Details of the Target

General Information of Target

Target ID LDTP13087
Target Name Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
Gene Name DPM3
Gene ID 54344
Synonyms
Dolichol-phosphate mannosyltransferase subunit 3; Dolichol-phosphate mannose synthase subunit 3; DPM synthase subunit 3; Dolichyl-phosphate beta-D-mannosyltransferase subunit 3; Mannose-P-dolichol synthase subunit 3; MPD synthase subunit 3; Prostin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVDITLLFRASVKTVKTRNKALGVAVGGGVDGSRDELFRRSPRPKGDFSSRAREVISHI
GKLRDFLLEHRKDYINAYSHTMSEYGRMTDTERDQIDQDAQIFMRTCSEAIQQLRTEAHK
EIHSQQVKEHRTAVLDFIEDYLKRVCKLYSEQRAIRVKRVVDKKRLSKLEPEPNTKTRES
TSSEKVSQSPSKDSEENPATEERPEKILAETQPELGTWGDGKGEDELSPEEIQMFEQENQ
RLIGEMNSLFDEVRQIEGRVVEISRLQEIFTEKVLQQEAEIDSIHQLVVGATENIKEGNE
DIREAIKNNAGFRVWILFFLVMCSFSLLFLDWYDS
Target Bioclass
Enzyme
Family
DPM3 family
Subcellular location
Endoplasmic reticulum membrane
Function Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the endoplasmic reticulum.
Uniprot ID
Q9P2X0
Ensemble ID
ENST00000341298.3
HGNC ID
HGNC:3007

