Details of the Target

General Information of Target

Target ID LDTP01208
Target Name Pre-mRNA-processing factor 40 homolog A (PRPF40A)
Gene Name PRPF40A
Gene ID 55660
Synonyms
FBP11; FLAF1; FNBP3; HIP10; HYPA; Pre-mRNA-processing factor 40 homolog A; Fas ligand-associated factor 1; Formin-binding protein 11; Formin-binding protein 3; Huntingtin yeast partner A; Huntingtin-interacting protein 10; HIP-10; Huntingtin-interacting protein A; Renal carcinoma antigen NY-REN-6
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRPGTGAERGGLMVSEMESHPPSQGPGDGERRLSGSSLCSGSWVSADGFLRRRPSMGHPG
MHYAPMGMHPMGQRANMPPVPHGMMPQMMPPMGGPPMGQMPGMMSSVMPGMMMSHMSQAS
MQPALPPGVNSMDVAAGTASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQ
LLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEGYQNTIVAGSLITKSNLHAMI
KAEESSKQEECTTTSTAPVPTTEIPTTMSTMAAAEAAAAVVAAAAAAAAAAAAANANAST
SASNTVSGTVPVVPEPEVTSIVATVVDNENTVTISTEEQAQLTSTPAIQDQSVEVSSNTG
EETSKQETVADFTPKKEEEESQPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMK
MIINDPRYSALAKLSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTST
TRYKKAEQMFGEMEVWNAISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDN
MANVTYSTTWSEAQQYLMDNPTFAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKSL
LRERRRQRKNRESFQIFLDELHEHGQLHSMSSWMELYPTISSDIRFTNMLGQPGSTALDL
FKFYVEDLKARYHDEKKIIKDILKDKGFVVEVNTTFEDFVAIISSTKRSTTLDAGNIKLA
FNSLLEKAEAREREREKEEARKMKRKESAFKSMLKQAAPPIELDAVWEDIRERFVKEPAF
EDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKKHHRKRSRSRSGSDSDDDDSH
SKKKRQRSESRSASEHSSSAESERSYKKSKKHKKKSKKRRHKSDSPESDAEREKDKKEKD
RESEKDRTRQRSESKHKSPKKKTGKDSGNWDTSGSELSEGELEKRRRTLLEQLDDDQ
Target Bioclass
Other
Family
PRPF40 family
Subcellular location
Nucleus speckle
Function
Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing.
Uniprot ID
O75400
Ensemble ID
ENST00000354363.11
HGNC ID
HGNC:16463

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		6.96  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
W1
 Probe Info  		26.47  LDD0235  [4]
Probe 1
 Probe Info  		Y159(225.32); Y388(16.37)  LDD3495  [5]
BTD
 Probe Info  		C185(0.24)  LDD2096  [6]
HHS-475
 Probe Info  		Y221(0.56)  LDD0264  [7]
DBIA
 Probe Info  		C39(1.10)  LDD0078  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K727(0.00); K476(0.00)  LDD0199  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
NAIA_5
 Probe Info  		C185(0.00); C39(0.00)  LDD2224  [12]
1d-yne
 Probe Info  		N.A.  LDD0356  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		K196(0.00); K433(0.00); K727(0.00)  LDD0010  [15]
SF
 Probe Info  		N.A.  LDD0028  [16]
STPyne
 Probe Info  		N.A.  LDD0009  [15]
Phosphinate-6
 Probe Info  		C804(0.00); C39(0.00)  LDD0018  [17]
1c-yne
 Probe Info  		K196(0.00); K755(0.00); K718(0.00)  LDD0228  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
AOyne
 Probe Info  		10.10  LDD0443  [19]
HHS-482
 Probe Info  		Y157(0.56); Y159(0.56); Y198(0.65); Y200(0.70)  LDD2239  [20]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C046
 Probe Info  		45.25  LDD1745  [21]
FFF probe6
 Probe Info  		20.00  LDD0467  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C39(0.88)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C39(1.14)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C39(1.13)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C39(1.42)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C39(0.99)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C39(1.09)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C39(1.22)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C39(1.33)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C39(1.70)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C39(1.61)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C39(1.22)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C39(1.14)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C39(1.35)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C39(1.44)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C39(1.11)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C39(1.14)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C39(1.18)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C39(1.27)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C39(1.19)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C39(1.24)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C39(1.09)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C39(1.50)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C39(1.39)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C39(1.07)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C39(1.22)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C39(1.05)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C39(1.64)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C39(2.55)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C39(1.03)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C39(1.28)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C39(1.26)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C39(1.51)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C39(0.80)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C39(0.83)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C39(0.73)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C39(0.63)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C39(0.72)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C39(0.80)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C39(0.84)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C39(0.78)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C39(0.72)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C39(0.66)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C39(0.63)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C39(1.01)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C39(0.93)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C39(0.75)