Details of the Target

General Information of Target

Target ID LDTP01584
Target Name Phosphoacetylglucosamine mutase (PGM3)
Gene Name PGM3
Gene ID 5238
Synonyms
AGM1; Phosphoacetylglucosamine mutase; PAGM; EC 5.4.2.3; Acetylglucosamine phosphomutase; N-acetylglucosamine-phosphate mutase; Phosphoglucomutase-3; PGM 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLGAITKYSALHAKPNGLILQYGTAGFRTKAEHLDHVMFRMGLLAVLRSKQTKSTIGVM
VTASHNPEEDNGVKLVDPLGEMLAPSWEEHATCLANAEEQDMQRVLIDISEKEAVNLQQD
AFVVIGRDTRPSSEKLSQSVIDGVTVLGGQFHDYGLLTTPQLHYMVYCRNTGGRYGKATI
EGYYQKLSKAFVELTKQASCSGDEYRSLKVDCANGIGALKLREMEHYFSQGLSVQLFNDG
SKGKLNHLCGADFVKSHQKPPQGMEIKSNERCCSFDGDADRIVYYYHDADGHFHLIDGDK
IATLISSFLKELLVEIGESLNIGVVQTAYANGSSTRYLEEVMKVPVYCTKTGVKHLHHKA
QEFDIGVYFEANGHGTALFSTAVEMKIKQSAEQLEDKKRKAAKMLENIIDLFNQAAGDAI
SDMLVIEAILALKGLTVQQWDALYTDLPNRQLKVQVADRRVISTTDAERQAVTPPGLQEA
INDLVKKYKLSRAFVRPSGTEDVVRVYAEADSQESADHLAHEVSLAVFQLAGGIGERPQP
GF
Target Bioclass
Enzyme
Family
Phosphohexose mutase family
Function
Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.
Uniprot ID
O95394
Ensemble ID
ENST00000506587.5
HGNC ID
HGNC:8907

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.L79M DBIA    Probe Info 
MEWO SNV: p.E223K DBIA    Probe Info 
OVK18 SNV: p.D299Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
W1
 Probe Info  		10.65  LDD0235  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K259(7.14); K354(4.45)  LDD0277  [4]
Probe 1
 Probe Info  		Y183(7.75); Y184(9.72); Y337(22.43)  LDD3495  [5]
DBIA
 Probe Info  		C228(1.32)  LDD3310  [6]
BTD
 Probe Info  		C212(1.75)  LDD1700  [7]
AHL-Pu-1
 Probe Info  		C200(2.45)  LDD0168  [8]
HHS-465
 Probe Info  		Y9(5.71)  LDD2237  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K453(0.00); K350(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C93(0.00); C200(0.00); C212(0.00); C348(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C200(0.00); C93(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C249(0.00); C168(0.00); C93(0.00); C200(0.00)  LDD0037  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
WYneO
 Probe Info  		C348(0.00); C200(0.00)  LDD0022  [15]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		N.A.  LDD0010  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1c-yne
 Probe Info  		K196(0.00); K8(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
AOyne
 Probe Info  		9.90  LDD0443  [19]
NAIA_5
 Probe Info  		C168(0.00); C249(0.00); C200(0.00); C212(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe14
 Probe Info  		12.03  LDD0477  [21]
FFF probe3
 Probe Info  		10.26  LDD0465  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C348(0.91)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C249(0.66); C348(0.96)  LDD2112  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C249(0.78); C348(1.21)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C249(1.08); C348(0.68); C200(1.00)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C249(1.55); C348(1.07)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C249(0.46)  LDD2132  [7]
 LDCM0025  4SU-RNA HEK-293T C200(2.45)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C200(2.96)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C200(0.99); C348(0.98); C212(1.07); C249(0.98)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C200(0.97); C348(1.06); C212(0.91); C249(1.02)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C200(1.01); C348(1.02); C212(0.98); C249(1.01)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C200(1.01); C348(1.00); C212(0.99); C249(0.98)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C200(1.01); C348(1.02); C212(1.00); C249(0.96)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C200(0.97); C348(0.99); C212(1.04); C249(1.04)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C200(1.03); C348(0.98); C212(0.93); C249(0.99)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C200(0.96); C348(1.03); C212(1.04); C249(1.10)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C200(0.97); C348(0.99); C212(1.03); C249(1.25)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C200(1.00); C348(1.04); C212(1.02); C249(1.03)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C200(0.98); C348(1.07); C212(1.04); C249(1.03)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C200(1.03); C348(1.09); C212(1.11); C249(1.02)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C200(1.01); C348(1.06); C212(1.11); C249(1.04)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C200(1.03); C348(1.00); C212(1.16); C249(1.04)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C200(1.04); C348(1.04); C212(1.08); C249(1.02)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C200(0.97); C348(1.01); C212(0.99); C249(1.01)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C200(1.02); C348(1.08); C212(0.92); C249(1.05)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C200(0.99); C348(1.02); C212(1.01); C249(1.03)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C200(1.01); C348(1.09); C212(1.01); C249(1.01)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C200(1.02); C348(0.97); C212(1.12); C249(1.05)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C200(1.05); C348(1.00); C212(1.16); C249(1.07)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C200(1.05); C348(1.08); C212(1.01); C249(1.01)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C200(0.97); C348(0.97); C212(1.03); C249(1.10)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