Details of the Target

General Information of Target

Target ID LDTP12319
Target Name Serine--tRNA ligase, mitochondrial (SARS2)
Gene Name SARS2
Gene ID 54938
Synonyms
SARSM; Serine--tRNA ligase, mitochondrial; EC 6.1.1.11; SerRSmt; Seryl-tRNA synthetase; SerRS; Seryl-tRNA(Ser/Sec) synthetase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSINLTVDIYIYLLSNARSVCGKQRSKQLYFLFSPKHYWRISHISLQRGFHTNIIRCKWT
KSEAHSCSKHCYSPSNHGLHIGILKLSTSAPKGLTKVNICMSRIKSTLNSVSKAVFGNQN
EMISRLAQFKPSSQILRKVSDSGWLKQKNIKQAIKSLKKYSDKSAEKSPFPEEKSHIIDK
EEDIGKRSLFHYTSSITTKFGDSFYFLSNHINSYFKRKEKMSQQKENEHFRDKSELEDKK
VEEGKLRSPDPGILAYKPGSESVHTVDKPTSPSAIPDVLQVSTKQSIANFLSRPTEGVQA
LVGGYIGGLVPKLKYDSKSQSEEQEEPAKTDQAVSKDRNAEEKKRLSLQREKIIARVSID
NRTRALVQALRRTTDPKLCITRVEELTFHLLEFPEGKGVAVKERIIPYLLRLRQIKDETL
QAAVREILALIGYVDPVKGRGIRILSIDGGGTRGVVALQTLRKLVELTQKPVHQLFDYIC
GVSTGAILAFMLGLFHMPLDECEELYRKLGSDVFSQNVIVGTVKMSWSHAFYDSQTWENI
LKDRMGSALMIETARNPTCPKVAAVSTIVNRGITPKAFVFRNYGHFPGINSHYLGGCQYK
MWQAIRASSAAPGYFAEYALGNDLHQDGGLLLNNPSALAMHECKCLWPDVPLECIVSLGT
GRYESDVRNTVTYTSLKTKLSNVINSATDTEEVHIMLDGLLPPDTYFRFNPVMCENIPLD
ESRNEKLDQLQLEGLKYIERNEQKMKKVAKILSQEKTTLQKINDWIKLKTDMYEGLPFFS
KL
Target Bioclass
Enzyme
Family
Class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily
Subcellular location
Mitochondrion matrix
Function
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Uniprot ID
Q9NP81
Ensemble ID
ENST00000221431.11
HGNC ID
HGNC:17697

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MELHO Substitution: p.R316_D317delinsSP DBIA    Probe Info 
MEWO Substitution: p.D317P DBIA    Probe Info 
MFE319 SNV: p.T246A DBIA    Probe Info 
NCIH2172 SNV: p.R155T DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.96  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
W1
 Probe Info  		49.40  LDD0235  [3]
TH211
 Probe Info  		Y52(7.48)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K110(0.70); K147(6.55); K195(9.40)  LDD0277  [6]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0384  [7]
BTD
 Probe Info  		C64(1.67)  LDD2136  [8]
AHL-Pu-1
 Probe Info  		C66(15.59)  LDD0170  [9]
DBIA
 Probe Info  		C328(12.04)  LDD0209  [10]
5E-2FA
 Probe Info  		H72(0.00); H175(0.00); H190(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		N.A.  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C425(0.00); C272(0.00); C64(0.00); C66(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C425(0.00); C272(0.00); C324(0.00); C328(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		C66(0.00); C425(0.00); C64(0.00)  LDD0026  [15]
NAIA_4
 Probe Info  		N.A.  LDD2226  [16]
TFBX
 Probe Info  		C425(0.00); C272(0.00)  LDD0027  [15]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
IPM
 Probe Info  		N.A.  LDD0005  [18]
NHS
 Probe Info  		N.A.  LDD0010  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
Acrolein
 Probe Info  		C425(0.00); C66(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		C425(0.00); H226(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		C425(0.00); C66(0.00)  LDD0218  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [16]
TPP-AC
 Probe Info  		N.A.  LDD0427  [22]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [23]
FFF probe2
 Probe Info  		10.54  LDD0463  [23]
FFF probe3
 Probe Info  		8.77  LDD0465  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C66(15.59)  LDD0170  [9]
 LDCM0214  AC1 HEK-293T C425(0.92); C455(0.90); C328(0.89); C64(1.01)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C425(1.09); C328(1.04); C64(0.87)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C425(1.07); C272(0.99); C455(1.08); C328(1.10)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C425(0.98); C455(1.13); C328(1.03); C64(0.97)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C425(1.07); C272(0.98); C328(0.99); C64(0.94)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C425(1.20); C272(0.97); C455(1.06); C328(1.04)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C425(0.96); C455(0.85); C328(0.92); C64(1.05)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C425(0.99); C328(0.94); C64(0.98)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C425(0.65); C272(0.64); C455(0.84); C328(0.44)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C425(1.04); C328(1.19); C64(0.95)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C425(1.11); C455(0.99); C328(0.95); C64(0.98)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C425(1.00); C272(1.05); C455(0.97); C328(0.94)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C425(1.00); C272(1.00); C328(0.95); C64(0.94)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C425(1.23); C272(1.15); C455(1.19); C328(1.18)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C425(1.07); C272(1.25); C455(0.99); C328(1.25)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C425(0.93); C455(0.91); C328(1.00); C64(0.93)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