Details of the Target

General Information of Target

Target ID LDTP04027
Target Name Matrin-3 (MATR3)
Gene Name MATR3
Gene ID 9782
Synonyms
KIAA0723; Matrin-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKSFQQSSLSRDSQGHGRDLSAAGIGLLAAATQSLSMPASLGRMNQGTARLASLMNLGM
SSSLNQQGAHSALSSASTSSHNLQSIFNIGSRGPLPLSSQHRGDADQASNILASFGLSAR
DLDELSRYPEDKITPENLPQILLQLKRRRTEEGPTLSYGRDGRSATREPPYRVPRDDWEE
KRHFRRDSFDDRGPSLNPVLDYDHGSRSQESGYYDRMDYEDDRLRDGERCRDDSFFGETS
HNYHKFDSEYERMGRGPGPLQERSLFEKKRGAPPSSNIEDFHGLLPKGYPHLCSICDLPV
HSNKEWSQHINGASHSRRCQLLLEIYPEWNPDNDTGHTMGDPFMLQQSTNPAPGILGPPP
PSFHLGGPAVGPRGNLGAGNGNLQGPRHMQKGRVETSRVVHIMDFQRGKNLRYQLLQLVE
PFGVISNHLILNKINEAFIEMATTEDAQAAVDYYTTTPALVFGKPVRVHLSQKYKRIKKP
EGKPDQKFDQKQELGRVIHLSNLPHSGYSDSAVLKLAEPYGKIKNYILMRMKSQAFIEME
TREDAMAMVDHCLKKALWFQGRCVKVDLSEKYKKLVLRIPNRGIDLLKKDKSRKRSYSPD
GKESPSDKKSKTDGSQKTESSTEGKEQEEKSGEDGEKDTKDDQTEQEPNMLLESEDELLV
DEEEAAALLESGSSVGDETDLANLGDVASDGKKEPSDKAVKKDGSASAAAKKKLKKVDKI
EELDQENEAALENGIKNEENTEPGAESSENADDPNKDTSENADGQSDENKDDYTIPDEYR
IGPYQPNVPVGIDYVIPKTGFYCKLCSLFYTNEEVAKNTHCSSLPHYQKLKKFLNKLAEE
RRQKKET
Target Bioclass
Other
Subcellular location
Nucleus matrix
Function
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins.
Uniprot ID
P43243
Ensemble ID
ENST00000394805.8
HGNC ID
HGNC:6912

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAKI1 Insertion: p.G583DfsTer7 DBIA    Probe Info 
CCFSTTG1 Insertion: p.G482EfsTer3 .
CMK SNV: p.T811A DBIA    Probe Info 
GB1 SNV: p.L383V DBIA    Probe Info 
HCT116 SNV: p.R192C DBIA    Probe Info 
HEC1 SNV: p.R19H DBIA    Probe Info 
HT115 Deletion: .
