Details of the Target

General Information of Target

Target ID LDTP05037
Target Name Ras-related C3 botulinum toxin substrate 1 (RAC1)
Gene Name RAC1
Gene ID 5879
Synonyms
TC25; Ras-related C3 botulinum toxin substrate 1; EC 3.6.5.2; Cell migration-inducing gene 5 protein; Ras-like protein TC25; p21-Rac1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR
DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP
PVKKRKRKCLLL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rho family
Subcellular location
Cell membrane
Function
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity. In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization.; [Isoform B]: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.
TTD ID
T88752
Uniprot ID
P63000
DrugMap ID
TT25NY8
Ensemble ID
ENST00000348035.9
HGNC ID
HGNC:9801
ChEMBL ID
CHEMBL6094

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.N39S DBIA    Probe Info 
CMK SNV: p.I21M DBIA    Probe Info 
DEL SNV: p.V85M; p.A88E DBIA    Probe Info 
HT1080 SNV: p.N92I DBIA    Probe Info 
IGR1 SNV: p.P29S DBIA    Probe Info 
JURKAT SNV: p.C18Y Compound 10    Probe Info 
KYSE150 SNV: p.P29S DBIA    Probe Info 
MDAMB157 SNV: p.P29S DBIA    Probe Info 
MDST8 SNV: p.D11E DBIA    Probe Info 
SHP77 SNV: p.Y32C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.93  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y154(5.50); Y139(20.00); Y98(10.03)  LDD0260  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K166(1.82)  LDD0274  [5]
STPyne
 Probe Info  		K133(4.93); K147(9.73); K183(7.52); K96(8.42)  LDD0277  [5]
BTD
 Probe Info  		C178(1.35); C157(3.79)  LDD1699  [6]
OPA-S-S-alkyne
 Probe Info  		K153(2.29)  LDD3494  [7]
Probe 1
 Probe Info  		Y139(14.22)  LDD3495  [8]
DBIA
 Probe Info  		C6(1.61); C124(1.13)  LDD3310  [9]
JZ128-DTB
 Probe Info  		C178(0.00); C157(0.00)  LDD0462  [10]
AHL-Pu-1
 Probe Info  		C178(5.75)  LDD0171  [11]
HHS-482
 Probe Info  		Y139(0.50)  LDD0285  [12]
HHS-475
 Probe Info  		Y98(0.87); Y139(0.98)  LDD0264  [13]
HHS-465
 Probe Info  		Y139(10.00); Y98(6.31)  LDD2237  [14]
ATP probe
 Probe Info  		K183(0.00); K184(0.00); K166(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C178(0.00); C105(0.00); C81(0.00); C157(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C157(0.00); C178(0.00); C6(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		C6(0.00); C157(0.00); C81(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C178(0.00); C105(0.00); C81(0.00); C157(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		N.A.  LDD0035  [19]
IPM
 Probe Info  		C157(0.00); C105(0.00); C178(0.00)  LDD0025  [20]
JW-RF-010
 Probe Info  		C157(0.00); C178(0.00); C6(0.00); C105(0.00)  LDD0026  [20]
TFBX
 Probe Info  		C157(0.00); C178(0.00); C6(0.00)  LDD0027  [20]
WYneN
 Probe Info  		C105(0.00); C157(0.00); C178(0.00); C6(0.00)  LDD0021  [21]
aHNE
 Probe Info  		N.A.  LDD0001  [21]
Compound 10
 Probe Info  		C157(0.00); C178(0.00)  LDD2216  [22]
Compound 11
 Probe Info  		C157(0.00); C178(0.00)  LDD2213  [22]
PF-06672131
 Probe Info  		N.A.  LDD0017  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
1c-yne
 Probe Info  		N.A.  LDD0228  [25]
Acrolein
 Probe Info  		C105(0.00); C178(0.00); H104(0.00)  LDD0217  [26]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [26]
Crotonaldehyde
 Probe Info  		C105(0.00); C178(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		C105(0.00); C178(0.00)  LDD0218  [26]
W1
 Probe Info  		C105(0.00); C178(0.00)  LDD0236  [27]
AOyne
 Probe Info  		11.30  LDD0443  [28]
MPP-AC
 Probe Info  		N.A.  LDD0428  [29]
NAIA_5
 Probe Info  		C178(0.00); C157(0.00); C105(0.00)  LDD2223  [30]
TER-AC
 Probe Info  		N.A.  LDD0426  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C178(0.59); C105(0.39); C157(0.29)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C178(0.78)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C178(0.62); C105(0.59)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C178(0.87); C105(0.89)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C178(0.80); C105(1.38)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C178(1.08); C105(1.61)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C178(1.04); C157(1.35)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C178(0.58); C105(0.59)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C178(0.69); C105(0.59)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C157(2.70)  LDD0172  [11]