C425(1.01); C328(1.06); C64(0.95)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C425(0.93); C272(0.89); C455(0.92); C328(0.88)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C425(0.99); C455(1.26); C328(0.92); C64(1.11)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C425(0.97); C272(1.09); C455(0.93); C328(0.96)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C425(0.98); C272(1.09); C455(0.91); C328(0.89)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C425(1.07); C272(1.06); C328(1.08); C64(0.95)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C425(1.13); C272(0.98); C455(0.88); C328(1.13)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C425(0.96); C272(1.14); C455(0.97); C328(1.17)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C425(0.97); C455(0.94); C328(1.02); C64(0.98)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C425(1.14); C328(1.09); C64(1.06)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C425(1.05); C272(1.11); C455(0.96); C328(1.06)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C425(1.01); C455(1.14); C328(0.98); C64(0.95)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C425(1.08); C272(0.93); C455(1.20); C328(1.27)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C425(1.07); C272(1.20); C328(1.12); C64(0.92)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C425(1.22); C272(1.07); C455(0.84); C328(0.97)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C425(1.13); C455(1.22); C328(0.97); C64(1.01)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C425(1.02); C272(0.92); C455(1.02); C328(1.11)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C425(1.06); C455(0.95); C328(0.97); C64(1.02)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C425(1.05); C328(1.05); C64(0.98)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C425(1.17); C272(1.04); C455(1.06); C328(1.05)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C425(1.13); C455(1.13); C328(1.07); C64(0.91)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C425(1.07); C272(1.02); C455(1.10); C328(0.97)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C425(1.17); C272(0.75); C328(1.19); C64(1.01)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C425(1.16); C272(1.26); C455(0.98); C328(0.87)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C425(0.99); C272(1.08); C455(1.00); C328(1.13)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C425(1.06); C455(0.97); C328(0.95); C64(0.98)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C425(1.00); C272(1.58); C455(1.04); C328(0.88)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C425(1.12); C328(1.13); C64(1.05)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C425(1.06); C272(1.09); C455(1.03); C328(1.01)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C425(1.17); C455(0.96); C328(0.96); C64(1.05)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C425(1.12); C272(1.35); C455(1.04); C328(1.04)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C425(1.16); C272(0.96); C328(0.98); C64(0.90)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C425(1.34); C272(1.05); C455(1.04); C328(1.03)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C425(1.04); C272(1.07); C455(1.05); C328(1.08)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C425(0.97); C455(1.12); C328(1.12); C64(1.19)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C425(1.10); C328(1.11); C64(1.02)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C425(1.13); C272(1.16); C455(1.01); C328(0.95)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C425(1.02); C272(0.89); C328(1.08); C64(0.86)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C425(1.04); C455(0.97); C328(1.00); C64(1.04)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C425(0.96); C272(1.01); C455(1.10); C328(1.15)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C425(1.14); C272(1.32); C328(1.19); C64(0.96)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C425(1.22); C272(1.00); C455(1.11); C328(1.17)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C425(0.98); C272(1.30); C455(1.19); C328(1.20)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C425(1.19); C272(1.03); C455(0.80); C328(1.14)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C425(0.94); C272(1.14); C455(1.06); C328(0.90)  LDD1569  [24]
 LDCM0248  AKOS034007472 HEK-293T C425(1.10); C272(1.04); C455(1.25); C328(1.03)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C425(0.99); C455(1.08); C328(0.99); C64(1.04)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C425(0.96); C272(1.03); C455(0.91); C328(1.08)  LDD1514  [24]
