Details of the Target

General Information of Target

Target ID LDTP04809
Target Name Epiplakin (EPPK1)
Gene Name EPPK1
Gene ID 83481
Synonyms
EPIPL; Epiplakin; 450 kDa epidermal antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGHTLPPLPVPGTNSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAA
MEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATT
GYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLL
DRETWHKLSELEPGTGDLRFLDPNTLERLTYHQLLERCVRAPGSGLALLPLKITFRSMGG
AVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLPEGHKKS
FFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAE
QAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALR
CGCLDEDTQRQLSQAGSFSDGTHGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGEPQGP
PFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSVEK
LAAKLSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLA
SVQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANK
GHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLL
EAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQ
LLERCVRDPETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSE
YFSEGRRRQLLRRYRQREVTLGQVAKLLEAETQRQADIMLPALRSRVTVHQLLEAGIIDQ
QLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVA
LALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQV
SVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSS
SETFPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPGAKD
GTSLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPR
GEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKA
SIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQA
ERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAAC
RLGLLDTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVL
EVDDHTAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQ
VVSAVTTLVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEM
DSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPVEN
RKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRL
LEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYL
QLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLL
SSPYFTEDRKRELIQEYGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLF
NSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSGCIAGVTVPSTREVMSLHEASRKE
LIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRD
PATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDI
YALISDQKHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWLLFPVNKAARDSEHIDDETR
RALEAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILE
LIEKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYL
EGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLR
LSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLE
AQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQL
LRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFY
REVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAA
TMEVKVGRLRGRAVPVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEE
APGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAAAARRQEQTL
RDATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEE
TEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTS
CIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVE
EAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIA
TGGVIDPVHSHRVPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRC
VPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVS
EDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEV
KVGRLRGRAVPVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGA
RPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAARRQEQTLRDATMEVQR
GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVS
FRGLRCQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPA
KDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVG
GEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVH
SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLY
MLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLS
RYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRA
VPVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWR
GPREPGPAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQTLRDATMEVQRGQFQGR
PVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRR
QVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGR
QEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEK
LLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPV
DVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAG
RGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGT
LTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPVWDV
LASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPG
PAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQTLRDATMEVQRGQFQGRPVSVWD
VLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSASE
LHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGHQEKMSI
YQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAER
AVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRR
GYFDEEMNRVLAHPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRGSAVH
QLSEELRCALRDARVMPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEEL
GATLTSLLAQAQAQARAEAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPVWDVLASG
YVSGAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGR
GDGDSGRSQREGQGEGETQEAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSSYL
SEAHRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGIL
GPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKG
VLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTD
PYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM
NRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSLQ
Target Bioclass
Other
Family
Plakin or cytolinker family
Subcellular location
Cytoplasm, cytoskeleton
Function
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization.
Uniprot ID
P58107
Ensemble ID
ENST00000615648.2
HGNC ID
HGNC:15577

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		33.65  LDD0235  [1]
STPyne
 Probe Info  		K2000(2.13)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K2707(3.42)  LDD3494  [3]
Probe 1
 Probe Info  		Y122(275.51); Y126(46.11); Y583(17.56); Y627(6.52)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C1151(6.27)  LDD0169  [5]
HHS-465
 Probe Info  		Y2413(6.96)  LDD2237  [6]
DBIA
 Probe Info  		C406(1.10); C927(0.91)  LDD0078  [7]
5E-2FA
 Probe Info  		H773(0.00); H5060(0.00); H2392(0.00); H4(0.00)  LDD2235  [8]
m-APA
 Probe Info  		H773(0.00); H5060(0.00); H2392(0.00); H2425(0.00)  LDD2231  [8]
CY-1
 Probe Info  		D2046(0.00); Q2047(0.00)  LDD0246  [9]
IA-alkyne
 Probe Info  		C406(0.00); C3471, C4005, C4539, C2940, C2404(0.00); C1707(0.00); C1490(0.00)  LDD0162  [10]
IPM
 Probe Info  		C406(0.00); C2940, C2404, C4539, C4005, C3471(0.00); C2761, C4360, C3292, C2225, C4893, C3826(0.00); C4893, C3826, C2761, C3292, C2225(0.00)  LDD0025  [11]
JW-RF-010
 Probe Info  		C2940, C4539, C4005, C2404, C3471(0.00); C2225, C3826, C4893, C3292, C2761, C4360(0.00); C406(0.00); C4893, C2225, C3826, C2761, C3292(0.00)  LDD0026  [11]
TFBX
 Probe Info  		C423(0.00); C2225, C3292, C2761, C4893, C3826(0.00); C421(0.00); C4539, C4005, C2940, C2404, C3471(0.00)  LDD0027  [11]
Acrolein
 Probe Info  		H4560(0.00); C4893(0.00); C406(0.00); C1102(0.00)  LDD0217  [12]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [12]
Crotonaldehyde
 Probe Info  		C4893(0.00); H4560(0.00); C1102(0.00); H212(0.00)  LDD0219  [12]
Methacrolein
 Probe Info  		C4893(0.00); C406(0.00); C1102(0.00); C927(0.00)  LDD0218  [12]
NAIA_5
 Probe Info  		C175(0.00); C2433(0.00); C1707(0.00); C3246(0.00)  LDD2223  [13]
TER-AC
 Probe Info  		N.A.  LDD0426  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C1151(6.27)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C1707(1.36); C2225(1.04); C406(0.93); C421(0.75)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C1490(0.72); C1707(1.23); C2225(0.93); C406(1.09)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C1490(0.32); C1707(0.65); C2225(0.80); C406(0.82)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C1490(0.40); C1707(0.75); C2225(0.86); C406(1.01)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C1490(0.37); C1707(0.82); C2225(0.84); C406(0.96)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C1490(0.34); C1707(0.92); C2225(0.77); C406(1.02)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C1490(0.37); C1707(0.81); C2225(0.88); C406(1.00)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C1490(0.43); C1707(0.78); C2225(0.81); C406(0.87)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C1490(0.33); C1707(0.65); C2225(0.79); C406(1.00)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C1490(0.43); C1707(0.68); C2225(0.84); C406(0.86)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C1490(0.43); C1707(0.51); C2225(0.82); C406(0.94)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C1490(0.51); C1707(0.56); C2225(0.88); C406(0.86)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C1490(0.65); C1707(1.08); C2225(0.91); C406(1.07)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C1490(0.44); C1707(0.68); C2225(0.76); C406(0.94)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C1490(0.40); C1707(0.62); C2225(0.76); C406(0.96)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C1490(0.38); C1707(0.76); C2225(0.72); C406(1.26)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C1490(1.13); C1707(1.21); C2225(1.02); C406(1.00)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C1490(0.91); C1707(1.08); C2225(0.87); C406(1.05)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C1490(0.97); C1707(1.18); C2225(0.95); C406(1.07)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C1490(1.09); C1707(1.08); C2225(0.88); C406(1.04)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C1490(1.10); C1707(1.22); C2225(0.94); C406(1.00)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C1490(1.17); C1707(1.11); C2225(0.86); C406(0.92)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C1490(1.43); C1707(1.03); C2225(0.97); C406(0.93)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C1490(0.76); C1707(1.35); C2225(0.99); C406(1.01)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C1490(1.00); C1707(0.94); C2225(0.98); C406(1.06)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C1490(1.17); C1707(1.25); C2225(1.16); C406(0.94)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C1490(1.10); C1707(1.06); C2225(0.95); C406(0.96)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C1490(1.22); C1707(0.97); C2225(1.21); C406(0.87)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C1490(0.98); C1707(1.07); C2225(0.99); C406(1.03)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C1490(1.05); C1707(1.42); C2225(0.90); C406(1.00)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C1490