 LDCM0026  4SU-RNA+native RNA DM93 C178(5.75)  LDD0171  [11]
 LDCM0214  AC1 HEK-293T C105(0.85); C157(1.01); C178(0.94); C81(0.91)  LDD1507  [31]
 LDCM0215  AC10 HEK-293T C105(0.92); C157(0.95); C178(0.96); C81(0.85)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C105(0.90); C157(1.03); C178(0.92); C18(0.96)  LDD1509  [31]
 LDCM0237  AC12 HEK-293T C105(0.94); C157(0.96); C178(0.97); C81(0.97)  LDD1510  [31]
 LDCM0259  AC14 HEK-293T C105(0.93); C157(1.10); C178(0.96); C81(0.91)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C105(0.92); C157(0.99); C178(0.92); C81(1.08)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C105(0.92); C157(0.93); C178(0.97); C81(1.02)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C105(1.00); C157(1.18); C178(0.93); C81(0.72)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C105(0.81); C157(1.05); C178(0.97); C18(0.87)  LDD1517  [31]
 LDCM0279  AC2 HEK-293T C105(1.00); C157(0.94); C178(1.01); C81(0.95)  LDD1518  [31]
 LDCM0280  AC20 HEK-293T C105(0.96); C157(1.02); C178(0.94); C81(1.09)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C105(0.98); C157(0.97); C178(0.95); C81(0.92)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C105(0.93); C157(0.93); C178(0.94); C81(0.93)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C105(0.96); C157(0.98); C178(0.96); C81(0.90)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C105(0.91); C157(1.05); C178(0.99); C81(0.89)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C105(0.95); C157(1.12); C178(0.96); C81(1.02)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C105(0.91); C157(1.13); C178(0.98); C81(0.99)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C105(0.99); C157(0.99); C178(0.96); C18(0.90)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C105(0.91); C157(1.09); C178(0.95); C81(1.03)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C105(0.99); C157(1.04); C178(0.96); C81(0.95)  LDD1528  [31]
 LDCM0290  AC3 HEK-293T C105(0.96); C157(0.97); C178(0.94); C18(0.86)  LDD1529  [31]
 LDCM0291  AC30 HEK-293T C105(0.98); C157(1.09); C178(0.99); C81(0.97)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C105(0.95); C157(1.17); C178(0.92); C81(0.95)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C105(0.97); C157(0.93); C178(0.97); C81(0.95)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C105(0.89); C157(0.98); C178(0.98); C81(1.13)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C105(0.85); C157(1.29); C178(0.98); C81(0.89)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C105(0.99); C157(1.04); C178(0.96); C18(1.04)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C105(0.90); C157(1.03); C178(0.97); C81(1.06)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C105(0.96); C157(1.02); C178(0.98); C81(1.06)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C105(0.94); C157(0.95); C178(0.99); C81(1.06)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C105(0.92); C157(0.97); C178(0.98); C81(0.87)  LDD1539  [31]
 LDCM0301  AC4 HEK-293T C105(1.01); C157(1.03); C178(0.93); C81(1.07)  LDD1540  [31]
 LDCM0302  AC40 HEK-293T C105(0.95); C157(1.06); C178(1.01); C81(0.91)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C105(0.92); C157(0.98); C178(0.98); C81(0.99)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C105(0.90); C157(1.18); C178(0.97); C81(0.96)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C105(0.92); C157(1.03); C178(0.99); C18(0.95)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C105(0.95); C157(0.99); C178(0.99); C81(1.05)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C105(0.86); C157(1.05); C178(0.95); C81(0.97)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C105(0.87); C157(0.99); C178(1.00); C81(0.93)  LDD1547  [31]
