Details of the Target

General Information of Target

Target ID LDTP01963
Target Name Albumin (ALB)
Gene Name ALB
Gene ID 213
Synonyms
Albumin
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
Target Type
Successful
Target Bioclass
Other
Family
ALB/AFP/VDB family
Subcellular location
Secreted
Function
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin.
TTD ID
T63068
Uniprot ID
P02768
DrugMap ID
TTFNGC9
Ensemble ID
ENST00000295897.9
HGNC ID
HGNC:399
ChEMBL ID
CHEMBL3253

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A239V; p.T444I .
ICC12 SNV: p.I412F .
NCIH1155 Insertion: p.R138PfsTer8 .
NCIH146 SNV: p.H559L DBIA    Probe Info 
NCIH3122 SNV: p.E580G .
RPMI8226 SNV: p.L599R .
SHP77 SNV: p.G95E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		4.71  LDD0215  [1]
W1
 Probe Info  		23.42  LDD0235  [2]
C-Sul
 Probe Info  		3.91  LDD0066  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
STPyne
 Probe Info  		K229(8.49); K298(6.59); K438(6.65); K499(4.35)  LDD0277  [5]
ONAyne
 Probe Info  		K229(6.21); K298(10.00)  LDD0275  [5]
OPA-S-S-alkyne
 Probe Info  		K229(5.69); K499(7.98); K438(10.03)  LDD3494  [6]
DBIA
 Probe Info  		C97(2.08)  LDD3314  [7]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
2PCA
 Probe Info  		N.A.  LDD0034  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
IPM
 Probe Info  		N.A.  LDD0005  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
TER-AC
 Probe Info  		N.A.  LDD0426  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [15]
STS-2
 Probe Info  		N.A.  LDD0138  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa C58(0.00); C289(0.00)  LDD0222  [13]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [8]
 LDCM0022  KB02 42-MG-BA C58(1.38)  LDD2244  [7]
 LDCM0023  KB03 42-MG-BA C58(1.48)  LDD2661  [7]
 LDCM0024  KB05 IGR37 C97(2.08)  LDD3314  [7]
 LDCM0109  NEM HeLa C289(0.00); C501(0.00)  LDD0231  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Albumin (ALB) ALB/AFP/VDB family P02768
Histone-binding protein RBBP4 (RBBP4) WD repeat RBAP46/RBAP48/MSI1 family Q09028
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 412 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Botulinum Toxin Type A BiotechDrug DB00083
Hyaluronidase (Ovine) BiotechDrug DB00070
Insulin Detemir BiotechDrug DB01307
Bulevirtide Peptide DB15248
Exenatide Protein/peptide DB01276
Liraglutide Protein/peptide DB06655
Lumasiran Small interfering RNA DB15935
Abemaciclib Small molecular drug DB12001
Abiraterone Small molecular drug DB05812
Acalabrutinib Small molecular drug DB11703
Acenocoumarol Small molecular drug DB01418
Acetaminophen Small molecular drug DB00316
Acetohexamide Small molecular drug DB00414
Acetylcysteine Small molecular drug DB06151
Acitretin Small molecular drug DB00459
Acyclovir Small molecular drug DB00787
Adenosine Small molecular drug DB00640
Alfentanil Small molecular drug DB00802
Alfuzosin Small molecular drug DB00346
Aluminium Small molecular drug DB01370
Amiodarone Small molecular drug DB01118
Amitriptyline Small molecular drug DB00321
Amoxicillin Small molecular drug DB01060
Ampicillin Small molecular drug DB00415
Amsacrine Small molecular drug DB00276
Apomorphine Small molecular drug DB00714
Argatroban Small molecular drug DB00278
Aripiprazole Small molecular drug DB01238
Arsenic Trioxide Small molecular drug DB01169
Artesunate Small molecular drug DB09274
Ascorbic Acid Small molecular drug DB00126
Asenapine Small molecular drug DB06216
Atazanavir Small molecular drug DB01072
Atenolol Small molecular drug DB00335
Atomoxetine Small molecular drug DB00289
Atorvastatin Small molecular drug DB01076
Auranofin Small molecular drug DB00995
Avanafil Small molecular drug DB06237
Azathioprine Small molecular drug DB00993
Azilsartan Medoxomil Small molecular drug DB08822
Benzatropine Small molecular drug DB00245
Benzocaine Small molecular drug DB01086
