Details of the Target

General Information of Target

Target ID LDTP01124
Target Name Probable phospholipid-transporting ATPase IIA (ATP9A)
Gene Name ATP9A
Gene ID 10079
Synonyms
ATPIIA; KIAA0611; Probable phospholipid-transporting ATPase IIA; EC 7.6.2.1; ATPase class II type 9A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDNIPLQPVRQKKRMDSRPRAGCCEWLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINN
QKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIRE
AVEEIRCYVRDKEVNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSE
KNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYVYAEEPNIDIHNFVGTFT
REDSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEV
NCLTKILFGALVVVSLVMVALQHFAGRWYLQIIRFLLLFSNIIPISLRVNLDMGKIVYSW
VIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKTGTLTQNEMIFKRLHLGTVAYGLDSMDE
VQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHEAVKAIALCHNVTPVYESNGVTD
QAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQ
IFPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLV
VAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVR
PTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFR
RKHDCALVISGDSLEVCLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLT
CAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSA
ALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKS
EVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLFESEFVHIVAISFTS
LILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLSFLWKVSVIT
LVSCLPLYVLKYLRRRFSPPSYSKLTS
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
Subcellular location
Early endosome membrane
Function
Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation. Also involved in endosome to trans-Golgi network retrograde transport. In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation. Appears to be implicated in intercellular communication by negatively regulating the release of exosomes. The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved. Required for the maintenance of neurite morphology and synaptic transmission.
Uniprot ID
O75110
Ensemble ID
ENST00000338821.6
HGNC ID
HGNC:13540

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
GB1 Substitution: p.Y53D .
HCT116 SNV: p.M318V .
HCT15 SNV: p.W27Ter; p.I356T DBIA    Probe Info 
HDQP1 SNV: p.Y1005C .
HEC1B SNV: p.E984G .
HT SNV: p.S140G .
LNCaP clone FGC SNV: p.R709H DBIA    Probe Info 
MEWO Substitution: p.P54F DBIA    Probe Info 
MFE319 SNV: p.Y329C DBIA    Probe Info 
NCIH1793 SNV: p.M401K DBIA    Probe Info 
NCIH2170 Deletion: p.K680_A684delinsN DBIA    Probe Info 
OVCAR8 SNV: p.I554V .
RKO SNV: p.W259R; p.H626Y .
SNGM SNV: p.G409R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.10  LDD0452  [1]
P3
 Probe Info  		2.28  LDD0454  [1]
IPM
 Probe Info  		C760(0.84)  LDD1701  [2]
DBIA
 Probe Info  		C781(0.80); C798(0.80)  LDD0531  [3]
IA-alkyne
 Probe Info  		C206(0.00); C185(0.00)  LDD0162  [4]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
NAIA_5
 Probe Info  		C206(0.00); C686(0.00); C492(0.00); C466(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C781(0.80); C798(0.80)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C781(0.65); C798(0.65)  LDD0532  [3]
 LDCM0216  AC100 PaTu 8988t C781(0.88); C798(0.88)  LDD1095  [3]
 LDCM0217  AC101 PaTu 8988t C781(0.84); C798(0.84)  LDD1096  [3]
 LDCM0218  AC102 PaTu 8988t C781(1.04); C798(1.04)  LDD1097  [3]
 LDCM0219  AC103 PaTu 8988t C781(0.82); C798(0.82)  LDD1098  [3]
 LDCM0220  AC104 PaTu 8988t C781(1.11); C798(1.11)  LDD1099  [3]
 LDCM0221  AC105 PaTu 8988t C781(1.00); C798(1.00)  LDD1100  [3]
 LDCM0222  AC106 PaTu 8988t C781(1.01); C798(1.01)  LDD1101  [3]
 LDCM0223  AC107 PaTu 8988t C781(1.21); C798(1.21)  LDD1102  [3]
 LDCM0224  AC108 PaTu 8988t C781(0.93); C798(0.93)  LDD1103  [3]
 LDCM0225  AC109 PaTu 8988t C781(0.86); C798(0.86)  LDD1104  [3]
 LDCM0226  AC11 HCT 116 C781(0.64); C798(0.64)  LDD0543  [3]
 LDCM0227  AC110 PaTu 8988t C781(0.79); C798(0.79)  LDD1106  [3]
 LDCM0228  AC111 PaTu 8988t C781(0.83); C798(0.83)  LDD1107  [3]
 LDCM0229  AC112 PaTu 8988t C781(0.87); C798(0.87)  LDD1108  [3]
 LDCM0230  AC113 PaTu 8988t C492(1.40); C781(0.90); C798(0.90)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C492(1.21); C781(0.86); C798(0.86)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C492(1.23); C781(1.14); C798(1.14)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C492(1.32); C781(1.02); C798(1.02)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C492(1.33); C781(1.03); C798(1.03)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C492(1.07); C781(0.68); C798(0.68)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C492(1.56); C781(0.78); C798(0.78)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C781(0.79); C798(0.79)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C492(1.01); C781(1.10); C798(1.10)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C492(1.38); C781(1.05); C798(1.05)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C492(0.86); C781(0.79); C798(0.79)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C492(1.15); C781(0.88); C798(0.88)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C492(1.16); C781(0.81); C798(0.81)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C492(1.00); C781(0.81); C798(0.81)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C492(1.69); C781(0.86); C798(0.86)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C492(1.57); C781(1.01); C798(1.01)  LDD1124  [3]
 LDCM0246  AC128 HCT 116 C781(0.84); C798(0.84)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C781(0.75); C798(0.75)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C781(0.76); C798(0.76)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C781(0.93); C798(0.93)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C781(0.76); C798(0.76)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C781(0.85); C798(0.85)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C781(0.73); C798(0.73)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C781(0.68); C798(0.68)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C781(0.76); C798(0.76)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C781(0.62); C798(0.62)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C781(0.62); C798(0.62)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C781(0.62); C798(0.62)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C781(0.73); C798(0.73)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C781(0.73); C798(0.73)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C781(0.71); C798(0.71)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C781(0.73); C798(0.73)  LDD0579  [3]