 LDCM0156  Aniline NCI-H1299 11.57  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C64(1.25)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa C64(0.00); C66(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C425(1.23); C272(1.26); C455(1.03); C328(1.20)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C425(1.33); C272(0.65); C328(0.88); C64(1.06)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C425(0.91); C272(1.08); C455(1.02); C328(1.06)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C425(1.08); C272(1.16); C455(1.04); C328(1.01)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C425(0.99); C272(0.92); C455(1.01); C328(0.97)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C425(0.93); C455(0.99); C328(1.02); C64(0.98)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C425(0.99); C272(1.02); C455(1.04); C328(0.98)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C425(1.11); C272(0.95); C455(1.00); C328(1.04)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C425(0.91); C272(1.01); C455(0.94); C328(1.02)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C425(0.95); C455(1.01); C328(0.97); C64(1.00)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C425(1.08); C272(1.00); C455(0.89); C328(0.95)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C425(1.26); C272(0.78); C455(1.00); C328(1.07)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C425(1.24); C272(0.75); C455(0.88); C328(0.90)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C425(0.96); C272(0.71); C455(0.96); C328(0.87)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C425(0.73); C455(0.91); C328(0.97); C64(0.80)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C425(1.00); C272(0.94); C455(1.02); C328(0.96)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C425(1.03); C272(0.82); C455(0.95); C328(1.05)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C425(1.00); C272(1.12); C455(1.06); C328(0.88)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C425(0.99); C455(1.03); C328(1.06); C64(0.95)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C425(1.03); C272(1.14); C455(1.04); C328(1.05)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C425(1.02); C272(1.53); C455(1.11); C328(1.06)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C425(1.01); C272(0.89); C455(0.96); C328(0.93)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C425(1.06); C455(1.04); C328(1.01); C64(0.97)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C425(0.91); C272(0.68); C455(1.12); C328(1.01)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C425(1.08); C272(1.35); C455(0.94); C328(1.10)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C425(1.16); C272(1.02); C455(1.13); C328(1.12)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C425(0.98); C272(1.02); C455(1.05); C328(0.88)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C425(0.96); C455(0.94); C328(0.94); C64(0.95)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C425(0.92); C272(1.40); C455(1.06); C328(0.94)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C425(1.19); C272(0.93); C455(1.39); C328(1.26)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C425(1.08); C272(1.14); C455(1.09); C328(1.07)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C425(1.06); C455(1.06); C328(1.10); C64(0.92)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C425(1.10); C272(1.17); C455(1.04); C328(1.11)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C425(0.98); C272(1.22); C455(1.08); C328(0.86)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C425(1.18); C272(0.99); C455(1.06); C328(1.16)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C425(0.81); C455(0.97); C328(0.81); C64(0.80)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C425(0.99); C272(0.94); C455(1.04); C328(1.14)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C425(0.99); C455(0.86); C328(0.82); C64(0.90)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C425(1.14); C328(1.09); C64(1.11)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C425(1.25); C272(0.85); C455(1.09); C328(0.95)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C425(1.10); C272(0.79); C455(1.03); C328(0.98)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C425(1.20); C455(0.98); C328(0.81); C64(1.05)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C425(1.44); C272(1.16); C455(1.24); C328(0.94)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C425(1.13); C272(0.70); C328(1.06); C64(1.12)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C425(1.07); C272(0.86); C455(0.98); C328(0.95)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C425(0.85); C272(0.78); C455(1.13); C328(0.94)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C425(0.96); C272(0.72); C455(1.26); C328(0.96)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C425(0.87); C272(1.10); C455(0.85); C328(0.87)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C425(0.92); C455(1.05); C328(1.00); C64(0.91)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