Details of the Target

General Information of Target

Target ID LDTP00551
Target Name Actin-related protein 2/3 complex subunit 2 (ARPC2)
Gene Name ARPC2
Gene ID 10109
Synonyms
ARC34; Actin-related protein 2/3 complex subunit 2; Arp2/3 complex 34 kDa subunit; p34-ARC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFDGVLYHISNPNGDKTKVMVSIS
LKFYKELQAHGADELLKRVYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLKRNC
FASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVESKKDRVTVVFSTVFKDDDDVVIGKV
FMQEFKEGRRASHTAPQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNASARDNT
INLIHTFRDYLHYHIKCSKAYIHTRMRAKTSDFLKVLNRARPDAEKKEMKTITGKTFSSR
Target Bioclass
Other
Family
ARPC2 family
Subcellular location
Cytoplasm, cytoskeleton
Function
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Uniprot ID
O15144
Ensemble ID
ENST00000295685.14
HGNC ID
HGNC:705
ChEMBL ID
CHEMBL4295657

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.07  LDD0402  [1]
CHEMBL5175495
 Probe Info  		7.05  LDD0196  [2]
CY4
 Probe Info  		9.60  LDD0244  [3]
N1
 Probe Info  		6.23  LDD0242  [3]
W1
 Probe Info  		14.66  LDD0235  [4]
C-Sul
 Probe Info  		9.01  LDD0066  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
ONAyne
 Probe Info  		K77(6.56)  LDD0274  [7]
OPA-S-S-alkyne
 Probe Info  		K186(1.46); K275(2.12)  LDD3494  [8]
Probe 1
 Probe Info  		Y153(33.89); Y253(112.57)  LDD3495  [9]
BTD
 Probe Info  		C120(0.98)  LDD2089  [10]
HHS-465
 Probe Info  		Y261(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C120(1.67)  LDD0531  [12]
5E-2FA
 Probe Info  		H193(0.00); H202(0.00); H111(0.00); H70(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K65(0.00); K275(0.00); K186(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
IPM
 Probe Info  		N.A.  LDD0025  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
NHS
 Probe Info  		K275(0.00); K157(0.00); K186(0.00)  LDD0010  [19]
SF
 Probe Info  		N.A.  LDD0028  [20]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
NAIA_5
 Probe Info  		C257(0.00); C120(0.00)  LDD2223  [22]
TER-AC
 Probe Info  		N.A.  LDD0426  [23]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [24]
STS-1
 Probe Info  		N.A.  LDD0068  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C120(0.62)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C120(0.87)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C120(0.46)  LDD2095  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C120(0.49)  LDD2132  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C120(0.67)  LDD2131  [10]
 LDCM0214  AC1 HCT 116 C120(1.67)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C120(1.15)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C120(0.94)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C120(0.67)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C120(0.63)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C120(0.63)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C120(0.60)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C120(0.64)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C120(0.69)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C120(0.76)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C120(0.82)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C120(0.78)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C120(1.15)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C120(0.74)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C120(0.75)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C120(0.75)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C120(1.40)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C120(1.21)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C120(1.15)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C120(1.20)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C120(1.13)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C120(1.15)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C120(1.10)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C120(1.02)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C120(1.26)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C120(1.23)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C120(1.23)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C120(1.22)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C120(1.33)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C120(1.26)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C120(1.16)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C120(1.20)  LDD0562  [12]
 LDCM0246  AC128 HEK-293T C120(0.87)  LDD0844  [12]
 LDCM0247  AC129 HEK-293T C120(0.78)  LDD0845  [12]
 LDCM0249  AC130 HEK-293T C120(0.72)  LDD0847  [12]
 LDCM0250  AC131 HEK-293T C120(0.80)  LDD0848  [12]
 LDCM0251  AC132 HEK-293T C120(0.80)  LDD0849  [12]
 LDCM0252  AC133 HEK-293T C120(0.67)  LDD0850  [12]
 LDCM0253  AC134 HEK-293T C120(0.73)  LDD0851  [12]
 LDCM0254  AC135 HEK-293T C120(0.75)  LDD0852  [12]
 LDCM0255  AC136 HEK-293T C120(1.12)  LDD0853  [12]
 LDCM0256  AC137 HEK-293T C120(0.75)  LDD0854  [12]
 LDCM0257  AC138 HEK-293T C120(0.79)  LDD0855  [12]
 LDCM0258  AC139 HEK-293T C120(0.73)  LDD0856  [12]
 LDCM0259  AC14 HCT 116 C120(1.12)  LDD0576  [12]
 LDCM0260  AC140 HEK-293T C120(0.50)  LDD0858  [12]
 LDCM0261  AC141 HEK-293T C120(0.79)  LDD0859  [12]
 LDCM0262  AC142 HEK-293T C120(0.70)  LDD0860  [12]
 LDCM0263  AC143 HEK-293T C120(0.82)  LDD0861  [12]
 LDCM0264  AC144 HEK-293T C120(0.85)  LDD0862  [12]
 LDCM0265  AC145 HEK-293T C120(0.70)  LDD0863  [12]
 LDCM0266  AC146 HEK-293T C120(0.80)  LDD0864  [12]
 LDCM0267  AC147 HEK-293T C120(0.82)  LDD0865  [12]
 LDCM0268  AC148 HEK-293T C120(0.72)  LDD0866  [12]
 LDCM0269  AC149 HEK-293T C120(0.47)  LDD0867  [12]
 LDCM0270  AC15 HCT 116 C120(0.92)  LDD0587  [12]
 LDCM0271  AC150 HEK-293T C120(0.72)  LDD0869  [12]
 LDCM0272  AC151 HEK-293T C120(0.75)  LDD0870  [12]
 LDCM0273  AC152 HEK-293T C120(0.82)  LDD0871  [12]
 LDCM0274  AC153 HEK-293T C120(0.86)  LDD0872  [12]
 LDCM0621  AC154 HEK-293T C120(0.99)  LDD2162  [12]
 LDCM0622  AC155 HEK-293T C120(0.70)  LDD2163  [12]
 LDCM0623  AC156 HEK-293T C120(0.80)  LDD2164  [12]
 LDCM0624  AC157 HEK-293T C120(1.02)  LDD2165  [12]
 LDCM0276  AC17 HCT 116 C120(0.93)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C120(0.90)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C120(0.89)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C120(1.29)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C120(0.83)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C120(0.87)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C120(0.92)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C120(0.85)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C120(1.36)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C120(0.97)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C120(0.81)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C120(0.86)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C120(0.81)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C120(0.74)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C120(1.22)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C120(0.71)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C120(0.84)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C120(0.71)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C120(0.77)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C120(0.69)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C120(1.30)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C120(1.06)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C120(1.60)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C120(1.04)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C120(1.01)