 LDCM0263  AC143 PaTu 8988t C492(0.96); C781(0.65); C798(0.65)  LDD1142  [3]
 LDCM0264  AC144 PaTu 8988t C492(0.81); C781(0.62); C798(0.62)  LDD1143  [3]
 LDCM0265  AC145 PaTu 8988t C492(0.80); C781(0.66); C798(0.66)  LDD1144  [3]
 LDCM0266  AC146 PaTu 8988t C492(0.74); C781(0.50); C798(0.50)  LDD1145  [3]
 LDCM0267  AC147 PaTu 8988t C492(0.82); C781(0.59); C798(0.59)  LDD1146  [3]
 LDCM0268  AC148 PaTu 8988t C492(1.01); C781(0.49); C798(0.49)  LDD1147  [3]
 LDCM0269  AC149 PaTu 8988t C492(1.15); C781(0.57); C798(0.57)  LDD1148  [3]
 LDCM0270  AC15 HCT 116 C781(0.64); C798(0.64)  LDD0587  [3]
 LDCM0271  AC150 PaTu 8988t C492(0.72); C781(0.50); C798(0.50)  LDD1150  [3]
 LDCM0272  AC151 PaTu 8988t C492(0.47); C781(0.54); C798(0.54)  LDD1151  [3]
 LDCM0273  AC152 PaTu 8988t C492(0.83); C781(0.66); C798(0.66)  LDD1152  [3]
 LDCM0274  AC153 PaTu 8988t C492(0.59); C781(0.50); C798(0.50)  LDD1153  [3]
 LDCM0621  AC154 PaTu 8988t C492(0.67); C781(0.48); C798(0.48)  LDD2166  [3]
 LDCM0622  AC155 PaTu 8988t C492(0.72); C781(0.55); C798(0.55)  LDD2167  [3]
 LDCM0623  AC156 PaTu 8988t C492(0.93); C781(0.46); C798(0.46)  LDD2168  [3]
 LDCM0624  AC157 PaTu 8988t C492(0.74); C781(0.48); C798(0.48)  LDD2169  [3]
 LDCM0276  AC17 HCT 116 C781(0.95); C798(0.95)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C781(0.87); C798(0.87)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C781(1.01); C798(1.01)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C781(0.96); C798(0.96)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C781(0.96); C798(0.96)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C781(0.92); C798(0.92)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C781(1.03); C798(1.03)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C781(0.92); C798(0.92)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C781(0.96); C798(0.96)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C781(0.58); C798(0.58)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C781(0.52); C798(0.52)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C781(0.54); C798(0.54)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C781(0.53); C798(0.53)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C781(0.56); C798(0.56)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C781(0.89); C798(0.89)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C781(0.52); C798(0.52)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C781(0.47); C798(0.47)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C781(0.49); C798(0.49)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C781(0.49); C798(0.49)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C781(0.46); C798(0.46)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C781(0.98); C798(0.98)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C781(0.95); C798(0.95)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C781(1.16); C798(1.16)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C781(0.93); C798(0.93)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C781(0.88); C798(0.88)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C781(0.81); C798(0.81)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C781(0.89); C798(0.89)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C781(1.02); C798(1.02)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C781(0.89); C798(0.89)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C781(0.81); C798(0.81)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C781(0.88); C798(0.88)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C781(0.94); C798(0.94)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C781(0.92); C798(0.92)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C781(0.97); C798(0.97)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C781(0.85); C798(0.85)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C781(0.90); C798(0.90)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C781(0.89); C798(0.89)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C781(0.83); C798(0.83)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C781(1.03); C798(1.03)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C781(0.89); C798(0.89)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C781(0.83); C798(0.83)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C781(0.92); C798(0.92)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C781(0.92); C798(0.92)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C781(0.92); C798(0.92)  LDD0636  [3]
 LDCM0320  AC57 PaTu 8988t C781(0.79); C798(0.79)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C781(0.90); C798(0.90)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C781(0.77); C798(0.77)  LDD1201  [3]
 LDCM0323  AC6 HCT 116 C781(0.69); C798(0.69)  LDD0640  [3]
 LDCM0324  AC60 PaTu 8988t C781(0.81); C798(0.81)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C781(0.88); C798(0.88)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C781(0.77); C798(0.77)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C781(0.78); C798(0.78)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C781(0.91); C798(0.91)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C781(0.99); C798(0.99)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C781(0.79); C798(0.79)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C781(0.85); C798(0.85)  LDD1210  [3]
 LDCM0332  AC68 PaTu 8988t C781(1.15); C798(1.15)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C781(0.95); C798(0.95)  LDD1212  [3]
 LDCM0334  AC7 HCT 116 C781(0.77); C798(0.77)  LDD0651  [3]