Benzylpenicillin Small molecular drug DB01053
Betamethasone Small molecular drug DB00443
Bismuth Small molecular drug D0OG5K
Budesonide Small molecular drug DB01222
Buspirone Small molecular drug DB00490
Butabarbital Small molecular drug DB00237
Cabotegravir Small molecular drug DB11751
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Captopril Small molecular drug DB01197
Carvedilol Small molecular drug DB01136
Cefalotin Small molecular drug DB00456
Cefazolin Small molecular drug DB01327
Cefmetazole Small molecular drug DB00274
Cefonicid Small molecular drug DB01328
Cefoperazone Small molecular drug DB01329
Cefotaxime Small molecular drug DB00493
Cefotetan Small molecular drug DB01330
Cefpiramide Small molecular drug DB00430
Ceftazidime Small molecular drug DB00438
Ceftriaxone Small molecular drug DB01212
Cephalexin Small molecular drug DB00567
Chlorcyclizine Small molecular drug DB08936
Chloroquine Small molecular drug DB00608
Chlorpromazine Small molecular drug DB00477
Chlorthalidone Small molecular drug DB00310
Cimetidine Small molecular drug DB00501
Cinnarizine Small molecular drug DB00568
Ciprofloxacin Small molecular drug DB00537
Cisplatin Small molecular drug DB00515
Clobetasol Propionate Small molecular drug DB01013
Clofazimine Small molecular drug DB00845
Clomipramine Small molecular drug DB01242
Clonazepam Small molecular drug DB01068
Clonidine Small molecular drug DB00575
Clopidogrel Small molecular drug DB00758
Cloxacillin Small molecular drug DB01147
Colchicine Small molecular drug DB01394
Conjugated Estrogens Small molecular drug DB00286
Cortisone Acetate Small molecular drug DB01380
Crizotinib Small molecular drug DB08865
Cyclizine Small molecular drug DB01176
Cyclobenzaprine Small molecular drug DB00924
Cyproheptadine Small molecular drug DB00434
Cysteamine Small molecular drug DB00847
Dabigatran Etexilate Small molecular drug DB06695
Dabrafenib Small molecular drug DB08912
Dacomitinib Small molecular drug DB11963
Darunavir Small molecular drug DB01264
Delafloxacin Small molecular drug DB11943
Desflurane Small molecular drug DB01189
Desogestrel Small molecular drug DB00304
Dexamethasone Small molecular drug DB01234
Dexibuprofen Small molecular drug DB09213
Diclofenac Small molecular drug DB00586
Dicloxacillin Small molecular drug DB00485
Dicoumarol Small molecular drug DB00266
Didanosine Small molecular drug DB00900
Diflunisal Small molecular drug DB00861
Digitoxin Small molecular drug DB01396
Diltiazem Small molecular drug DB00343
Dolutegravir Small molecular drug DB08930
Doxepin Small molecular drug DB01142
Doxorubicin Small molecular drug DB00997
Doxylamine Small molecular drug DB00366
Dronedarone Small molecular drug DB04855
Duloxetine Small molecular drug DB00476
Dutasteride Small molecular drug DB01126
Echothiophate Small molecular drug DB01057
Edoxudine Small molecular drug DB13421
Efavirenz Small molecular drug DB00625
Emtricitabine Small molecular drug DB00879
Enalapril Small molecular drug DB00584
Enflurane Small molecular drug DB00228
Enzalutamide Small molecular drug DB08899
Ephedrine Small molecular drug DB01364
Erlotinib Small molecular drug DB00530
Ertapenem Small molecular drug DB00303
Ertugliflozin Small molecular drug DB11827
Estetrol Small molecular drug DB12235
Estradiol Small molecular drug DB00783
Estradiol Acetate Small molecular drug DB13952
Estradiol Cypionate Small molecular drug DB13954
Estradiol Valerate Small molecular drug DB13956
Estrone Small molecular drug DB00655
Estrone Sulfate Small molecular drug DB04574
Etacrynic Acid Small molecular drug DB00903
Ethinylestradiol Small molecular drug DB00977
Etodolac Small molecular drug DB00749
Etonogestrel Small molecular drug DB00294
Evans Blue Small molecular drug D0P2CS
Favipiravir Small molecular drug DB12466
Febuxostat Small molecular drug DB04854
Fenofibrate Small molecular drug DB01039