(1.23); C1707(1.21); C2225(1.11); C406(1.18)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C1490(1.12); C1707(1.23); C2225(1.08); C406(1.13)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C1490(1.40); C1707(1.45); C2225(1.20); C406(1.24)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1490(1.13); C1707(1.44); C2225(1.10); C406(0.95)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1490(1.06); C1707(1.48); C2225(0.99); C406(1.16)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1490(1.09); C1707(1.34); C2225(0.99); C406(0.90)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1490(1.05); C1707(1.33); C2225(0.97); C406(1.21)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1490(1.10); C1707(1.60); C2225(1.07); C406(1.10)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1490(1.16); C1707(1.36); C2225(0.95); C406(1.21)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1490(1.41); C1707(1.61); C2225(0.96); C406(1.13)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1490(1.36); C1707(1.18); C2225(1.02); C406(1.22)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1490(1.16); C1707(1.19); C2225(1.07); C406(1.06)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1490(1.19); C1707(1.36); C2225(0.90); C406(1.31)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1490(1.01); C1707(1.43); C2225(1.00); C406(1.33)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C1490(0.85); C1707(1.55); C2225(0.93); C406(1.00)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1490(1.29); C1707(1.40); C2225(0.90); C406(1.36)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1490(1.29); C1707(1.29); C2225(0.88); C406(1.24)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1490(1.48); C1707(1.48); C2225(1.19); C406(1.08)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C1707(1.04); C2225(0.81); C406(1.08); C421(1.46)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C2225(0.66); C611(0.91); C927(1.07); C1707(1.07)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C2225(0.75); C927(1.01); C611(1.07); C1707(1.11)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C2225(0.67); C421(0.92); C423(0.92); C406(1.06)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C2225(0.72); C611(0.87); C406(0.93); C421(1.24)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C2225(0.73); C611(0.92); C1707(1.15); C406(1.29)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C2225(0.65); C611(1.05); C421(1.07); C423(1.07)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C1490(0.76); C2225(0.85); C421(0.86); C927(0.98)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C2225(0.77); C611(1.02); C421(1.03); C423(1.03)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C2225(0.81); C611(0.82); C406(0.97); C927(1.07)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C2225(0.74); C611(1.01); C421(1.05); C423(1.05)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C2225(0.73); C421(1.04); C423(1.04); C611(1.14)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1707(1.20); C2225(0.67); C406(0.89); C421(1.25)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1707(1.30); C2225(0.65); C406(1.43); C421(0.86)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1707(1.26); C2225(0.83); C406(1.17); C421(0.90)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1707(1.05); C2225(0.82); C406(1.16); C421(1.95)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C2225(0.91); C1707(0.98); C927(1.03); C406(1.30)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C927(0.93); C1707(0.96); C406(1.16); C2225(1.17)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C927(0.88); C2225(0.94); C1707(1.02); C406(1.11)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C421(0.91); C423(0.91); C2225(0.95); C406(1.04)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C2225(0.88); C927(0.89); C1707(0.97); C406(1.05)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C927(0.87); C1707(0.96); C2225(1.08); C406(1.08)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C1707(0.94); C927(0.95); C406(1.00); C2225(1.05)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C927(0.88); C1707(0.94); C2225(1.06); C406(1.28)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C2225(0.87); C927(0.91); C406(1.00); C1707(1.23)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C2225(0.81); C927(0.98); C1707(1.05); C406(1.09)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C2225(0.69); C611(0.78); C421(0.89); C423(0.89)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C2225(0.63); C421(0.89); C423(0.89); C611(0.90)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C2225(0.67); C611(0.81); C421(0.86); C423(0.86)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C421(0.51); C423(0.51); C2225(0.66); C611(0.69)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C2225(0.95); C421(1.01); C423(1.01); C406(1.07)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C421(0.50); C423(0.50); C2225(0.63); C611(0.66)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C2225(0.66); C421(0.72); C423(0.72); C611(0.80)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C2225(0.58); C421(0.60); C423(0.60); C611(0.71)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C2225(0.60); C611(0.81); C421(0.93); C423(0.93)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C2225(0.64); C611(0.