 LDCM0335  AC70 PaTu 8988t C781(1.04); C798(1.04)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C781(0.92); C798(0.92)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C781(1.21); C798(1.21)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C781(1.21); C798(1.21)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C781(1.21); C798(1.21)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C781(0.89); C798(0.89)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C781(1.15); C798(1.15)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C781(1.02); C798(1.02)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C781(1.13); C798(1.13)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C781(0.92); C798(0.92)  LDD1223  [3]
 LDCM0345  AC8 HCT 116 C781(0.72); C798(0.72)  LDD0662  [3]
 LDCM0346  AC80 PaTu 8988t C781(1.33); C798(1.33)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C781(1.16); C798(1.16)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C781(1.08); C798(1.08)  LDD1227  [3]
 LDCM0349  AC83 HCT 116 C781(0.84); C798(0.84)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C781(0.83); C798(0.83)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C781(0.85); C798(0.85)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C781(0.89); C798(0.89)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C781(0.80); C798(0.80)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C781(0.88); C798(0.88)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C781(0.99); C798(0.99)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C781(1.17); C798(1.17)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C781(0.90); C798(0.90)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C781(0.88); C798(0.88)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C781(0.98); C798(0.98)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C781(1.08); C798(1.08)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C781(0.82); C798(0.82)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C781(1.20); C798(1.20)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C781(0.79); C798(0.79)  LDD0681  [3]
 LDCM0365  AC98 PaTu 8988t C781(0.97); C798(0.97)  LDD1244  [3]
 LDCM0366  AC99 PaTu 8988t C781(1.14); C798(1.14)  LDD1245  [3]
 LDCM0248  AKOS034007472 HCT 116 C781(0.78); C798(0.78)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C781(0.73); C798(0.73)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C781(0.60); C798(0.60)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C492(0.88)  LDD2171  [3]
 LDCM0632  CL-Sc Hep-G2 C686(0.50)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C781(1.54); C798(1.54)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C781(0.94); C798(0.94)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C781(0.79); C798(0.79)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C781(0.64); C798(0.64)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C781(0.74); C798(0.74)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C781(0.93); C798(0.93)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C781(0.77); C798(0.77)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C781(0.89); C798(0.89)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C781(0.80); C798(0.80)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C781(0.82); C798(0.82)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C781(0.85); C798(0.85)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C781(0.84); C798(0.84)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C781(1.10); C798(1.10)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C781(0.89); C798(0.89)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C781(0.83); C798(0.83)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C781(0.81); C798(0.81)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C781(0.51); C798(0.51)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C781(0.57); C798(0.57)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C781(0.57); C798(0.57)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C781(0.54); C798(0.54)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C781(0.87); C798(0.87)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C781(1.00); C798(1.00)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C781(0.91); C798(0.91)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C781(1.17); C798(1.17)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C781(1.01); C798(1.01)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C781(1.89); C798(1.89)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C781(0.78); C798(0.78)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C781(0.83); C798(0.83)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C781(0.88); C798(0.88)  LDD0712  [3]
 LDCM0396  CL125 PaTu 8988t C781(0.76); C798(0.76)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C781(0.81); C798(0.81)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C781(0.86); C798(0.86)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C781(0.88); C798(0.88)  LDD1278  [3]
 LDCM0400  CL13 HCT 116 C781(0.95); C798(0.95)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C781(1.04); C798(1.04)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C781(0.97); C798(0.97)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C781(0.79); C798(0.79)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C781(0.64); C798(0.64)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C781(0.58); C798(0.58)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C781(0.64); C798(0.64)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C781(1.36); C798(1.36)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C781(0.61); C798(0.61)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C781(0.58); C798(0.58)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C781(0.78); C798(0.78)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C781(0.72); C798(0.72)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C781(0.64); C798(0.64)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C781(0.75); C798(0.75)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C781(0.64); C798(0.64)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C781(0.75); C798(0.75)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