 LDCM0309  AC47 HEK-293T C105(0.86); C157(0.99); C178(0.98); C81(1.02)  LDD1548  [31]
 LDCM0310  AC48 HEK-293T C105(0.89); C157(1.25); C178(1.00); C81(1.10)  LDD1549  [31]
 LDCM0311  AC49 HEK-293T C105(0.85); C157(1.01); C178(0.96); C81(1.13)  LDD1550  [31]
 LDCM0312  AC5 HEK-293T C105(0.97); C157(1.02); C178(1.00); C81(1.00)  LDD1551  [31]
 LDCM0313  AC50 HEK-293T C105(0.94); C157(1.32); C178(0.98); C81(0.94)  LDD1552  [31]
 LDCM0314  AC51 HEK-293T C105(0.91); C157(1.01); C178(0.97); C18(0.93)  LDD1553  [31]
 LDCM0315  AC52 HEK-293T C105(1.00); C157(1.02); C178(0.97); C81(1.15)  LDD1554  [31]
 LDCM0316  AC53 HEK-293T C105(0.95); C157(0.99); C178(0.99); C81(1.13)  LDD1555  [31]
 LDCM0317  AC54 HEK-293T C105(0.89); C157(0.99); C178(0.99); C81(1.07)  LDD1556  [31]
 LDCM0318  AC55 HEK-293T C105(0.93); C157(1.02); C178(0.92); C81(0.93)  LDD1557  [31]
 LDCM0319  AC56 HEK-293T C105(0.92); C157(1.16); C178(1.00); C81(1.19)  LDD1558  [31]
 LDCM0320  AC57 HEK-293T C105(0.80); C157(1.02); C178(1.01); C81(1.15)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C105(0.87); C157(0.92); C178(0.98); C81(0.70)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C105(0.93); C157(1.00); C178(0.98); C18(1.15)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C105(0.94); C157(0.97); C178(0.99); C81(0.95)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C105(0.82); C157(0.92); C178(0.99); C81(1.18)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C105(0.82); C157(1.00); C178(0.98); C81(0.90)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C105(0.81); C157(1.05); C178(1.01); C81(0.98)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C105(0.84); C157(0.91); C178(0.99); C81(0.89)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C105(0.89); C157(1.12); C178(1.00); C81(1.10)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C105(1.05); C157(0.92); C178(0.98); C81(0.87)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C105(0.97); C157(1.31); C178(0.98); C81(1.05)  LDD1569  [31]
 LDCM0545  Acetamide MDA-MB-231 C178(0.35); C105(0.53)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C178(0.60); C105(0.76)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C105(0.90); C157(1.02); C178(0.97); C81(1.01)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C105(0.91); C157(1.02); C178(0.98); C81(1.06)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C105(0.97); C157(1.23); C178(1.00); C81(0.95)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 11.92  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C178(0.40); C105(0.80)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C105(0.00); C178(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C178(1.08); C105(0.73); C178(0.70); C157(0.52)  LDD2227  [30]
 LDCM0367  CL1 HEK-293T C105(0.78); C157(0.94); C178(0.90); C81(1.20)  LDD1571  [31]
 LDCM0368  CL10 HEK-293T C105(0.96); C157(1.20); C178(0.61); C81(0.95)  LDD1572  [31]
 LDCM0369  CL100 HEK-293T C105(0.97); C157(1.03); C178(0.91); C81(1.05)  LDD1573  [31]
 LDCM0370  CL101 HEK-293T C105(0.88); C157(0.83); C178(0.96); C81(1.16)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C105(0.85); C157(0.86); C178(0.92); C81(1.03)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C105(0.90); C157(0.92); C178(1.00); C81(1.01)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C105(0.98); C157(0.98); C178(0.91); C81(1.27)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C105(0.89); C157(0.97); C178(0.94); C81(0.88)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C105(0.98); C157(0.90); C178(0.92); C81(1.00)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C105(0.99); C157(0.91); C178(0.94); C81(1.06)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C105(0.97); C157(1.05); C178(0.97); C81(1.02)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C105(0.90); C157(0.83); C178(0.98); C81(0.99)  LDD1582  [31]
 LDCM0379  CL11 HEK-293T C105(0.68); C157(1.21); C178(0.44); C81(0.91)  LDD1583  [31]