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C120(1.53)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C120(1.05)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C120(1.10)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C120(0.98)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C120(0.79)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C120(1.43)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C120(1.35)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C120(0.62)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C120(0.93)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C120(0.74)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C120(0.69)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C120(1.48)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C120(0.64)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C120(0.69)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C120(0.72)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C120(1.08)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C120(0.81)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C120(0.99)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C120(0.65)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C120(1.11)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C120(0.85)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C120(0.71)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C120(0.93)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C120(0.75)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C120(0.89)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C120(0.83)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C120(0.89)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C120(0.88)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C120(0.99)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C120(1.07)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C120(0.78)  LDD0648  [12]
 LDCM0334  AC7 HCT 116 C120(1.05)  LDD0651  [12]
 LDCM0345  AC8 HCT 116 C120(0.96)  LDD0662  [12]
 LDCM0349  AC83 HCT 116 C120(0.73)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C120(0.75)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C120(0.72)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C120(0.81)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C120(0.97)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C120(0.86)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C120(0.73)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C120(1.19)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C120(0.74)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C120(0.61)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C120(0.75)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C120(0.88)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C120(1.08)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C120(0.78)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C120(0.78)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C120(0.12)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C120(0.68)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C120(0.85)  LDD2138  [10]
 LDCM0248  AKOS034007472 HCT 116 C120(1.30)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C120(1.43)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C120(0.76)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.43  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C120(1.21)  LDD2171  [12]
 LDCM0498  BS-3668 MDA-MB-231 C120(0.86)  LDD2091  [10]
 LDCM0108  Chloroacetamide HeLa C120(0.00); H263(0.00); H245(0.00)  LDD0222  [21]
 LDCM0367  CL1 HCT 116 C120(0.99)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C120(0.86)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C120(1.18)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C120(1.10)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C120(1.23)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C120(1.60)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C120(1.01)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C120(0.88)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C120(0.62)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C120(0.78)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C120(0.82)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C120(0.90)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C120(0.93)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C120(0.60)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C120(0.80)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C120(0.95)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C120(0.69)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C120(0.71)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C120(0.74)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C120(0.85)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C120(0.81)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C120(1.08)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C120(1.15)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C120(0.94)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C120(0.90)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C120(0.89)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C120(0.77)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C120(0.90)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C120(0.70)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C120(0.91)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C120(1.03)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C120(0.90)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C120(1.05)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C120(0.93)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C120(1.05)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C120(0.65)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C120(0.70)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C120(0.89)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C120(1.07)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C120(0.95)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C120(1.14)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C120(0.86)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C120(0.77)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C120(0.66)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C120(0.89)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C120(0.92)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C120(0.86)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C120(0.99)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C120(0.96)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C120(0.78)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C120(0.84)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C120(1.14)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C120(0.96)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C120(1.04)  LDD0737  [12]
 LDCM0421  CL32 HEK-293T C120(1.04)  LDD1625  [26]
 LDCM0422  CL33 HEK-293T C120(1.10)  LDD1626  [26]
 LDCM0423  CL34 HEK-293T C120(1.05)  LDD1627  [26]
 LDCM0424  CL35 HEK-293T C120(1.00)  LDD1628  [26]
 LDCM0425  CL36 HEK-293T C120(0.99)  LDD1629  [26]
 LDCM0426  CL37 HEK-293T C120(0.94)  LDD1630  [26]
 LDCM0428  CL39 HEK-293T C120(1.05)  LDD1632  [26]
 LDCM0429  CL4 HCT 116 C120(0.92)  LDD0746  [12]
 LDCM0430  CL40 HEK-293T C120(1.10)  LDD1634  [26]
 LDCM0431  CL41 HEK-293T C120(1.03)  LDD1635  [26]
 LDCM0432  CL42 HEK-293T C120(0.98)  LDD1636  [26]
 LDCM0433  CL43 HEK-293T C120(1.06)  LDD1637  [26]
 LDCM0434  CL44 HEK-293T C120(1.01)  LDD1638  [26]
 LDCM0435  CL45 HEK-293T C120(1.10)  LDD1639  [26]
