Details of the Target

General Information of Target

Target ID LDTP04083
Target Name ATP-dependent DNA helicase Q1 (RECQL)
Gene Name RECQL
Gene ID 5965
Synonyms
RECQ1; RECQL1; ATP-dependent DNA helicase Q1; EC 5.6.2.4; DNA 3'-5' helicase Q1; DNA helicase, RecQ-like type 1; RecQ1; DNA-dependent ATPase Q1; RecQ protein-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASVSALTEELDSITSELHAVEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNE
YDSSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKS
LCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNK
NSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGI
LKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDF
IEDIVKLINGRYKGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKW
SANEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKADCILYYGF
GDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRVLMAQHFDEVWNSEACNKMCDNCCK
DSAFERKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGKGAAKLRVAGVVAPTLPRE
DLEKIIAHFLIQQYLKEDYSFTAYATISYLKIGPKANLLNNEAHAITMQVTKSTQNSFRA
ESSQTCHSEQGDKKMEEKNSGNFQKKAANMLQQSGSKNTGAKKRKIDDA
Target Bioclass
Enzyme
Family
Helicase family, RecQ subfamily
Subcellular location
Nucleus
Function
DNA helicase that plays a role in DNA damage repair and genome stability. Exhibits a magnesium- and ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Full-length protein unwinds forked DNA substrates, resolves Holliday junctions, and has DNA strand annealing activity. Plays a role in restoring regressed replication forks. Required to restart stalled replication forks induced by abortive topoisomerase 1 and 2 lesions. May play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens.
Uniprot ID
P46063
Ensemble ID
ENST00000421138.6
HGNC ID
HGNC:9948
ChEMBL ID
CHEMBL1293236

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y61(16.34)  LDD0257  [2]
STPyne
 Probe Info  		K193(10.00); K487(1.22); K501(2.73)  LDD0277  [3]
Probe 1
 Probe Info  		Y398(15.27)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C49(4.02); C270(2.02)  LDD0168  [5]
HHS-475
 Probe Info  		Y492(0.84); Y61(1.93)  LDD0264  [6]
DBIA
 Probe Info  		C478(1.24); C606(1.17); C49(1.03); C321(1.03)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K180(0.00); K185(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C414(0.00); C274(0.00); C447(0.00); C493(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C414(0.00); C274(0.00); C321(0.00); C223(0.00)  LDD0036  [10]
IPIAA_L
 Probe Info  		C223(0.00); C414(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C414(0.00); C274(0.00); C321(0.00); C493(0.00)  LDD0037  [10]
BTD
 Probe Info  		N.A.  LDD0004  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
WYneO
 Probe Info  		C606(0.00); C270(0.00)  LDD0022  [12]
aHNE
 Probe Info  		N.A.  LDD0001  [12]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		C270(0.00); C479(0.00)  LDD0005  [12]
TFBX
 Probe Info  		C270(0.00); C321(0.00); C606(0.00); C493(0.00)  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Ox-W18
 Probe Info  		W227(0.00); W466(0.00)  LDD2175  [16]
Acrolein
 Probe Info  		C606(0.00); C224(0.00); C479(0.00); C447(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C606(0.00); C479(0.00); C478(0.00)  LDD0218  [17]
W1
 Probe Info  		C606(0.00); C493(0.00); C447(0.00)  LDD0236  [18]
AOyne
 Probe Info  		12.60  LDD0443  [19]
NAIA_5
 Probe Info  		C606(0.00); C414(0.00); C274(0.00); C493(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [20]
HHS-482
 Probe Info  		Y61(1.35)  LDD2239  [21]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		7.52  LDD0464  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C606(0.71)  LDD2142  [24]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C606(0.87)  LDD2112  [24]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C606(1.21)  LDD2095  [24]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C493(1.73)  LDD2117  [24]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C606(0.57)  LDD2132  [24]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C606(0.76)  LDD2131  [24]
 LDCM0025  4SU-RNA HEK-293T C49(4.02); C270(2.02)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C49(2.97); C606(2.03)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C414(0.93); C471(0.78); C478(1.20); C479(1.02)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C321(0.82); C414(0.72); C447(0.67); C471(1.13)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C321(0.45); C447(0.54); C475(0.86); C478(0.91)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C321(0.42); C447(0.48); C475(0.87); C478(0.95)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C321(0.48); C447(0.66); C475(0.77); C478(0.86)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C321(0.29); C447(0.46); C475(0.76); C478(1.12)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C321(0.52); C447(0.80); C475(1.04); C478(1.13)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C321(0.35); C447(0.49); C475(0.76); C478(1.14)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C321(0.33); C447(0.40); C475(0.83); C478(1.04)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C321(0.29); C447(0.54); C475(0.81); C478(1.36)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C321(0.54); C447(0.50); C475(0.70); C478(0.93)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