 LDCM0380  CL110 HEK-293T C105(0.91); C157(0.89); C178(0.91); C81(0.73)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C105(0.94); C157(1.00); C178(0.92); C81(1.01)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C105(0.94); C157(1.01); C178(0.96); C81(1.02)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C105(0.88); C157(0.94); C178(1.00); C81(1.06)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C105(0.83); C157(0.87); C178(0.90); C81(0.93)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C105(0.99); C157(1.00); C178(0.96); C81(1.01)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C105(0.99); C157(0.96); C178(0.99); C81(1.10)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C105(0.86); C157(0.94); C178(1.01); C81(1.14)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C105(0.91); C157(0.86); C178(1.00); C81(1.13)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C105(0.93); C157(0.98); C178(1.01); C81(0.86)  LDD1593  [31]
 LDCM0390  CL12 HEK-293T C105(0.96); C157(1.07); C178(0.83); C81(1.23)  LDD1594  [31]
 LDCM0391  CL120 HEK-293T C105(0.96); C157(0.96); C178(1.00); C81(0.97)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C105(0.87); C157(1.04); C178(0.98); C81(1.02)  LDD1596  [31]
 LDCM0393  CL122 HEK-293T C105(0.94); C157(0.89); C178(0.92); C81(0.88)  LDD1597  [31]
 LDCM0394  CL123 HEK-293T C105(0.87); C157(0.99); C178(0.92); C81(0.92)  LDD1598  [31]
 LDCM0395  CL124 HEK-293T C105(0.93); C157(1.12); C178(0.91); C81(1.10)  LDD1599  [31]
 LDCM0396  CL125 HEK-293T C105(0.88); C157(0.97); C178(0.96); C81(1.09)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C105(0.83); C157(0.84); C178(0.99); C81(0.86)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C105(0.93); C157(0.98); C178(1.00); C81(1.02)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C105(0.92); C157(0.94); C178(0.99); C81(1.11)  LDD1603  [31]
 LDCM0400  CL13 HEK-293T C105(0.84); C157(1.06); C178(0.90); C81(1.02)  LDD1604  [31]
 LDCM0401  CL14 HEK-293T C105(0.92); C157(1.04); C178(0.95); C81(0.97)  LDD1605  [31]
 LDCM0402  CL15 HEK-293T C105(0.88); C157(1.01); C178(0.89); C81(1.02)  LDD1606  [31]
 LDCM0403  CL16 HEK-293T C105(1.04); C157(0.99); C178(0.97); C81(1.04)  LDD1607  [31]
 LDCM0404  CL17 HEK-293T C105(0.88); C157(0.97); C178(0.88); C81(1.10)  LDD1608  [31]
 LDCM0405  CL18 HEK-293T C105(0.95); C157(1.11); C178(0.98); C81(1.09)  LDD1609  [31]
 LDCM0406  CL19 HEK-293T C105(0.99); C157(1.18); C178(1.00); C18(0.79)  LDD1610  [31]
 LDCM0407  CL2 HEK-293T C105(1.04); C157(1.08); C178(0.94); C81(1.24)  LDD1611  [31]
 LDCM0408  CL20 HEK-293T C105(1.04); C157(1.04); C178(0.86); C81(0.87)  LDD1612  [31]
 LDCM0409  CL21 HEK-293T C105(0.90); C157(1.33); C178(0.53); C81(1.00)  LDD1613  [31]
 LDCM0410  CL22 HEK-293T C105(1.07); C157(1.11); C178(0.65); C81(1.01)  LDD1614  [31]
 LDCM0411  CL23 HEK-293T C105(1.00); C157(1.20); C178(0.41); C81(0.88)  LDD1615  [31]
 LDCM0412  CL24 HEK-293T C105(1.02); C157(1.00); C178(0.82); C81(1.14)  LDD1616  [31]
 LDCM0413  CL25 HEK-293T C105(0.91); C157(0.99); C178(0.93); C81(0.88)  LDD1617  [31]
 LDCM0414  CL26 HEK-293T C105(0.98); C157(1.05); C178(0.93); C81(1.05)  LDD1618  [31]
 LDCM0415  CL27 HEK-293T C105(0.98); C157(0.87); C178(0.95); C81(0.94)  LDD1619  [31]
 LDCM0416  CL28 HEK-293T C105(1.01); C157(1.02); C178(0.92); C81(1.21)  LDD1620  [31]
 LDCM0417  CL29 HEK-293T C105(0.92); C157(1.13); C178(0.99); C81(0.95)  LDD1621  [31]
 LDCM0418  CL3 HEK-293T C105(1.10); C157(1.05); C178(0.99); C81(1.11)  LDD1622  [31]
 LDCM0419  CL30 HEK-293T C105(0.95); C157(1.01); C178(0.99); C81(0.90)  LDD1623  [31]
 LDCM0420  CL31 HEK-293T C105(0.94); C157(1.05); C178(0.91); C18(0.73)  LDD1624  [31]
 LDCM0421  CL32 HEK-293T C105(0.98); C157(1.02); C178(0.83); C81(1.02)  LDD1625  [31]
 LDCM0422  CL33 HEK-293T C105(0.88); C157(1.14); C178(0.51); C81(0.89)  LDD1626  [31]
 LDCM0423  CL34 HEK-293T C105(1.04); C157(1.10); C178(0.63); C81(0.93)  LDD1627  [31]
 LDCM0424  CL35 HEK-293T C105(1.10); C157(1.10); C178(0.34); C81(1.00)  LDD1628  [31]
 LDCM0425  CL36 HEK-293T C105(1.04); C157(1.40); C178(0.76); C81(1.01)  LDD1629  [31]
 LDCM0426  CL37 HEK-293T C105(0.89); C157(0.87); C178(0.97); C81(1.11)  LDD1630  [31]
 LDCM0428  CL39 HEK-293T C105(0.94); C157(0.93); C178(0.95); C81(0.79)  LDD1632  [31]