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C39(0.78)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C39(0.64)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C39(0.89); C580(0.97)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C580(0.76); C39(0.86)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C39(0.75); C580(0.78)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C39(0.93); C580(1.01)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C580(0.80); C39(0.97)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C580(0.51); C39(0.83)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C580(0.64); C39(0.95)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C39(1.10)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C39(0.80); C580(0.94)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C39(0.88); C580(0.98)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C580(0.69); C39(0.87)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C580(0.53); C39(0.75)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C39(0.79); C580(0.75)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C39(0.86); C580(0.82)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C39(0.88); C580(1.12)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C39(0.77); C580(1.07)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C39(0.64); C580(1.04)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C39(0.44); C580(0.62)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C39(0.48); C580(0.85)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C39(1.04)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C39(0.74); C580(1.06)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C39(0.51); C580(0.88)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C39(0.74); C580(1.02)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C39(0.53); C580(0.81)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C39(0.40); C580(1.07)  LDD0601  [8]
 LDCM0285  AC25 HEK-293T C39(1.00)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C39(1.03)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C39(1.01); C804(0.99)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C39(0.93)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C39(0.99)  LDD1528  [24]
 LDCM0290  AC3 HCT 116 C39(0.92)  LDD0607  [8]
 LDCM0291  AC30 HEK-293T C39(0.95)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C39(0.96)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C39(0.97)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C39(1.27)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C39(1.05)  LDD1534  [24]
 LDCM0296  AC35 HCT 116 C580(1.17)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C580(1.05)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C580(1.04)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C580(1.10)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C580(1.14)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C39(0.83)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C580(0.75)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C580(1.09)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C580(0.85)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C580(1.10)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C580(0.83)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C580(0.72)  LDD0624  [8]
 LDCM0308  AC46 HEK-293T C39(0.98)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C39(1.02)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C39(1.04)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C39(1.03)  LDD1550  [24]
 LDCM0312  AC5 HCT 116 C39(0.74)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C39(1.05)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C39(0.95); C804(0.98)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C39(0.97)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C39(0.83)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C39(0.99)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C39(1.01)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C39(1.05)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C39(0.96)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C39(0.67)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C39(0.83)  LDD0920  [8]
 LDCM0323  AC6 HCT 116 C39(1.05)  LDD0640  [8]
 LDCM0324  AC60 HEK-293T C39(0.68)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C39(0.88)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C39(0.83)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C39(0.82)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C39(0.76)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C39(0.76)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C39(0.85)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C39(0.69)  LDD0929  [8]
 LDCM0332  AC68 HCT 116 C39(0.95)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C39(1.30)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C39(1.08)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C39(1.13)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C39(1.04)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C39(1.43)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C39(1.98)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C39(1.54)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C39(2.11)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C39(1.35)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C39(1.55)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C39(1.20)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C39(1.23)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C39(1.13)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C39(1.63)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C39(0.98)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C39(1.61)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C580(0.33); C39(1.69)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