73); C421(0.95); C423(0.95)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C406(0.81); C1707(0.85); C611(0.87); C927(0.97)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C406(0.94); C611(0.98); C1707(1.00); C2225(1.05)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C406(0.93); C927(0.94); C611(0.96); C2225(1.05)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C1707(0.86); C406(0.91); C927(1.03); C611(1.04)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1707(0.95); C406(0.97); C611(0.99); C927(1.00)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C421(0.83); C423(0.83); C2225(0.96); C406(1.04)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C927(0.94); C2225(0.98); C406(1.07); C611(1.11)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C406(0.79); C2225(0.99); C927(1.03); C611(1.03)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C1707(0.92); C2225(0.96); C421(1.03); C423(1.03)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C1707(0.97); C611(1.00); C927(1.09); C2225(1.11)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C2225(0.92); C927(0.96); C1707(1.04); C611(1.08)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C927(0.92); C2225(0.95); C406(1.09); C1707(1.21)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C423(0.83); C2225(0.92); C1490(0.95); C611(0.99)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C423(0.71); C421(0.86); C1490(0.96); C2225(0.96)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C423(0.87); C406(1.06); C421(1.10); C2225(1.11)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C423(0.54); C611(0.78); C421(0.83); C2225(0.99)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C406(0.91); C421(0.91); C423(0.91); C2225(0.97)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C423(0.63); C421(0.84); C2225(0.89); C1490(0.93)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C423(0.83); C1490(0.92); C406(0.95); C421(0.99)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C2225(0.87); C1490(0.92); C421(0.99); C406(1.02)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C611(0.91); C1490(0.97); C2225(0.99); C423(1.09)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C423(0.66); C421(0.72); C611(0.86); C2225(0.95)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C611(0.78); C1490(1.08); C2225(1.11); C423(1.15)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C611(0.77); C423(0.79); C421(0.91); C2225(1.07)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C421(0.93); C423(0.93); C2225(0.93); C1707(0.95)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C611(0.76); C2225(0.86); C421(0.89); C423(0.89)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C611(0.77); C2225(0.92); C421(1.05); C423(1.05)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1490(0.66); C2225(0.80); C927(0.91); C423(0.91)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C611(0.87); C2225(0.95); C421(0.97); C423(0.97)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C611(0.80); C2225(0.95); C421(1.04); C423(1.04)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C611(0.74); C2225(1.00); C1707(1.12); C406(1.27)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C2225(0.99); C611(1.02); C1707(1.10); C927(1.10)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C2225(1.08); C1707(1.09); C927(1.23); C406(1.43)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C611(0.90); C2225(1.00); C421(1.03); C423(1.03)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C611(0.83); C2225(0.91); C1707(1.06); C421(1.07)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C421(0.82); C423(0.82); C611(0.94); C2225(0.99)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C421(0.91); C423(0.91); C1707(1.06); C406(1.08)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C421(1.04); C423(1.04); C406(1.04); C1707(1.12)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C1490(0.80); C2225(0.88); C927(0.94); C406(1.08)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C421(0.93); C423(0.93); C1707(1.01); C2225(1.12)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C2225(1.14); C1707(1.17); C406(1.19); C421(1.23)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C421(0.74); C423(0.74); C2225(1.00); C1707(1.03)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C421(1.16); C423(1.16); C406(1.20); C2225(1.29)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C421(1.06); C423(1.06); C406(1.22); C1707(1.25)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C406(1.07); C2225(1.16); C421(1.16); C423(1.16)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C421(0.96); C423(0.96); C406(1.11); C2225(1.19)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C421(1.03); C423(1.03); C2225(1.09); C927(1.22)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C1707(0.99); C2225(1.15); C927(1.19); C406(1.24)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C421(0.94); C423(0.94); C1707(1.01); C2225(1.06)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C1490(0.67); C2225(0.86); C927(0.95); C406(1.06)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C421(0.99); C423(0.99); C1707(1.15); C406(1.22)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C1707(0.88); C421(0.93); C423(0.93); C406(0.99)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C406(1.00); C421(1.11); C423(1.11); C1707(1.22)