Details of the Target

General Information of Target

Target ID LDTP11625
Target Name Ribosome biogenesis protein WDR12 (WDR12)
Gene Name WDR12
Gene ID 55759
Synonyms
Ribosome biogenesis protein WDR12; WD repeat-containing protein 12
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPSTRASEVLCSTNVSHYEL
QVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNIT
TYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGC
IHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQ
DLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESR
MKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA
SSLLSHVFFKQMKEESQDSILSLLPPAYNKPSISLPPVLPWTEPECDFPDEKDSYWEF
Target Bioclass
Other
Family
WD repeat WDR12/YTM1 family
Subcellular location
Nucleus, nucleolus
Function Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {|HAMAP-Rule:MF_03029}.
Uniprot ID
Q9GZL7
Ensemble ID
ENST00000261015.5
HGNC ID
HGNC:14098

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.64  LDD0402  [1]
W1
 Probe Info  		12.00  LDD0235  [2]
BTD
 Probe Info  		C185(2.23)  LDD1700  [3]
HHS-482
 Probe Info  		Y89(1.86)  LDD0285  [4]
HHS-475
 Probe Info  		Y89(0.86)  LDD0264  [5]
HHS-465
 Probe Info  		Y89(5.20)  LDD2237  [6]
DBIA
 Probe Info  		C302(1.07); C309(1.07)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C205(0.00); C272(0.00); C97(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C205(0.00); C272(0.00); C309(0.00); C302(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
Acrolein
 Probe Info  		C97(0.00); C309(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		H420(0.00); C302(0.00)  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
NAIA_5
 Probe Info  		C205(0.00); C375(0.00); C272(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C185(0.98); C184(0.75)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C185(1.33)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C205(1.31); C97(0.78)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C205(1.08); C302(1.02); C309(1.02); C97(1.22)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C302(0.87); C309(0.87)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C302(0.90); C309(0.90)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C302(0.93); C309(0.93)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C302(0.94); C309(0.94)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C302(0.91); C309(0.91)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C302(1.00); C309(1.00)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C302(0.92); C309(0.92)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C302(1.12); C309(1.42)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C302(0.79); C309(0.99)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C302(0.77); C309(0.98)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C205(1.01); C302(0.92); C309(0.92); C97(1.01)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C302(1.01); C309(0.88)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C302(0.87); C309(0.96)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C302(1.04); C309(1.11)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C302(1.24); C309(1.24)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C302(1.14); C309(1.14)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C302(1.14); C309(1.14)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C302(1.20); C309(1.20)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C302(1.10); C309(1.10)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C302(1.13); C309(1.13)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C302(0.95); C309(0.95)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C205(0.98); C302(0.88); C309(0.88); C97(1.05)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C302(1.05); C309(1.05)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C302(1.15); C309(1.15)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C302(1.14); C309(1.14)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C302(1.22); C309(1.22)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C302(1.07); C309(1.07)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C302(1.06); C309(1.06)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C302(1.24); C309(1.24)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C302(1.12); C309(1.12)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C302(1.24); C309(1.24); C97(1.06)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C302(1.30); C309(1.30); C97(0.41)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C302(1.29); C309(1.29); C97(0.97)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C302(1.25); C309(1.25); C97(0.89)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C302(1.23); C309(1.23); C97(0.80)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C302(1.35); C309(1.35); C97(0.79)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C302(1.05); C309(1.05); C97(1.18)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C302(1.18); C309(1.18); C97(1.01)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C302(1.35); C309(1.35); C97(0.73)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C302(1.20); C309(1.20); C97(1.07)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C302(1.10); C309(1.10); C97(0.68)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C302(1.23); C309(1.23); C97(0.80)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C205(0.90); C302(1.02); C309(1.02); C97(1.04)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C302(1.18); C309(1.18); C97(1.14)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C302(1.18); C309(1.18); C97(0.81)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C302(1.17); C309(1.17); C97(0.99)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C309(0.94); C302(1.11)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C309(1.03); C302(1.22)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C309(1.02); C302(1.13)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C309(1.08); C302(1.27)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C309(0.97); C302(1.16)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C309(1.14); C302(1.34)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C309(1.09); C302(1.33)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C302(0.92); C309(0.92); C205(1.10); C97(1.63)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C309(0.98); C302(1.21)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C309(0.89); C302(1.02)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C309(1.12); C302(1.43)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C309(1.09); C302(1.43)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C302(1.14); C309(0.99)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C302(1.28); C309(1.00)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C302(1.18); C309(0.96)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C302(1.13); C309(0.91)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C205(0.82); C97(0.84)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C205(0.90); C97(1.81)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C97(0.92); C205(0.93)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C97(1.07); C205(1.23)