Details of the Target

General Information of Target

Target ID LDTP06952
Target Name DBIRD complex subunit ZNF326 (ZNF326)
Gene Name ZNF326
Gene ID 284695
Synonyms
ZIRD; DBIRD complex subunit ZNF326; Zinc finger protein 326; Zinc finger protein interacting with mRNPs and DBC1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFEDDYTHSACRNTYQGFNGMDRDYGPGSYGGMDRDYGHGSYGGQRSMDSYLNQSYGMD
NHSGGGGGSRFGPYESYDSRSSLGGRDLYRSGYGFNEPEQSRFGGSYGGRFESSYRNSLD
SFGGRNQGGSSWEAPYSRSKLRPGFMEDRGRENYSSYSSFSSPHMKPAPVGSRGRGTPAY
PESTFGSRNYDAFGGPSTGRGRGRGHMGDFGSIHRPGIVVDYQNKSTNVTVAAARGIKRK
MMQPFNKPSGTFIKKPKLAKPMEKISLSKSPTKTDPKNEEEEKRRIEARREKQRRRREKN
SEKYGDGYRMAFTCSFCKFRTFEEKDIELHLESSSHQETLDHIQKQTKFDKVVMEFLHEC
MVNKFKKTSIRKQQTNNQTEVVKIIEKDVMEGVTVDDHMMKVETVHCSACSVYIPALHSS
VQQHLKSPDHIKGKQAYKEQIKRESVLTATSILNNPIVKARYERFVKGENPFEIQDHSQD
QQIEGDEEDEEKIDEPIEEEEDEDEEEEAEEVGEVEEVEEVEEVREGGIEGEGNIQGVGE
GGEVGVVGEVEGVGEVEEVEELEEETAKEEPADFPVEQPEEN
Target Bioclass
Other
Family
AKAP95 family
Subcellular location
Nucleus matrix
Function
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.
Uniprot ID
Q5BKZ1
Ensemble ID
ENST00000340281.9
HGNC ID
HGNC:14104

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.T450K .
IGR37 SNV: p.E280Q DBIA    Probe Info 
IGR39 SNV: p.E280Q DBIA    Probe Info 
JURKAT SNV: p.E565G .
NCIH1155 SNV: p.H358Y DBIA    Probe Info 
OVCAR8 SNV: p.P98S DBIA    Probe Info 
OVK18 SNV: p.N377K DBIA    Probe Info 
RKO Deletion: p.N300TfsTer41 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
W1
 Probe Info  		23.33  LDD0235  [3]
TH211
 Probe Info  		Y136(16.89)  LDD0260  [4]
ONAyne
 Probe Info  		K140(0.00); K459(0.00)  LDD0273  [5]
Probe 1
 Probe Info  		Y74(30.24); Y77(8.20); Y93(17.98); Y107(75.57)  LDD3495  [6]
AHL-Pu-1
 Probe Info  		C360(2.36)  LDD0168  [7]
DBIA
 Probe Info  		C314(0.45); C317(0.45)  LDD0533  [8]
5E-2FA
 Probe Info  		H40(0.00); H62(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K364(0.00); K366(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
IPM
 Probe Info  		N.A.  LDD0147  [13]
SF
 Probe Info  		Y77(0.00); Y74(0.00); Y107(0.00); Y93(0.00)  LDD0028  [14]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		C12(0.00); C410(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		29.86  LDD1845  [19]
C187
 Probe Info  		19.84  LDD1865  [19]
C191
 Probe Info  		17.03  LDD1868  [19]
C193
 Probe Info  		7.46  LDD1869  [19]
C338
 Probe Info  		17.63  LDD2001  [19]
C346
 Probe Info  		10.27  LDD2007  [19]
C348
 Probe Info  		16.34  LDD2009  [19]
C420
 Probe Info  		9.99  LDD2075  [19]
FFF probe11
 Probe Info  		20.00  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe2
 Probe Info  		20.00  LDD0463  [20]
FFF probe3
 Probe Info  		20.00  LDD0464  [20]
OEA-DA
 Probe Info  		5.91  LDD0046  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C360(2.36)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C360(2.86)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C360(1.10); C314(0.92)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C314(0.91); C317(1.02)  LDD0813  [8]
 LDCM0216  AC100 HCT 116 C314(0.45); C317(0.45)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C314(0.49); C317(0.49)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C314(0.45); C317(0.45)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C314(0.23); C317(0.23)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C314(0.32); C317(0.32)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C314(0.29); C317(0.29)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C314(0.27); C317(0.27)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C314(0.20); C317(0.20)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C314(0.60); C317(0.60)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C314(0.72); C317(0.72)  LDD0542  [8]
 LDCM0226  AC11 HEK-293T C314(1.00); C317(1.01)  LDD0824  [8]
 LDCM0227  AC110 HCT 116 C314(0.59); C317(0.59)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C314(0.53); C317(0.53)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C314(0.32); C317(0.32)  LDD0546  [8]
 LDCM0230  AC113 HEK-293T C317(1.01)  LDD0828  [8]
 LDCM0231  AC114 HEK-293T C317(1.02)  LDD0829  [8]
 LDCM0232  AC115 HEK-293T C317(1.03)  LDD0830  [8]
 LDCM0233  AC116 HEK-293T C317(1.13)  LDD0831  [8]
 LDCM0234  AC117 HEK-293T C317(1.22)  LDD0832  [8]
 LDCM0235  AC118 HEK-293T C317(1.28)  LDD0833  [8]
 LDCM0236  AC119 HEK-293T C317(1.52)  LDD0834  [8]
 LDCM0237  AC12 HEK-293T C314(1.00); C317(1.02)  LDD0835  [8]
 LDCM0238  AC120 HEK-293T C317(1.33)  LDD0836  [8]
 LDCM0239  AC121 HEK-293T C317(1.34)  LDD0837  [8]
 LDCM0240  AC122 HEK-293T C317(1.88)  LDD0838  [8]
 LDCM0241  AC123 HEK-293T C317(1.63)  LDD0839  [8]
 LDCM0242  AC124 HEK-293T C317(1.45)  LDD0840  [8]
 LDCM0243  AC125 HEK-293T C317(1.64)  LDD0841  [8]
 LDCM0244  AC126 HEK-293T C317(2.48)  LDD0842  [8]
 LDCM0245  AC127 HEK-293T C317(2.62)  LDD0843  [8]
 LDCM0259  AC14 HEK-293T C314(1.10); C317(1.13)  LDD0857  [8]
 LDCM0263  AC143 HCT 116 C314(1.01); C317(1.01)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C314(0.49); C317(0.49)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C314(0.78); C317(0.78)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C314(0.75); C317(0.75)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C314(0.41); C317(0.41)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C314(0.27); C317(0.27)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C314(0.49); C317(0.49)  LDD0586  [8]
 LDCM0270  AC15 HEK-293T C314(1.19); C317(1.27)  LDD0868  [8]