C580(0.42); C39(1.12)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C580(0.61); C39(1.50)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C580(0.55); C39(1.33)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C39(1.24); C580(1.27)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C580(0.74); C39(1.36)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C580(0.41); C39(1.60)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C39(1.27); C580(1.28)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C580(0.33); C39(1.63)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C580(0.33); C39(1.60)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C580(0.61); C39(1.34)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C580(0.67); C39(1.19)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C39(1.40); C580(1.78)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C580(0.59); C39(1.62)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C580(0.38); C39(1.48)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C39(1.17)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C39(1.45)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C39(1.04)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C39(1.25)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C39(1.03)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.73  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C39(1.10)  LDD0078  [8]
 LDCM0630  CCW28-3 231MFP C39(1.01)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C185(20.00); C39(1.67); C39(1.31); C39(0.90)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C39(0.80)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C39(0.77)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C39(0.98)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C39(0.95)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C39(1.02)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C39(1.11)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C39(1.05)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C580(0.73); C39(0.75)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C39(0.59); C580(0.67)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C39(0.50); C580(0.66)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C39(0.51); C580(0.58)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C39(0.48); C580(0.80)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C39(1.10)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C39(0.39); C580(0.67)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C39(0.50); C580(0.82)  LDD0698  [8]
 LDCM0382  CL112 HEK-293T C39(0.95)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C39(0.96)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C39(1.12)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C39(0.86)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C39(1.00)  LDD1590  [24]
 LDCM0387  CL117 HCT 116 C580(0.63)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C580(0.86)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C580(0.75)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C39(0.75)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C580(0.95)  LDD0708  [8]
 LDCM0392  CL121 HEK-293T C39(1.00)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C39(0.85)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C39(0.87)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C39(0.93)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C39(0.80)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C39(0.70)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C39(0.95)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C39(0.90)  LDD0997  [8]
 LDCM0400  CL13 HCT 116 C39(0.84)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C39(0.77)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C39(0.91)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C39(0.99)  LDD0720  [8]
 LDCM0404  CL17 HEK-293T C39(1.26)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C39(1.19)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C39(1.13)  LDD1004  [8]
 LDCM0407  CL2 HCT 116 C39(0.89)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C39(1.04)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C39(1.15)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C39(1.29)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C39(0.90)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C39(0.87)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C39(1.15)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C39(0.95)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C39(0.96)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C39(1.05)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C39(1.06)  LDD1015  [8]
 LDCM0418  CL3 HCT 116 C39(0.85)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C39(1.07)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C39(0.98); C804(0.82)  LDD1624  [24]
 LDCM0421  CL32 HCT 116 C39(1.01)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C39(1.47)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C39(1.03)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C39(0.92)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C39(0.92)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C39(0.81)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C39(1.07)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C39(0.85)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C39(1.00)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C39(1.09)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C39(0.83)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C39(0.86)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C39(0.74)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C39(0.77)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C39(1.16)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C39(1.02)