Details of the Target

General Information of Target

Target ID LDTP01534
Target Name Luc7-like protein 3 (LUC7L3)
Gene Name LUC7L3
Gene ID 51747
Synonyms
CREAP1; CROP; O48; Luc7-like protein 3; Cisplatin resistance-associated-overexpressed protein; Luc7A; Okadaic acid-inducible phosphoprotein OA48-18; cAMP regulatory element-associated protein 1; CRE-associated protein 1; CREAP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEK
IHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAG
PTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIE
SFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEE
PDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHS
SRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKS
YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTS
EDIKSEGDTQSN
Target Bioclass
Other
Family
Luc7 family
Subcellular location
Nucleus speckle
Function Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.
Uniprot ID
O95232
Ensemble ID
ENST00000240304.5
HGNC ID
HGNC:24309

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.L171P DBIA    Probe Info 
HT115 SNV: p.R102Q .
NCIH1155 SNV: p.V201I DBIA    Probe Info 
SNU1 Insertion: p.L86FfsTer14 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.04  LDD0402  [1]
P1
 Probe Info  		1.68  LDD0448  [2]
P3
 Probe Info  		5.68  LDD0454  [2]
STPyne
 Probe Info  		K72(3.11); K78(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y220(48.54)  LDD3495  [4]
AF-1
 Probe Info  		3.35  LDD0421  [5]
P21
 Probe Info  		1.74  LDD0408  [6]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [7]
THZ1-DTB
 Probe Info  		C43(1.03)  LDD0460  [7]
BTD
 Probe Info  		C35(1.19)  LDD2093  [8]
HHS-475
 Probe Info  		Y37(0.95)  LDD0264  [9]
HHS-465
 Probe Info  		Y37(10.00)  LDD2237  [10]
DBIA
 Probe Info  		C192(2.14); C195(2.14); C35(1.57); C58(1.36)  LDD0080  [11]
ATP probe
 Probe Info  		K60(0.00); K231(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C58(0.00); C35(0.00); C40(0.00); C43(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C35(0.00); C40(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C58(0.00); C35(0.00); C40(0.00); C43(0.00)  LDD0037  [13]
IPM
 Probe Info  		N.A.  LDD0025  [16]
NHS
 Probe Info  		N.A.  LDD0010  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
Methacrolein
 Probe Info  		C58(0.00); C35(0.00)  LDD0218  [19]
W1
 Probe Info  		N.A.  LDD0236  [20]
NAIA_5
 Probe Info  		C58(0.00); C35(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe2
 Probe Info  		20.00  LDD0463  [22]
IMP2070
 Probe Info  		1.57  LDD0370  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C35(1.15)  LDD2117  [8]
 LDCM0214  AC1 HCT 116 C40(0.84); C192(1.46); C195(1.46); C43(0.75)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C40(1.20); C43(1.21); C58(0.93)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C40(0.63); C43(0.60); C58(1.44)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C40(0.72); C43(0.66); C58(1.22)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C40(0.94); C43(0.94); C58(1.19)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C40(1.21); C43(1.19); C58(1.47)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C40(0.88); C43(0.85); C58(1.12)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C40(0.80); C43(0.79); C58(1.46)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C40(0.95); C43(0.96); C58(1.59)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C40(0.92); C43(0.80); C58(1.34)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C40(0.75); C43(0.86); C58(1.30)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C40(1.09); C43(1.09); C58(1.02)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C40(1.39); C43(1.16); C58(0.84)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C40(1.04); C43(1.13); C58(1.26)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C40(0.87); C43(0.85); C58(1.25)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C40(0.83); C43(0.78); C58(1.46)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C40(0.59); C43(0.64); C58(0.99)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C40(0.69); C43(0.68); C58(0.88)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C40(0.79); C43(0.80); C58(0.90)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C40(0.61); C43(0.63); C58(0.91)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C40(0.67); C43(0.68); C58(0.98)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C40(0.57); C43(0.57); C58(1.03)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C40(0.63); C43(0.57); C58(0.85)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C40(1.10); C43(1.16); C58(1.01)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C40(0.82); C43(0.77); C58(0.82)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C40(0.57); C43(0.62); C58(0.97)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C40(0.61); C43(0.67); C58(0.85)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C40(0.69); C43(0.71); C58(1.10)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C40(0.59); C43(0.63); C58(0.96)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C40(1.58); C43(1.43); C58(0.78)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C40(0.76); C43(0.74); C58(0.90)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C40(0.74); C43(0.79); C58(0.92)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C40(1.04); C308(1.40); C43(1.04); C58(1.43)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C40(0.65); C308(1.01); C43(0.65); C58(1.00)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C40(0.70); C308(1.28); C43(0.70); C58(1.37)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C40(2.20); C308(1.14); C43(2.20); C58(0.73)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C40(0.66); C308(1.19); C43(0.66); C58(0.99)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C40(0.59); C308(1.27); C43(0.59); C58(1.25)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C40(0.68); C308(1.26); C43(0.68); C58(1.23)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C40(0.83); C308(1.21); C43(0.83); C58(1.34)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C40(0.63); C308(1.09); C43(0.63); C58(1.10)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C40(0.62); C308(1.08); C43(0.62); C58(1.02)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C40(0.49); C308(1.32); C43(0.49); C58(1.09)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C40(0.65); C308(1.30); C43(0.65); C58(1.09)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C40(1.14); C43(1.04); C58(0.73)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C40(0.57); C308(1.34); C43(0.57); C58(1.29)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C40(0.54); C308(1.17); C43(0.54); C58(1.10)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C40(0.41); C308(1.15); C43(0.41); C58(0.82)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C40(1.20); C308(0.83); C43(1.11); C58(1.32)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C308(0.94); C58(1.00); C40(1.62); C43(1.64)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C58(0.95); C308(0.95); C40(1.38); C43(1.42)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C308(0.98); C58(1.13); C43(1.26); C40(1.30)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C58(0.91); C308(1.01); C40(1.75); C43(1.80)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C308(1.29); C43(1.54); C40(1.64); C58(1.80)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C308(1.06); C43(1.22); C40(1.32); C58(1.40)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C58(0.84); C43(1.24); C40(1.29)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C308(0.88); C43(1.04); C58(1.04); C40(1.14)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C308(0.85); C58(1.05); C40(1.34); C43(1.39)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C308(0.85); C58(1.09); C40(1.84); C43(2.32)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C308(1.20); C58(1.52); C43(1.70); C40(1.84)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C40(1.50); C308(1.02); C43(1.57); C58(1.05)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C40(1.74); C308(0.93); C43(1.83); C58(1.14)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C40(1.37); C308(0.80); C43(1.34); C58(1.07)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C40(1.46); C308(0.88); C43(1.43); C58(1.15)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C192(0.93); C195(0.97); C58(1.01); C43(1.23)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C58(0.86); C195(0.91); C192(0.96); C40(1.61)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C58(0.97); C195(0.97); C192(1.11); C40(1.33)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C43(0.60); C40(0.71); C192(1.25); C195(1.25)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C58(1.04); C195(1.09); C192(1.23); C40(1.34)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C58(0.91); C195(1.14); C192(1.23); C40(1.52)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C195(1.13); C58(1.17); C40(1.27); C192(1.27)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C192(0.88); C195(0.95); C40(1.17); C43(1.23)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C58(1.09); C195(1.10); C192(1.14); C40(1.36)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C43(0.89); C192(0.91); C195(0.91); C40(0.91)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C43(0.69); C40(0.73); C192(0.94); C195(0.94)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C43(0.82); C40(0.91); C192(1.21); C195(1.21)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C192(0.90); C195(0.90); C43(0.90); C40(1.03)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C192(0.93); C195(0.93); C43(0.95); C40(0.95)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C43(0.57); C40(0.70); C192(1.27); C195(1.27)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C192(0.91); C195(0.91); C43(1.02); C40(1.09)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C192(0.86); C195(0.86); C40(1.05); C43(1.05)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C43(0.88); C192(0.94); C195(0.94); C40(0.94)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C192(0.85); C195(0.85); C43(1.06); C40(1.09)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C192(0.83); C195(0.83); C58(1.23); C43(1.32)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C58(0.80); C192(0.91); C195(0.91); C40(1.04)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C40(0.84); C58(0.87); C43(0.89); C192(0.98)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C58(0.73); C40(0.91); C43(1.00); C192(1.12)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C40(0.96); C43(0.99); C58(1.04); C192(1.24)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C43(0.86); C40(0.87); C58(1.04); C192(1.07)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C43(0.68); C40(0.82); C192(1.27); C195(1.27)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C40(1.01); C58(1.02); C43(1.08); C192