 LDCM0429  CL4 HEK-293T C105(1.11); C157(1.14); C178(0.93); C81(1.13)  LDD1633  [31]
 LDCM0430  CL40 HEK-293T C105(0.98); C157(0.93); C178(1.02); C81(0.99)  LDD1634  [31]
 LDCM0431  CL41 HEK-293T C105(0.84); C157(1.03); C178(0.95); C81(0.87)  LDD1635  [31]
 LDCM0432  CL42 HEK-293T C105(0.95); C157(1.26); C178(0.95); C81(0.66)  LDD1636  [31]
 LDCM0433  CL43 HEK-293T C105(0.98); C157(1.05); C178(1.01); C18(0.98)  LDD1637  [31]
 LDCM0434  CL44 HEK-293T C105(0.92); C157(1.05); C178(0.87); C81(0.99)  LDD1638  [31]
 LDCM0435  CL45 HEK-293T C105(0.90); C157(0.99); C178(0.59); C81(0.75)  LDD1639  [31]
 LDCM0436  CL46 HEK-293T C105(0.97); C157(1.12); C178(0.64); C81(0.93)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C105(1.02); C157(1.16); C178(0.38); C81(0.97)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C105(0.96); C157(1.18); C178(0.76); C81(1.18)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C105(0.87); C157(1.05); C178(0.94); C81(1.10)  LDD1643  [31]
 LDCM0440  CL5 HEK-293T C105(0.98); C157(1.02); C178(0.96); C81(1.21)  LDD1644  [31]
 LDCM0441  CL50 HEK-293T C105(0.93); C157(0.88); C178(0.94); C81(1.22)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C105(1.10); C157(0.98); C178(0.92); C81(1.06)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C105(0.93); C157(1.05); C178(0.92); C81(1.01)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C105(0.91); C157(1.25); C178(0.89); C81(0.80)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C105(1.02); C157(1.10); C178(1.00); C18(1.27)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C105(1.09); C157(0.93); C178(0.84); C81(0.83)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C105(0.91); C157(1.06); C178(0.60); C81(0.85)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C105(0.94); C157(1.04); C178(0.64); C81(0.83)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C105(1.01); C157(1.12); C178(0.43); C81(0.85)  LDD1653  [31]
 LDCM0451  CL6 HEK-293T C105(0.94); C157(1.16); C178(0.90); C81(0.82)  LDD1654  [31]
 LDCM0452  CL60 HEK-293T C105(1.00); C157(1.16); C178(0.78); C81(1.07)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C105(0.90); C157(0.87); C178(0.96); C81(1.01)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C105(0.96); C157(1.02); C178(0.97); C81(1.19)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C105(0.91); C157(0.95); C178(0.92); C81(1.03)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C105(0.91); C157(1.10); C178(0.90); C81(1.08)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C105(0.94); C157(1.03); C178(0.99); C81(1.01)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C105(0.91); C157(1.32); C178(0.97); C81(0.98)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C105(0.94); C157(1.05); C178(0.95); C18(0.91)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C105(0.93); C157(0.95); C178(0.83); C81(0.81)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C105(0.95); C157(1.05); C178(0.67); C81(1.12)  LDD1664  [31]
 LDCM0462  CL7 HEK-293T C105(1.03); C157(1.17); C178(0.99); C18(0.62)  LDD1665  [31]
 LDCM0463  CL70 HEK-293T C105(0.97); C157(0.97); C178(0.73); C81(0.87)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C105(0.96); C157(1.00); C178(0.47); C81(1.03)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C105(1.03); C157(1.28); C178(0.86); C81(1.00)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C105(0.88); C157(1.08); C178(0.95); C81(1.08)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C105(1.00); C157(0.96); C178(0.90); C81(0.97)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C105(0.96); C157(0.96); C178(0.98); C81(1.06)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C105(0.75); C157(1.06); C178(0.92); C81(0.94)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C105(1.01); C157(1.04); C178(0.97); C81(0.88)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C105(0.97); C157(1.11); C178(0.96); C18(1.07)  LDD1675  [31]
 LDCM0473  CL8 HEK-293T C105(0.69); C157(0.97); C178(0.70); C81(0.86)  LDD1676  [31]