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C39(1.00)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C39(0.81)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C39(0.68)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C39(0.84)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C39(0.81)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C39(1.21)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C39(0.95)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C39(1.01)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C39(0.90)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C39(0.77)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C39(0.80)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C39(0.97)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C39(0.88)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C39(0.84)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C39(0.87)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C39(0.99)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C39(0.86)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C39(0.84)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C39(0.94)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C39(1.10)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C39(1.17)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C39(0.97); C804(1.08)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C39(0.98)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C39(0.97)  LDD1664  [24]
 LDCM0462  CL7 HCT 116 C39(0.61)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C39(0.98)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C39(1.15)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C39(1.07)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C39(0.97)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C39(0.92)  LDD1670  [24]
 LDCM0469  CL76 HCT 116 C39(0.96)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C39(0.80)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C39(1.08)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C39(0.85)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C39(1.15)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C39(0.97)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C39(0.79)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C39(0.76)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C39(0.97)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C39(1.00)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C39(0.87)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C39(0.91)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C39(0.84)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C39(0.81)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C39(0.98)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C39(0.80)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C39(1.41)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C39(1.41)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C39(0.89)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C39(0.81)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C39(0.95)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C39(1.61)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C39(0.91)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C39(0.87)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C39(1.00)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C39(1.03)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C39(1.47)  LDD1698  [24]
 LDCM0625  F8 Ramos C39(0.78)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C185(3.01)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C185(0.55)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C185(1.93); C39(1.39)  LDD2191  [26]
 LDCM0576  Fragment14 Ramos C185(0.67); C39(0.79)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C185(1.90)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C185(1.63); C39(0.92)  LDD2195  [26]
 LDCM0578  Fragment27 Ramos C39(0.52)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C185(0.25); C39(2.29)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C185(5.97); C39(0.57)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C185(1.15)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C185(2.78); C39(0.58)  LDD2201  [26]
 LDCM0468  Fragment33 HEK-293T C39(0.93)  LDD1671  [24]
 LDCM0596  Fragment38 Ramos C185(0.94); C39(0.80)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C185(0.92); C39(1.08)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C39(1.01)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C185(0.65); C39(0.76)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C185(1.56); C39(0.80)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C185(0.56); C39(1.89)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C185(2.90)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y221(0.56)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y221(0.44)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y221(0.54)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y221(0.62)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y221(0.80)  LDD0268  [7]
 LDCM0022  KB02 HCT 116 C39(4.50)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C39(2.88)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C39(4.10)  LDD0082  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C185(0.24)  LDD2096  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C185(0.57)  LDD2116  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C185(1.05)  LDD2120  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 34 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) 5'-AMP-activated protein kinase gamma subunit family P54619
N-alpha-acetyltransferase 60 (NAA60) Acetyltransferase family Q9H7X0
Putative aldo-keto reductase family 1 member C8 (AKR1C8) Aldo/keto reductase family Q5T2L2
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