Insertion: p.K479_E481dup
SNV: .		 DBIA    Probe Info 
MOLT4 SNV: p.R182G; p.R255C; p.S397N; p.Q785Ter IA-alkyne    Probe Info 
SW1573 SNV: p.R562Ter DBIA    Probe Info 
SW756 Deletion: p.E210del DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 50 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.56  LDD0402  [1]
P2
 Probe Info  		2.82  LDD0449  [2]
P3
 Probe Info  		3.67  LDD0450  [2]
P8
 Probe Info  		10.00  LDD0451  [2]
A-EBA
 Probe Info  		3.37  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
TH211
 Probe Info  		Y213(20.00); Y214(20.00); Y250(20.00); Y827(20.00)  LDD0257  [5]
TH216
 Probe Info  		Y508(13.54); Y158(9.09); Y128(5.82)  LDD0259  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		K491(0.00); K181(0.00); K588(0.00); K245(0.00)  LDD0273  [7]
Probe 1
 Probe Info  		Y128(25.12); Y158(13.16); Y171(15.73); Y214(7.43)  LDD3495  [8]
BTD
 Probe Info  		C821(2.62); C803(1.28)  LDD1700  [9]
AHL-Pu-1
 Probe Info  		C230(2.42)  LDD0170  [10]
HHS-475
 Probe Info  		Y202(1.03)  LDD0264  [11]
DBIA
 Probe Info  		C552(1.92); C806(1.53)  LDD0080  [12]
5E-2FA
 Probe Info  		H551(0.00); H101(0.00); H505(0.00)  LDD2235  [13]
AMP probe
 Probe Info  		N.A.  LDD0200  [14]
ATP probe
 Probe Info  		K473(0.00); K588(0.00); K798(0.00); K804(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C230(0.00); C552(0.00); C806(0.00); C821(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C806(0.00); C552(0.00)  LDD0032  [16]
IPIAA_H
 Probe Info  		C821(0.00); C806(0.00)  LDD0030  [17]
IPIAA_L
 Probe Info  		C230(0.00); C293(0.00); C821(0.00); C552(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C230(0.00); C552(0.00); C806(0.00); C821(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [20]
aHNE
 Probe Info  		N.A.  LDD0001  [20]
1d-yne
 Probe Info  		K132(0.00); K611(0.00); K146(0.00)  LDD0356  [21]
Compound 10
 Probe Info  		C230(0.00); C552(0.00); C806(0.00)  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
IPM
 Probe Info  		N.A.  LDD0005  [20]
NHS
 Probe Info  		K487(0.00); K479(0.00); K571(0.00); K836(0.00)  LDD0010  [20]
SF
 Probe Info  		Y202(0.00); Y810(0.00); Y213(0.00); Y214(0.00)  LDD0028  [23]
STPyne
 Probe Info  		K478(0.00); K491(0.00); K3(0.00); K798(0.00)  LDD0009  [20]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		C803(0.00); C293(0.00); C821(0.00); C563(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		K617(0.00); K245(0.00); K719(0.00); K798(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		H499(0.00); H505(0.00); C821(0.00); H204(0.00)  LDD0217  [25]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [25]
Crotonaldehyde
 Probe Info  		H505(0.00); H401(0.00); H204(0.00); H101(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C552(0.00); H401(0.00); H499(0.00); C821(0.00)  LDD0218  [25]
W1
 Probe Info  		C552(0.00); C821(0.00); C806(0.00); Y508(0.00)  LDD0236  [26]
AOyne
 Probe Info  		6.40  LDD0443  [27]
NAIA_5
 Probe Info  		C230(0.00); C563(0.00); C552(0.00); C806(0.00)  LDD2223  [28]
TPP-AC
 Probe Info  		N.A.  LDD0427  [29]
HHS-465
 Probe Info  		K245(0.00); Y202(0.00); Y243(0.00)  LDD2240  [30]
HHS-482
 Probe Info  		Y158(0.82); Y202(1.83); Y213(0.64)  LDD2239  [31]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C232
 Probe Info  		34.78  LDD1905  [32]
C338
 Probe Info  		11.96  LDD2001  [32]
FFF probe11
 Probe Info  		5.12  LDD0471  [33]
FFF probe13
 Probe Info  		13.62  LDD0475  [33]
FFF probe2
 Probe Info  		6.46  LDD0463  [33]
FFF probe3
 Probe Info  		8.06  LDD0464  [33]
FFF probe4
 Probe Info  		5.35  LDD0466  [33]
JN0003
 Probe Info  		8.64  LDD0469  [33]
STS-1
 Probe Info  		N.A.  LDD0137  [34]
STS-2
 Probe Info  		N.A.  LDD0138  [34]
VE-P
 Probe Info  		N.A.  LDD0396  [35]
DA-2
 Probe Info  		N.A.  LDD0070  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C821(0.27)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C806(0.77); C821(0.64); C552(0.85)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C806(0.55)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C806(0.69)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C806(1.53); C803(0.98); C821(1.14); C552(1.66)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C821(1.46)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C821(0.70)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C806(0.70); C821(0.34); C552(1.21); C230(0.97)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C806(0.46); C821(0.74)  LDD2131  [9]
 LDCM0025  4SU-RNA DM93 C230(2.42)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA DM93 C230(2.53)  LDD0171  [10]
 LDCM0214  AC1 HCT 116 C293(0.89); C296(0.89); C552(1.47); C806(0.99)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C293(0.67); C296(0.67); C552(0.88); C806(0.98)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C293(0.50); C296(0.50); C552(0.55); C806(0.59)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C293(0.54); C296(0.54); C552(0.59); C806(0.60)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C293(0.56); C296(0.56); C552(0.64); C806(0.65)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C293(0.38); C296(0.38); C552(0.52); C806(0.58)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C293(0.42); C296(0.42); C552(0.56); C806(0.63)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C293(0.39); C296(0.39); C552(0.51); C806(0.61)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C293(0.41); C296(0.41); C552(0.56); C806(0.57)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C293(0.38); C296(0.39); C552(0.57); C806(0.52)