Details of the Target

General Information of Target

Target ID LDTP10650
Target Name Serpin B11 (SERPINB11)
Gene Name SERPINB11
Gene ID 89778
Synonyms
Serpin B11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLYAAAAGVLAGVESRQGSIKGLVYSSNFQNVKQLYALVCETQRYSAVLDAVIASAGLL
RAEKKLRPHLAKVLVYELLLGKGFRGGGGRWKALLGRHQARLKAELARLKVHRGVSRNED
LLEVGSRPGPASQLPRFVRVNTLKTCSDDVVDYFKRQGFSYQGRASSLDDLRALKGKHFL
LDPLMPELLVFPAQTDLHEHPLYRAGHLILQDRASCLPAMLLDPPPGSHVIDACAAPGNK
TSHLAALLKNQGKIFAFDLDAKRLASMATLLARAGVSCCELAEEDFLAVSPSDPRYHEVH
YILLDPSCSGSGMPSRQLEEPGAGTPSPVRLHALAGFQQRALCHALTFPSLQRLVYSTCS
LCQEENEDVVRDALQQNPGAFRLAPALPAWPHRGLSTFPGAEHCLRASPETTLSSGFFVA
VIERVEVPR
Target Bioclass
Other
Family
Serpin family, Ov-serpin subfamily
Subcellular location
Cytoplasm
Function Has no serine protease inhibitory activity, probably due to variants in the scaffold impairing conformational change.
Uniprot ID
Q96P15
Ensemble ID
ENST00000382749.9
HGNC ID
HGNC:14221

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		10.00  LDD0452  [1]
P3
 Probe Info  		10.00  LDD0454  [1]
P8
 Probe Info  		10.00  LDD0455  [1]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.