Details of the Target

General Information of Target

Target ID LDTP05014
Target Name Small ribosomal subunit protein eS26 (RPS26)
Gene Name RPS26
Gene ID 6231
Synonyms
Small ribosomal subunit protein eS26; 40S ribosomal protein S26
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNIVEAAAVRDISEASVFD
AYVLPKLYVKLHYCVSCAIHSKVVRNRSREARKDRTPPPRFRPAGAAPRPPPKPM
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS26 family
Subcellular location
Cytoplasm, cytosol
Function Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P62854
Ensemble ID
ENST00000356464.10
HGNC ID
HGNC:10414

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		4.23  LDD0452  [1]
P2
 Probe Info  		2.34  LDD0453  [1]
P3
 Probe Info  		10.00  LDD0450  [1]
P8
 Probe Info  		4.24  LDD0455  [1]
C-Sul
 Probe Info  		2.11  LDD0066  [2]
TH211
 Probe Info  		Y62(14.44); Y73(13.19)  LDD0257  [3]
TH214
 Probe Info  		Y62(19.49); Y73(6.66)  LDD0258  [3]
TH216
 Probe Info  		Y62(10.06)  LDD0259  [3]
STPyne
 Probe Info  		K113(9.58)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K113(7.15)  LDD3494  [5]
Probe 1
 Probe Info  		Y62(6.89)  LDD3495  [6]
BTD
 Probe Info  		C26(0.98)  LDD1700  [7]
HHS-482
 Probe Info  		Y62(0.54)  LDD0285  [8]
HHS-465
 Probe Info  		Y62(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C74(1.24); C77(1.24)  LDD0078  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C74(0.00); C77(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C74(0.00); C77(0.00)  LDD0037  [11]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
JW-RF-010
 Probe Info  		C23(0.00); C77(0.00); C74(0.00); C26(0.00)  LDD0026  [15]
TFBX
 Probe Info  		C74(0.00); C77(0.00); C26(0.00); C23(0.00)  LDD0027  [15]
IPM
 Probe Info  		C77(0.00); C23(0.00)  LDD0005  [16]
OSF
 Probe Info  		N.A.  LDD0029  [17]
SF
 Probe Info  		Y62(0.00); Y73(0.00)  LDD0028  [17]
Phosphinate-6
 Probe Info  		C23(0.00); C77(0.00)  LDD0018  [18]
1c-yne
 Probe Info  		N.A.  LDD0228  [19]
Acrolein
 Probe Info  		C74(0.00); H72(0.00); H17(0.00); C77(0.00)  LDD0217  [20]
Cinnamaldehyde
 Probe Info  		C74(0.00); C77(0.00)  LDD0220  [20]
Crotonaldehyde
 Probe Info  		C74(0.00); H17(0.00); H80(0.00); C26(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		C74(0.00); H17(0.00); C26(0.00)  LDD0218  [20]
NAIA_5
 Probe Info  		C26(0.00); C23(0.00); C77(0.00); C74(0.00)  LDD2223  [21]
HHS-475
 Probe Info  		Y62(1.38)  LDD2238  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C26(0.72)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C26(0.83); C23(1.26)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C26(0.55)  LDD2117  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C26(1.14)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C23(0.72)  LDD2132  [7]
 LDCM0216  AC100 PaTu 8988t C74(1.30); C77(1.25)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C74(1.13); C77(1.11)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C74(0.95); C77(1.09)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C74(1.26); C77(1.16)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C74(0.98); C77(0.98)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C74(1.18); C77(1.25)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C74(1.12); C77(1.07)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C74(1.41); C77(1.26)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C74(1.32); C77(1.24)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C74(1.11); C77(1.08)  LDD1104  [10]
 LDCM0227  AC110 PaTu 8988t C74(1.45); C77(1.38)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C74(1.34); C77(1.27)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C74(1.27); C77(1.25)  LDD1108  [10]
 LDCM0230  AC113 PaTu 8988t C74(0.68); C77(0.76)  LDD1109  [10]
 LDCM0231  AC114 PaTu 8988t C74(0.57); C77(0.70)  LDD1110  [10]
 LDCM0232  AC115 PaTu 8988t C74(0.68); C77(0.80)  LDD1111  [10]
 LDCM0233  AC116 PaTu 8988t C74(0.65); C77(0.73)  LDD1112  [10]
 LDCM0234  AC117 PaTu 8988t C74(0.56); C77(0.64)  LDD1113  [10]
 LDCM0235  AC118 PaTu 8988t C74(0.75); C77(0.78)  LDD1114  [10]
 LDCM0236  AC119 PaTu 8988t C74(0.67); C77(0.75)  LDD1115  [10]
 LDCM0238  AC120 PaTu 8988t C74(0.68); C77(0.81)  LDD1117  [10]
 LDCM0239  AC121 PaTu 8988t C74(0.56); C77(0.63)  LDD1118  [10]
 LDCM0240  AC122 PaTu 8988t C74(0.86); C77(0.96)  LDD1119  [10]
 LDCM0241  AC123 PaTu 8988t C74(1.13); C77(1.18)  LDD1120  [10]
 LDCM0242  AC124 PaTu 8988t C74(1.01); C77(0.97)  LDD1121  [10]
 LDCM0243  AC125 PaTu 8988t C74(1.47); C77(1.12)  LDD1122  [10]
 LDCM0244  AC126 PaTu 8988t C74(0.89); C77(0.97)  LDD1123  [10]
 LDCM0245  AC127 PaTu 8988t C74(0.95); C77(0.95)  LDD1124  [10]
 LDCM0246  AC128 PaTu 8988t C74(0.59); C77(0.60)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C74(0.76); C77(0.76)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C74(0.69); C77(0.70)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C74(0.82); C77(0.81)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C74(1.04); C77(0.99)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C74(0.85); C77(0.87)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C74(0.92); C77(0.89)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C74(0.79); C77(0.81)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C74(0.65); C77(0.65)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C74(0.72); C77(0.73)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C74(0.80); C77(0.78)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C74(0.58); C77(0.59)  LDD1137  [10]
 LDCM0260  AC140 PaTu 8988t C74(0.86); C77(0.85)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C74(0.83); C77(0.80)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C74(0.80); C77(0.82)  LDD1141  [10]
 LDCM0349  AC83 PaTu 8988t C74(0.88); C77(0.86)  LDD1228  [10]
