Details of the Target

General Information of Target

Target ID LDTP02307
Target Name Annexin A5 (ANXA5)
Gene Name ANXA5
Gene ID 308
Synonyms
ANX5; ENX2; PP4; Annexin A5; Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CPB-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTL
FGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPE
ELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALF
QAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAV
VKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMI
KGDTSGDYKKALLLLCGEDD
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Annexin family
Function This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
TTD ID
T72195
Uniprot ID
P08758
DrugMap ID
TT2Z83I
Ensemble ID
ENST00000296511.10
HGNC ID
HGNC:543

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		7.03  LDD0452  [1]
P2
 Probe Info  		10.00  LDD0449  [1]
P3
 Probe Info  		10.00  LDD0450  [1]
P8
 Probe Info  		4.25  LDD0455  [1]
CHEMBL5175495
 Probe Info  		7.49  LDD0196  [2]
C-Sul
 Probe Info  		2.34  LDD0066  [3]
FBP2
 Probe Info  		3.82  LDD0323  [4]
TH211
 Probe Info  		Y148(20.00); Y308(11.21); Y256(9.60)  LDD0257  [5]
TH214
 Probe Info  		Y308(20.00); Y94(15.26)  LDD0258  [5]
TH216
 Probe Info  		Y308(20.00); Y94(16.32); Y148(12.38)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
AZ-9
 Probe Info  		E52(1.16); E17(1.26)  LDD2208  [7]
ONAyne
 Probe Info  		N.A.  LDD0273  [8]
Probe 1
 Probe Info  		Y94(15.53)  LDD3495  [9]
m-APA
 Probe Info  		9.27  LDD0403  [10]
THZ1-DTB
 Probe Info  		C316(1.06)  LDD0460  [11]
DA-P3
 Probe Info  		4.11  LDD0185  [12]
HHS-482
 Probe Info  		Y129(0.90); Y133(1.42); Y148(1.13); Y250(0.89)  LDD0285  [13]
HHS-475
 Probe Info  		Y297(0.74); Y148(0.84); Y256(0.88); Y257(0.99)  LDD0264  [14]
HHS-465
 Probe Info  		Y297(1.99); Y308(10.00)  LDD2237  [15]
DBIA
 Probe Info  		C316(0.51)  LDD0532  [16]
W1
 Probe Info  		K76(0.54)  LDD0238  [17]
5E-2FA
 Probe Info  		N.A.  LDD2235  [18]
ATP probe
 Probe Info  		K97(0.00); K101(0.00)  LDD0199  [19]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [20]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [21]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [20]
ATP probe
 Probe Info  		K101(0.00); K290(0.00); K29(0.00)  LDD0035  [22]
IPM
 Probe Info  		N.A.  LDD0025  [23]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [23]
TFBX
 Probe Info  		N.A.  LDD0027  [23]
1d-yne
 Probe Info  		N.A.  LDD0356  [24]
NHS
 Probe Info  		N.A.  LDD0010  [25]
PF-06672131
 Probe Info  		N.A.  LDD0017  [26]
SF
 Probe Info  		K97(0.00); Y257(0.00); Y256(0.00); K309(0.00)  LDD0028  [27]
STPyne
 Probe Info  		K97(0.00); K101(0.00)  LDD0009  [25]
1c-yne
 Probe Info  		K29(0.00); K70(0.00); K260(0.00)  LDD0228  [24]
Acrolein
 Probe Info  		H267(0.00); C316(0.00)  LDD0217  [28]
Methacrolein
 Probe Info  		H267(0.00); C316(0.00)  LDD0218  [28]
AOyne
 Probe Info  		4.30  LDD0443  [29]
NAIA_5
 Probe Info  		N.A.  LDD2223  [30]
TER-AC
 Probe Info  		N.A.  LDD0426  [31]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.63  LDD0475  [32]
FFF probe14
 Probe Info  		8.88  LDD0477  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C316(0.19)  LDD1093  [16]
 LDCM0215  AC10 HCT 116 C316(0.51)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C316(0.57)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C316(0.57)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C316(0.47)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C316(0.24)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C316(0.28)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C316(0.32)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C316(0.30)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C316(0.22)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C316(0.40)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C316(0.41)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C316(0.44)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C316(0.42)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C316(0.52)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C316(0.26)  LDD0546  [16]
 LDCM0237  AC12 HCT 116 C316(0.78)  LDD0554  [16]
 LDCM0246  AC128 HCT 116 C316(0.31)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C316(1.56)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C316(0.63)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C316(1.02)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C316(1.21)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C316(0.79)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C316(0.57)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C316(0.52)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C316(0.74)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C316(0.98)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C316(0.74)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C316(0.86)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C316(0.61)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C316(0.63)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C316(0.83)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C316(2.11)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C316(1.09)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C316(0.87)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C316(1.04)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C316(0.93)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C316(0.80)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C316(0.41)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C316(0.76)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C316(0.47)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C316(1.22)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C316(0.83)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C316(0.68)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C316(0.40)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C316(0.81)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C316(0.97)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C316(1.00)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C316(0.86)  LDD2161  [16]