 LDCM0474  CL80 HEK-293T C105(1.09); C157(1.07); C178(0.91); C81(0.92)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C105(1.00); C157(1.07); C178(0.70); C81(1.13)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C105(1.03); C157(1.01); C178(0.78); C81(0.85)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C105(0.96); C157(1.11); C178(0.58); C81(0.90)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C105(0.94); C157(1.15); C178(0.90); C81(1.28)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C105(0.92); C157(1.01); C178(0.94); C81(1.11)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C105(0.90); C157(0.87); C178(0.98); C81(1.04)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C105(0.87); C157(1.03); C178(0.93); C81(0.93)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C105(1.00); C157(0.96); C178(0.95); C81(1.15)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C105(0.92); C157(1.04); C178(0.99); C81(1.02)  LDD1686  [31]
 LDCM0484  CL9 HEK-293T C105(1.05); C157(1.10); C178(0.65); C81(1.02)  LDD1687  [31]
 LDCM0485  CL90 HEK-293T C105(0.79); C157(1.04); C178(0.86); C81(0.62)  LDD1688  [31]
 LDCM0486  CL91 HEK-293T C105(1.05); C157(1.04); C178(0.97); C18(1.28)  LDD1689  [31]
 LDCM0487  CL92 HEK-293T C105(0.84); C157(1.01); C178(0.93); C81(0.92)  LDD1690  [31]
 LDCM0488  CL93 HEK-293T C105(0.93); C157(1.08); C178(0.80); C81(1.14)  LDD1691  [31]
 LDCM0489  CL94 HEK-293T C105(0.92); C157(0.93); C178(0.90); C81(0.93)  LDD1692  [31]
 LDCM0490  CL95 HEK-293T C105(0.81); C157(1.27); C178(0.67); C81(0.89)  LDD1693  [31]
 LDCM0491  CL96 HEK-293T C105(0.93); C157(1.29); C178(0.95); C81(1.10)  LDD1694  [31]
 LDCM0492  CL97 HEK-293T C105(0.86); C157(0.90); C178(0.93); C81(0.97)  LDD1695  [31]
 LDCM0493  CL98 HEK-293T C105(0.95); C157(0.95); C178(0.98); C81(0.93)  LDD1696  [31]
 LDCM0494  CL99 HEK-293T C105(0.96); C157(0.89); C178(0.94); C81(0.96)  LDD1697  [31]
 LDCM0634  CY-0357 Hep-G2 C178(50.00)  LDD2228  [30]
 LDCM0495  E2913 HEK-293T C105(1.01); C157(1.08); C178(0.99); C81(1.11)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C105(1.37); C178(0.85)  LDD1702  [6]
 LDCM0625  F8 Ramos C178(1.20); C157(0.73); C6(0.50); C105(8.96)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C178(0.61); C157(0.61); C6(0.40); C105(0.37)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C178(0.05); C157(0.00)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C178(0.70); C157(0.87); C6(0.61); C105(0.29)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C178(1.05); C157(0.68); C6(1.04); C105(0.41)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C178(0.67); C157(0.46); C6(0.64); C105(0.87)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C178(0.49); C157(0.76); C6(0.51); C105(0.42)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C178(1.01); C157(0.83); C6(0.77); C105(0.36)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C178(1.24); C157(0.76); C6(0.62)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C178(1.00); C157(0.78); C6(0.96)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C178(0.67); C157(0.44); C6(0.62); C105(0.68)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C178(1.20); C157(1.05); C6(1.18); C105(0.48)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C178(0.97); C157(0.90); C6(0.84); C105(1.56)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C178(0.63); C157(0.61); C6(0.41); C105(0.42)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C105(0.99); C157(0.96); C178(0.92); C81(1.00)  LDD1671  [31]
 LDCM0596  Fragment38 Ramos C178(0.92); C157(0.79); C6(0.90); C105(0.55)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C178(0.83); C157(0.91); C6(0.59); C105(0.72)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C105(0.91); C157(0.89); C178(0.95); C81(0.98)  LDD1631  [31]
 LDCM0610  Fragment52 Ramos C178(1.12); C157(0.84); C6(1.67); C105(0.75)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C178(1.54); C157(0.89); C6(1.57); C105(0.19)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C178(0.62); C157(0.81); C6(0.46); C105(0.53)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C178(0.58); C157(0.79); C6(0.56); C105(0.09)  LDD2188  [32]