 LDCM0436  CL46 HCT 116 C120(1.09)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C120(0.95)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C120(1.05)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C120(1.22)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C120(1.08)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C120(1.10)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C120(1.12)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C120(1.03)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C120(1.02)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C120(0.91)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C120(1.06)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C120(0.85)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C120(1.00)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C120(1.08)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C120(1.04)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C120(1.06)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C120(0.99)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C120(1.03)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C120(0.91)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C120(0.91)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C120(0.78)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C120(0.97)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C120(0.67)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C120(0.82)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C120(0.80)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C120(0.99)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C120(1.10)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C120(0.89)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C120(0.74)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C120(0.94)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C120(0.80)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C120(0.87)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C120(0.91)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C120(0.68)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C120(0.87)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C120(0.92)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C120(0.81)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C120(1.11)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C120(1.13)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C120(1.35)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C120(1.03)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C120(0.94)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C120(0.89)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C120(0.89)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C120(1.14)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C120(1.26)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C120(1.03)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C120(1.03)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C120(0.86)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C120(1.42)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C120(1.25)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C120(1.41)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C120(1.11)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C120(1.42)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C120(1.59)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C120(1.38)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C120(1.31)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C120(1.29)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C120(1.06)  LDD1698  [26]
 LDCM0625  F8 Ramos C120(0.72)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C120(0.56)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C120(0.08)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C120(0.72)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C120(0.93)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C120(0.83)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C120(0.66)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C120(0.98)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C120(0.91)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C120(0.87)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C120(0.66)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C120(0.97)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C120(1.17)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C120(0.45)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C120(0.70)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C120(0.76)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C120(0.66)  LDD2184  [27]
 LDCM0427  Fragment51 HEK-293T C120(1.01)  LDD1631  [26]
 LDCM0610  Fragment52 Ramos C120(1.03)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C120(0.94)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C120(0.76)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C120(0.58)  LDD2188  [27]
 LDCM0107  IAA HeLa H245(0.00); C120(0.00); H263(0.00)  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C120(0.95)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C120(0.93)  LDD1497  [26]
 LDCM0024  KB05 HMCB C120(1.69)  LDD3312  [28]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C120(1.15)  LDD2121  [10]
 LDCM0109  NEM HeLa H245(0.00); H263(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C120(0.98)  LDD2089  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C120(0.20)  LDD2096  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C120(1.19)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C120(0.56)  LDD2100  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C120(0.58)  LDD2104  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C120(0.91)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C120(0.83)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C120(0.76)  LDD2109  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C120(0.66)  LDD2114  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C120(0.47)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C120(0.46)  LDD2118  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C120(0.30)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C120(1.18)  LDD2123  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C120(0.33)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C120(1.00)  LDD2127  [10]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C120(0.49)  LDD2128  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C120(1.45)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C120(1.05)  LDD2137  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C120(0.54)  LDD2141  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C120(0.29)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C120(0.91)  LDD2146  [10]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C120(0.37)  LDD2149  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C120(0.81)  LDD2150  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C120(0.33)  LDD2151  [10]
 LDCM0131  RA190 MM1.R C120(1.23)  LDD0304  [29]
 LDCM0021  THZ1 HCT 116 C120(1.21)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vinculin (VCL) Vinculin/alpha-catenin family P18206
Coronin-1B (CORO1B) WD repeat coronin family Q9BR76

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2s)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-13-thiazolidin-4-one . DB08236
N-[2-(2-methyl-1h-indol-3-yl)Ethyl]Thiophene-2-carboxamide . DB08235

References

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2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
23 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.