C200(1.09); C348(1.09); C212(1.04); C249(1.05)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C200(0.98); C348(0.97); C212(0.94); C249(1.04)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C200(0.90); C348(1.07); C212(0.95); C249(1.02)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C200(1.04); C348(1.03); C212(0.97); C249(1.12)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C200(1.03); C348(0.99); C212(0.98); C249(0.95)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C200(0.96); C348(0.99); C212(0.94); C249(0.95)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C200(0.95); C348(1.03); C212(1.08); C249(1.02)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C200(0.99); C348(1.00); C212(1.02); C249(0.97)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C200(1.06); C348(0.98); C212(0.96); C249(0.98)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C200(0.99); C348(1.10); C212(0.96); C249(1.10)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C200(0.97); C348(1.00); C212(0.90); C249(0.97)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C200(1.01); C348(1.10); C212(1.10); C249(1.01)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C200(1.02); C348(1.02); C212(0.91); C249(1.07)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C200(1.00); C348(0.94); C212(0.91); C249(1.00)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C200(0.99); C348(1.06); C212(0.97); C249(0.97)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C200(0.98); C348(1.00); C212(1.01); C249(0.97)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C200(0.98); C348(0.97); C212(1.01); C249(1.05)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C200(1.00); C348(1.01); C212(0.89); C249(0.97)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C200(1.05); C348(0.94); C212(0.93); C249(0.99)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C200(1.02); C348(0.99); C212(1.01); C249(1.02)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C200(0.94); C348(1.07); C212(1.05); C249(1.05)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C200(1.01); C348(0.98); C212(0.90); C249(1.04)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C200(0.94); C348(0.99); C212(0.96); C249(0.95)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C200(0.90); C348(1.00); C212(0.94); C249(0.93)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C200(0.99); C348(0.98); C212(1.06); C249(0.98)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C200(1.00); C348(0.97); C212(1.05); C249(1.06)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C200(0.99); C348(0.99); C212(0.86); C249(1.01)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C200(1.03); C348(0.98); C212(0.93); C249(0.98)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C200(1.05); C348(1.08); C212(1.00); C249(1.02)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C200(1.04); C348(0.99); C212(1.00); C249(1.03)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C200(0.99); C348(1.04); C212(1.12); C249(1.05)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C200(1.04); C348(0.99); C212(0.98); C249(0.97)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C200(0.97); C348(0.97); C212(1.06); C249(1.00)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C200(1.04); C348(1.04); C212(1.11); C249(1.04)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C200(1.02); C348(1.00); C212(0.98); C249(1.03)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C200(1.05); C348(1.09); C212(1.02); C249(1.07)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C200(1.04); C348(0.95); C212(1.10); C249(1.06)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C200(1.11); C348(1.13); C212(1.07); C249(1.00)  LDD1569  [22]
 LDCM0545  Acetamide MDA-MB-231 C348(0.39)  LDD2138  [7]
 LDCM0248  AKOS034007472 HEK-293T C200(1.01); C348(0.99); C212(1.03); C249(0.97)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C200(0.99); C348(0.94); C212(0.91); C249(1.02)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C200(1.06); C348(1.13); C212(0.95); C249(1.00)  LDD1514  [22]
 LDCM0156  Aniline NCI-H1299 11.43  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C348(0.52)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C249(0.00); C200(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C93(20.00); C200(20.00)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C200(0.93); C348(0.96); C212(0.93); C249(0.98)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C200(0.83); C348(1.01); C212(1.10); C249(0.95)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C200(1.04); C348(1.02); C212(1.01); C249(0.96)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C200(1.03); C348(0.99); C212(0.97); C249(0.95)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C200(1.03); C348(0.94); C212(0.99); C249(0.96)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C200(0.94); C348(0.94); C212(0.88); C249(1.01)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C200(1.03); C348(0.97); C212(0.97); C249(0.98)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C200(1.11); C348(0.99); C212(0.94); C249(1.02)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C200(1.05); C348(0.98); C212(1.27); C249(1.07)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C200(0.97); C348(1.03); C212(0.98); C249(0.98)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C200(1.01); C348(1.04); C212(1.17); C249(1.01)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