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C421(0.66); C423(0.66); C2225(0.74); C1707(0.89)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C421(0.60); C423(0.60); C2225(0.76); C1707(0.86)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C421(0.68); C423(0.68); C2225(0.75); C1707(0.80)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C2225(0.72); C421(0.79); C423(0.79); C1707(0.82)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1707(0.82); C2225(0.84); C421(0.85); C423(0.85)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C2225(0.73); C421(0.75); C423(0.75); C1707(0.84)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C421(0.72); C423(0.72); C2225(0.78); C1707(0.93)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C2225(0.84); C1707(0.92); C406(0.97); C421(1.07)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C421(0.75); C423(0.75); C2225(0.82); C1707(1.01)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C421(0.73); C423(0.73); C2225(0.74); C1707(0.99)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C421(0.63); C423(0.63); C1707(0.75); C2225(0.83)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C2225(0.66); C1707(0.72); C421(0.86); C423(0.86)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1707(0.85); C421(0.96); C423(0.96); C2225(1.00)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C2225(0.79); C1707(1.07); C421(1.08); C423(1.08)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C421(0.61); C423(0.61); C1707(0.71); C2225(0.73)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C1490(0.42); C421(0.53); C423(0.53); C2225(0.75)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C1490(0.46); C421(0.62); C423(0.62); C1707(0.71)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C1490(1.11); C1707(1.26); C2225(0.97); C406(1.00)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C2225(0.92); C1490(0.93); C927(0.96); C406(1.04)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C421(0.78); C1490(0.79); C2225(0.82); C927(0.84)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C406(1.10); C927(0.91)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa H4560(0.00); C4893(0.00); C406(0.00); C1380(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C2404(20.00); C1380(20.00); C611(4.06); C1151(1.60)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C1707(0.95); C406(0.97); C611(1.03); C927(1.04)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C406(0.84); C2225(0.88); C423(0.88); C421(0.98)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C421(0.69); C423(0.69); C2225(0.91); C611(0.95)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C1490(0.64); C2225(0.78); C927(0.93); C406(1.15)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C2225(0.89); C1490(0.92); C927(0.96); C1707(1.30)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C1490(0.82); C2225(0.99); C927(1.00); C406(1.07)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C1490(0.90); C2225(0.93); C406(1.00); C421(1.06)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C1707(0.90); C2225(0.92); C927(0.95); C406(1.38)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C927(0.99); C2225(1.06); C1707(1.12); C406(1.35)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C2225(1.07); C927(1.08); C1707(1.18); C406(1.35)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C2225(0.94); C927(0.96); C1707(1.02); C406(1.41)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C2225(0.89); C1707(0.96); C927(1.05); C406(1.39)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C423(0.90); C927(0.91); C2225(0.93); C421(0.98)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C2225(0.86); C1707(0.96); C927(1.02); C406(2.02)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C1707(0.82); C2225(0.88); C927(1.01); C406(1.42)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C611(0.80); C421(0.91); C423(0.91); C1707(0.95)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C421(0.58); C423(0.58); C2225(0.64); C611(0.70)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C421(0.52); C423(0.52); C611(0.63); C2225(0.74)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C421(0.59); C423(0.59); C2225(0.70); C611(0.73)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C2225(0.66); C611(0.82); C421(0.89); C423(0.89)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C2225(0.95); C421(0.98); C423(0.98); C1707(1.03)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C421(0.96); C423(0.96); C2225(0.98); C1707(1.01)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C421(0.94); C423(0.94); C1707(0.99); C406(1.06)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C406(0.89); C423(0.97); C927(1.01); C421(1.14)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C406(0.89); C1707(0.94); C2225(0.97); C611(0.98)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C611(0.71); C421(0.72); C2225(0.83); C1707(0.84)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C423(0.75); C611(0.78); C421(0.91); C2225(0.92)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C423(0.85); C611(0.95); C421(0.95); C2225(0.96)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C423(0.69); C421(0.72); C2225(0.98); C1490(1.01)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C611(0.84); C2225(0.94); C1707(0.97); C927(1.06)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