 LDCM0276  AC17 PaTu 8988t C316(0.47)  LDD1155  [16]
 LDCM0277  AC18 PaTu 8988t C316(0.21)  LDD1156  [16]
 LDCM0278  AC19 PaTu 8988t C316(0.37)  LDD1157  [16]
 LDCM0279  AC2 PaTu 8988t C316(0.38)  LDD1158  [16]
 LDCM0280  AC20 PaTu 8988t C316(0.21)  LDD1159  [16]
 LDCM0281  AC21 PaTu 8988t C316(0.14)  LDD1160  [16]
 LDCM0282  AC22 PaTu 8988t C316(0.10)  LDD1161  [16]
 LDCM0283  AC23 PaTu 8988t C316(0.16)  LDD1162  [16]
 LDCM0284  AC24 PaTu 8988t C316(0.49)  LDD1163  [16]
 LDCM0285  AC25 HCT 116 C316(0.54)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C316(0.47)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C316(0.43)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C316(0.32)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C316(0.43)  LDD0606  [16]
 LDCM0290  AC3 PaTu 8988t C316(0.44)  LDD1169  [16]
 LDCM0291  AC30 HCT 116 C316(0.40)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C316(0.48)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C316(0.20)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C316(0.26)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C316(0.18)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C316(2.11)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C316(1.95)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C316(1.87)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C316(1.58)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C316(1.09)  LDD0617  [16]
 LDCM0301  AC4 PaTu 8988t C316(0.66)  LDD1180  [16]
 LDCM0302  AC40 HCT 116 C316(0.70)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C316(1.46)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C316(1.13)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C316(1.24)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C316(0.92)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C316(0.62)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C316(0.99)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C316(0.77)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C316(1.26)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C316(0.23)  LDD0628  [16]
 LDCM0312  AC5 PaTu 8988t C316(0.22)  LDD1191  [16]
 LDCM0313  AC50 HCT 116 C316(0.31)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C316(2.97)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C316(1.10)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C316(0.52)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C316(0.50)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C316(0.28)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C316(0.17)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C316(0.34)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C316(0.28)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C316(0.20)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C316(0.41)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C316(0.35)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C316(0.48)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C316(0.15)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C316(0.36)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C316(0.18)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C316(0.28)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C316(0.32)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C316(0.06)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C316(0.54)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C316(0.36)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C316(0.66)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C316(0.17)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C316(0.87)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C316(0.49)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C316(0.10)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C316(0.11)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C316(0.10)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C316(0.30)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C316(0.25)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C316(0.66)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C316(0.61)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C316(0.49)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C316(0.40)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C316(0.68)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C316(0.11)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C316(0.12)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C316(0.16)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C316(0.47)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C316(0.65)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C316(1.45)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C316(0.60)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C316(0.32)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C316(14.79)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C316(0.10)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C316(0.16)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C316(0.61)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C316(0.74)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C316(1.26)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C316(0.34)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C316(0.24)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C316(0.04)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C316(0.46)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C316(0.88)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C316(0.62)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C316(0.15)  LDD0592  [16]