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C97(0.85); C205(0.98)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C97(0.89); C205(1.01)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C205(0.81); C97(0.81)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C205(0.79); C97(0.83)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C205(0.82); C97(0.87)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C97(0.98); C302(1.02); C309(1.02)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C97(1.04); C302(1.14); C309(1.14)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C97(1.09); C302(1.17); C309(1.17)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C97(1.10); C302(1.14); C309(1.14)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C97(0.98); C302(1.18); C309(1.18)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C97(0.97); C205(1.10)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C97(0.99); C302(1.21); C309(1.21)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C302(1.12); C309(1.12); C97(1.23)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C302(1.07); C309(1.07); C97(1.29)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C97(1.14); C302(1.15); C309(1.15)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C302(1.09); C309(1.09); C97(1.28)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C302(0.86); C309(0.86); C205(1.09); C97(1.29)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C302(0.87); C309(0.87); C205(1.12); C97(1.15)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C302(1.09); C309(1.09); C205(1.12); C97(1.41)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C302(1.04); C309(1.04); C97(1.05); C205(1.06)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C302(0.89); C309(0.89); C205(1.17); C97(1.27)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C97(0.92); C205(1.22)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C302(1.04); C309(1.04); C97(1.17); C205(1.19)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C205(1.04); C302(1.14); C309(1.14); C97(1.24)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C302(0.88); C309(0.88); C205(1.12); C97(1.33)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C205(1.12); C302(1.18); C309(1.18); C97(1.34)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C205(1.07); C97(1.15); C302(1.21); C309(1.21)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C302(1.13); C309(1.13); C205(1.15); C97(1.34)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C302(1.00); C309(1.07); C97(1.24)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C302(0.90); C309(1.02); C97(1.29)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C302(0.95); C309(1.03); C97(1.12)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C302(1.08); C309(1.10); C97(1.84)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C97(0.87); C205(1.25)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C302(0.95); C309(0.98); C97(1.50)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C302(0.91); C309(1.04); C97(1.09)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C302(0.95); C309(1.00); C97(1.40)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C302(0.93); C309(1.08); C97(1.27)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C302(0.85); C309(1.00); C97(1.40)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C309(0.96); C302(1.04); C97(1.47)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C302(0.88); C309(0.90); C97(1.54)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C302(1.26); C309(1.26); C97(1.62)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C302(1.32); C309(1.32); C97(1.65)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C302(1.23); C309(1.23); C97(1.93)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C97(1.01); C302(1.02); C309(1.02); C205(1.09)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C302(1.24); C309(1.24); C97(1.62)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C302(1.42); C309(1.42); C97(1.50)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C302(1.31); C309(1.31); C97(1.79)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C302(1.16); C309(1.16); C97(2.70)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C302(1.27); C309(1.27); C97(2.00)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C302(1.37); C309(1.37); C97(2.04)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C302(1.48); C309(1.48); C97(2.10)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C302(1.17); C309(1.17); C97(1.74)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C302(0.91); C309(0.91); C205(1.68)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C205(1.02); C302(1.09); C309(1.09)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C302(0.89); C309(0.89); C97(0.98); C205(1.03)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C302(0.96); C309(0.96); C205(1.49)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C302(1.06); C309(1.06); C205(1.35)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C302(1.00); C309(1.00); C205(1.12)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C302(0.95); C309(0.95); C205(1.16)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C302(0.98); C309(0.98); C205(1.15)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C302(0.75); C309(0.75); C205(0.92)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C302(1.00); C309(1.00); C205(1.22)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C302(1.01); C309(1.01); C205(1.42)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C302(0.96); C309(0.96); C205(1.30)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C302(0.88); C309(0.88); C205(1.04)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C205(0.81); C302(0.90); C309(0.90); C97(1.13)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C205(0.83); C302(0.98); C309(0.98)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C302(1.15); C309(1.15); C205(1.32)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C302(0.39); C309(0.39); C205(0.48)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C302(1.18); C309(1.18)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C302(1.18); C309(1.18)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C302(1.12); C309(1.12)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C302(1.10); C309(1.10)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C302(1.07); C309(1.07)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C302(1.13); C309(1.13)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C302(1.08); C309(1.08)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C302(0.99); C309(0.99)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C302(1.13); C309(1.13)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C302(1.22); C309(1.22)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C302(1.09); C309(1.09)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C302(1.21); C309(1.21)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C302(1.18); C309(1.18)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C302(1.17); C309(1.17)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C302(1.22); C309(1.22)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C302(0.51); C309(0.51)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C302(0.79); C309(0.79)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C205(1.26); C302(1.02); C309(1.02); C97(1.23)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C302(1.06); C309(1.06); C205(1.17); C97(1.21)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C205(1.23); C302(1.29); C309(1.29); C97(1.57)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.66  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C302(1.07); C309(1.07)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C97(0.00); H420(0.00); C302(0.00); C309(0.00)  LDD0222  [14]