Fenoprofen Small molecular drug DB00573
Fentanyl Small molecular drug DB00813
Fexofenadine Small molecular drug DB00950
Flecainide Small molecular drug DB01195
Fludrocortisone Small molecular drug DB00687
Fluorouracil Small molecular drug DB00544
Fluoxetine Small molecular drug DB00472
Flurbiprofen Small molecular drug DB00712
Formoterol Small molecular drug DB00983
Fosphenytoin Small molecular drug DB01320
Fospropofol Small molecular drug DB06716
Fostemsavir Small molecular drug DB11796
Furosemide Small molecular drug DB00695
Gadobenate Dimeglumine Small molecular drug D01OIL
Gadofosveset Small molecular drug D0H0WK
Gatifloxacin Small molecular drug DB01044
Gefitinib Small molecular drug DB00317
Gemfibrozil Small molecular drug DB01241
Gilteritinib Small molecular drug DB12141
Glasdegib Small molecular drug DB11978
Gliclazide Small molecular drug DB01120
Glipizide Small molecular drug DB01067
Glyburide Small molecular drug DB01016
Glycopyrronium Small molecular drug DB00986
Guaiacol Small molecular drug DB11359
Halothane Small molecular drug DB01159
Hydralazine Small molecular drug DB01275
Hydrochlorothiazide Small molecular drug DB00999
Hydroflumethiazide Small molecular drug DB00774
Hydromorphone Small molecular drug DB00327
Hydroquinone Small molecular drug DB09526
Hydroxychloroquine Small molecular drug DB01611
Hydroxyzine Small molecular drug DB00557
Ibrexafungerp Small molecular drug DB12471
Ibrutinib Small molecular drug DB09053
Ibuprofen Small molecular drug DB01050
Icosapent Small molecular drug DB00159
Imatinib Small molecular drug DB00619
Imipramine Small molecular drug DB00458
Indapamide Small molecular drug DB00808
Indomethacin Small molecular drug DB00328
Iodipamide Small molecular drug D07OIX
Ipratropium Small molecular drug DB00332
Irbesartan Small molecular drug DB01029
Irinotecan Small molecular drug DB00762
Isoflurane Small molecular drug DB00753
Isoflurophate Small molecular drug DB00677
Isoniazid Small molecular drug DB00951
Isoprenaline Small molecular drug DB01064
Isotretinoin Small molecular drug DB00982
Istradefylline Small molecular drug DB11757
Ivacaftor Small molecular drug DB08820
Ketoconazole Small molecular drug DB01026
Ketoprofen Small molecular drug DB01009
Labetalol Small molecular drug DB00598
Lamivudine Small molecular drug DB00709
Lamotrigine Small molecular drug DB00555
Lauric Acid Small molecular drug DB03017
Letrozole Small molecular drug DB01006
Levamlodipine Small molecular drug DB09237
Levocetirizine Small molecular drug DB06282
Levodopa Small molecular drug DB01235
Levofloxacin Small molecular drug DB01137
Levothyroxine Small molecular drug DB00451
Liothyronine Small molecular drug DB00279
Liotrix Small molecular drug DB01583
Lopinavir Small molecular drug DB01601
Losartan Small molecular drug DB00678
Lovastatin Small molecular drug DB00227
Lumacaftor Small molecular drug DB09280
Macitentan Small molecular drug DB08932
Maribavir Small molecular drug DB06234
Meclizine Small molecular drug DB00737
Medroxyprogesterone Acetate Small molecular drug DB00603
Mefenamic Acid Small molecular drug DB00784
Meloxicam Small molecular drug DB00814
Meperidine Small molecular drug DB00454
Methadone Small molecular drug DB00333
Methotrexate Small molecular drug DB00563
Methyldopa Small molecular drug DB00968
Methylprednisolone Small molecular drug DB00959
Methyltestosterone Small molecular drug DB06710
Metoprolol Small molecular drug DB00264
Miconazole Small molecular drug DB01110
Mirabegron Small molecular drug DB08893
Morphine Small molecular drug DB00295
Mycophenolic Acid Small molecular drug DB01024
Nabumetone Small molecular drug DB00461
Nafcillin Small molecular drug DB00607
Naloxone Small molecular drug DB01183
Naproxen Small molecular drug DB00788
Nateglinide Small molecular drug DB00731
Nebivolol Small molecular drug DB04861
Nelfinavir Small molecular drug DB00220
Neratinib Small molecular drug DB11828