 LDCM0156  Aniline NCI-H1299 9.27  LDD0403  [10]
 LDCM0087  Capsaicin HEK-293T 4.11  LDD0185  [12]
 LDCM0108  Chloroacetamide HeLa H267(0.00); C316(0.00)  LDD0222  [28]
 LDCM0367  CL1 HCT 116 C316(1.11)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C316(0.35)  LDD0685  [16]
 LDCM0369  CL100 PaTu 8988t C316(0.58)  LDD1248  [16]
 LDCM0370  CL101 HCT 116 C316(0.39)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C316(0.75)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C316(0.78)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C316(0.66)  LDD0690  [16]
 LDCM0374  CL105 PaTu 8988t C316(0.63)  LDD1253  [16]
 LDCM0375  CL106 PaTu 8988t C316(0.47)  LDD1254  [16]
 LDCM0376  CL107 PaTu 8988t C316(0.74)  LDD1255  [16]
 LDCM0377  CL108 PaTu 8988t C316(0.48)  LDD1256  [16]
 LDCM0378  CL109 PaTu 8988t C316(0.35)  LDD1257  [16]
 LDCM0379  CL11 HCT 116 C316(0.21)  LDD0696  [16]
 LDCM0380  CL110 PaTu 8988t C316(0.34)  LDD1259  [16]
 LDCM0381  CL111 PaTu 8988t C316(0.08)  LDD1260  [16]
 LDCM0382  CL112 HCT 116 C316(0.92)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C316(0.22)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C316(0.53)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C316(0.44)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C316(0.49)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C316(0.22)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C316(0.93)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C316(0.99)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C316(0.17)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C316(1.51)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C316(0.71)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C316(0.64)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C316(0.46)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C316(0.34)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C316(0.94)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C316(0.61)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C316(0.59)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C316(0.24)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C316(0.41)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C316(0.74)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C316(0.31)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C316(0.86)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C316(1.18)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C316(1.00)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C316(0.83)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C316(1.08)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C316(0.66)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C316(0.65)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C316(0.50)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C316(0.75)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C316(0.55)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C316(0.94)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C316(0.68)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C316(0.86)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C316(1.17)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C316(0.66)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C316(0.97)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C316(0.73)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C316(0.45)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C316(0.72)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C316(0.44)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C316(0.12)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C316(0.13)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C316(0.19)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C316(0.10)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C316(0.15)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C316(0.77)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C316(0.24)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C316(0.21)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C316(0.04)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C316(0.08)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C316(0.24)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C316(0.14)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C316(2.30)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C316(2.21)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C316(1.81)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C316(1.39)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C316(0.74)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C316(2.00)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C316(1.56)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C316(1.48)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C316(2.09)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C316(1.61)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C316(1.89)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C316(1.09)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C316(1.71)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C316(1.96)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C316(1.15)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C316(0.55)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C316(1.24)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C316(0.86)