C321(0.75); C447(0.90); C475(1.00); C478(0.89)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C321(0.57); C414(0.68); C447(0.60); C471(1.36)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C321(0.44); C447(0.40); C475(0.73); C478(0.95)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C321(0.47); C447(0.43); C475(0.72); C478(0.91)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C321(0.29); C447(0.42); C475(0.74); C478(1.11)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C321(1.01); C414(0.60); C447(1.47); C475(1.18)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C321(0.82); C414(0.50); C447(1.01); C475(1.02)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C321(0.76); C414(0.38); C447(1.08); C475(0.96)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C321(0.75); C414(0.35); C447(1.04); C475(1.04)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C321(0.76); C414(0.50); C447(0.81); C475(1.14)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C321(0.86); C414(0.51); C447(0.98); C475(1.03)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C321(0.77); C414(0.46); C447(0.93); C475(1.10)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C321(0.91); C414(1.01); C447(0.84); C471(1.43)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C321(0.88); C414(0.49); C447(1.18); C475(1.06)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C321(0.75); C414(0.52); C447(0.72); C475(1.16)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C321(0.91); C414(0.63); C447(1.09); C475(1.15)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C321(0.92); C414(0.57); C447(0.89); C475(1.05)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C321(0.83); C414(0.46); C447(0.89); C475(1.14)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C321(0.98); C414(0.93); C447(0.99); C475(1.12)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C321(0.77); C414(0.34); C447(0.93); C475(1.21)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C321(0.82); C414(0.35); C447(1.01); C475(1.08)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C223(0.66); C224(0.66); C321(1.38); C447(1.92)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C223(0.85); C224(0.85); C321(1.38); C447(1.36)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C223(0.86); C224(0.86); C321(1.10); C447(1.39)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C223(0.87); C224(0.87); C321(1.25); C447(1.64)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C223(1.01); C224(1.01); C321(0.99); C447(0.84)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C223(0.75); C224(0.75); C321(1.14); C447(1.19)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C223(0.66); C224(0.66); C321(0.78); C447(0.95)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C223(0.74); C224(0.74); C321(0.95); C447(1.01)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C223(1.04); C224(1.04); C321(0.94); C447(0.93)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C223(0.87); C224(0.87); C321(0.96); C447(0.92)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C223(0.84); C224(0.84); C321(0.81); C447(0.70)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C223(0.95); C224(0.95); C321(0.74); C447(0.59)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C321(0.86); C414(0.78); C447(0.80); C471(1.38)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C223(0.82); C224(0.82); C321(0.65); C447(0.54)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C223(0.78); C224(0.78); C321(0.72); C447(0.59)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C223(0.99); C224(0.99); C321(1.07); C447(0.84)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C447(0.80); C471(0.84); C321(0.85); C414(0.89)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C447(0.49); C321(0.55); C414(0.62); C223(0.72)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C447(0.54); C321(0.65); C223(0.77); C224(0.77)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C321(0.63); C447(0.66); C414(0.70); C223(0.83)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C447(0.45); C321(0.56); C414(0.58); C223(0.66)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C414(0.24); C447(0.25); C321(0.26); C223(0.53)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C447(0.43); C321(0.45); C414(0.48); C223(0.67)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C447(0.71); C414(0.76); C321(0.88); C471(1.00)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C447(0.72); C414(0.80); C321(0.80); C478(0.96)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C447(0.68); C321(0.80); C414(0.82); C223(0.85)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C447(0.43); C414(0.46); C321(0.51); C223(0.70)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C447(0.23); C321(0.24); C414(0.26); C223(0.48)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C223(0.72); C224(0.72); C321(0.53); C414(0.64)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C223(0.76); C224(0.76); C321(0.59); C414(0.75)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C223(1.07); C224(1.07); C321(0.85); C414(1.00)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C223(0.77); C224(0.77); C321(0.71); C414(1.00)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C471(0.72); C479(0.82); C414(0.83); C447(0.90)