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C293(0.53); C296(0.58); C552(0.59); C806(0.68)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C293(0.53); C296(0.59); C552(0.62); C806(0.71)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C293(0.64); C296(0.64); C552(1.01); C806(0.85)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C293(0.49); C296(0.53); C552(0.62); C806(0.62)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C293(0.49); C296(0.53); C552(0.59); C806(0.61)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C293(0.40); C296(0.42); C552(0.52); C806(0.50)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C293(1.02); C296(1.02); C552(0.98); C806(1.01)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C293(0.73); C296(0.73); C552(0.89); C806(0.96)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C293(0.62); C296(0.62); C552(0.83); C806(0.88)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C293(0.66); C296(0.66); C552(0.80); C806(0.89)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C293(0.68); C296(0.68); C552(0.86); C806(0.91)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C293(0.68); C296(0.68); C552(0.95); C806(0.93)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C293(0.71); C296(0.71); C552(0.90); C806(0.89)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C293(0.77); C296(0.77); C552(0.98); C806(1.01)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C293(0.79); C296(0.79); C552(0.85); C806(0.99)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C293(0.94); C296(0.94); C552(0.99); C806(1.10)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C293(0.79); C296(0.79); C552(0.98); C806(0.95)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C293(0.85); C296(0.85); C552(0.91); C806(1.19)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C293(0.88); C296(0.88); C552(0.86); C806(0.96)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C293(0.90); C296(0.90); C552(0.93); C806(1.16)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C293(0.55); C296(0.55); C552(0.81); C806(0.98)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C293(0.65); C296(0.65); C552(0.85); C806(0.99)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C293(0.64); C296(0.64); C552(0.98); C806(0.94)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C293(0.83); C296(0.83); C552(1.12); C806(0.93)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C293(0.66); C296(0.66); C552(1.00); C806(0.84)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C293(1.03); C296(1.03); C552(0.96); C806(0.95)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C293(0.88); C296(0.88); C552(1.16); C806(0.88)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C293(0.79); C296(0.79); C552(1.05); C806(0.81)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C293(0.71); C296(0.71); C552(0.94); C806(0.79)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C293(0.71); C296(0.71); C552(1.04); C806(0.87)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C293(0.90); C296(0.90); C552(1.01); C806(0.82)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C293(0.98); C296(0.98); C552(1.00); C806(0.88)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C293(0.78); C296(0.78); C552(1.01); C806(0.86)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C293(0.81); C296(0.81); C552(1.03); C806(0.82)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C293(0.73); C296(0.73); C552(0.94); C806(1.10)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C293(0.79); C296(0.79); C552(1.02); C806(0.79)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C293(0.77); C296(0.77); C552(0.98); C806(0.76)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C293(1.12); C296(1.12); C552(1.32); C806(0.89)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C293(0.79); C296(0.79); C552(0.84); C806(0.88)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C293(0.39); C296(0.39); C552(0.67); C806(0.80)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C293(0.57); C296(0.57); C552(0.77); C806(0.89)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C293(0.48); C296(0.48); C552(0.73); C806(0.78)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C293(0.40); C296(0.40); C552(0.68); C806(0.78)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C293(0.28); C296(0.28); C552(0.72); C806(0.78)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C293(0.42); C296(0.42); C552(0.66); C806(0.69)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C293(0.62); C296(0.62); C552(0.83); C806(0.93)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C293(0.67); C296(0.67); C552(0.74); C806(0.82)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C293(0.68); C296(0.68); C806(0.81); C552(0.84)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C293(0.44); C296(0.44); C552(0.65); C806(0.80)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C293(0.22); C296(0.22); C552(0.74); C806(0.78)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C293(0.42); C296(0.42); C552(0.67); C806(0.79)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C293(0.45); C296(0.45); C552(0.63); C806(0.78)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C293(0.79); C296(0.79); C552(0.87); C806(0.88)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C293(0.74); C296(0.74); C552(0.83); C806(0.90)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C552(0.89); C806(0.91)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C806(0.91); C552(0.92)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C806(0.85); C552(1.11)