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.A71T .
PF382 SNV: p.C67G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		6.96  LDD0066  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
IA-alkyne
 Probe Info  		C67(1.76)  LDD0304  [3]
m-APA
 Probe Info  		11.06  LDD0403  [4]
DBIA
 Probe Info  		C97(2.48)  LDD3312  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
BTD
 Probe Info  		C67(0.95)  LDD2090  [7]
HPAP
 Probe Info  		6.85  LDD0063  [8]
EA-probe
 Probe Info  		N.A.  LDD0440  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
aHNE
 Probe Info  		N.A.  LDD0001  [14]
ENE
 Probe Info  		N.A.  LDD0006  [14]
IPM
 Probe Info  		N.A.  LDD0005  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C67(0.74)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C67(0.77)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C67(1.49)  LDD2117  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C67(0.91)  LDD2103  [7]
 LDCM0214  AC1 HEK-293T C67(1.02)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C67(1.25)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C67(1.18)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C67(1.12)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C67(1.07)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C67(1.16)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C67(1.05)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C67(1.34)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C67(1.05)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C67(1.06)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C67(1.15)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C67(1.65)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C67(1.16)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C67(1.09)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C67(1.15)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C67(1.01)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C67(1.21)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C67(1.22)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C67(1.18)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C67(0.83)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C67(1.17)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C67(1.14)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C67(1.21)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C67(1.16)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C67(1.07)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C67(1.17)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C67(1.24)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C67(1.07)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C67(1.06)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C67(1.08)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C67(1.28)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C67(1.14)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C67(1.14)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C67(1.02)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C67(1.09)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C67(1.32)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C67(1.11)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C67(1.12)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C67(1.15)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C67(0.99)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C67(1.14)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C67(1.05)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C67(0.81)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C67(1.12)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C67(1.26)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C67(1.14)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C67(1.03)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C67(1.10)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C67(1.12)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C67(1.12)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C67(1.16)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C67(1.38)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C67(1.14)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C67(1.06)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C67(1.19)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C67(1.26)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C67(1.12)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C67(1.23)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C67(1.24)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C67(1.27)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C67(1.27)  LDD1569  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C67(0.88)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C67(0.91)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C67(0.98)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C67(1.11)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 11.06  LDD0403  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C67(1.67)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C67(1.85)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C67(1.73)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C67(1.03)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C67(1.13)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C67(1.28)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C67(1.23)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C67(1.04)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C67(1.43)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C67(1.21)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C67(1.21)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C67(1.03)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C67(1.20)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C67(1.44)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C67(1.12)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C67(1.28)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C67(1.21)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C67(1.08)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C67(1.15)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C67(1.22)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C67(1.07)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C67(0.88)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C67(1.11)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C67(1.23)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C67(1.42)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C67(1.10)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C67(0.82)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C67(1.08)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C67(1.42)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C67(0.98)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C67(1.20)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C67(1.15)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C67(1.16)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C67(1.22)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C67(0.68)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C67(1.08)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C67(1.45)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C67(1.09)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C67(1.19)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C67(1.10)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C67(1.47)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C67(1.02)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C67(1.12)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C67(1.28)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C67(1.23)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C67(1.30)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C67(1.45)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C67(1.33)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C67(1.08)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C67(1.11)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C67(1.09)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C67(0.98)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C67(1.13)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C67(1.07)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C67(1.26)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C67(1.19)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C67(2.63)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C67(1.32)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C67(1.49)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C67(1.39)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C67(1.04)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C67(1.06)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C67(0.91)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C67(1.13)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C67(1.07)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C67(1.00)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C67(1.29)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C67(1.28)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C67(1.27)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C67(1.41)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C67(1.51)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C67(1.31)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C67(0.85)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C67(1.13)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C67(1.07)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C67(1.06)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C67(1.12)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C67(1.76)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C67(1.39)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C67(1.24)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C67(1.48)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C67(1.35)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C67(1.45)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C67(1.41)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C67(1.36)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C67(0.89)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C67(0.98)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C67(1.16)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C67(1.03)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C67(0.96)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C67(1.25)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C67(1.32)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C67(1.20)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C67(1.57)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C67(1.30)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C67(1.21)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C67(1.40)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C67(1.35)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C67(1.47)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C67(1.08)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C67(1.06)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C67(1.08)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C67(1.34)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C67(1.31)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C67(2.40)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C67(1.15)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C67(1.10)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C67(1.35)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C67(1.33)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C67(1.46)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C67(1.27)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C67(1.04)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C67(1.29)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C67(1.03)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C67(1.01)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C67(1.02)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C67(1.98)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C67(1.30)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C67(1.31)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C67(1.35)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C67(1.29)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C67(1.73)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C67(1.44)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C67(1.23)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C67(1.05)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C67(1.34)  LDD1697  [17]
 LDCM0634  CY-0357 Hep-G2 C67(0.55)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C67(1.13)  LDD1698  [17]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [9]
 LDCM0625  F8 Ramos C67(1.46)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C67(3.20)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C67(0.32)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C67(9.20)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C67(0.87)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C67(17.81)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C67(20.00)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C67(1.19)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C67(1.79)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C67(0.79)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C67(0.66)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C67(1.14)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C67(1.60)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C67(6.79)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C67(1.05)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C67(2.38)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C67(9.09)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C67(0.97)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C67(0.96)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C67(0.76)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C67(3.34)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C67(14.37)  LDD2188  [18]
 LDCM0015  HNE MDA-MB-231 C67(1.17)  LDD0346  [18]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HEK-293T C67(0.93)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C67(1.01)  LDD1497  [17]
 LDCM0024  KB05 HMCB C97(2.48)  LDD3312  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C67(1.10)  LDD2102  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C67(0.95)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C67(0.89)  LDD2092  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C67(1.03)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C67(1.51)  LDD2098  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C67(0.69)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C67(0.51)  LDD2104  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C67(0.93)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C67(0.96)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C67(0.84)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C67(0.88)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C67(0.81)  LDD2110  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C67(0.49)  LDD2115  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C67(1.00)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C67(0.91)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C67(1.40)  LDD2127  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C67(0.90)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C67(0.62)  LDD2134  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C67(1.60)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C67(0.95)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C67(1.10)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C67(1.04)  LDD2141  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C67(1.81)  LDD2144  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C67(0.56)  LDD2148  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C67(1.95)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C67(0.97)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C67(0.86); C67(0.70)  LDD2207  [19]
 LDCM0014  Panhematin K562 6.85  LDD0063  [8]
 LDCM0131  RA190 MM1.R C67(1.76)  LDD0304  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dolichol-phosphate mannosyltransferase subunit 1 (DPM1) Glycosyltransferase 2 family O60762
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BOS complex subunit TMEM147 (TMEM147) TMEM147 family Q9BVK8
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) DPM2 family O94777
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.