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C414(0.63); C471(0.64); C475(0.76); C478(0.90)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C471(0.76); C475(0.79); C478(0.85); C414(0.86)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C414(0.82); C471(0.84); C49(0.96); C606(1.02)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C479(0.75); C471(0.83); C493(0.92); C414(0.93)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C478(0.78); C475(0.80); C479(0.81); C414(0.83)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C471(0.78); C478(0.82); C447(0.86); C493(0.93)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C471(0.69); C475(0.73); C414(0.76); C479(0.76)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C606(0.77); C479(0.86); C471(0.88); C447(0.96)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C471(0.69); C321(0.85); C475(0.86); C479(0.86)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C447(0.63); C493(0.67); C321(0.69); C414(0.71)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C321(0.69); C493(0.74); C447(0.75); C414(0.76)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C321(0.66); C493(0.67); C447(0.67); C414(0.73)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C493(0.62); C447(0.63); C475(0.72); C479(0.72)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C414(0.77); C471(0.79); C49(0.89); C606(1.01)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C493(0.58); C447(0.61); C321(0.76); C475(0.82)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C321(0.67); C493(0.67); C447(0.71); C414(0.84)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C447(0.49); C321(0.50); C493(0.52); C414(0.53)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C321(0.58); C493(0.66); C414(0.70); C447(0.82)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C321(0.54); C493(0.60); C414(0.70); C471(0.77)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C471(0.81); C478(1.04); C479(1.12); C493(1.24)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C471(0.70); C475(0.98); C479(0.99); C414(1.01)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C471(0.82); C606(1.00); C414(1.03); C479(1.09)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C471(0.80); C475(0.90); C479(0.94); C478(1.06)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C414(0.73); C471(0.73); C447(0.75); C475(0.93)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C414(0.67); C471(0.82); C49(0.98); C606(1.18)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C471(0.62); C414(0.71); C321(0.74); C447(0.76)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C471(0.63); C414(0.83); C475(0.88); C479(0.94)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C471(0.80); C414(0.88); C493(0.89); C321(0.90)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C471(0.74); C475(0.90); C414(0.90); C447(0.93)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C471(0.70); C414(0.80); C447(0.85); C321(0.88)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C471(0.55); C447(0.64); C414(0.68); C321(0.69)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C493(0.68); C447(0.80); C471(0.83); C606(0.95)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C447(0.73); C471(0.74); C321(0.78); C414(0.81)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C447(0.66); C493(0.72); C471(0.95); C475(0.95)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C321(0.49); C414(0.51); C447(0.52); C471(0.58)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C49(0.64); C414(0.72); C471(0.81); C606(1.20)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C321(0.46); C414(0.49); C447(0.50); C471(0.69)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C493(0.69); C606(0.82); C447(0.87); C471(0.95)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C493(0.73); C447(0.83); C471(0.84); C321(0.91)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C321(0.64); C414(0.71); C447(0.77); C471(0.78)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C321(0.65); C471(0.67); C414(0.68); C447(0.72)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C321(0.44); C414(0.44); C471(0.67); C447(0.67)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C321(0.34); C414(0.40); C447(0.47); C471(0.49)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C321(0.62); C447(0.78); C414(0.79); C493(0.98)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C321(0.63); C447(0.78); C414(0.86); C493(0.92)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C321(0.41); C414(0.53); C447(0.56); C493(0.84)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C447(0.72); C414(0.72); C471(0.79); C321(0.80)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C321(0.61); C414(0.64); C447(0.71); C493(0.93)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C321(0.73); C447(0.77); C414(0.87); C493(0.94)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C321(0.42); C447(0.53); C414(0.57); C475(0.84)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C321(0.60); C414(0.63); C447(0.68); C493(0.87)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C321(0.40); C447(0.52); C414(0.69); C493(0.84)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C321(0.58); C414(0.61); C447(0.64); C493(1.17)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C414(0.70); C321(0.71