C781(0.75); C798(0.75)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C781(0.72); C798(0.72)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C781(1.06); C798(1.06)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C781(0.71); C798(0.71)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C781(0.68); C798(0.68)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C781(0.54); C798(0.54)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C781(0.56); C798(0.56)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C781(0.57); C798(0.57)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C781(0.60); C798(0.60)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C781(0.58); C798(0.58)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C781(0.71); C798(0.71)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C781(0.57); C798(0.57)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C781(1.22); C798(1.22)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C781(0.71); C798(0.71)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C781(0.64); C798(0.64)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C781(0.62); C798(0.62)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C781(0.62); C798(0.62)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C781(0.49); C798(0.49)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C781(0.56); C798(0.56)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C781(1.47); C798(1.47)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C781(1.26); C798(1.26)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C781(1.69); C798(1.69)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C781(1.18); C798(1.18)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C781(1.06); C798(1.06)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C781(1.37); C798(1.37)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C781(1.36); C798(1.36)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C781(1.29); C798(1.29)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C781(1.10); C798(1.10)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C781(1.16); C798(1.16)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C781(1.05); C798(1.05)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C781(1.00); C798(1.00)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C781(1.08); C798(1.08)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C781(1.46); C798(1.46)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C781(1.36); C798(1.36)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C781(0.87); C798(0.87)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C781(1.25); C798(1.25)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C781(0.93); C798(0.93)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C781(0.87); C798(0.87)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C781(0.73); C798(0.73)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C781(0.70); C798(0.70)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C781(0.95); C798(0.95)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C781(0.85); C798(0.85)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C781(0.69); C798(0.69)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C781(0.70); C798(0.70)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C781(0.78); C798(0.78)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C781(1.41); C798(1.41)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C781(0.67); C798(0.67)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C781(0.74); C798(0.74)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C781(0.95); C798(0.95)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C781(0.75); C798(0.75)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C781(0.69); C798(0.69)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C781(0.77); C798(0.77)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C781(0.85); C798(0.85)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C781(1.02); C798(1.02)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C781(0.91); C798(0.91)  LDD1351  [3]
 LDCM0473  CL8 HCT 116 C781(0.95); C798(0.95)  LDD0790  [3]
 LDCM0474  CL80 PaTu 8988t C781(0.80); C798(0.80)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C781(0.93); C798(0.93)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C781(0.85); C798(0.85)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C781(0.91); C798(0.91)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C781(0.82); C798(0.82)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C781(0.92); C798(0.92)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C781(0.84); C798(0.84)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C781(0.82); C798(0.82)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C781(0.91); C798(0.91)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C781(0.96); C798(0.96)  LDD1362  [3]
 LDCM0484  CL9 HCT 116 C781(1.02); C798(1.02)  LDD0801  [3]
 LDCM0485  CL90 PaTu 8988t C781(1.03); C798(1.03)  LDD1364  [3]
 LDCM0486  CL91 HCT 116 C781(1.00); C798(1.00)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C781(1.09); C798(1.09)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C781(0.91); C798(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C781(0.85); C798(0.85)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C781(0.79); C798(0.79)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C781(0.92); C798(0.92)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C781(1.12); C798(1.12)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C781(1.02); C798(1.02)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C781(0.81); C798(0.81)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C31(1.00)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C781(0.75); C798(0.75)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C781(0.71); C798(0.71)  LDD0744  [3]
 LDCM0022  KB02 A204 C686(1.24)  LDD2252  [8]
 LDCM0023  KB03 MDA-MB-231 C760(0.84)  LDD1701  [2]
 LDCM0024  KB05 HMCB C760(2.09)  LDD3312  [8]
 LDCM0021  THZ1 HCT 116 C492(0.88)  LDD2173  [3]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840