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C806(0.85); C293(0.93); C296(0.93); C552(1.28)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C552(0.85); C806(0.95)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C552(0.87); C806(0.98)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C552(1.03); C806(1.06)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C806(0.95); C552(1.49)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C552(0.86); C806(0.94)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C806(0.83); C552(0.94)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C806(0.72); C552(0.92)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C806(0.68); C552(0.80)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C806(0.65); C552(0.81)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C806(0.71); C552(0.75)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C806(0.92); C293(0.99); C296(0.99); C552(1.84)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C806(0.60); C552(0.70)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C806(0.67); C552(0.83)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C806(0.69); C552(0.69)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C806(0.67); C552(0.82)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C806(0.61); C552(0.65)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C806(1.11); C552(1.15)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C806(0.97); C552(1.03)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C806(1.07); C552(1.20)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C552(0.94); C806(1.12)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C552(0.97); C806(1.02)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C293(0.89); C296(0.89); C806(0.97); C552(1.82)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C806(1.01); C552(1.05)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C806(0.98); C552(1.00)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C806(0.90); C552(0.92)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C806(0.94); C552(0.94)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C806(0.94); C552(1.20)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C806(0.90); C552(1.20)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C806(0.89); C552(0.92)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C806(0.92); C552(1.01)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C806(0.93); C552(1.13)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C552(0.81); C806(0.92)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C293(0.83); C296(0.83); C806(0.93); C552(1.89)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C552(0.80); C806(0.85)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C552(1.10); C806(1.23)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C552(0.88); C806(0.95)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C806(0.83); C552(0.85)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C552(0.83); C806(0.85)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C806(0.92); C552(0.94)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C806(0.85); C552(0.88)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C552(0.67); C806(0.83)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C552(0.78); C806(0.83)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C552(0.69); C806(0.71)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C293(0.63); C296(0.63); C552(0.73); C806(0.86)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C806(0.70); C552(0.73)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C806(0.76); C552(0.83)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C806(0.72); C552(0.72)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C806(0.75); C552(0.80)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C552(0.71); C806(0.72)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C806(0.58); C552(0.86)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C806(0.63); C552(0.90)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C806(0.55); C552(0.74)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C293(0.80); C296(0.80); C806(1.06)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C293(1.01); C296(1.01); C806(1.13)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C552(0.96); C293(0.98); C296(0.98); C806(1.02)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C293(0.54); C296(0.54); C806(1.00)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C293(0.96); C296(0.96); C806(1.32)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C293(0.76); C296(0.76); C806(1.05)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C293(0.48); C296(0.48); C806(0.96)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C293(0.53); C296(0.53); C806(1.09)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C293(0.41); C296(0.41); C806(0.97)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C293(0.75); C296(0.75); C806(1.08)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C293(0.86); C296(0.86); C806(1.18)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C293(0.91); C296(0.91); C806(1.08)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C806(0.92); C293(0.93); C296(0.93)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C552(0.82); C293(0.82); C296(0.82); C806(0.95)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C293(0.80); C296(0.80); C806(1.10)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C806(1.02); C293(1.36); C296(1.36)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