Details of the Target

General Information of Target

Target ID LDTP05832
Target Name Urea transporter 1 (SLC14A1)
Gene Name SLC14A1
Gene ID 6563
Synonyms
HUT11; JK; RACH1; UT1; UTE; Urea transporter 1; Solute carrier family 14 member 1; Urea transporter, erythrocyte
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFID
WILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASG
LYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPF
NMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPW
TGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGM
FMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIY
KMPLSKVTYPEENRIFYLQAKKRMVESPL
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Urea transporter family
Subcellular location
Cell membrane
Function
Mediates the transport of urea driven by a concentration gradient across the cell membrane of erythrocytes. Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism. Facilitates water transport in erythrocytes.
TTD ID
T92794
Uniprot ID
Q13336
DrugMap ID
TTWVJU1
Ensemble ID
ENST00000321925.9
HGNC ID
HGNC:10918
ChEMBL ID
CHEMBL2390814

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.P363T .
EFO27 SNV: p.R383S .
L428 SNV: p.T339N .
MCC13 SNV: p.P199S .
SW1271 SNV: p.L109F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		10.00  LDD0452  [1]
P2
 Probe Info  		10.00  LDD0453  [1]
P3
 Probe Info  		10.00  LDD0454  [1]
P8
 Probe Info  		10.00  LDD0455  [1]
DBIA
 Probe Info  		C81(2.08)  LDD3457  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ICC10 C81(1.14)  LDD2379  [2]
 LDCM0023  KB03 ICC21 C81(1.96)  LDD2805  [2]
 LDCM0024  KB05 SW403 C81(2.08)  LDD3457  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Butyrophilin subfamily 2 member A2 (BTN2A2) BTN/MOG family Q8WVV5
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial fission 1 protein (FIS1) FIS1 family Q9Y3D6
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Protein SNORC (SNORC) . Q6UX34
Thrombospondin type-1 domain-containing protein 7B (THSD7B) . Q9C0I4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Urea Small molecular drug DB03904

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840