C200(1.00); C348(1.02); C212(1.04); C249(0.97)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C200(0.88); C348(1.02); C212(1.06); C249(1.05)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C200(0.99); C348(0.95); C212(1.04); C249(0.96)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C200(1.03); C348(1.01); C212(0.97); C249(1.07)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C200(1.07); C348(1.06); C212(1.00); C249(0.92)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C200(1.03); C348(1.05); C212(1.05); C249(0.99)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C200(0.93); C348(1.03); C212(1.11); C249(0.96)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C200(0.92); C348(0.96); C212(1.04); C249(1.04)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C200(1.01); C348(0.99); C212(1.07); C249(1.00)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C200(0.99); C348(1.02); C212(1.02); C249(0.94)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C200(1.07); C348(0.95); C212(0.96); C249(1.00)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C200(1.00); C348(1.01); C212(1.00); C249(0.99)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C200(0.97); C348(1.06); C212(0.84); C249(1.00)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C200(0.97); C348(0.99); C212(1.14); C249(0.97)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C200(1.01); C348(0.98); C212(1.01); C249(1.02)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C200(0.95); C348(0.96); C212(1.20); C249(1.08)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C200(0.90); C348(0.97); C212(0.97); C249(0.97)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C200(1.00); C348(0.97); C212(0.90); C249(0.97)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C200(1.08); C348(1.04); C212(1.03); C249(0.95)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C200(1.05); C348(1.06); C212(1.08); C249(1.01)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C200(1.06); C348(1.04); C212(1.06); C249(0.94)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C200(1.05); C348(1.01); C212(0.96); C249(1.00)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C200(0.99); C348(0.86); C212(0.91); C249(0.87)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C200(1.00); C348(0.90); C212(0.94); C249(1.07)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C200(0.87); C348(0.80); C212(0.88); C249(1.00)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C200(1.03); C348(0.95); C212(0.89); C249(0.81)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C200(0.94); C348(0.83); C212(0.88); C249(0.92)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C200(1.01); C348(1.01); C212(0.89); C249(1.00)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C200(0.97); C348(1.01); C212(0.88); C249(0.98)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C200(1.01); C348(0.88); C212(1.05); C249(1.04)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C200(1.07); C348(1.02); C212(0.98); C249(0.99)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C200(0.82); C348(0.96); C212(0.93); C249(0.93)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C200(0.93); C348(1.01); C212(1.10); C249(0.92)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C200(0.89); C348(1.01); C212(1.06); C249(1.03)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C200(0.97); C348(1.08); C212(1.01); C249(0.99)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C200(1.01); C348(0.99); C212(0.94); C249(0.96)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C200(1.04); C348(0.91); C212(0.94); C249(0.98)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C200(1.01); C348(0.94); C212(1.00); C249(1.00)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C200(1.09); C348(0.96); C212(1.04); C249(0.96)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C200(1.01); C348(0.99); C212(0.94); C249(0.97)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C200(0.96); C348(0.84); C212(1.01); C249(1.09)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C200(1.00); C348(1.06); C212(0.96); C249(1.02)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C200(0.98); C348(0.97); C212(1.04); C249(0.99)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C200(1.00); C348(1.01); C212(0.92); C249(1.00)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C200(0.81); C348(1.09); C212(1.26); C249(0.97)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C200(0.97); C348(1.01); C212(1.19); C249(1.08)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C200(0.94); C348(1.05); C212(1.16); C249(1.10)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C200(0.99); C348(1.20); C212(1.18); C249(1.03)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C200(1.03); C348(0.96); C212(0.92); C249(0.92)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C200(1.08); C348(0.99); C212(0.99); C249(1.10)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C200(0.97); C348(0.88); C212(0.89); C249(1.01)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C200(1.12); C348(0.96); C212(0.99); C249(0.94)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C200(1.00); C348(1.03); C212(0.90); C249(0.98)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C200(1.03); C348(1.10); C212(0.97); C249(0.96)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C200(1.01); C348(1.09); C212(1.07); C249(1.21)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C200(1.13); C