DNA-directed RNA polymerase II subunit RPB9 (POLR2I) Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family P36954
Ubiquitin-like-conjugating enzyme ATG10 (ATG10) ATG10 family Q9H0Y0
Bile acid-CoA:amino acid N-acyltransferase (BAAT) C/M/P thioester hydrolase family Q14032
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
Ethanolamine-phosphate cytidylyltransferase (PCYT2) Cytidylyltransferase family Q99447
Cytochrome P450 2C8 (CYP2C8) Cytochrome P450 family P10632
DNA polymerase alpha subunit B (POLA2) DNA polymerase alpha subunit B family Q14181
Methylthioribose-1-phosphate isomerase (MRI1) EIF-2B alpha/beta/delta subunits family Q9BV20
Eukaryotic translation initiation factor 3 subunit F (EIF3F) EIF-3 subunit F family O00303
Amine oxidase [flavin-containing] B (MAOB) Flavin monoamine oxidase family P27338
Cytochrome c oxidase assembly factor 7 (COA7) Hcp beta-lactamase family Q96BR5
Dihydropyrimidinase-related protein 5 (DPYSL5) Hydantoinase/dihydropyrimidinase family Q9BPU6
Calpain-2 catalytic subunit (CAPN2) Peptidase C2 family P17655
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Tyrosine-protein phosphatase non-receptor type 4 (PTPN4) Protein-tyrosine phosphatase family P29074
E3 ubiquitin-protein ligase RNF10 (RNF10) RNF10 family Q8N5U6
Ribonuclease SLFN12 (SLFN12) Schlafen family Q8IYM2
Dehydrogenase/reductase SDR family member 1 (DHRS1) Short-chain dehydrogenases/reductases (SDR) family Q96LJ7
GTP-binding protein Rheb (RHEB) Rheb family Q15382
Chromodomain-helicase-DNA-binding protein 3 (CHD3) SNF2/RAD54 helicase family Q12873
Protein-glutamine gamma-glutamyltransferase 5 (TGM5) Transglutaminase family O43548
Protein-glutamine gamma-glutamyltransferase K (TGM1) Transglutaminase family P22735
Tubulin alpha-1C chain (TUBA1C) Tubulin family Q9BQE3
Cholinesterase (BCHE) Type-B carboxylesterase/lipase family P06276
Ubiquitin-conjugating enzyme E2 A (UBE2A) Ubiquitin-conjugating enzyme family P49459
Ubiquitin-conjugating enzyme E2 G1 (UBE2G1) Ubiquitin-conjugating enzyme family P62253
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) . Q1L5Z9
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Telomerase-binding protein EST1A (SMG6) . Q86US8
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
45 kDa calcium-binding protein (SDF4) CREC family Q9BRK5
Cilium assembly protein DZIP1 (DZIP1) DZIP C2H2-type zinc-finger protein family Q86YF9
Huntingtin (HTT) Huntingtin family P42858
Peripherin-2 (PRPH2) PRPH2/ROM1 family P23942
Phosphatidylinositol transfer protein beta isoform (PITPNB) PtdIns transfer protein family P48739
Secretory carrier-associated membrane protein 1 (SCAMP1) SCAMP family O15126
Alpha-synuclein (SNCA) Synuclein family P37840
Nucleoporin Nup43 (NUP43) . Q8NFH3
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Homeobox protein DLX-3 (DLX3) Distal-less homeobox family O60479
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 597 (ZNF597) Krueppel C2H2-type zinc-finger protein family Q96LX8
LIM/homeobox protein Lhx5 (LHX5) . Q9H2C1
Myc proto-oncogene protein (MYC) . P01106
Transcription factor p65 (RELA) . Q04206
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet basic protein (PPBP) Intercrine alpha (chemokine CxC) family P02775
Other
Click To Hide/Show 47 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A4 (ANXA4) Annexin family P09525
Splicing factor 1 (SF1) BBP/SF1 family Q15637
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Beta-crystallin B3 (CRYBB3) Beta/gamma-crystallin family P26998
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) CDKN2 cyclin-dependent kinase inhibitor family P42773
Cancer/testis antigen family 45 member A1 (CT45A1) CT45 family Q5HYN5
Cyclin-C (CCNC) Cyclin family P24863
Cyclin-L1 (CCNL1) Cyclin family Q9UK58
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Dedicator of cytokinesis protein 10 (DOCK10) DOCK family Q96BY6
Cilium assembly protein DZIP1L (DZIP1L) DZIP C2H2-type zinc-finger protein family Q8IYY4
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Protein FAM167A (FAM167A) FAM167 (SEC) family Q96KS9
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Cytosolic iron-sulfur assembly component 2B (CIAO2B) MIP18 family Q9Y3D0
NF-kappa-B-activating protein (NKAP) NKAP family Q8N5F7
Perilipin-3 (PLIN3) Perilipin family O60664
SH3 domain-binding protein 5-like (SH3BP5L) SH3BP5 family Q7L8J4
Small integral membrane protein 12 (SMIM12) SMIM12 family Q96EX1
Vacuolar-sorting protein SNF8 (SNF8) SNF8 family Q96H20
SNW domain-containing protein 1 (SNW1) SNW family Q13573
RNA-binding protein 39 (RBM39) Splicing factor SR family Q14498
Splicing regulatory glutamine/lysine-rich protein 1 (SREK1) Splicing factor SR family Q8WXA9
Protein sprouty homolog 4 (SPRY4) Sprouty family Q9C004
CST complex subunit TEN1 (TEN1) TEN1 family Q86WV5
General transcription factor IIH subunit 1 (GTF2H1) TFB1 family P32780
Ankyrin repeat and EF-hand domain-containing protein 1 (ANKEF1) . Q9NU02
Arfaptin-2 (ARFIP2) . P53365
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Cysteine-rich C-terminal protein 1 (CRCT1) . Q9UGL9
FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) . Q6ZNL6
Galectin-9C (LGALS9C) . Q6DKI2
Period circadian protein homolog 1 (PER1) . O15534
PRKCA-binding protein (PICK1) . Q9NRD5
Protein C12orf4 (C12orf4) . Q9NQ89
Protein SPMIP2 (SPMIP2) . Q96LM5
Protein SREK1IP1 (SREK1IP1) . Q8N9Q2
Serine/Arginine-related protein 53 (RSRC1) . Q96IZ7
Spermatogenesis-associated serine-rich protein 1 (SPATS1) . Q496A3
Splicing factor 3A subunit 1 (SF3A1) . Q15459
Syntenin-2 (SDCBP2) . Q9H190
Telethonin (TCAP) . O15273
Testicular spindle-associated protein SHCBP1L (SHCBP1L) . Q9BZQ2
TP53-binding protein 1 (TP53BP1) . Q12888
Uncharacterized protein C3orf36 (C3orf36) . Q3SXR2
Uncharacterized protein NKAPD1 (NKAPD1) . Q6ZUT1
WW domain binding protein 1-like (WBP1L) . Q9NX94

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578