); C447(0.76); C493(0.92)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C321(0.20); C414(0.26); C447(0.27); C493(0.67)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C414(0.79); C321(0.79); C49(0.82); C447(0.86)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C321(0.66); C414(0.71); C49(0.82); C223(0.90)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C321(0.83); C447(0.93); C414(0.93); C606(0.95)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C414(0.35); C321(0.35); C447(0.58); C478(0.74)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C49(0.73); C471(0.85); C606(0.94); C447(0.95)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C321(0.63); C475(0.73); C479(0.73); C414(0.74)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C321(0.27); C414(0.31); C447(0.49); C471(0.67)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C321(0.28); C414(0.33); C447(0.55); C471(0.74)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C321(0.23); C414(0.25); C471(0.50); C447(0.52)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C321(0.53); C414(0.57); C447(0.66); C471(0.81)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C321(0.45); C414(0.48); C447(0.70); C223(0.74)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C49(0.78); C471(0.94); C414(0.94); C321(0.95)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C321(0.70); C414(0.78); C475(0.82); C479(0.85)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C447(0.78); C321(0.82); C493(0.90); C475(1.00)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C321(0.57); C414(0.65); C447(0.72); C471(0.88)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C49(0.78); C414(0.82); C223(0.92); C224(0.92)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C321(0.22); C414(0.24); C447(0.45); C471(0.63)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C274(0.25); C321(0.36); C475(0.55); C479(0.62)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C274(0.26); C321(0.45); C475(0.55); C479(0.60)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C274(0.27); C223(0.65); C224(0.65); C493(0.74)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C274(0.23); C321(0.78); C493(0.78); C475(0.82)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C274(0.24); C493(0.81); C475(0.93); C478(0.94)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C274(0.23); C493(0.73); C475(0.75); C479(0.80)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C274(0.25); C321(0.64); C475(0.69); C493(0.70)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C274(0.21); C493(0.83); C606(0.87); C49(0.87)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C274(0.32); C321(0.33); C475(0.59); C479(0.60)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C274(0.22); C321(0.52); C479(0.55); C475(0.61)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C274(0.29); C479(0.71); C321(0.72); C475(0.73)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C274(0.35); C479(0.81); C475(0.82); C493(0.82)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C274(0.22); C493(0.88); C478(0.95); C49(0.96)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C274(0.62); C475(0.65); C321(0.67); C223(0.75)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C274(0.17); C321(0.57); C475(0.60); C493(0.65)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C321(0.19); C447(0.38); C475(0.73); C493(0.82)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C321(0.43); C447(0.49); C475(0.81); C493(0.85)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C606(0.46)  LDD2138  [24]
 LDCM0248  AKOS034007472 HCT 116 C321(0.82); C414(0.92); C447(0.80); C471(1.29)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C321(0.69); C447(0.80); C475(0.82); C478(0.82)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C414(0.40); C447(0.46); C471(0.71); C321(0.72)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.36  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C478(1.24); C606(1.17); C49(1.03); C321(1.03)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C606(0.38)  LDD2091  [24]
 LDCM0108  Chloroacetamide HeLa C606(0.00); C447(0.00); C493(0.00); C224(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C606(0.76); C606(0.75); C606(0.75)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C606(0.82); C479(0.93); C478(1.02); C447(1.03)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C447(0.70); C414(0.70); C493(0.85); C321(0.87)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C414(0.67); C471(0.80); C49(0.81); C478(0.97)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C414(0.70); C447(0.76); C471(0.99); C475(1.03)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C447(0.80); C606(0.83); C414(0.85); C475(0.96)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C447(0.71); C414(0.84); C606(0.86); C475(0.94)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C414(0.83); C447(0.90); C475(0.92); C478(0.92)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C471(0.64); C414(0.65); C475(0.68); C321(0.71)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C414(0.48); C471(0.48); C475(0.59); C321(0.60)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C414(0.57); C321(0.62); C471(0.66); C475(0.74)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C414(0.56); C471(0.61); C475(0.