Nevirapine Small molecular drug DB00238
Nifedipine Small molecular drug DB01115
Nifurtimox Small molecular drug DB11820
Nintedanib Small molecular drug DB09079
Niraparib Small molecular drug DB11793
Norelgestromin Small molecular drug DB06713
Norethisterone Small molecular drug DB00717
Norgestimate Small molecular drug DB00957
Nortriptyline Small molecular drug DB00540
Olanzapine Small molecular drug DB00334
Olaparib Small molecular drug DB09074
Oleic Acid Small molecular drug DB04224
Olopatadine Small molecular drug DB00768
Omadacycline Small molecular drug DB12455
Orlistat Small molecular drug DB01083
Orphenadrine Small molecular drug DB01173
Oxybutynin Small molecular drug DB01062
Oxycodone Small molecular drug DB00497
Oxymetholone Small molecular drug DB06412
Oxyphenbutazone Small molecular drug D06ZPS
Oxytetracycline Small molecular drug DB00595
Palbociclib Small molecular drug DB09073
Palmitic Acid Small molecular drug DB03796
Pemetrexed Small molecular drug DB00642
Perphenazine Small molecular drug DB00850
Phenindamine Small molecular drug DB01619
Phenol Small molecular drug DB03255
Phenprocoumon Small molecular drug DB00946
Phenytoin Small molecular drug DB00252
Pioglitazone Small molecular drug DB01132
Pipotiazine Small molecular drug DB01621
Piroxicam Small molecular drug DB00554
Pitavastatin Small molecular drug DB08860
Pitolisant Small molecular drug DB11642
Polythiazide Small molecular drug DB01324
Pralatrexate Small molecular drug DB06813
Prasugrel Small molecular drug DB06209
Prednisolone Small molecular drug DB00860
Prednisone Small molecular drug DB00635
Probenecid Small molecular drug DB01032
Promethazine Small molecular drug DB01069
Propofol Small molecular drug DB00818
Propranolol Small molecular drug DB00571
Prucalopride Small molecular drug DB06480
Pseudoephedrine Small molecular drug DB00852
Pyridoxine Small molecular drug DB00165
Quinapril Small molecular drug DB00881
Quinidine Small molecular drug DB00908
Raloxifene Small molecular drug DB00481
Relugolix Small molecular drug DB11853
Repaglinide Small molecular drug DB00912
Rifampicin Small molecular drug DB01045
Rifamycin Small molecular drug DB11753
Rilpivirine Small molecular drug DB08864
Riociguat Small molecular drug DB08931
Risperidone Small molecular drug DB00734
Ritonavir Small molecular drug DB00503
Rosiglitazone Small molecular drug DB00412
Rosuvastatin Small molecular drug DB01098
Roxadustat Small molecular drug DB04847
Rufinamide Small molecular drug DB06201
Ruxolitinib Small molecular drug DB08877
Salicylic Acid Small molecular drug DB00936
Salmeterol Small molecular drug DB00938
Saquinavir Small molecular drug DB01232
Selumetinib Small molecular drug DB11689
Semaglutide Small molecular drug DB13928
Sertraline Small molecular drug DB01104
Sevoflurane Small molecular drug DB01236
Simeprevir Small molecular drug DB06290
Sirolimus Small molecular drug DB00877
Sodium Lauryl Sulfate Small molecular drug D05ATI
Spi-1005 Small molecular drug D0B1FE
Spironolactone Small molecular drug DB00421
Stavudine Small molecular drug DB00649
Sulfamerazine Small molecular drug DB01581
Sulfamethazine Small molecular drug DB01582
Sulfamethizole Small molecular drug DB00576
Sulfamethoxazole Small molecular drug DB01015
Sulfasalazine Small molecular drug DB00795
Sulindac Small molecular drug DB00605
Sulpiride Small molecular drug DB00391
Suprofen Small molecular drug DB00870
Tacrolimus Small molecular drug DB00864
Tamoxifen Small molecular drug DB00675
Telaprevir Small molecular drug DB05521
Tenofovir Alafenamide Small molecular drug DB09299
Tepotinib Small molecular drug DB15133
Terbinafine Small molecular drug DB00857
Terfenadine Small molecular drug DB00342
Testosterone Small molecular drug DB00624
Testosterone Propionate Small molecular drug DB01420
Testosterone Undecanoate Small molecular drug DB13946