C2225(0.86); C611(0.91); C421(0.95); C423(0.95)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C611(0.86); C2225(0.89); C927(0.96); C1707(0.97)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C421(0.84); C423(0.84); C2225(0.88); C611(0.89)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C406(0.93); C423(1.00); C927(1.01); C421(1.12)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C2225(0.86); C406(0.88); C927(0.92); C1707(0.97)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C927(0.88); C1707(0.91); C406(1.02); C2225(1.18)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C611(0.72); C2225(0.76); C1707(0.98); C406(1.00)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C421(0.75); C423(0.75); C2225(0.85); C1707(0.94)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C611(0.87); C421(0.94); C423(0.94); C406(0.95)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C2225(0.89); C421(0.90); C423(0.90); C406(0.95)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C406(0.84); C1707(0.89); C927(0.93); C2225(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C421(0.75); C423(0.75); C2225(0.77); C611(0.81)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C611(0.83); C2225(0.85); C421(0.87); C423(0.87)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C421(0.87); C423(0.87); C2225(0.90); C611(0.98)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C421(0.68); C423(0.68); C2225(0.81); C611(0.91)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C2225(0.81); C406(0.96); C611(1.02); C421(1.12)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C1707(1.13); C2225(0.81); C406(1.30); C421(0.77)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C1707(0.99); C2225(0.76); C406(0.84); C421(0.72)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C1707(1.05); C2225(0.82); C406(0.96); C421(1.17)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C1707(1.06); C2225(0.81); C406(0.98); C421(1.03)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C1707(1.26); C2225(0.81); C406(0.99); C421(0.75)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C1707(0.91); C2225(1.26); C406(0.90); C421(1.05)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C1707(1.11); C2225(0.89); C406(0.91); C421(1.07)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C1707(0.89); C2225(0.83); C406(1.02); C421(0.86)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C1707(1.08); C2225(1.02); C406(1.14); C421(1.29)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C1707(0.95); C2225(0.73); C406(1.11); C421(1.06)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C1707(0.81); C2225(0.77); C406(1.23); C421(0.74)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C1707(0.97); C2225(0.72); C406(1.18); C421(0.50)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C1707(0.87); C2225(0.72); C406(1.28); C421(0.58)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C1707(0.91); C2225(0.76); C406(1.22); C421(0.99)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C1707(0.99); C2225(0.77); C406(1.25); C421(0.65)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C1707(0.88); C2225(1.00); C406(0.94); C421(1.22)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C1707(0.94); C2225(0.75); C406(1.21); C421(0.96)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C1707(0.89); C2225(0.73); C406(1.15); C421(0.73)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C1707(0.89); C2225(0.82); C406(1.37); C421(0.85)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C1707(0.97); C2225(0.81); C406(1.33); C421(0.65)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C1707(1.00); C2225(0.82); C406(1.27); C421(0.65)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C1707(0.90); C2225(0.83); C406(1.24); C421(0.60)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C1707(1.12); C2225(0.94); C406(0.95); C421(1.74)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C1707(0.98); C2225(0.90); C406(0.96); C421(1.48)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C1707(1.13); C2225(0.91); C406(0.91); C421(1.64)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C1707(1.18); C2225(1.01); C406(1.03); C421(1.17)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C1707(0.97); C2225(1.05); C406(0.90); C421(1.12)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C1707(1.12); C2225(1.00); C406(1.15); C421(1.53)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C1707(1.10); C2225(1.12); C406(1.09); C421(1.80)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C1707(1.34); C2225(0.81); C406(0.92); C421(1.50)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C1707(1.03); C2225(0.90); C406(0.88); C421(1.55)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C1707(1.06); C2225(1.04); C406(0.82); C421(1.32)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C1707(1.32); C2225(1.03); C406(0.91); C421(1.42)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C1707(1.16); C2225(0.98); C406(0.91); C421(1.23)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C1707(0.98); C2225(1.08); C406(0.96); C421(1.68)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C1707(1.09); C2225(0.89); C406(0.93); C421(1.72)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C1707(0.96); C2225(1.02); C406(0.95); C421(1.05)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C1707(1