 LDCM0116  HHS-0101 DM93 Y98(0.87); Y139(0.98)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y98(0.87); Y139(0.98)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y98(0.85); Y139(0.87)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y98(0.97); Y139(0.98)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y139(0.86); Y98(0.98)  LDD0268  [13]
 LDCM0107  IAA HeLa C105(0.00); C178(0.00); H104(0.00); H103(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y139(0.50)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y139(0.53)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y139(0.90)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y139(3.07)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y139(1.56); Y154(1.16)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y139(0.31); Y154(0.15)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y139(0.64); Y154(0.47)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y139(0.54)  LDD0292  [12]
 LDCM0179  JZ128 PC-3 C178(0.00); C157(0.00)  LDD0462  [10]
 LDCM0022  KB02 Ramos C178(0.62); C157(0.95); C6(0.44); C105(0.46)  LDD2182  [32]
 LDCM0023  KB03 MDA-MB-231 C178(0.97)  LDD1701  [6]
 LDCM0024  KB05 COLO792 C6(1.61); C124(1.13)  LDD3310  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C178(1.91)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C178(0.43); C105(0.88)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C178(0.53); C105(0.87)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C178(1.46)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C178(1.12); C105(0.92)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C178(1.01); C105(1.38)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C178(1.94); C105(0.79)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C178(0.61); C105(0.54)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C178(0.76)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C178(0.80); C105(1.07)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C178(0.80); C105(1.36)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C178(0.59); C105(0.44); C157(0.45)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C178(0.64)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C178(0.77); C105(0.34)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C178(1.39); C105(1.44)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C178(0.95); C157(0.26)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C178(0.81); C105(0.95)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C178(0.37); C157(0.47)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C178(0.60); C105(1.10)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C178(3.68); C157(0.36)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C178(0.87); C105(1.06)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C178(1.08); C105(0.49)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C178(0.39); C105(0.62)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C178(0.66); C105(0.72)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C178(0.75); C105(0.74)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C178(2.93); C105(2.07)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C178(0.83)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C178(0.87); C105(0.70)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C178(0.75); C105(1.20)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C178(0.62); C105(1.05)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C178(0.67); C105(1.14)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C178(0.60)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C178(0.76); C105(1.87)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C105(0.63)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C178(0.82); C105(1.16)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C178(0.50)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C178(0.37); C105(0.56)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C178(0.93); C105(1.11)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C178(0.99); C105(1.51)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C178(0.82); C105(1.37)