C425(0.85); C272(1.18); C455(1.12); C328(0.99)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C425(0.97); C455(0.95); C328(1.11); C64(0.90)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C425(1.10); C455(1.00); C328(0.84); C64(1.01)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C425(0.96); C328(1.04); C64(1.02)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C425(1.05); C272(0.90); C455(0.98); C328(0.93)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C425(0.99); C455(0.95); C328(0.87); C64(1.01)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C425(1.47); C272(0.99); C455(1.27); C328(0.89)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C425(0.99); C272(0.78); C328(0.98); C64(1.06)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C425(1.04); C272(0.73); C455(0.75); C328(0.97)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C425(0.88); C272(0.81); C455(1.02); C328(0.95)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C425(1.11); C272(1.24); C455(1.13); C328(1.18)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C425(1.03); C455(1.05); C328(1.09); C64(0.94)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C425(0.93); C272(1.07); C455(1.04); C328(0.96)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C425(1.06); C272(1.44); C455(0.93); C328(1.12)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C425(1.05); C455(0.85); C328(1.15); C64(1.23)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C425(0.99); C328(1.15); C64(0.96)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C425(1.02); C272(0.85); C455(1.05); C328(1.01)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C425(1.34); C455(0.89); C328(0.98); C64(1.12)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C425(1.09); C272(0.86); C455(1.05); C328(1.04)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C425(1.00); C272(0.71); C328(1.13); C64(1.13)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C425(1.11); C272(0.72); C455(0.72); C328(1.05)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C425(0.84); C272(0.72); C455(1.05); C328(1.18)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C425(0.89); C272(1.21); C455(1.17); C328(1.13)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C425(0.99); C455(0.89); C328(0.85); C64(0.98)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C425(0.89); C272(1.00); C455(0.87); C328(0.99)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C425(0.88); C272(0.92); C455(0.90); C328(1.14)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C425(0.97); C455(0.80); C328(0.90); C64(0.86)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C425(1.17); C328(0.99); C64(1.00)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C425(1.05); C272(0.77); C455(0.95); C328(1.00)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C425(0.92); C455(0.93); C328(0.95); C64(0.98)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C425(1.10); C272(0.64); C455(1.09); C328(0.75)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C425(0.94); C272(0.52); C328(0.87); C64(0.97)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C425(1.12); C272(0.83); C455(0.80); C328(1.10)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C425(1.17); C328(0.96); C64(1.10)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C425(0.86); C272(0.79); C455(0.99); C328(1.00)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C425(0.84); C272(0.83); C455(1.03); C328(1.16)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C425(1.12); C272(1.70); C455(1.00); C328(1.00)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C425(1.12); C455(1.08); C328(1.12); C64(0.92)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C425(0.91); C272(1.08); C455(0.88); C328(1.06)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C425(0.95); C455(0.86); C328(1.03); C64(0.90)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C425(1.10); C328(1.09); C64(1.04)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C425(1.21); C272(1.04); C455(0.93); C328(1.13)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C425(1.13); C455(0.95); C328(1.00); C64(1.01)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C425(1.10); C272(0.96); C455(1.08); C328(1.03)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C425(1.22); C272(0.94); C455(1.02); C328(0.85)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C425(0.93); C272(0.83); C328(1.21); C64(1.13)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C425(1.35); C272(0.73); C455(0.91); C328(1.00)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C425(0.90); C272(0.74); C455(1.13); C328(1.01)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C425(0.97); C272(0.74); C455(1.24); C328(1.13)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C425(1.10); C272(1.37); C455(1.15); C328(1.08)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