 LDCM0271  AC150 HCT 116 C314(0.71); C317(0.71)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C314(0.78); C317(0.78)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C314(0.46); C317(0.46)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C314(0.25); C317(0.25)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C314(0.53); C317(0.53)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C314(0.49); C317(0.49)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C314(0.85); C317(0.85)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C314(0.90); C317(0.90)  LDD2161  [8]
 LDCM0276  AC17 HEK-293T C314(1.14); C317(1.19)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C314(0.90); C317(1.02)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C314(0.93); C317(1.05)  LDD0876  [8]
 LDCM0279  AC2 HEK-293T C360(1.04); C317(0.90); C314(0.98)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C314(1.08); C317(1.26)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C314(1.07); C317(1.16)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C314(0.94); C317(1.29)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C314(0.92); C317(1.35)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C314(0.95); C317(1.09)  LDD0882  [8]
 LDCM0285  AC25 HCT 116 C360(0.98)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C360(1.05)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C360(1.06)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C360(1.05)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C360(0.96)  LDD0606  [8]
 LDCM0290  AC3 HEK-293T C360(1.03); C314(0.97)  LDD1529  [22]
 LDCM0291  AC30 HCT 116 C360(1.13)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C360(1.07)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C360(0.91)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C360(0.92)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C360(0.93)  LDD0612  [8]
 LDCM0296  AC35 HEK-293T C314(1.03); C317(1.03); C360(0.76)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C314(1.14); C317(1.14); C360(1.10)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C314(1.06); C317(1.06); C360(0.81)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C314(0.85); C317(0.85); C360(0.81)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C314(0.77); C317(0.77); C360(1.00)  LDD0898  [8]
 LDCM0301  AC4 HEK-293T C360(0.96); C314(1.13)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C314(0.95); C317(0.95); C360(1.55)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C314(0.89); C317(0.89); C360(0.77)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C314(0.78); C317(0.78); C360(0.79)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C314(0.91); C317(0.91); C360(0.78)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C314(0.89); C317(0.89); C360(1.02)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C314(0.82); C317(0.82); C360(1.41)  LDD0905  [8]
 LDCM0308  AC46 HCT 116 C360(0.88)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C360(0.94)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C360(1.23)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C360(0.74)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C317(0.97); C314(0.91)  LDD1551  [22]
 LDCM0313  AC50 HCT 116 C360(0.69)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C360(1.05)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C360(0.92)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C360(0.77)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C360(0.80)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C360(0.69)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C360(0.68)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C314(0.39); C317(0.39)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C314(0.36); C317(0.36)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C314(0.28); C317(0.28)  LDD0639  [8]
 LDCM0323  AC6 HEK-293T C314(0.78); C317(1.07)  LDD0921  [8]
 LDCM0324  AC60 HCT 116 C314(0.45); C317(0.45)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C314(0.72); C317(0.72)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C314(0.28); C317(0.28)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C314(0.40); C317(0.40)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C314(0.26); C317(0.26)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C314(0.29); C317(0.29)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C314(0.33); C317(0.33)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C314(0.14); C317(0.14)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C314(0.63); C317(0.63)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C314(0.57); C317(0.57)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C314(0.98); C317(1.12)  LDD0932  [8]
 LDCM0335  AC70 HCT 116 C314(0.28); C317(0.28)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C314(1.08); C317(1.08)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C314(0.58); C317(0.58)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C314(0.28); C317(0.28)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C314(0.31); C317(0.31)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C314(0.31); C317(0.31)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C314(0.36); C317(0.36)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C314(0.50); C317(0.50)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C314(1.01); C317(1.01)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C314(0.63); C317(0.63)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C314(0.90); C317(1.34)  LDD0943  [8]
 LDCM0346  AC80 HCT 116 C314(0.47); C317(0.47)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C314(1.15); C317(1.15)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C314(0.33); C317(0.33)  LDD0665  [8]
