Details of the Target

General Information of Target

Target ID LDTP03509
Target Name Endoplasmic reticulum resident protein 29 (ERP29)
Gene Name ERP29
Gene ID 10961
Synonyms
C12orf8; ERP28; Endoplasmic reticulum resident protein 29; ERp29; Endoplasmic reticulum resident protein 28; ERp28; Endoplasmic reticulum resident protein 31; ERp31
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MAAAVPRAAFLSPLLPLLLGFLLLSAPHGGSGLHTKGALPLDTVTFYKVIPKSKFVLVKF
DTQYPYGEKQDEFKRLAENSASSDDLLVAEVGISDYGDKLNMELSEKYKLDKESYPVFYL
FRDGDFENPVPYTGAVKVGAIQRWLKGQGVYLGMPGCLPVYDALAGEFIRASGVEARQAL
LKQGQDNLSSVKETQKKWAEQYLKIMGKILDQGEDFPASEMTRIARLIEKNKMSDGKKEE
LQKSLNILTAFQKKGAEKEEL
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum lumen
Function
Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER.
Uniprot ID
P30040
Ensemble ID
ENST00000261735.4
HGNC ID
HGNC:13799

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RKO SNV: p.I141T DBIA    Probe Info 
RL952 SNV: p.G255R DBIA    Probe Info 
SW948 SNV: p.A2V DBIA    Probe Info 
TE8 Deletion: p.E200SfsTer4 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.16  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
W1
 Probe Info  		10.73  LDD0235  [3]
TH211
 Probe Info  		Y64(17.45); Y66(16.36)  LDD0260  [4]
C-Sul
 Probe Info  		6.13  LDD0066  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
ONAyne
 Probe Info  		K107(6.39)  LDD0275  [7]
OPA-S-S-alkyne
 Probe Info  		K137(6.12)  LDD3494  [8]
Probe 1
 Probe Info  		Y64(267.85); Y66(87.35); Y96(17.67); Y119(7.87)  LDD3495  [9]
HHS-482
 Probe Info  		Y64(1.32); Y66(0.97)  LDD0285  [10]
HHS-475
 Probe Info  		Y151(0.60); Y66(0.72); Y47(1.01); Y64(1.35)  LDD0264  [11]
HHS-465
 Probe Info  		Y64(10.00)  LDD2237  [12]
DBIA
 Probe Info  		C157(1.06)  LDD0531  [13]
ATP probe
 Probe Info  		K137(0.00); K204(0.00); K208(0.00); K69(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
IPM
 Probe Info  		N.A.  LDD0147  [17]
NHS
 Probe Info  		K243(0.00); K192(0.00)  LDD0010  [18]
SF
 Probe Info  		Y64(0.00); Y66(0.00)  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		K137(0.00); K243(0.00)  LDD0228  [21]
MPP-AC
 Probe Info  		N.A.  LDD0428  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [23]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
TPP-AC
 Probe Info  		N.A.  LDD0427  [22]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		12.70  LDD0471  [24]
FFF probe12
 Probe Info  		12.06  LDD0473  [24]
FFF probe13
 Probe Info  		8.84  LDD0475  [24]
FFF probe14
 Probe Info  		12.69  LDD0477  [24]
FFF probe2
 Probe Info  		9.36  LDD0463  [24]
FFF probe3
 Probe Info  		6.56  LDD0464  [24]
JN0003
 Probe Info  		9.07  LDD0469  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]
OEA-DA
 Probe Info  		7.05  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C157(1.06)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C157(1.29)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C157(0.84)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C157(0.81)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C157(0.83)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C157(1.17)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C157(1.04)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C157(0.98)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C157(0.75)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C157(1.02)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C157(0.76)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C157(0.88)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C157(1.19)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C157(0.78)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C157(0.82)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C157(1.03)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C157(1.09)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C157(1.08)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C157(1.25)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C157(1.21)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C157(1.11)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C157(1.13)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C157(1.18)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C157(1.12)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C157(1.26)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C157(1.02)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C157(0.92)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C157(0.91)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C157(1.16)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C157(1.25)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C157(1.19)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C157(1.01)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C157(0.98)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C157(0.68)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C157(0.84)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C157(0.75)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C157(0.81)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C157(0.89)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C157(0.92)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C157(0.91)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C157(0.99)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C157(0.87)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C157(0.99)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C157(0.81)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C157(1.39)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C157(0.98)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C157(0.85)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C157(0.81)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C157(1.03)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C157(1.13)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C157(0.91)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C157(1.40)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C157(1.24)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C157(0.97)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C157(1.10)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C157(1.32)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C157(1.31)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C157(1.01)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C157(1.11)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C157(0.69)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C157(1.14)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C157(1.13)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C157(1.12)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C157(1.05)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C157(0.96)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C157(0.98)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C157(0.93)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C157(1.25)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C157(0.97)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C157(0.90)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C157(0.85)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C157(0.96)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C157(1.09)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C157(0.88)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C157(0.97)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C157(1.09)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C157(1.10)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C157(1.13)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C157(1.09)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C157(1.68)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