64); C321(0.65)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C414(0.64); C479(0.74); C475(0.74); C493(0.82)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C414(0.49); C447(0.55); C493(0.72); C321(0.91)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C414(0.52); C321(0.63); C475(0.63); C471(0.67)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C414(0.70); C471(0.73); C493(0.76); C475(0.76)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C475(0.72); C479(0.72); C321(0.74); C414(0.74)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C493(0.54); C447(0.62); C321(0.63); C414(0.66)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C493(0.64); C447(0.67); C475(0.68); C479(0.68)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C493(0.65); C414(0.75); C321(0.75); C447(0.78)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C321(0.63); C414(0.65); C447(0.76); C493(0.80)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C471(0.40); C414(0.41); C321(0.44); C447(0.48)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C471(0.58); C414(0.86); C321(0.88); C447(0.91)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C447(0.81); C414(0.83); C471(0.90); C321(0.92)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C414(0.43); C447(0.56); C493(0.81); C321(0.93)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C471(0.65); C414(0.77); C447(0.83); C475(0.85)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C471(0.72); C493(0.75); C447(0.83); C479(0.84)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C471(0.68); C414(0.73); C321(0.75); C447(0.76)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C471(0.56); C321(0.61); C447(0.67); C414(0.68)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C321(0.49); C414(0.52); C471(0.56); C447(0.58)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C414(0.92); C49(0.97); C606(0.97); C447(0.99)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C321(1.01); C414(1.01); C606(1.02); C447(1.04)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C493(0.92); C447(0.94); C321(0.94); C49(1.07)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C321(0.46); C414(0.54); C447(0.62); C475(0.92)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C414(0.83); C447(0.84); C493(0.87); C321(1.07)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C447(0.89); C606(0.91); C479(0.99); C414(1.06)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C414(0.68); C447(0.72); C321(0.77); C493(0.87)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C475(0.72); C321(0.84); C447(0.92); C493(0.93)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C475(0.79); C49(0.81); C606(0.87); C493(0.90)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C49(0.88); C493(0.98); C475(1.01); C321(1.13)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C475(0.83); C321(0.84); C49(0.85); C414(0.92)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C479(0.84); C606(0.95); C478(0.97); C475(1.05)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C321(0.48); C475(0.63); C447(0.74); C493(0.87)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C321(0.34); C447(0.57); C475(0.58); C414(0.61)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C321(0.28); C447(0.37); C414(0.51); C475(0.57)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C475(0.80); C321(0.83); C447(0.92); C493(1.02)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C321(0.40); C414(0.64); C447(0.63); C475(0.65)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C321(0.54); C414(0.67); C447(0.51); C475(0.62)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C321(0.65); C414(1.04); C447(0.82); C475(0.75)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C321(0.59); C414(0.89); C447(0.79); C475(0.80)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C321(0.52); C414(0.96); C447(0.72); C475(0.64)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C321(0.49); C414(0.82); C447(0.66); C475(0.77)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C321(1.23); C414(1.07); C447(0.95); C475(1.22)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C321(0.82); C414(1.38); C447(1.08); C475(0.85)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C223(0.91); C224(0.91); C274(1.00); C321(0.98)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C223(0.93); C224(0.93); C274(0.98); C321(1.02)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C223(0.80); C224(0.80); C274(0.70); C321(1.07)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C223(0.69); C224(0.69); C274(0.82); C321(0.48)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C223(0.70); C224(0.70); C274(0.83); C321(0.57)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C223(0.68); C224(0.68); C274(0.89); C321(0.72)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C223(0.53); C224(0.53); C274(0.65); C321(0.45)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C223(0.74); C224(0.74); C274(0.46); C321(0.50)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C321(1.19); C414(0.99); C447(1.02); C475(1.16)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C223(0.67); C224(0.67); C274(0.91); C321(0.71)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C223(0.75); C224(0.75); C274(0.96); C321(0.68)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