 LDCM0350  AC84 PaTu 8988t C74(1.03); C77(0.98)  LDD1229  [10]
 LDCM0351  AC85 PaTu 8988t C74(0.73); C77(0.66)  LDD1230  [10]
 LDCM0352  AC86 PaTu 8988t C74(0.81); C77(0.75)  LDD1231  [10]
 LDCM0353  AC87 PaTu 8988t C74(0.69); C77(0.66)  LDD1232  [10]
 LDCM0354  AC88 PaTu 8988t C74(0.94); C77(0.91)  LDD1233  [10]
 LDCM0355  AC89 PaTu 8988t C74(0.94); C77(0.90)  LDD1234  [10]
 LDCM0357  AC90 PaTu 8988t C74(0.98); C77(1.00)  LDD1236  [10]
 LDCM0358  AC91 PaTu 8988t C74(0.89); C77(0.86)  LDD1237  [10]
 LDCM0359  AC92 PaTu 8988t C74(0.99); C77(0.95)  LDD1238  [10]
 LDCM0360  AC93 PaTu 8988t C74(0.87); C77(0.78)  LDD1239  [10]
 LDCM0361  AC94 PaTu 8988t C74(0.94); C77(0.94)  LDD1240  [10]
 LDCM0362  AC95 PaTu 8988t C74(0.81); C77(0.79)  LDD1241  [10]
 LDCM0363  AC96 PaTu 8988t C74(1.09); C77(1.04)  LDD1242  [10]
 LDCM0364  AC97 PaTu 8988t C74(0.95); C77(1.02)  LDD1243  [10]
 LDCM0365  AC98 PaTu 8988t C74(1.30); C77(1.26)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C74(1.04); C77(1.02)  LDD1245  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C26(0.78)  LDD2113  [7]
 LDCM0020  ARS-1620 HCC44 C74(1.24); C77(1.24)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C26(0.56)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C74(0.00); H17(0.00); C77(0.00); H80(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C74(0.63)  LDD2227  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C77(5.66); C26(1.29); C23(1.09)  LDD1702  [7]
 LDCM0107  IAA HeLa C74(0.00); H17(0.00); H72(0.00); C77(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y62(0.54)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y62(0.35)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y62(0.98)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y62(2.59)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y62(1.34)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y62(0.34)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y62(0.27)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y62(0.65)  LDD0292  [8]
 LDCM0022  KB02 A673 C26(1.66)  LDD2261  [23]
 LDCM0023  KB03 Jurkat C23(5,655.37)  LDD0209  [24]
 LDCM0024  KB05 NB1 C26(1.23)  LDD3340  [23]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C26(1.07)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C26(0.52)  LDD2121  [7]
 LDCM0109  NEM HeLa H17(0.00); H80(0.00); H72(0.00); C74(0.00)  LDD0223  [20]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C26(1.10)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C26(1.04); C23(1.01); C74(1.24)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C26(0.84); C77(1.05)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C26(1.45); C23(1.85)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C26(0.61); C23(0.81)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C26(1.01)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C26(1.31); C23(0.99)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C26(0.75)  LDD2099  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C26(0.85)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C23(0.67)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C26(1.43)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C26(0.65); C23(1.01)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C26(0.71)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C26(0.60); C23(0.85)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C26(1.03)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C26(1.01)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C26(0.62)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C26(0.74)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C26(0.35)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C23(1.21)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C23(1.07)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C26(1.56); C77(0.59)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C26(0.68); C23(0.84); C77(0.55); C74(0.71)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C23(0.52)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C26(0.45); C74(1.16)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C23(0.72)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C26(0.53); C23(0.97)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C23(0.98)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C26(0.47); C23(0.91)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C26(0.69); C23(0.71)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C26(0.77); C23(0.74)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C26(0.51)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C26(0.52)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C26(0.64)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C26(0.87)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C26(0.63); C23(0.83)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C26(0.98)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C26(0.62)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C23(0.91)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C26(0.81); C23(0.82)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C26(2.33)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C26(0.68)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C26(1.81); C77(1.35)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C26(0.43)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C23(1.01)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C23(0.62)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C23(0.64)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C26(2.12)  LDD2153  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-rRNA-processing protein TSR2 homolog (TSR2) TSR2 family Q969E8

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
24 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.