(1.17)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C40(0.81); C43(0.85); C58(0.94); C192(0.94)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C40(0.92); C43(0.94); C58(1.02); C192(1.03)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C192(0.93); C195(0.93); C40(0.94); C43(0.95)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C58(0.92); C192(1.03); C195(1.03); C40(1.06)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C58(0.94); C40(0.96); C43(1.05); C192(1.48)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C58(0.90); C308(1.00); C43(1.17); C40(1.25)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C43(0.82); C58(0.86); C40(0.86); C308(1.18)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C43(0.76); C40(0.83); C58(1.04); C308(1.46)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C308(1.09); C43(1.39); C40(1.46); C58(1.53)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C43(0.66); C40(0.84); C192(1.30); C195(1.30)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C43(1.16); C40(1.17); C308(1.24); C58(1.27)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C58(0.61); C40(1.14); C43(1.17); C308(1.21)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C58(0.75); C40(1.06); C43(1.11); C308(1.17)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C308(1.00); C43(1.18); C40(1.18); C58(1.20)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C308(1.07); C43(1.20); C58(1.25); C40(1.32)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C308(1.22); C40(1.27); C43(1.30); C58(1.50)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C308(1.41); C40(1.42); C43(1.48); C58(2.13)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C192(0.76); C195(0.76); C58(0.79); C40(1.01)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C192(0.91); C195(0.91); C58(1.08); C40(1.54)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C192(0.86); C195(0.86); C40(0.94); C43(0.94)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C58(1.03); C43(1.30); C40(1.31)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C58(0.88); C192(0.91); C195(0.91); C40(1.23)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C40(0.90); C43(0.90); C192(1.03); C195(1.03)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C58(0.91); C192(0.99); C195(0.99); C40(1.27)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C192(0.84); C195(0.84); C58(0.95); C40(0.97)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C58(0.58); C192(0.92); C195(0.92); C40(0.99)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C40(0.57); C43(0.57); C58(0.87); C192(1.05)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C40(0.67); C43(0.67); C192(0.93); C195(0.93)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C40(0.53); C43(0.53); C58(0.70); C192(0.96)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C195(0.85); C192(0.90); C43(0.92); C40(1.00)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C195(0.83); C192(0.95); C43(1.04); C40(1.17)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C58(0.92); C40(1.20); C43(1.21)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C195(0.73); C192(0.79); C40(0.81); C43(0.81)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C43(0.82); C40(0.92); C192(0.98); C195(1.06)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C195(0.87); C192(0.95); C43(1.15); C40(1.22)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C195(0.85); C192(0.89); C43(1.04); C40(1.20)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C192(0.98); C195(0.99); C43(1.11); C40(1.30)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C195(0.81); C192(0.92); C43(1.06); C40(1.16)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C43(0.96); C192(0.97); C195(1.01); C40(1.10)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C195(1.05); C192(1.09); C43(1.12); C40(1.15)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C43(0.85); C195(0.90); C40(0.92); C192(0.96)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C43(0.69); C40(0.80); C195(0.93); C192(1.06)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C58(1.11); C40(1.40); C43(1.49)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C43(0.94); C192(1.01); C195(1.02); C40(1.04)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C43(0.80); C40(0.86); C195(0.91); C192(0.97)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C192(0.87); C195(0.90); C43(1.07); C40(1.10)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C192(1.01); C195(1.01); C308(1.04); C40(1.14)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C308(0.93); C43(1.06); C40(1.28); C192(1.41)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C192(0.63); C195(0.63); C308(0.84); C40(1.01)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C308(0.77); C40(0.89); C192(0.94); C195(0.94)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C308(0.78); C192(0.79); C195(0.79); C40(0.86)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C308(0.72); C192(0.81); C195(0.81); C40(1.09)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C308(0.89); C40(1.19); C192(1.21); C195(1.21)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C192(0.76); C195(0.76); C308(0.83); C40(1.01)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C308(0.94); C40(1.13); C192(1.14); C195(1.14)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C308(1.04); C192(1.14); C195(1.14); C40(1.36)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C308(0.78); C40(1.04); C192(1.08); C195(1.08)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C192(0.69); C195(0.69); C308(0.70); C58(0.96)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C308(0.71); C192(0.77); C195(0.77); C40(0.90)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C308(0.77); C192(0.83); C195(0.83); C40(1.07)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C308(0.91); C192(1.08); C195(1.08); C40(1.23)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C43(0.48); C40(0.56); C58(1.80)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C43(0.69); C40(0.77); C58(1.24)  LDD0683  [11]