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C178(2.81); C105(1.65)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C178(0.65); C105(1.06)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C178(0.59); C105(0.64)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C178(0.97); C105(0.84)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C178(3.59); C105(1.58)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C178(4.79); C157(4.81)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C178(0.77); C105(1.07)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C178(3.47)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C178(0.35); C105(0.55)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C178(0.76); C105(0.90)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C178(0.41); C105(0.54)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C178(0.92); C105(0.81)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C178(1.62)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C178(0.89)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C178(0.74)  LDD2207  [33]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Baculoviral IAP repeat-containing protein 2 (BIRC2) IAP family Q13490
E3 ubiquitin-protein ligase XIAP (XIAP) IAP family P98170
Inositol polyphosphate 5-phosphatase OCRL (OCRL) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q01968
Purine nucleoside phosphorylase (PNP) PNP/MTAP phosphorylase family P00491
Protein kinase C iota type (PRKCI) AGC Ser/Thr protein kinase family P41743
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
E3 ubiquitin-protein ligase SH3RF1 (SH3RF1) SH3RF family Q7Z6J0
E3 ubiquitin-protein ligase SH3RF3 (SH3RF3) SH3RF family Q8TEJ3
GTP-binding protein Rit1 (RIT1) Ras family Q92963
Putative E3 ubiquitin-protein ligase UNKL (UNKL) Unkempt family Q9H9P5
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
E3 ubiquitin-protein ligase HACE1 (HACE1) . Q8IYU2
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Beclin-1 (BECN1) Beclin family Q14457
Caveolin-1 (CAV1) Caveolin family Q03135
Filamin-B (FLNB) Filamin family O75369
MyoD family inhibitor (MDFI) MDFI family Q99750
Protein S100-B (S100B) S-100 family P04271
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Jun (JUN) BZIP family P05412
THAP domain-containing protein 3 (THAP3) . Q8WTV1
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein AATF (AATF) AATF family Q9NY61
Dedicator of cytokinesis protein 1 (DOCK1) DOCK family Q14185
Dedicator of cytokinesis protein 2 (DOCK2) DOCK family Q92608
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein SET (SET) Nucleosome assembly protein (NAP) family Q01105
Partitioning defective 6 homolog alpha (PARD6A) PAR6 family Q9NPB6
Partitioning defective 6 homolog beta (PARD6B) PAR6 family Q9BYG5
Partitioning defective 6 homolog gamma (PARD6G) PAR6 family Q9BYG4
Prefoldin subunit 2 (PFDN2) Prefoldin subunit beta family Q9UHV9
Rho GDP-dissociation inhibitor 1 (ARHGDIA) Rho GDI family P52565
Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) TNFAIP8 family Q6P589
U3 small nucleolar RNA-associated protein 14 homolog A (UTP14A) UTP14 family Q9BVJ6
Arfaptin-2 (ARFIP2) . P53365
Beta-chimaerin (CHN2) . P52757
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
BTB/POZ domain-containing protein KCTD17 (KCTD17) . Q8N5Z5
Harmonin (USH1C) . Q9Y6N9
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) . Q8TCU6
Proto-oncogene vav (VAV1) . P15498
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940
Rho GTPase-activating protein 45 (ARHGAP45) . Q92619
Rho guanine nucleotide exchange factor 7 (ARHGEF7) . Q14155

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azathioprine Small molecular drug DB00993
Dextromethorphan Small molecular drug DB00514
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-diphosphate Small molecular drug DB04315
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Eht-1864 Small molecular drug D0M9ER

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
30 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
31 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.