348(0.99); C212(0.98); C249(0.99)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C200(0.92); C348(1.02); C212(1.07); C249(0.98)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C200(0.94); C348(1.13); C212(1.02); C249(0.97)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C200(0.93); C348(1.08); C212(1.09); C249(1.08)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C200(0.93); C348(1.24); C212(0.93); C249(1.11)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C200(1.12); C348(1.00); C212(1.06); C249(0.95)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C200(0.98); C348(0.87); C212(0.84); C249(0.95)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C200(1.04); C348(0.95); C212(1.14); C249(0.96)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C200(1.03); C348(0.97); C212(0.95); C249(0.96)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C200(0.94); C348(0.94); C212(0.92); C249(0.94)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C200(0.86); C348(1.02); C212(1.03); C249(0.99)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C200(1.03); C348(1.11); C212(1.04); C249(1.06)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C200(1.00); C348(1.07); C212(1.03); C249(0.98)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C200(0.89); C348(1.12); C212(1.06); C249(1.01)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C200(0.92); C348(1.08); C212(1.19); C249(0.95)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C200(0.91); C348(1.01); C212(1.09); C249(1.02)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C200(0.89); C348(0.98); C212(0.92); C249(1.00)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C200(0.94); C348(1.18); C212(1.08); C249(1.02)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C200(1.09); C348(0.99); C212(0.97); C249(0.96)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C200(0.96); C348(0.98); C212(0.96); C249(0.97)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C200(1.06); C348(0.95); C212(0.96); C249(1.01)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C200(0.97); C348(0.97); C212(0.98); C249(0.92)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C200(1.00); C348(0.97); C212(0.93); C249(0.94)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C200(1.05); C348(1.07); C212(0.91); C249(0.98)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C200(1.05); C348(1.04); C212(0.90); C249(1.00)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C200(0.97); C348(1.07); C212(1.00); C249(0.99)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C200(0.94); C348(1.05); C212(0.92); C249(0.96)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C200(1.00); C348(1.02); C212(0.89); C249(0.93)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C200(0.95); C348(1.06); C212(1.11); C249(0.96)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C200(0.92); C348(0.99); C212(1.06); C249(1.04)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C200(1.01); C348(1.05); C212(0.96); C249(1.04)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C200(1.01); C348(1.05); C212(0.97); C249(1.00)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C200(1.03); C348(0.98); C212(0.96); C249(1.03)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C200(1.02); C348(0.95); C212(1.07); C249(0.99)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C200(0.93); C348(0.98); C212(0.84); C249(0.94)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C200(1.04); C348(1.10); C212(0.97); C249(1.02)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C200(1.02); C348(1.09); C212(1.03); C249(0.97)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C200(0.76); C348(0.94); C212(1.03); C249(1.07)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C200(0.95); C348(1.07); C212(1.07); C249(0.94)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C200(1.00); C348(1.00); C212(1.04); C249(0.97)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C200(0.96); C348(1.04); C212(1.11); C249(1.02)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C200(0.91); C348(1.08); C212(1.10); C249(0.99)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C200(0.99); C348(1.15); C212(0.98); C249(1.11)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C200(1.19); C348(0.97); C212(1.03); C249(0.96)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C200(1.15); C348(0.92); C212(1.14); C249(0.98)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C200(1.02); C348(0.96); C212(0.93); C249(1.00)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C200(1.04); C348(1.00); C212(1.13); C249(1.00)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C200(0.99); C348(0.96); C212(0.89); C249(1.06)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C200(0.90); C348(1.06); C212(1.02); C249(0.94)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C200(0.83); C348(1.03); C212(1.02); C249(1.05)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C200(1.10); C348(1.06); C212(1.02); C249(1.07)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C200(0.91); C348(0.97); C212(1.06); C249(0.98)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C200(0.92); C348(1.02); C212(1.00); C249(0.96)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C200(0.98); C348(1.05); C212(1.07); C249(0.97)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C200(0.84); C348(1.03); C212(1.15); C249(1.16)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C200(0.97); C348(1.09); C212(0.89); C249(1.04)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C200(1.01); C348(0.97); C212(1.02); C249(0.94)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C200(1.02); C348(1.00); C212(0.96); C249(1.00)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C200(1.03); C348(1.00); C212(0.95); C249(1.01)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C200(0.98); C348(0.94); C212(0.48); C249(1.04)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C249(2.20); C348(2.05)  LDD1702  [7]