C293(0.39); C296(0.39); C806(0.93)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C293(0.32); C296(0.32); C806(0.55); C552(1.01)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C293(0.41); C296(0.41); C806(0.56); C552(0.89)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C806(0.53); C293(0.55); C296(0.55); C552(1.00)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C293(0.51); C296(0.51); C806(0.57); C552(0.96)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C806(0.69); C293(0.84); C296(0.84); C552(1.12)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C293(0.59); C296(0.59); C806(0.61); C552(0.81)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C293(0.42); C296(0.42); C806(0.54); C552(0.92)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C806(0.73); C293(0.83); C296(0.83); C552(0.93)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C293(0.30); C296(0.30); C806(0.59); C552(0.89)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C293(0.33); C296(0.33); C806(0.58); C552(0.92)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C293(0.57); C296(0.57); C806(0.58); C552(0.83)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C806(0.54); C293(0.59); C296(0.59); C552(1.07)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C806(0.63); C293(0.82); C296(0.82); C552(0.90)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C293(0.43); C296(0.43); C806(0.54); C552(1.10)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C293(0.46); C296(0.46); C806(0.53); C552(0.78)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C293(0.17); C296(0.17); C806(0.45); C552(0.55)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C293(0.59); C296(0.59); C806(0.61); C552(0.63)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C821(0.33)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C803(1.04); C821(0.66)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C293(1.02); C296(1.02); C552(0.97); C806(0.92)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C293(0.80); C296(0.80); C806(0.97); C552(1.09)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C293(0.43); C296(0.43); C552(0.71); C806(0.82)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C552(1.01)  LDD2171  [12]
 LDCM0498  BS-3668 MDA-MB-231 C806(0.87); C821(0.44); C230(0.57)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa H499(0.00); C552(0.00); H505(0.00); H401(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C806(20.00); C230(1.28); C821(1.05); C230(0.78)  LDD2227  [28]
 LDCM0367  CL1 HCT 116 C552(0.86); C806(1.05); C293(1.12); C296(1.12)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C552(0.73); C293(0.78); C296(0.78); C806(0.91)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C293(0.75); C296(0.75); C806(0.92); C552(1.43)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C293(0.69); C296(0.69); C552(0.82); C806(0.90)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C293(0.80); C296(0.80); C806(1.01); C552(1.04)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C552(0.97); C806(1.00); C293(1.15); C296(1.15)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C293(0.82); C296(0.82); C806(0.89); C552(0.96)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C552(0.62); C806(0.90)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C552(0.86); C806(0.88)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C552(0.87); C806(0.94)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C552(0.71); C806(0.87)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C552(0.68); C806(0.80)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C293(0.74); C296(0.74); C552(0.88); C806(1.00)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C806(0.71); C552(0.76)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C806(0.78); C552(1.08)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C806(0.85); C552(0.93)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C806(0.67); C552(0.68)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C552(0.72); C806(0.75)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C806(0.68); C552(0.71)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C806(0.65); C552(0.79)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C552(1.03); C806(1.10)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C806(0.95); C552(1.02)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C552(0.91); C806(0.98)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C293(0.76); C296(0.76); C552(0.80); C806(0.84)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C806(0.96); C552(0.97)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C552(0.79); C806(0.87)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C806(0.83); C552(0.96)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C552(0.78); C806(0.80)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C806(0.82); C552(0.83)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C806(0.80); C552(1.00)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C806(0.77); C552(0.89)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C806(0.79); C552(0.91)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C552(0.72); C806(0.77)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C293(0.88); C296(0.88); C806(0.90); C552(0.98)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C552(0.81); C293(0.88); C296(0.88); C806(0.90)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C806(0.76); C293(0.92); C296(0.92); C552(1.02)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C552(0.95); C806