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C316(0.73)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C316(0.44)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C316(0.35)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C316(0.68)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C316(0.19)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C316(0.31)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C316(0.44)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C316(1.11)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C316(0.30)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C316(0.47)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C316(0.42)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C316(0.74)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C316(0.43)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C316(0.40)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C316(0.62)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C316(0.63)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C316(0.49)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C316(0.22)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C316(0.15)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C316(1.25)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C316(0.39)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C316(0.09)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C316(0.14)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C316(0.05)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C316(0.43)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C316(2.41)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C316(0.43)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C316(0.18)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C316(0.06)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C316(0.50)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C316(0.99)  LDD0802  [16]
 LDCM0486  CL91 PaTu 8988t C316(0.65)  LDD1365  [16]
 LDCM0487  CL92 PaTu 8988t C316(0.39)  LDD1366  [16]
 LDCM0488  CL93 PaTu 8988t C316(0.51)  LDD1367  [16]
 LDCM0489  CL94 PaTu 8988t C316(0.42)  LDD1368  [16]
 LDCM0490  CL95 PaTu 8988t C316(0.24)  LDD1369  [16]
 LDCM0491  CL96 PaTu 8988t C316(0.60)  LDD1370  [16]
 LDCM0492  CL97 PaTu 8988t C316(0.51)  LDD1371  [16]
 LDCM0493  CL98 PaTu 8988t C316(0.27)  LDD1372  [16]
 LDCM0494  CL99 PaTu 8988t C316(0.40)  LDD1373  [16]
 LDCM0495  E2913 HEK-293T C316(0.88)  LDD1698  [34]
 LDCM0468  Fragment33 HCT 116 C316(0.44)  LDD0785  [16]
 LDCM0427  Fragment51 HCT 116 C316(0.05)  LDD0744  [16]
 LDCM0116  HHS-0101 DM93 Y297(0.74); Y148(0.84); Y256(0.88); Y257(0.99)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y148(0.83); Y94(0.89); Y297(0.94); Y308(1.00)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y297(0.76); Y257(0.84); Y94(0.85); Y148(0.85)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y148(0.95); Y94(1.00); Y256(1.05); Y297(1.15)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y94(0.85); Y256(0.87); Y148(0.89); Y308(1.03)  LDD0268  [14]
 LDCM0107  IAA HeLa H267(0.00); C316(0.00)  LDD0221  [28]
 LDCM0123  JWB131 DM93 Y129(0.90); Y133(1.42); Y148(1.13); Y250(0.89)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y129(0.60); Y133(0.44); Y148(0.65); Y213(1.86)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y129(0.82); Y133(0.69); Y148(0.94); Y213(0.69)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y129(6.76); Y133(6.73); Y148(4.52); Y213(1.96)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y129(5.13); Y133(2.67); Y148(2.36); Y213(1.39)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y129(1.32); Y133(1.81); Y148(1.88); Y213(0.20)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y129(0.70); Y133(0.57); Y148(0.66); Y213(0.61)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y129(0.61); Y133(0.92); Y148(0.78); Y213(0.61)  LDD0292  [13]
 LDCM0022  KB02 HEK-293T C316(0.97)  LDD1492  [34]
 LDCM0023  KB03 HEK-293T C316(0.91)  LDD1497  [34]
 LDCM0024  KB05 HMCB C316(2.28)  LDD3312  [35]
 LDCM0109  NEM HeLa N.A.  LDD0223  [28]
 LDCM0131  RA190 MM1.R C316(1.19)  LDD0304  [36]
 LDCM0021  THZ1 HeLa S3 C316(1.06)  LDD0460  [11]
 LDCM0111  W14 Hep-G2 K76(0.54)  LDD0238  [17]
 LDCM0113  W17 Hep-G2 K76(0.61)  LDD0240  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein goosecoid-2 (GSC2) Paired homeobox family O15499
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fluocinolone Acetonide Small molecular drug DB00591
Copper . DB09130
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Diannexin . D07FQL
Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
14-dideoxy-5-dehydro-o2-sulfo-glucuronic Acid Small molecular drug DB03981
14-dideoxy-o2-sulfo-glucuronic Acid Small molecular drug DB03935
No6-disulfo-glucosamine Small molecular drug DB03959
K201 Free Base . DB02929
L-alpha-glycerophosphorylserine . DB02497
L-thioproline . DB02846
Sn-glycero-3-phosphoethanolamine . DB03484

References

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2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
19 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
20 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
23 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
24 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
29 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
30 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
31 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
32 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
33 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
34 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
35 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
36 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.