Tetracycline Small molecular drug DB00759
Thiamine Small molecular drug DB00152
Thiothixene Small molecular drug DB01623
Tibolone Small molecular drug DB09070
Ticagrelor Small molecular drug DB08816
Tiludronic Acid Small molecular drug DB01133
Tivozanib Small molecular drug DB11800
Tocainide Small molecular drug DB01056
Tofacitinib Small molecular drug DB08895
Tolbutamide Small molecular drug DB01124
Tolmetin Small molecular drug DB00500
Topiramate Small molecular drug DB00273
Torasemide Small molecular drug DB00214
Tretinoin Small molecular drug DB00755
Triamcinolone Small molecular drug DB00620
Trifluridine Small molecular drug DB00432
Triflusal Small molecular drug DB08814
Trihexyphenidyl Small molecular drug DB00376
Trimetazidine Small molecular drug DB09069
Tripelennamine Small molecular drug DB00792
Triprolidine Small molecular drug DB00427
Ulipristal Small molecular drug DB08867
Valproic Acid Small molecular drug DB00313
Vandetanib Small molecular drug DB05294
Vemurafenib Small molecular drug DB08881
Verapamil Small molecular drug DB00661
Vericiguat Small molecular drug DB15456
Vismodegib Small molecular drug DB08828
Vitamin A Small molecular drug DB00162
Warfarin Small molecular drug DB00682
Zalcitabine Small molecular drug DB00943
Zidovudine Small molecular drug DB00495
Zileuton Small molecular drug DB00744
Ziprasidone Small molecular drug DB00246
Abrocitinib . DB14973
Albumin Human . D0I0VI
Aluminium Phosphate . DB14517
Aluminum Acetate . DB14518
Arbutin . DB11217
Aripiprazole Lauroxil . DB14185
Artenimol . DB11638
Belumosudil . DB16703
Betamethasone Phosphate . DB14669
Butamben . DB11148
Calcium Citrate . DB11093
Cefiderocol . DB14879
Chloramphenicol Succinate . DB07565
Chlortetracycline . DB09093
Colchiceine . DB15534
Copanlisib . DB12483
Copper . DB09130
Darolutamide . DB12941
Dexamethasone Acetate . DB14649
Diosmin . DB08995
Elexacaftor . DB15444
Estradiol Benzoate . DB13953
Estradiol Dienanthate . DB13955
Finerenone . DB16165
Fluoroestradiol F-18 . DB15690
Futibatinib . DB15149
Glycyrrhizic Acid . DB13751
Grazoprevir . DB11575
Human Interferon Beta . DB14999
Insulin Degludec . DB09564
Iodine . DB05382
Iopodic Acid . DB09333
Linzagolix . DB17083
Lorpiprazole . DB09195
Medrogestone . DB09124
Methylene Blue . DB09241
Opium . DB11130
Patent Blue . DB13967
Pexidartinib . DB12978
Potassium Perchlorate . DB09418
Prednisolone Acetate . DB15566
Prednisolone Phosphate . DB14631
Ripretinib . DB14840
Silver . DB12965
Somapacitan . DB15093
Stearic Acid . DB03193
Testosterone Cypionate . DB13943
Testosterone Enanthate . DB13944
Thimerosal . DB11590
Thyroid Porcine . DB09100
Tirzepatide . DB15171
Vinflunine . DB11641
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Activated Recombinant Fvii-albumin Fusion Protein . D0C0CE
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vobarilizumab Antibody D9J6XV
Ru-101 . D0YW6P
Investigative
Click To Hide/Show 22 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acepromazine Small molecular drug DB01614
Arachidonic Acid Small molecular drug DB04557
Blonanserin Small molecular drug DB09223
Camptothecin Small molecular drug DB04690
Capric Acid Small molecular drug DB03600
Glyphosate Small molecular drug DB04539
Grapiprant Small molecular drug DB12836
Magnesium Salicylate Small molecular drug DB01397
Myristic Acid Small molecular drug DB08231
Quercetin Small molecular drug DB04216
Resveratrol Small molecular drug DB02709
Tanespimycin Small molecular drug DB05134
Tenofovir Small molecular drug DB14126
Thioproperazine Small molecular drug DB01622
Topiroxostat Small molecular drug DB01685
Aniline . DB06728
Aranidipine . DB09229
Arotinolol . DB09204
Dichlorvos . DB11397
Hypericin . DB13014
Imidafenacin . DB09262
Ormeloxifene . DB13310
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zomepirac Small molecular drug DB04828

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.