(1.17)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C552(0.67); C806(0.91)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C806(1.01); C552(1.32)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C806(0.96); C552(0.96)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C552(0.92); C806(1.12); C293(1.24); C296(1.24)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C806(0.87); C552(0.96)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C806(0.88); C552(1.09)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C806(1.22); C552(1.49)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C552(0.94); C806(1.07)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C806(1.03); C552(1.16)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C552(1.05); C806(1.01)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C552(1.88); C806(1.06)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C552(0.96); C806(1.00)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C552(1.15); C806(0.84)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C552(1.14); C806(1.00)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C293(1.00); C296(1.00); C552(0.85); C806(1.08)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C552(1.14); C806(1.16)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C293(0.87); C296(0.87); C552(0.75); C806(0.95)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C293(1.05); C296(1.05); C552(0.91); C806(0.95)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C293(0.68); C296(0.68); C552(0.73); C806(0.83)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C293(0.49); C296(0.49); C552(0.69); C806(0.81)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C293(0.45); C296(0.45); C552(0.62); C806(0.97)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C293(0.48); C296(0.48); C552(0.65); C806(0.90)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C293(0.39); C296(0.39); C552(0.63); C806(0.99)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C293(0.40); C296(0.40); C552(0.62); C806(0.86)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C293(0.90); C296(0.90); C552(0.85); C806(0.97)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C293(0.53); C296(0.53); C552(0.62); C806(0.88)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C293(0.55); C296(0.55); C552(0.66); C806(0.98)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C293(0.31); C296(0.31); C552(0.67); C806(0.93)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C293(0.33); C296(0.33); C552(0.63); C806(0.93)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C293(0.52); C296(0.52); C552(0.62); C806(1.08)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C293(0.50); C296(0.50); C552(0.65); C806(0.86)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C293(1.11); C296(1.11); C552(0.72); C806(1.00)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C293(1.07); C296(1.07); C552(0.62); C806(0.88)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C293(1.01); C296(1.01); C552(0.75); C806(1.13)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C293(0.98); C296(0.98); C552(0.66); C806(1.06)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C293(0.98); C296(0.98); C552(0.99); C806(1.06)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C293(1.06); C296(1.06); C552(0.73); C806(1.22)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C293(1.06); C296(1.06); C552(0.78); C806(1.08)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C293(0.93); C296(0.93); C552(0.78); C806(1.02)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C293(0.93); C296(0.93); C552(0.73); C806(1.01)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C293(0.94); C296(0.94); C552(0.69); C806(1.04)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C293(1.01); C296(1.01); C552(0.72); C806(1.22)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C293(1.06); C296(1.06); C552(0.79); C806(1.04)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C293(0.98); C296(0.98); C552(0.77); C806(1.30)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C293(1.07); C296(1.07); C552(0.70); C806(1.06)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C293(0.93); C296(0.93); C552(0.83); C806(0.99)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C293(1.09); C296(1.09); C552(0.99); C806(1.03)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C293(1.02); C296(1.02); C552(0.58); C806(1.24)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C552(0.73); C806(1.14)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C552(0.77); C806(1.00)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C552(0.64); C806(1.10)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C552(0.72); C806(0.99)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C552(0.58); C806(1.09)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C552(0.60); C806(1.05)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C552(0.69); C806(1.11)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C552(0.79); C806(1.43)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C552(0.48); C806(1.87)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C293(0.88); C296(0.88); C552(1.02); C806(1.01)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C552(0.71); C806(1.01)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C552(0.96); C806(1.16)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C552(0.98); C806(0.74)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C552(0.58); C806(1.16)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