.12); C2225(0.95); C406(1.07); C421(1.02)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C1707(1.07); C2225(0.91); C406(1.00); C421(1.10)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C1707(1.08); C2225(0.88); C406(1.13); C421(1.15)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C1707(0.88); C2225(0.93); C406(1.28); C421(1.05)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C1707(1.08); C2225(0.82); C406(1.44); C421(0.96)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C1707(0.95); C2225(0.76); C406(1.73); C421(1.03)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C1707(0.86); C2225(0.94); C406(1.19); C421(0.95)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C1707(1.10); C2225(0.83); C406(1.64); C421(0.74)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C1707(0.99); C2225(0.82); C406(1.33); C421(0.92)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C1707(0.85); C2225(0.70); C406(1.27); C421(1.02)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C1707(1.05); C2225(1.33); C406(1.13); C421(0.96)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C1707(1.04); C2225(0.83); C406(0.92); C421(0.95)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C1707(0.85); C2225(0.86); C406(1.18); C421(0.73)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C1707(0.79); C2225(0.81); C406(1.42); C421(0.72)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C1707(0.90); C2225(0.99); C406(1.09); C421(0.88)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C1707(0.85); C2225(0.81); C406(1.35); C421(0.86)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C1707(0.95); C2225(0.72); C406(1.22); C421(0.97)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C1490(0.91); C1707(1.00); C2225(1.20); C406(1.04)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C1490(0.96); C1707(0.83); C2225(1.09); C406(1.49)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C1490(0.93); C1707(1.27); C2225(0.98); C406(0.98)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C1490(0.84); C1707(1.09); C2225(0.91); C406(1.06)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C1707(1.04); C2225(1.22); C406(0.90); C421(0.80)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C1490(1.37); C1707(1.14); C2225(1.33); C406(0.99)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C1490(0.93); C1707(1.07); C2225(0.90); C406(1.02)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C1490(0.90); C1707(1.36); C2225(0.88); C406(0.97)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C1490(0.89); C1707(1.36); C2225(0.87); C406(3.61)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C1490(0.99); C1707(1.48); C2225(0.90); C406(1.42)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C1490(0.80); C1707(1.15); C2225(0.90); C406(0.96)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C1490(0.99); C1707(1.21); C2225(1.02); C406(0.91)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C1490(0.93); C1707(1.18); C2225(1.02); C406(1.00)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C1490(0.83); C1707(1.24); C2225(0.95); C406(0.88)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C1490(1.07); C1707(1.40); C2225(1.07); C406(0.87)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C1707(1.04); C2225(1.31); C406(1.14); C421(1.04)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C1490(1.08); C1707(1.04); C2225(1.14); C406(0.97)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C1707(1.34); C2225(0.89); C406(1.03); C421(1.01)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C1707(1.12); C2225(0.97); C406(0.97); C421(0.83)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C1707(1.18); C2225(0.99); C406(0.97); C421(1.02)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C1707(1.09); C2225(0.89); C406(1.02); C421(0.67)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C1707(1.04); C2225(0.82); C406(3.05); C421(0.74)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C1707(1.11); C2225(0.85); C406(1.04); C421(0.82)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C1707(1.08); C2225(0.82); C406(1.21); C421(0.80)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C1707(1.19); C2225(0.83); C406(1.06); C421(0.82)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C1707(1.26); C2225(0.91); C406(1.02); C421(0.77)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C1707(0.61)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C406(1.04)  LDD1698  [15]
 LDCM0468  Fragment33 HCT 116 C1707(0.80); C2225(0.84); C406(1.13); C421(0.79)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C1707(0.67); C2225(0.77); C406(1.29); C421(0.58)  LDD0744  [7]
 LDCM0107  IAA HeLa H4560(0.00); C927(0.00); C4893(0.00); H662(0.00)  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C406(1.13); C2225(1.00); C1888(0.91); C927(1.02)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C406(1.00); C2225(1.06); C1888(1.06); C927(0.95)  LDD1497  [15]
 LDCM0024  KB05 G361 C2225(1.87)  LDD3311  [16]
 LDCM0109  NEM HeLa H4560(0.00); H4855(0.00); H443(0.00); C4893(0.00)  LDD0223  [12]
 LDCM0021  THZ1 HCT 116 C1707(1.15); C2225(1.01)  LDD2173  [7]
 LDCM0111  W14 Hep-G2 C1490(0.65)  LDD0238  [1]
 LDCM0112  W16 Hep-G2 C406(0.59)  LDD0239  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor substrate 15 (EPS15) . P42566

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840