C157(1.28)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C157(1.28)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C157(1.18)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C157(1.55)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C157(0.79)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C157(1.04)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C157(0.96)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C157(0.95)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C157(1.08)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C157(1.15)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C157(0.97)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C157(0.90)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C157(0.91)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C157(1.05)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C157(1.01)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C157(1.09)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C157(0.96)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C157(1.07)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C157(1.45)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C157(0.80)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C157(1.11)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C157(0.70)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C157(0.78)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C157(1.03)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C157(0.97)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C157(0.99)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C157(0.79)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C157(0.41)  LDD0636  [13]
 LDCM0320  AC57 HEK-293T C157(1.04)  LDD0918  [13]
 LDCM0321  AC58 HEK-293T C157(0.95)  LDD0919  [13]
 LDCM0322  AC59 HEK-293T C157(0.88)  LDD0920  [13]
 LDCM0323  AC6 HCT 116 C157(1.61)  LDD0640  [13]
 LDCM0324  AC60 HEK-293T C157(0.91)  LDD0922  [13]
 LDCM0325  AC61 HEK-293T C157(2.01)  LDD0923  [13]
 LDCM0326  AC62 HEK-293T C157(1.05)  LDD0924  [13]
 LDCM0327  AC63 HEK-293T C157(1.15)  LDD0925  [13]
 LDCM0328  AC64 HEK-293T C157(0.91)  LDD0926  [13]
 LDCM0329  AC65 HEK-293T C157(1.03)  LDD0927  [13]
 LDCM0330  AC66 HEK-293T C157(0.85)  LDD0928  [13]
 LDCM0331  AC67 HEK-293T C157(0.93)  LDD0929  [13]
 LDCM0332  AC68 HCT 116 C157(1.08)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C157(0.86)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C157(1.41)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C157(1.15)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C157(1.28)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C157(0.70)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C157(0.80)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C157(0.72)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C157(0.40)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C157(2.34)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C157(1.24)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C157(1.08)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C157(1.62)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C157(1.25)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C157(1.34)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C157(0.92)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C157(0.44)  LDD0665  [13]
 LDCM0349  AC83 HEK-293T C157(0.75)  LDD0947  [13]
 LDCM0350  AC84 HEK-293T C157(1.03)  LDD0948  [13]
 LDCM0351  AC85 HEK-293T C157(0.82)  LDD0949  [13]
 LDCM0352  AC86 HEK-293T C157(0.76)  LDD0950  [13]
 LDCM0353  AC87 HEK-293T C157(0.85)  LDD0951  [13]
 LDCM0354  AC88 HEK-293T C157(0.75)  LDD0952  [13]
 LDCM0355  AC89 HEK-293T C157(0.97)  LDD0953  [13]
 LDCM0357  AC90 HEK-293T C157(0.99)  LDD0955  [13]
 LDCM0358  AC91 HEK-293T C157(1.18)  LDD0956  [13]
 LDCM0359  AC92 HEK-293T C157(0.72)  LDD0957  [13]
 LDCM0360  AC93 HEK-293T C157(0.86)  LDD0958  [13]
 LDCM0361  AC94 HEK-293T C157(0.78)  LDD0959  [13]
 LDCM0362  AC95 HEK-293T C157(0.84)  LDD0960  [13]
 LDCM0363  AC96 HEK-293T C157(0.84)  LDD0961  [13]
 LDCM0364  AC97 HEK-293T C157(1.34)  LDD0962  [13]
 LDCM0365  AC98 HCT 116 C157(0.23)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C157(0.63)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C157(1.38)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C157(1.28)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C157(1.40)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 12.49  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C157(0.92)  LDD2171  [13]
 LDCM0367  CL1 HCT 116 C157(0.76)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C157(0.83)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C157(1.12)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C157(1.51)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C157(1.24)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C157(1.24)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C157(1.06)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C157(1.19)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C157(1.40)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C157(1.15)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C157(1.20)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C157(0.99)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C157(0.83)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C157(0.98)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C157(0.89)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C157(1.14)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C157(1.38)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C157(1.79)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C157(1.20)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C157(1.38)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C157(0.64)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C157(1.02)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C157(1.07)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C157(0.72)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C157(1.02)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C157(1.06)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C157(0.84)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C157(0.87)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C157(0.85)  LDD0712  [13]
 LDCM0396  CL125 HEK-293T C157(0.94)  LDD0994  [13]
 LDCM0397  CL126 HEK-293T C157(1.52)  LDD0995  [13]
 LDCM0398  CL127 HEK-293T C157(1.15)  LDD0996  [13]
 LDCM0399  CL128 HEK-293T C157(0.97)  LDD0997  [13]
 LDCM0400  CL13 HCT 116 