Details of the Target

General Information of Target

Target ID LDTP12159
Target Name Cytochrome P450 3A43 (CYP3A43)
Gene Name CYP3A43
Gene ID 64816
Synonyms
Cytochrome P450 3A43; EC 1.14.14.1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNS
SKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDT
SIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRL
LVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQ
LGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNI
TFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFK
IDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYK
LFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDG
MKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRR
CRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG
Target Bioclass
Enzyme
Family
Cytochrome P450 family
Subcellular location
Endoplasmic reticulum membrane
Function Exhibits low testosterone 6-beta-hydroxylase activity.
Uniprot ID
Q9HB55
Ensemble ID
ENST00000222382.5
HGNC ID
HGNC:17450
ChEMBL ID
CHEMBL5792

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.V369I .
DANG SNV: p.P315L .
HCT15 SNV: p.I149M .
HT115 SNV: p.F215V; p.K378N; p.D380Y .
MEWO SNV: p.M181I .
OPM2 SNV: p.F203L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
aHNE
 Probe Info  		N.A.  LDD0001  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 57 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acalabrutinib Small molecular drug DB11703
Brigatinib Small molecular drug DB12267
Budesonide Small molecular drug DB01222
Cobicistat Small molecular drug DB09065
Crizotinib Small molecular drug DB08865
Daclatasvir Small molecular drug DB09102
Dexamethasone Small molecular drug DB01234
Dextropropoxyphene Small molecular drug DB00647
Diacerein Small molecular drug DB11994
Dolutegravir Small molecular drug DB08930
Elagolix Small molecular drug DB11979
Ethosuximide Small molecular drug DB00593
Fluvoxamine Small molecular drug DB00176
Glecaprevir Small molecular drug DB13879
Idelalisib Small molecular drug DB09054
Istradefylline Small molecular drug DB11757
Itraconazole Small molecular drug DB01167
Lonafarnib Small molecular drug DB06448
Lopinavir Small molecular drug DB01601
Lorlatinib Small molecular drug DB12130
Loxoprofen Small molecular drug DB09212
Mebendazole Small molecular drug DB00643
Methadone Small molecular drug DB00333
Methylprednisolone Small molecular drug DB00959
Midostaurin Small molecular drug DB06595
Naldemedine Small molecular drug DB11691
Nefazodone Small molecular drug DB01149
Netupitant Small molecular drug DB09048
Olanzapine Small molecular drug DB00334
Oxymetholone Small molecular drug DB06412
Phenelzine Small molecular drug DB00780
Pibrentasvir Small molecular drug DB13878
Prednisone Small molecular drug DB00635
Relugolix Small molecular drug DB11853
Remoxipride Small molecular drug DB00409
Rifampicin Small molecular drug DB01045
Rifapentine Small molecular drug DB01201
Rucaparib Small molecular drug DB12332
Sotorasib Small molecular drug DB15569
Tazemetostat Small molecular drug DB12887
Testosterone Small molecular drug DB00624
Testosterone Undecanoate Small molecular drug DB13946
Thiopental Small molecular drug DB00599
Troleandomycin Small molecular drug DB13179
Ursodeoxycholic Acid Small molecular drug DB01586
Dexamethasone Acetate . DB14649
Elbasvir . DB11574
Lemborexant . DB11951
Letermovir . DB12070
Myrrh . DB11605
Omega-3-carboxylic Acids . DB09568
Prednisolone Phosphate . DB14631
Selpercatinib . DB15685
Testosterone Cypionate . DB13943
Testosterone Enanthate . DB13944
Tucatinib . DB11652
Zanubrutinib . DB15035
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Foretinib Small molecular drug DB12307
Quercetin Small molecular drug DB04216
Rhein Small molecular drug DB13174

References

1 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764