 LDCM0367  CL1 HCT 116 C97(0.60); C205(0.81); C302(0.96); C309(0.96)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C97(0.64); C302(0.93); C309(0.93); C205(0.95)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C97(0.95); C205(1.26)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C205(0.90); C97(1.10); C302(1.22); C309(1.22)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C302(0.95); C309(0.95); C205(1.01); C97(1.06)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C205(0.89); C302(1.04); C309(1.04); C97(1.05)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C205(0.79); C97(0.95); C302(1.05); C309(1.05)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C205(0.84); C97(1.01)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C205(0.95); C97(1.29)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C205(0.86); C97(1.13)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C205(1.07); C97(1.26)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C97(0.83); C205(0.90)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C97(0.71); C302(1.11); C309(1.11); C205(1.51)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C205(0.88); C97(0.92)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C205(0.86); C97(0.99)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C302(0.99); C309(0.99); C97(0.99)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C302(1.09); C309(1.09); C97(1.10)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C97(0.94); C302(1.19); C309(1.19)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C302(1.08); C309(1.08); C97(1.20)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C302(0.98); C309(0.98); C97(0.98)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C302(0.91); C309(0.91); C205(1.15); C97(1.45)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C302(1.06); C309(1.06); C97(1.09); C205(1.14)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C302(1.02); C309(1.02); C205(1.07); C97(1.17)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C97(1.01); C302(1.12); C309(1.12); C205(1.18)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C302(0.85); C309(0.85); C97(1.12); C205(1.28)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C302(0.91); C309(1.10); C97(1.84)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C302(0.99); C309(1.00); C97(1.68)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C309(1.03); C302(1.18); C97(1.58)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C309(1.19); C302(1.19); C97(1.48)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C302(1.07); C309(1.07); C97(1.15)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C302(1.15); C309(1.15); C97(1.69)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C302(1.19); C309(1.19); C97(1.49)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C302(1.00); C309(1.00); C97(1.39)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C205(0.94); C97(1.00); C302(1.12); C309(1.12)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C97(0.56); C205(0.94); C302(1.02); C309(1.02)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C205(0.45); C97(0.67); C302(1.18); C309(1.18)  LDD0719  [7]
 LDCM0403  CL16 PaTu 8988t C97(1.10); C302(0.96); C309(0.96)  LDD1282  [7]
 LDCM0404  CL17 HCT 116 C97(1.18)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C97(1.01)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C97(1.13)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C97(0.64); C205(0.91); C302(0.92); C309(0.92)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C97(1.20)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C97(1.27)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C97(1.11)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C97(2.02)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C97(0.89)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C97(1.23)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C97(0.96)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C97(1.42)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C97(0.99)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C97(1.10)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C205(0.97); C302(0.91); C309(0.91); C97(0.67)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C97(1.27)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C205(0.59); C302(1.15); C309(1.15); C97(1.03)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C205(0.86); C302(1.53); C309(1.53); C97(1.20)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C205(1.02); C302(1.43); C309(1.43); C97(1.00)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C205(0.49); C302(1.38); C309(1.38); C97(1.18)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C205(0.69); C302(1.48); C309(1.48); C97(0.90)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C205(0.58); C302(1.41); C309(1.41); C97(1.25)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C205(0.56); C302(1.50); C309(1.50); C97(1.01)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C205(0.79); C302(1.36); C309(1.36); C97(1.10)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C205(1.28); C302(1.16); C309(1.16); C97(0.56)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C205(0.71); C302(1.17); C309(1.17); C97(0.75)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C205(0.82); C302(1.34); C309(1.34); C97(0.96)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C205(0.64); C302(1.34); C309(1.34); C97(0.89)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C205(0.62); C302(1.52); C309(1.52); C97(0.93)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C205(0.62); C302(1.55); C309(1.55); C97(1.21)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C205(0.82); C302(1.31); C309(1.31); C97(1.22)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C205(0.73); C302(0.71); C309(0.71)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C205(0.70); C302(0.73); C309(0.73)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C205(0.71); C302(0.80); C309(0.80)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C205(0.84); C302(0.86); C309(0.86)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C205(0.90); C302(1.05); C309(1.05); C97(0.88)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C205(0.75); C302(0.83); C309(0.83)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C205(0.83); C302(0.72); C309(0.72)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C205(0.83); C302(0.78); C309(0.78)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C205(0.75); C302(0.91); C309(0.91)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C205(0.75); C302(0.