C552(0.81); C806(0.86)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C293(1.09); C296(1.09); C552(0.87); C806(1.05)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C293(0.81); C296(0.81); C552(0.77); C806(1.28)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C293(1.16); C296(1.16); C552(0.81); C806(0.85)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C293(0.94); C296(0.94); C552(0.72); C806(0.87)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C293(0.83); C296(0.83); C552(1.00); C806(0.93)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C293(1.35); C296(1.35); C552(0.92); C806(1.17)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C293(0.84); C296(0.84); C552(0.86); C806(0.92)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C293(0.79); C296(0.79); C552(0.79); C806(0.87)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C293(0.79); C296(0.79); C552(0.81); C806(0.81)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C293(0.73); C296(0.73); C552(0.82); C806(0.79)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C293(0.99); C296(0.99); C552(0.78); C806(0.80)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C293(1.10); C296(1.10); C552(0.94); C806(0.91)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C293(0.94); C296(0.94); C552(0.99); C806(0.80)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C293(0.82); C296(0.82); C552(0.84); C806(0.89)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C293(0.63); C296(0.63); C552(0.95); C806(0.72)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C293(0.86); C296(0.86); C552(0.90); C806(0.96)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C293(1.20); C296(1.20); C552(0.94); C806(0.87)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C293(0.79); C296(0.79); C552(0.99); C806(0.87)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C293(0.87); C296(0.87); C552(0.84); C806(0.87)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C293(1.30); C296(1.30); C552(1.03); C806(1.20)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C293(0.78); C296(0.78); C552(1.14); C806(1.00)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C293(0.70); C296(0.70); C552(0.86); C806(0.84)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C293(0.87); C296(0.87); C552(0.96); C806(0.92)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C293(0.84); C296(0.84); C552(1.01); C806(0.85)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C293(0.75); C296(0.75); C552(1.33); C806(0.82)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C293(0.81); C296(0.81); C552(1.44); C806(0.89)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C230(0.72)  LDD2228  [28]
 LDCM0495  E2913 HEK-293T C821(1.08); C552(1.03); C806(0.83); C230(1.02)  LDD1698  [37]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C552(2.16); C230(1.18)  LDD1702  [9]
 LDCM0625  F8 Ramos C806(0.73); C821(2.63); C552(1.46)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C806(0.57); C821(0.69); C552(0.49)  LDD2189  [38]
 LDCM0573  Fragment11 Ramos C806(0.86); C821(20.00); C230(0.49)  LDD2190  [38]
 LDCM0574  Fragment12 Ramos C806(0.72); C821(0.66); C552(0.48)  LDD2191  [38]
 LDCM0575  Fragment13 Ramos C806(1.15)  LDD2192  [38]
 LDCM0576  Fragment14 Ramos C806(1.09); C821(0.89); C552(0.93); C230(0.92)  LDD2193  [38]
 LDCM0579  Fragment20 Ramos C806(0.63); C821(0.67); C552(0.44)  LDD2194  [38]
 LDCM0580  Fragment21 Ramos C806(1.27); C552(0.71)  LDD2195  [38]
 LDCM0582  Fragment23 Ramos C806(0.87); C552(0.45)  LDD2196  [38]
 LDCM0578  Fragment27 Ramos C806(1.14)  LDD2197  [38]
 LDCM0586  Fragment28 Ramos C806(0.67); C552(0.68); C230(0.92)  LDD2198  [38]
 LDCM0588  Fragment30 Ramos C806(0.83); C821(0.76); C552(1.96)  LDD2199  [38]
 LDCM0589  Fragment31 Ramos C806(1.21)  LDD2200  [38]
 LDCM0590  Fragment32 Ramos C806(0.57); C552(0.47)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C552(0.67); C806(1.12)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C806(0.68)  LDD2203  [38]
 LDCM0566  Fragment4 Ramos C806(0.69); C821(0.92); C552(0.57); C230(0.92)  LDD2184  [38]
 LDCM0427  Fragment51 HCT 116 C293(0.33); C296(0.33); C552(0.64); C806(1.05)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C806(0.84)  LDD2204  [38]
 LDCM0614  Fragment56 Ramos C806(0.90); C821(0.76); C552(0.86)  LDD2205  [38]
 LDCM0569  Fragment7 Ramos C806(0.62); C821(0.69); C552(0.74); C230(1.26)  LDD2186  [38]
 LDCM0571  Fragment9 Ramos C806(0.59); C821(0.42); C552(0.32)  LDD2188  [38]
 LDCM0149  GA MCF-7 C563(2.15)  LDD0379  [39]
 LDCM0116  HHS-0101 DM93 Y202(1.03)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y202(1.29)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y202(1.32)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y202(0.77)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y202(0.46)  LDD0268  [11]
 LDCM0107  IAA HeLa H499(0.00); H505(0.00); C293(0.00); C821(0.00)  LDD0221  [25]
 LDCM0022  KB02 HCT 116 C552(1.92); C806(1.53)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C552(1.59); C806(1.86)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C552(2.19); C806(1.88)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C821(1.10)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C821(0.57)  LDD2121  [9]