 LDCM0166  Afatinib A431 3.35  LDD0421  [5]
 LDCM0248  AKOS034007472 HCT 116 C40(1.00); C43(1.05); C58(0.85)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C58(0.79); C43(1.22); C40(1.35)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C58(0.94); C40(1.40); C43(1.43)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C58(1.06); C192(1.23); C195(1.23); C40(1.16)  LDD2171  [11]
 LDCM0108  Chloroacetamide HeLa C35(0.00); C58(0.00)  LDD0222  [19]
 LDCM0367  CL1 HCT 116 C40(1.01); C58(1.05); C43(1.23)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C43(1.16); C58(1.33); C40(1.35)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C43(0.60); C40(0.75); C192(1.08); C195(1.08)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C58(0.85); C43(1.13); C40(1.16)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C58(0.69); C40(1.02); C43(1.13)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C58(0.73); C40(1.10); C43(1.33)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C58(0.90); C40(1.16); C43(1.18)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C58(0.95); C195(1.03); C192(1.15); C40(1.31)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C58(0.81); C195(1.08); C192(1.13); C40(1.70)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C192(0.97); C58(0.99); C195(1.04); C43(1.31)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C58(0.76); C195(0.97); C192(1.00); C43(1.70)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C195(1.08); C192(1.13); C58(1.14); C40(1.32)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C58(1.50); C40(1.53); C43(1.53)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C192(0.93); C195(0.99); C58(1.10); C40(1.25)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C192(0.91); C195(0.93); C58(1.06); C40(1.35)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C40(0.72); C43(0.73); C192(0.77); C195(0.77)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C192(0.95); C195(0.95); C43(1.00); C40(1.04)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C192(0.75); C195(0.75); C43(0.76); C40(0.78)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C40(0.84); C43(0.85); C192(0.97); C195(0.97)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C43(0.66); C40(0.69); C192(0.95); C195(0.95)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C192(1.09); C195(1.09); C40(1.19); C43(1.28)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C43(0.87); C40(0.89); C58(1.07); C192(1.31)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C58(1.01); C40(1.15); C43(1.15); C192(1.32)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C40(1.61); C43(1.69); C58(1.89)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C43(0.81); C40(0.83); C192(0.89); C195(0.89)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C58(1.49); C308(1.61); C40(1.81); C43(2.91)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C308(0.93); C43(0.96); C40(1.06); C58(1.07)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C58(1.03); C308(1.07); C43(1.26); C40(1.27)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C308(0.91); C58(1.27); C43(1.27); C40(1.33)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C192(0.82); C195(0.82); C40(0.87); C43(0.87)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C192(0.72); C195(0.72); C40(1.15); C43(1.15)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C192(0.80); C195(0.80); C40(0.93); C43(0.93)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C192(0.94); C195(0.94); C58(0.97); C40(1.30)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C58(1.48); C40(2.04); C43(2.35)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C58(1.27); C40(1.29); C43(1.46)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C43(0.98); C40(1.05); C58(1.55)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C58(0.92); C40(1.09); C43(1.12); C192(1.73)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C43(0.96); C58(0.97); C192(1.11); C195(1.11)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C43(0.92); C192(1.28); C195(1.28); C58(1.29)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C58(1.11); C43(1.43); C40(1.45); C192(1.46)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C58(0.81); C43(0.97); C40(0.97)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C58(1.38); C43(1.42); C192(1.67); C195(1.67)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C192(1.48); C195(1.48); C58(1.61); C40(2.38)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C192(1.57); C195(1.57); C43(1.87); C58(2.06)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C58(1.16); C192(1.19); C195(1.19); C43(2.49)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C43(1.14); C58(1.59); C40(1.75); C192(1.82)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C40(1.66); C192(1.55); C195(1.55); C43(0.88)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C40(3.45); C192(1.39); C195(1.39); C43(1.46)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C40(1.48); C192(1.71); C195(1.71); C43(1.17)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C40(1.63); C192(1.82); C195(1.82); C43(1.84)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C40(1.78); C192(2.13); C195(2.13); C43(1.19)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C40(1.16); C43(1.07); C58(0.95)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C40(1.99); C192(1.92); C195(1.92); C43(1.18)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C40(1.34); C192(0.94); C195(0.94); C43(0.94)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C40(1.46); C192(0.86); C195(0.86); C43(1.11)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C40(1.46); C192(0.79); C195(0.79); C43(1.28)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C40(1.85); C192(1.12); C195(1.12); C43(1.55)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C40(1.72); C192(1.31); C195(1.31); C43(1.36)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C40(1.39); C192(1.02); C195(1.02); C43(1.26)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C40(1.80); C192(1.08); C195(1.08); C43(1.56)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C40(1.73); C192(0.87); C195(0.87); C43(1.47)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C40(1.03); C43(1.15); C58(1.18)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C40(1.47); C192(1.06); C195(1.06); C43(1.42)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C40(1.42); C192(1.10); C195(1.10); C43(1.22)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C40(1.58); C192(1.05); C195(1.05); C43(1.20)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C40(1.82); C192(1.18); C195(1.18); C43(1.47)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C40(1.84); C192(0.91); C195(0.91); C43(1.53)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C40(2.02); C192(1.13); C195(1.13); C43(1.65)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C40(0.95); C192(1.39); C195(1.39); C58(1.06)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C40(0.82); C192(1.28); C195(1.28); C58(1.04)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C40(1.36); C192(1.19); C195(1.19); C58(1.11)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C40(1.12); C192(1.32); C195(1.32); C58(0.87)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C40(1.09); C43(1.16); C58(1.25)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C40(0.85); C192(1.00); C195(1.00); C58(1.22)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C40(0.95); C192(1.12); C195(1.12); C58(1.07)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C40(0.95); C192(1.16); C195(1.16); C58(1.13)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C40(0.95); C192(1.14); C195(1.14); C58(1.01)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C40(1.01); C192(0.98); C195(0.98); C58(0.82)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C40(1.10); C192(1.08); C195(1.08); C58(0.84)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C40(0.81); C192(1.24); C195(1.24); C58(0.80)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C40(0.94); C192(1.49); C195(1.49); C58(0.66)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C40(0.97); C192(1.03); C195(1.03); C58(0.75)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C40(0.96); C192(1.10); C195(1.10); C58(0.72)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C40(1.17); C43(1.02); C58(1.26)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C40(1.17); C192(1.03); C195(1.03); C58(0.83)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C40(0.76); C192(1.09); C195(1.11); C43(0.76)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C40(0.79); C192(1.22); C195(1.15); C43(0.79)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C40(0.71); C192(1.04); C195(1.14); C43(0.71)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C40(0.88); C192(1.14); C195(1.07); C43(0.88)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C40(0.68); C192(1.12); C195(1.10); C43(0.68)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C40(0.79); C192(1.04); C195(1.08); C43(0.79)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C40(0.98); C192(1.08); C195(1.20); C43(0.98)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C40(0.78); C192(1.27); C195(1.29); C43(0.78)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C40(1.05); C192(1.77); C195(1.61); C43(1.05)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C40(1.22); C43(0.95); C58(1.74)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C40(0.87); C192(1.33); C195(1.22); C43(0.87)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C40(0.90); C192(1.27); C195(1.41); C43(0.90)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C40(0.70); C192(1.60); C195(1.48); C43(0.70)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C40(3.42); C192(1.07); C195(1.28); C43(3.42)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C40(1.42); C192(1.19); C195(1.15); C43(1.42)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C40(1.38); C192(0.81); C195(0.81); C58(1.08)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C40(4.98); C192(0.76); C195(0.83); C58(1.01)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C40(0.99); C192(0.68); C195(0.75); C58(1.18)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C40(1.49); C192(0.78); C195(0.75); C58(1.26)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C40(1.77); C43(1.85