 LDCM0572  Fragment10 Ramos C200(0.94)  LDD2189  [23]
 LDCM0574  Fragment12 Ramos C200(0.49)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C200(0.35)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C200(0.30)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C200(0.67)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C200(0.65)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C200(0.58)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C200(2.18)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C200(0.56)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C200(1.38)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C200(0.60)  LDD2200  [23]
 LDCM0468  Fragment33 HEK-293T C200(1.09); C348(0.99); C212(0.94); C249(0.99)  LDD1671  [22]
 LDCM0596  Fragment38 Ramos C200(0.31)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C200(0.67)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C200(1.04); C348(0.95); C212(0.99); C249(0.98)  LDD1631  [22]
 LDCM0610  Fragment52 Ramos C200(1.10)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C200(1.53)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C200(0.43)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C200(1.13)  LDD2188  [23]
 LDCM0022  KB02 HEK-293T C200(0.92); C348(0.95); C212(0.96); C249(0.99)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C200(1.07); C348(1.04); C212(1.01); C249(0.96)  LDD1497  [22]
 LDCM0024  KB05 COLO792 C228(1.32)  LDD3310  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C249(1.67); C348(0.87); C200(1.08)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C348(0.60)  LDD2121  [7]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C249(0.60); C348(0.71)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C348(0.91); C200(1.13)  LDD2090  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C348(0.80)  LDD2093  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C249(0.09); C348(0.27)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C249(0.88)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C249(0.75)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C249(1.50); C200(0.95)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C348(0.60)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C348(0.78)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C348(1.21)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C348(1.02); C200(1.23)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C348(0.58)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C348(1.47)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C249(0.38); C348(0.75)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C249(0.78); C200(0.88)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C249(1.32)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C348(0.71)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C249(0.61)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C249(1.63); C348(0.57)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C348(0.60)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C249(2.00); C212(2.43)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C249(0.48)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C348(0.49)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C249(0.92); C200(1.11)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C348(0.41)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C249(1.13); C348(1.33)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C249(0.34); C348(0.38)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C249(1.51)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C249(0.75)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C249(0.94); C348(0.76)  LDD2129  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C249(0.54); C212(0.37)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C249(1.62); C212(1.39)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C348(1.02); C200(1.10)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C249(1.06); C348(0.78)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C212(1.75)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C249(1.01); C348(0.71); C200(0.95)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C348(0.73); C200(0.71)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C249(1.01)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C249(1.97); C348(1.22)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C249(0.35); C348(0.38)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C249(0.98)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C249(0.96)  LDD2147  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C249(0.46); C348(0.35)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C200(0.80)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C200(1.22)  LDD2207  [24]

References

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2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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