 LDCM0109  NEM HeLa H499(0.00); H505(0.00); H204(0.00); H401(0.00)  LDD0223  [25]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C806(1.63); C803(1.01); C821(0.47); C230(0.52)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C821(1.25)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C821(1.32); C552(1.00)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C803(1.25); C821(1.24)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C821(2.25)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C821(0.42); C230(0.41)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C803(0.64); C821(0.57)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C821(0.79); C230(1.06)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C806(1.40); C803(1.01); C821(1.09); C552(1.50)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C806(0.49); C821(0.31); C552(0.46); C230(0.91)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C803(1.41); C821(0.78); C552(0.88)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C806(0.36); C821(0.32)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C821(1.57); C230(2.31)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C821(0.24); C552(0.26); C230(0.56); C293(0.70)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C806(1.54); C803(0.96); C821(1.00)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C821(0.29); C552(0.68); C230(0.51)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C806(0.87); C803(0.69); C821(0.75); C552(1.13)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C821(0.39); C552(1.03); C293(0.28)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C803(0.96); C821(1.06)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C806(0.53); C821(0.39); C552(0.29)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C803(1.11); C821(0.41); C552(0.54)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C821(0.70)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C803(0.76); C821(0.71); C230(0.56)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C803(0.94); C821(2.47)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C803(0.71); C821(0.69); C230(0.73); C293(0.55)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C803(0.22); C821(0.65); C552(0.70); C230(0.65)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C806(1.15); C803(1.16); C821(0.98); C552(1.70)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C803(0.30); C821(0.60)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C803(0.97); C821(0.89); C552(1.08)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C821(0.59); C230(0.51)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C806(1.31); C803(1.10); C821(1.17); C552(1.17)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C821(0.75); C230(0.38); C293(0.56)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C803(1.29); C821(1.28)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C803(0.92); C821(0.46)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C803(0.38); C821(0.48); C552(0.43)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C803(1.47); C821(1.56); C552(2.02)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C806(1.48); C803(1.22); C821(1.10); C552(1.80)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C806(1.10); C821(1.03); C552(1.18); C293(0.58)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C821(2.62); C803(1.28)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C803(0.85); C821(0.86); C552(1.09)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C806(0.75); C821(0.44); C552(0.94)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C803(0.77); C821(0.79); C230(0.63); C293(0.64)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C803(1.22); C821(1.60); C552(2.48)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C806(0.35); C821(0.17)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C803(0.93); C821(0.98); C552(1.07); C230(0.41)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C821(1.39); C293(0.90)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C803(0.73); C821(0.59)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C803(0.45); C821(0.68)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C806(1.04); C821(0.35); C552(0.84)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C803(0.48); C821(0.50); C230(1.01)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C821(1.98)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C230(1.46)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C230(1.28)  LDD2207  [40]
 LDCM0021  THZ1 HCT 116 C552(1.01)  LDD2173  [12]
 LDCM0111  W14 Hep-G2 Q501(1.10)  LDD0238  [26]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dexamethasone-induced Ras-related protein 1 (RASD1) RasD family Q9Y272
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) Nuclear hormone receptor family P22736
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5-hydroxytryptamine receptor 7 (HTR7) G-protein coupled receptor 1 family P34969
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Matrin-3 (MATR3) . P43243
Puratrophin-1 (PLEKHG4) . Q58EX7
TAR DNA-binding protein 43 (TARDBP) . Q13148
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
27 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
30 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
31 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
32 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
33 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
34 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
35 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
36 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
37 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
38 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
39 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23.
40 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.