Details of the Target

General Information of Target

Target ID LDTP05997
Target Name Beta-1-syntrophin (SNTB1)
Gene Name SNTB1
Gene ID 6641
Synonyms
SNT2B1; Beta-1-syntrophin; 59 kDa dystrophin-associated protein A1 basic component 1; DAPA1B; BSYN2; Syntrophin-2; Tax interaction protein 43; TIP-43
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGI
GTATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQEL
GGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQAL
KRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRD
RKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDL
LTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMP
RRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRD
LSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQ
SPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA
Target Bioclass
Other
Family
Syntrophin family
Subcellular location
Cell membrane, sarcolemma
Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Uniprot ID
Q13884
Ensemble ID
ENST00000395601.7
HGNC ID
HGNC:11168

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL78 SNV: p.M248I .
CCK81 SNV: p.V156M .
MEWO SNV: p.E213K; p.S422F .
NCIH1650 SNV: p.E336D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		18.68  LDD0235  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
AHL-Pu-1
 Probe Info  		C69(2.22)  LDD0171  [4]
DBIA
 Probe Info  		C69(1.14)  LDD1508  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C69(2.22)  LDD0171  [4]
 LDCM0215  AC10 HEK-293T C69(1.14)  LDD1508  [5]
 LDCM0270  AC15 HEK-293T C69(0.77)  LDD1513  [5]
 LDCM0277  AC18 HEK-293T C69(1.00)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C69(1.05)  LDD1518  [5]
 LDCM0283  AC23 HEK-293T C69(1.13)  LDD1522  [5]
 LDCM0286  AC26 HEK-293T C69(1.47)  LDD1525  [5]
 LDCM0292  AC31 HEK-293T C69(0.94)  LDD1531  [5]
 LDCM0295  AC34 HEK-293T C69(1.33)  LDD1534  [5]
 LDCM0300  AC39 HEK-293T C69(0.70)  LDD1539  [5]
 LDCM0304  AC42 HEK-293T C69(1.19)  LDD1543  [5]
 LDCM0309  AC47 HEK-293T C69(0.96)  LDD1548  [5]
 LDCM0313  AC50 HEK-293T C69(1.14)  LDD1552  [5]
 LDCM0318  AC55 HEK-293T C69(0.98)  LDD1557  [5]
 LDCM0321  AC58 HEK-293T C69(1.04)  LDD1560  [5]
 LDCM0327  AC63 HEK-293T C69(0.82)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C69(0.98)  LDD1568  [5]
 LDCM0156  Aniline NCI-H1299 12.24  LDD0403  [1]
 LDCM0371  CL102 HEK-293T C69(1.36)  LDD1575  [5]
 LDCM0375  CL106 HEK-293T C69(1.11)  LDD1579  [5]
 LDCM0379  CL11 HEK-293T C69(0.94)  LDD1583  [5]
 LDCM0380  CL110 HEK-293T C69(1.03)  LDD1584  [5]
 LDCM0384  CL114 HEK-293T C69(1.39)  LDD1588  [5]
 LDCM0388  CL118 HEK-293T C69(1.05)  LDD1592  [5]
 LDCM0393  CL122 HEK-293T C69(1.70)  LDD1597  [5]
 LDCM0397  CL126 HEK-293T C69(1.12)  LDD1601  [5]
 LDCM0401  CL14 HEK-293T C69(1.98)  LDD1605  [5]
 LDCM0405  CL18 HEK-293T C69(1.09)  LDD1609  [5]
 LDCM0407  CL2 HEK-293T C69(1.26)  LDD1611  [5]
 LDCM0411  CL23 HEK-293T C69(0.95)  LDD1615  [5]
 LDCM0414  CL26 HEK-293T C69(1.09)  LDD1618  [5]
 LDCM0419  CL30 HEK-293T C69(1.26)  LDD1623  [5]
 LDCM0424  CL35 HEK-293T C69(0.87)  LDD1628  [5]
 LDCM0432  CL42 HEK-293T C69(1.09)  LDD1636  [5]
 LDCM0437  CL47 HEK-293T C69(1.09)  LDD1641  [5]
 LDCM0441  CL50 HEK-293T C69(1.09)  LDD1645  [5]
 LDCM0445  CL54 HEK-293T C69(1.05)  LDD1648  [5]
 LDCM0450  CL59 HEK-293T C69(0.95)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C69(1.08)  LDD1654  [5]
 LDCM0454  CL62 HEK-293T C69(1.23)  LDD1657  [5]
 LDCM0458  CL66 HEK-293T C69(1.10)  LDD1661  [5]
 LDCM0464  CL71 HEK-293T C69(0.95)  LDD1667  [5]
 LDCM0467  CL74 HEK-293T C69(1.10)  LDD1670  [5]
 LDCM0471  CL78 HEK-293T C69(1.09)  LDD1674  [5]
 LDCM0477  CL83 HEK-293T C69(0.86)  LDD1680  [5]
 LDCM0480  CL86 HEK-293T C69(1.11)  LDD1683  [5]
 LDCM0485  CL90 HEK-293T C69(0.85)  LDD1688  [5]
 LDCM0490  CL95 HEK-293T C69(0.71)  LDD1693  [5]
 LDCM0493  CL98 HEK-293T C69(1.33)  LDD1696  [5]
 LDCM0427  Fragment51 HEK-293T C69(1.29)  LDD1631  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid-transporting ATPase ABCA1 (ABCA1) ABCA family O95477
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dystrophin (DMD) . P11532

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402