C157(0.95)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C157(0.78)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C157(0.80)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C157(1.21)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C157(1.13)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C157(1.36)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C157(1.43)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C157(0.90)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C157(1.34)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C157(1.27)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C157(0.50)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C157(1.26)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C157(1.12)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C157(1.37)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C157(1.22)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C157(1.34)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C157(1.69)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C157(1.47)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C157(0.92)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C157(1.15)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C157(0.96)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C157(1.02)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C157(0.79)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C157(0.89)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C157(0.94)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C157(0.97)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C157(0.82)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C157(1.01)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C157(0.88)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C157(1.02)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C157(1.00)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C157(0.41)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C157(0.71)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C157(1.04)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C157(0.93)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C157(0.90)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C157(1.00)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C157(0.93)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C157(0.90)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C157(0.93)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C157(0.89)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C157(0.80)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C157(0.96)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C157(0.83)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C157(0.88)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C157(0.79)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C157(1.26)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C157(0.78)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C157(0.88)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C157(0.89)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C157(0.93)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C157(1.03)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C157(0.98)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C157(0.98)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C157(0.99)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C157(1.15)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C157(1.03)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C157(1.22)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C157(1.22)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C157(1.11)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C157(0.90)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C157(1.01)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C157(1.00)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C157(1.09)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C157(1.14)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C157(1.21)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C157(1.15)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C157(0.93)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C157(1.04)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C157(1.18)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C157(1.17)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C157(0.68)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C157(1.12)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C157(1.15)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C157(0.86)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C157(1.21)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C157(0.57)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C157(1.40)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C157(1.19)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C157(1.31)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C157(1.25)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C157(0.41)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C157(0.84)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C157(0.78)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C157(0.95)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C157(0.89)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C157(1.07)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C157(1.14)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C157(1.12)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C157(1.02)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C157(1.08)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C157(1.09)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C157(1.20)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C157(1.11)  LDD1698  [27]
 LDCM0572  Fragment10 Ramos C157(0.88)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C157(0.52)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C157(0.55)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C157(2.45)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C157(0.95)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C157(0.75)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C157(0.99)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C157(1.23)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C157(0.94)  LDD2197  [28]
 LDCM0588  Fragment30 Ramos C157(1.08)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C157(0.91)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C157(0.67)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C157(1.03)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C157(1.20)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C157(0.55)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C157(0.49)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C157(1.03)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C157(1.64)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C157(1.00)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C157(0.84)  LDD2188  [28]
 LDCM0116  HHS-0101 DM93 Y151(0.60); Y66(0.72); Y47(1.01); Y64(1.35)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y151(0.57); Y64(0.83); Y66(0.90); Y47(0.97)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y66(0.42); Y151(0.52); Y96(0.85); Y64(1.38)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y151(0.63); Y64(0.85); Y47(0.87); Y66(1.15)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y151(0.44); Y47(0.49); Y66(0.53); Y96(0.53)  LDD0268  [11]
 LDCM0123  JWB131 DM93 Y64(1.32); Y66(0.97)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y64(0.84); Y66(0.88)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y64(1.25); Y66(1.11)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y64(4.45); Y66(2.00); Y96(8.06)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y64(2.17); Y66(1.51); Y96(8.74)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y64(1.03); Y66(1.52)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y64(0.55); Y66(0.80)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y64(0.95); Y66(1.36); Y96(8.67)  LDD0292  [10]
 LDCM0022  KB02 HEK-293T C157(1.02)  LDD1492  [27]
 LDCM0023  KB03 HEK-293T C157(1.01)  LDD1497  [27]
 LDCM0024  KB05 COLO792 C157(0.70)  LDD3310  [29]
 LDCM0131  RA190 MM1.R C157(1.42)  LDD0304  [30]
 LDCM0021  THZ1 HCT 116 C157(0.92)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Desumoylating isopeptidase 1 (DESI1) DeSI family Q6ICB0
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Nucleotide sugar transporter SLC35B4 (SLC35B4) Nucleotide-sugar transporter family Q969S0
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Adiponectin (ADIPOQ) . Q15848
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B) . Q9P0W2
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nurim (NRM) Nurim family Q8IXM6
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.