 LDCM0349  AC83 HEK-293T C360(0.61)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C360(0.64)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C360(0.83)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C360(0.56)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C360(0.63)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C360(0.77)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C360(0.55)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C360(0.78)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C360(0.82)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C360(0.60)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C360(0.34)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C360(0.40)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C360(0.70)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C360(0.45)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C360(0.63)  LDD0962  [8]
 LDCM0365  AC98 HCT 116 C314(0.14); C317(0.14)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C314(0.55); C317(0.55)  LDD0683  [8]
 LDCM0248  AKOS034007472 HEK-293T C314(1.04); C317(1.08)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C314(1.13); C317(1.32)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C314(0.92); C317(1.21)  LDD0873  [8]
 LDCM0156  Aniline NCI-H1299 13.58  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C314(1.19); C317(1.19)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C12(0.88); C12(0.73)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C360(1.13)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C360(0.82)  LDD0685  [8]
 LDCM0369  CL100 HEK-293T C360(1.05); C317(0.87); C314(0.86)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C314(0.77); C317(1.32)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C314(0.77); C317(1.26)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C314(0.97); C317(1.31)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C314(0.88); C317(1.21)  LDD0971  [8]
 LDCM0374  CL105 HEK-293T C314(0.80); C317(1.02)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C314(1.07); C317(0.92)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C314(0.88); C317(1.04)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C314(0.98); C317(1.12)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C314(0.90); C317(0.91)  LDD0976  [8]
 LDCM0379  CL11 HCT 116 C360(0.76)  LDD0696  [8]
 LDCM0380  CL110 HEK-293T C314(1.27); C317(0.97)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C314(0.96); C317(0.95)  LDD0979  [8]
 LDCM0382  CL112 HCT 116 C360(1.06)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C360(0.88)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C360(1.00)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C360(1.06)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C360(1.11)  LDD0703  [8]
 LDCM0387  CL117 HEK-293T C314(1.04); C317(1.04); C360(1.22)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C314(1.54); C317(1.54); C360(0.73)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C314(1.04); C317(1.04); C360(0.98)  LDD0987  [8]
 LDCM0390  CL12 HCT 116 C360(0.74)  LDD0707  [8]
 LDCM0391  CL120 HEK-293T C314(0.79); C317(0.79); C360(0.84)  LDD0989  [8]
 LDCM0392  CL121 HCT 116 C360(0.76)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C360(1.04)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C360(0.78)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C360(0.76)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C314(0.99); C317(0.99)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C314(0.92); C317(0.92)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C314(0.83); C317(0.83)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C314(0.33); C317(0.33)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C360(0.91)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C360(0.88)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C360(1.04)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C317(1.37)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C317(1.10)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C317(1.50)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C317(1.13)  LDD1004  [8]
 LDCM0407  CL2 HCT 116 C360(1.03)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C317(1.29)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C317(1.20)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C317(1.23)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C317(0.97)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C317(1.07)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C317(1.23)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C317(1.09)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C317(1.07)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C317(0.95)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C317(1.02)  LDD1015  [8]
 LDCM0418  CL3 HCT 116 C360(1.01)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C317(1.59)  LDD1017  [8]
 LDCM0420  CL31 HCT 116 C314(0.80); C317(0.80); C360(0.94)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C314(1.13); C317(1.13); C360(1.14)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C314(0.75); C317(0.75); C360(0.85)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C314(0.49); C317(0.49); C360(0.90)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C314(0.58); C317(0.58); C360(0.77)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C314(0.72); C317(0.72); C360(0.73)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C314(0.45); C317(0.45); C360(0.84)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C314(0.50); C317(0.50); C360(0.88)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C360(0.96)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C314(0.65); C317(0.65); C360(0.80)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C314(0.62); C317(0.62); C360(0.70)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C314(0.43); C317(0.43); C360(0.70)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C314(0.47); C317(0.47); C360(0.61)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C314(0.66); C317(0.66); C360(0.90)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C314(0.58); C317(0.58); C360(0.93)  LDD0752  [8]