C223(0.52); C224(0.52); C274(0.46); C321(0.28)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C223(0.66); C224(0.66); C274(0.61); C321(0.35)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C223(0.84); C224(0.84); C274(0.79); C321(0.66)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C223(0.83); C224(0.83); C274(0.55); C321(0.47)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C223(1.10); C224(1.10); C321(1.26); C475(1.18)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C223(1.16); C224(1.16); C321(1.27); C475(1.22)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C223(1.01); C224(1.01); C321(1.22); C475(1.14)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C223(1.00); C224(1.00); C321(1.10); C475(1.39)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C321(1.18); C414(1.06); C447(0.89); C475(1.41)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C223(1.00); C224(1.00); C321(1.03); C475(1.11)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C223(1.01); C224(1.01); C321(1.28); C475(1.11)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C223(0.95); C224(0.95); C321(1.35); C475(1.20)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C223(0.88); C224(0.88); C321(1.40); C475(1.21)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C223(1.11); C224(1.11); C321(0.90); C475(1.03)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C223(0.95); C224(0.95); C321(1.53); C475(1.19)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C223(1.01); C224(1.01); C321(0.90); C475(1.16)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C223(0.98); C224(0.98); C321(1.00); C475(1.35)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C223(1.25); C224(1.25); C321(1.27); C475(1.15)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C223(1.01); C224(1.01); C321(0.95); C475(1.30)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C321(1.00); C414(0.89); C447(0.79); C475(1.29)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C223(0.87); C224(0.87); C321(1.03); C475(1.24)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C223(0.90); C224(0.90); C414(0.88); C447(0.76)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C223(0.85); C224(0.85); C414(0.87); C447(0.73)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C223(0.77); C224(0.77); C414(0.57); C447(0.62)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C223(0.60); C224(0.60); C414(0.57); C447(0.60)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C223(0.91); C224(0.91); C414(0.68); C447(0.75)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C223(0.60); C224(0.60); C414(0.39); C447(0.48)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C223(0.70); C224(0.70); C414(0.62); C447(0.77)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C223(0.75); C224(0.75); C414(0.80); C447(0.75)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C223(1.29); C224(1.29); C414(1.38); C447(1.09)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C321(0.98); C414(0.67); C447(0.72); C475(1.31)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C223(0.76); C224(0.76); C414(0.71); C447(0.78)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C223(0.70); C224(0.70); C414(0.65); C447(0.65)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C223(0.95); C224(0.95); C414(0.86); C447(0.78)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C223(0.76); C224(0.76); C414(2.31); C447(0.96)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C223(0.71); C224(0.71); C414(1.08); C447(0.81)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C274(1.23); C321(0.82); C475(0.97); C478(1.00)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C274(1.32); C321(2.21); C475(0.78); C478(0.82)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C274(1.20); C321(0.70); C475(0.78); C478(0.81)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C274(1.10); C321(0.55); C475(0.80); C478(0.86)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C321(0.71); C414(0.45); C447(0.57); C475(1.10)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C274(1.30); C321(1.48); C475(1.05); C478(1.05)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C274(1.22); C321(0.73); C475(0.87); C478(0.96)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C274(1.37); C321(0.35); C475(0.86); C478(0.90)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C274(0.96); C321(0.49); C475(0.88); C478(0.90)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C274(0.95); C321(0.35); C475(0.85); C478(0.78)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C274(1.22); C321(0.68); C475(0.97); C478(0.97)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C274(1.13); C321(0.96); C475(1.03); C478(1.03)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C274(1.12); C321(0.69); C475(0.99); C478(1.05)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C274(1.42); C321(0.49); C475(0.85); C478(0.90)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C274(1.34); C321(0.29); C475(0.75); C478(0.71)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C321(0.77); C414(0.97); C447(0.87); C475(1.14)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C274(1.56); C321(0.84); C475(0.92); C478(0.96)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C414(0.70); C471(0.98); C478(1.60); C479(1.61)