C739(1.82); C506(2.20); C680(1.83)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C506(0.83)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C739(0.73); C506(0.77); C365(1.08)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C506(0.67)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C739(0.82); C506(0.70); C680(0.98)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C506(0.71)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C739(1.05); C506(0.96)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C506(0.82)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C739(0.94); C506(0.81)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C739(0.55); C506(0.51)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C739(0.43); C506(0.68)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C739(1.09); C506(0.98)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C506(1.02)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C739(0.94); C506(0.94); C680(0.67); C464(1.04)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C739(1.32); C506(1.29); C680(1.05)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C739(0.73); C506(0.80)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C739(1.05); C42(1.92)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C506(0.99)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C739(2.48); C506(2.64); C680(2.74)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C42(0.18)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C739(0.91); C506(0.76)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C739(0.44); C506(0.75)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C506(0.80)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C506(0.45)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C506(0.91)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C506(1.11)  LDD2153  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C730(1.05)  LDD2207  [39]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Protein HID1 (HID1) Hid-1 family Q8IV36

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
21 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
25 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
26 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
27 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
28 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
29 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
30 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD038010
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