); C58(1.75)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C40(1.42); C192(0.75); C195(0.79); C58(0.99)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C40(1.18); C192(0.73); C195(0.81); C58(1.14)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C40(1.98); C192(0.92); C195(0.87); C58(1.29)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C40(1.85); C192(0.75); C195(0.72); C58(1.26)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C40(1.73); C192(0.70); C195(0.72); C58(1.44)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C40(1.37); C192(1.05); C195(1.01); C58(1.15)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C40(1.08); C192(0.75); C195(0.71); C58(0.98)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C40(1.15); C192(0.71); C195(0.72); C58(0.98)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C40(1.65); C192(0.76); C195(0.74); C58(1.12)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C40(1.38); C192(0.95); C195(0.90); C58(1.50)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C40(1.40); C43(1.23); C58(1.43)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C40(0.79); C192(1.05); C195(1.05); C58(0.74)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C40(0.62); C192(1.04); C195(1.04); C43(0.51)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C40(0.59); C192(0.92); C195(0.92); C43(0.48)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C40(0.93); C192(1.25); C195(1.25); C43(0.68)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C40(0.87); C192(1.07); C195(1.07); C43(0.72)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C40(0.69); C192(1.09); C195(1.09); C43(0.59)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C40(0.64); C192(1.11); C195(1.11); C43(0.59)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C40(0.77); C192(1.12); C195(1.12); C43(0.81)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C40(0.65); C192(1.08); C195(1.08); C43(0.55)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C40(0.72); C192(1.28); C195(1.28); C43(0.62)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C35(0.92); C58(0.81); C40(0.90); C40(1.18)  LDD1698  [24]
 LDCM0625  F8 Ramos C35(1.93); C58(1.75); 0.56  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C35(0.79); C58(0.99); 0.87  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C35(0.25); C58(0.06); 0.80  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C35(1.27); C58(0.51); 1.28  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C35(1.49); C58(0.88); 0.92  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C35(1.15); C58(0.41); 0.76  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C35(1.15); C58(0.40); 1.34  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C35(0.90); C58(1.24); 0.63  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C35(1.52); C58(0.77); 0.78  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C35(1.01); C58(1.12); 0.69  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C35(0.62); C58(0.60); 0.36  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C35(1.09); C58(1.05); 1.41  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C35(0.91); C58(0.80); 0.62  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C35(0.80); C58(0.65); 0.74  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C40(0.93); C192(1.29); C195(1.21); C43(0.93)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C35(0.92); C58(1.06); 1.57  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C35(1.05); C58(0.84); 0.87  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C40(1.83); C192(1.11); C195(1.11); C43(1.88)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C35(1.00); C58(0.73); 0.53  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C35(1.06); C58(0.71); 0.86  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C35(0.97); C58(0.56); 0.75  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C35(0.94); C58(0.46); 0.68  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y37(0.95)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y37(0.97)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y37(0.94)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y37(1.00)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y37(0.86)  LDD0268  [9]
 LDCM0107  IAA HeLa H62(0.00); H31(0.00)  LDD0221  [19]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [7]
 LDCM0022  KB02 HCT 116 C192(2.14); C195(2.14); C35(1.57); C58(1.36)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C192(2.93); C195(2.93); C35(1.75); C58(1.22)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C192(2.49); C195(2.49); C35(1.58); C58(1.18)  LDD0082  [11]
 LDCM0145  MCC950 THP-1 1.57  LDD0370  [23]
 LDCM0109  NEM HeLa H62(0.00); C58(0.00)  LDD0224  [19]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C35(1.19)  LDD2093  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C35(1.53)  LDD2111  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C35(0.71)  LDD2119  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C35(1.34)  LDD2129  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C35(1.36)  LDD2136  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C58(0.77); C58(0.55)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C35(0.93); C43(0.82); C58(0.75); C58(0.72)  LDD2207  [26]
 LDCM0158  P27 BxPC-3 1.74  LDD0408  [6]
 LDCM0021  THZ1 HeLa S3 C43(1.03)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
6 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.