C425(0.85); C272(1.09); C455(1.08); C328(1.07)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C425(1.02); C455(1.05); C328(0.95); C64(1.09)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C425(1.01); C328(0.97); C64(0.94)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C425(1.17); C272(0.88); C455(1.02); C328(0.94)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C425(1.34); C455(0.82); C328(1.16); C64(1.12)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C425(1.04); C455(0.91); C328(0.89); C64(0.95)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C425(1.09); C272(1.03); C455(1.18); C328(1.02)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C425(0.92); C272(0.92); C328(1.26); C64(1.02)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C425(1.10); C272(0.80); C455(0.81); C328(0.98)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C425(1.01); C272(0.86); C455(1.08); C328(1.05)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C425(1.02); C272(0.96); C455(1.26); C328(1.13)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C425(1.02); C272(0.98); C455(1.17); C328(1.00)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C425(1.08); C455(1.33); C328(1.07); C64(1.03)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C425(1.22); C272(1.39); C455(1.03); C328(1.13)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C425(1.03); C455(1.05); C328(1.06); C64(1.04)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C425(1.09); C272(0.83); C455(1.20); C328(0.90)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C425(1.09); C328(0.79); C64(0.90)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C425(1.21); C272(1.05); C455(1.17); C328(0.96)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C425(1.13); C455(0.85); C328(0.97); C64(0.90)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C425(1.24); C272(0.97); C455(1.16); C328(0.91)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C425(0.99); C272(0.90); C328(1.04); C64(0.96)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C425(1.22); C272(0.73); C455(0.70); C328(0.85)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C425(1.30); C272(0.79); C455(1.24); C328(1.02)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C425(1.25); C272(1.00); C455(1.04); C328(1.01)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C425(1.04); C272(0.85); C455(1.03); C328(0.97)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C425(0.97); C455(1.08); C328(0.89); C64(0.91)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C425(1.02); C455(1.01); C328(1.04); C64(0.94)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C328(2.50)  LDD1702  [8]
 LDCM0204  EV-97 T cell C64, C66(12.96)  LDD0525  [26]
 LDCM0625  F8 Ramos C272(1.00); C425(1.21)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C272(1.01); 0.89  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C272(0.24); 0.32  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C272(0.80); 0.87  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C272(0.89); 1.20  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C272(0.82); 3.52  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C272(0.71); 0.72  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C272(0.92); 0.88  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C272(0.78); 1.06  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C272(0.96); 1.41  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C272(0.93); 0.93  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C272(1.04); 0.93  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C272(0.94); 1.17  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C272(1.07)  LDD2201  [27]
 LDCM0468  Fragment33 HEK-293T C425(1.08); C455(1.00); C328(1.06); C64(0.97)  LDD1671  [24]
 LDCM0596  Fragment38 Ramos C272(0.80); 0.57  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C272(0.90)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C425(0.98); C272(0.98); C455(1.30); C328(1.13)  LDD1631  [24]
 LDCM0610  Fragment52 Ramos C272(0.89); 1.43  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C272(0.86); 0.87  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C272(1.29); C425(0.84)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C272(0.90)  LDD2188  [27]
 LDCM0107  IAA HeLa H226(0.00); H175(0.00); H72(0.00)  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C425(1.00); C272(1.15); C66(1.06); C64(0.99)  LDD1492  [24]
 LDCM0023  KB03 Jurkat C328(12.04)  LDD0209  [10]
 LDCM0024  KB05 HMCB C427(2.37); C274(1.61)  LDD3312  [28]
 LDCM0109  NEM HeLa N.A.  LDD0223  [20]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C64(1.67)  LDD2136  [8]
 LDCM0099  Phenelzine MDA-MB-231 20.00  LDD0384  [7]
 LDCM0112  W16 Hep-G2 C64(0.60); C66(0.60)  LDD0239  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840