82); C309(0.82)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C205(0.73); C302(0.75); C309(0.75)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C205(0.77); C302(0.71); C309(0.71)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C205(0.68); C302(0.82); C309(0.82)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C205(0.76); C302(0.74); C309(0.74)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C205(0.88); C302(0.71); C309(0.71)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C205(0.99); C302(1.15); C309(1.15); C97(0.73)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C205(0.73); C302(0.73); C309(0.73)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C205(1.15); C302(0.96); C309(0.96); C97(0.85)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C205(0.96); C302(0.86); C309(0.86); C97(0.74)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C205(0.96); C302(0.87); C309(0.87); C97(0.87)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C205(1.14); C302(0.99); C309(0.99); C97(1.03)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C205(1.07); C302(1.02); C309(1.02); C97(0.88)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C205(1.00); C302(1.06); C309(1.06); C97(1.23)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C205(1.23); C302(1.12); C309(1.12); C97(1.11)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C205(1.04); C302(1.11); C309(1.11); C97(0.85)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C205(1.08); C302(1.24); C309(1.24); C97(0.89)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C205(1.28); C302(1.07); C309(1.07); C97(0.86)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C205(1.18); C302(1.04); C309(1.04); C97(0.94)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C205(0.93); C302(1.05); C309(1.05); C97(0.82)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C205(1.12); C302(0.91); C309(0.91); C97(0.84)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C205(0.99); C302(1.09); C309(1.09); C97(0.96)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C205(1.02); C302(1.06); C309(1.06); C97(0.85)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C302(0.92); C309(0.92)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C302(0.77); C309(0.77)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C302(0.99); C309(0.99)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C302(0.92); C309(0.92)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C205(1.10); C302(1.24); C309(1.24); C97(1.06)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C302(0.93); C309(0.93)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C302(0.79); C309(0.79)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C302(0.88); C309(0.88)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C302(0.79); C309(0.79)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C302(1.05); C309(1.05)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C302(0.97); C309(0.97)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C302(0.98); C309(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C302(0.83); C309(0.83)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C302(0.83); C309(0.83)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C302(0.92); C309(0.92)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C205(1.11); C302(0.96); C309(0.96); C97(0.77)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C302(1.04); C309(1.04)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C205(1.06); C97(1.07)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C205(1.00); C97(0.73)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C205(1.02); C97(0.97)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C205(1.07); C97(1.21)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C205(1.09); C97(0.95)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C205(1.08); C97(1.01)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C205(1.01); C97(0.94)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C205(1.03); C97(1.04)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C205(1.18); C97(0.76)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C97(0.74); C309(1.00)  LDD1698  [16]
 LDCM0468  Fragment33 HCT 116 C205(1.01); C302(0.99); C309(0.99); C97(0.95)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C205(0.64); C302(1.34); C309(1.34); C97(0.98)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y89(0.86)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y89(0.78)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y89(0.77)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y89(0.91)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y89(0.80)  LDD0268  [5]
 LDCM0107  IAA HeLa C302(0.00); C97(0.00); H420(0.00); C309(0.00)  LDD0221  [14]
 LDCM0123  JWB131 DM93 Y89(1.86)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y89(1.27)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y89(0.97)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y89(3.84)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y89(2.46)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y89(0.17)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y89(1.28)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y89(1.10)  LDD0292  [4]
 LDCM0022  KB02 HEK-293T C309(0.98); C302(1.07)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C309(0.90); C302(0.99)  LDD1497  [16]
 LDCM0024  KB05 COLO792 C97(1.13)  LDD3310  [17]
 LDCM0109  NEM HeLa H420(0.00); H385(0.00); H354(0.00)  LDD0223  [14]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C185(1.21)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C185(1.02); C184(1.12)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C205(0.63)  LDD2100  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C185(1.08); C184(0.93)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C185(0.88)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C185(1.05)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C185(1.66); C184(1.07)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C184(0.73)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C184(0.63)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C185(0.95); C184(0.80)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C185(1.00); C184(0.69)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C184(0.74)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C185(1.27)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C184(1.28)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C184(0.82)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C185(2.23)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C185(1.01); C184(0.97)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C184(0.98)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C185(1.69)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C185(1.07); C184(0.99)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C185(1.24)  LDD2147  [3]
 LDCM0021  THZ1 HCT 116 C302(1.07); C309(1.07); C205(1.09)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pescadillo homolog (PES1) Pescadillo family O00541
Ribosome biogenesis protein BOP1 (BOP1) WD repeat BOP1/ERB1 family Q14137
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840