 LDCM0436  CL46 HEK-293T C360(0.95)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C360(0.87)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C360(0.92)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C360(1.00)  LDD1037  [8]
 LDCM0440  CL5 HCT 116 C360(1.07)  LDD0757  [8]
 LDCM0441  CL50 HEK-293T C360(0.95)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C360(0.71)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C360(0.96)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C360(1.05)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C360(0.96)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C360(0.92)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C360(0.89)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C360(1.19)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C360(0.93)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C360(0.87)  LDD1048  [8]
 LDCM0451  CL6 HCT 116 C360(1.05)  LDD0768  [8]
 LDCM0452  CL60 HEK-293T C360(0.74)  LDD1050  [8]
 LDCM0453  CL61 HCT 116 C314(0.84); C317(0.84)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C314(0.73); C317(0.73)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C314(0.70); C317(0.70)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C314(0.47); C317(0.47)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C314(0.78); C317(0.78)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C314(0.42); C317(0.42)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C314(0.51); C317(0.51)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C314(0.78); C317(0.78)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C314(1.38); C317(1.38)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C360(0.89)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C314(0.94); C317(0.94)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C314(0.58); C317(0.58)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C314(0.87); C317(0.87)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C314(0.54); C317(0.54)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C314(0.60); C317(0.60)  LDD0784  [8]
 LDCM0469  CL76 HEK-293T C314(0.89); C317(1.05)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C314(0.74); C317(0.97)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C314(0.96); C317(1.88)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C314(1.12); C317(1.52)  LDD1070  [8]
 LDCM0473  CL8 HCT 116 C360(0.62)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C314(0.91); C317(1.08)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C314(0.91); C317(1.11)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C314(0.92); C317(0.88)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C314(1.10); C317(1.06)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C314(1.02); C317(1.38)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C314(1.08); C317(1.89)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C314(0.86); C317(1.51)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C314(0.85); C317(1.29)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C314(0.77); C317(1.25)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C314(0.98); C317(1.53)  LDD1081  [8]
 LDCM0484  CL9 HCT 116 C360(0.87)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C314(0.76); C317(1.01)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C360(1.05); C314(0.86)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C360(1.00); C314(0.89)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C317(0.84); C314(0.78)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C360(1.08); C317(0.93); C314(0.76)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C360(0.91); C317(0.74); C314(0.68)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C360(1.25); C317(0.93); C314(0.92)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C360(0.99); C317(0.99); C314(0.95)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C360(1.01); C314(0.93)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C360(0.96); C314(1.01)  LDD1697  [22]
 LDCM0634  CY-0357 Hep-G2 C12(0.61)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C360(0.88); C314(0.77)  LDD1698  [22]
 LDCM0468  Fragment33 HCT 116 C314(0.64); C317(0.64)  LDD0785  [8]
 LDCM0427  Fragment51 HCT 116 C314(0.40); C317(0.40); C360(0.72)  LDD0744  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C360(1.00); C317(1.05)  LDD1492  [22]
 LDCM0023  KB03 HEK-293T C360(0.99); C317(0.89)  LDD1497  [22]
 LDCM0024  KB05 COLO792 C360(1.36)  LDD3310  [23]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C12(0.80)  LDD2207  [24]
 LDCM0021  THZ1 HCT 116 C314(1.19); C317(1.19)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen [starch] synthase, muscle (GYS1) Glycosyltransferase 3 family P13807
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BMP/retinoic acid-inducible neural-specific protein 1 (BRINP1) BRINP family O60477
Importin subunit alpha-6 (KPNA5) Importin alpha family O15131
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Spectrin alpha chain, erythrocytic 1 (SPTA1) Spectrin family P02549
Gem-associated protein 4 (GEMIN4) . P57678
Vimentin-type intermediate filament-associated coiled-coil protein (VMAC) . Q2NL98

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.