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C414(0.74); C471(1.19); C478(1.47); C479(1.50)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C414(0.97); C471(0.93); C478(1.12); C479(1.02)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C414(0.69); C471(0.89); C478(1.08); C479(0.95)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C414(0.57); C471(1.01); C478(1.74); C479(1.84)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C414(0.71); C471(1.06); C478(1.23); C479(1.17)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C414(0.79); C471(0.85); C478(2.10); C479(2.12)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C414(0.59); C471(0.86); C478(1.13); C479(1.07)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C414(0.69); C471(0.92); C478(1.18); C479(1.10)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C606(0.51)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C606(1.00); C493(1.01); C49(0.99); C321(1.10)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C471(2.05); C606(1.87)  LDD1702  [24]
 LDCM0625  F8 Ramos C606(1.30); C49(1.42); C493(0.97); C321(0.99)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C606(1.40); C49(0.68); C493(0.51)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C606(0.41); C49(0.83); C493(5.50); C321(0.32)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C606(0.89); C49(0.54); C493(0.73)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C606(1.14); C49(1.08); C493(1.16)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C606(0.53); C49(0.58); C493(1.00); C321(0.59)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C606(0.77); C49(0.44); C493(0.52)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C606(1.18); C49(1.05); C493(1.32)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C606(1.94); C49(1.37); C493(1.81)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C606(1.81); C49(2.48)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C606(0.60); C49(0.75); C493(0.74); C321(0.54)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C606(1.79); C49(1.46); C493(1.42)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C606(0.90); C49(0.82); C493(1.45)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C606(1.78); C49(0.59); C493(0.70)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C223(0.87); C224(0.87); C414(0.72); C447(0.77)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C606(1.80); C49(1.39); C493(1.57)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C606(0.56); C49(0.88); C493(0.60); C321(0.76)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C223(0.70); C224(0.70); C274(0.55); C321(0.36)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C606(1.86); C49(0.74); C493(1.79)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C606(2.18); C49(0.70); C493(1.38)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C606(0.60); C49(0.62); C493(0.54); C321(0.69)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C606(0.93); C49(0.50); C493(0.59)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y492(0.84); Y61(1.93)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y492(0.56); Y61(0.75)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y492(1.08); Y61(1.65)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y492(0.74); Y61(1.63)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y492(0.98); Y61(1.56)  LDD0268  [6]
 LDCM0107  IAA HeLa C447(0.00); C224(0.00)  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C475(1.90); C606(1.31); C321(1.02); C478(1.26)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C475(1.77); C606(0.96); C321(1.33); C478(1.31)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C475(1.74); C606(1.44); C321(1.29); C478(1.11)  LDD0082  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C606(0.50)  LDD2121  [24]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C606(0.60)  LDD2092  [24]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C493(1.31)  LDD2093  [24]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C606(1.23)  LDD2094  [24]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C606(0.98)  LDD2096  [24]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C493(1.81)  LDD2099  [24]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C606(0.91); C493(0.48)  LDD2100  [24]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C606(0.83)  LDD2104  [24]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C606(0.48)  LDD2106  [24]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C606(0.73)  LDD2108  [24]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C606(0.90); C493(0.74)  LDD2109  [24]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C493(0.70)  LDD2115  [24]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C606(0.73)  LDD2116  [24]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C606(1.10)  LDD2118  [24]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C493(1.88)  LDD2119  [24]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C606(0.59)  LDD2122  [24]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C606(0.86); C493(1.22)  LDD2123  [24]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C606(0.67)  LDD2124  [24]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C606(0.88); C493(1.14)  LDD2125  [24]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C606(1.01)  LDD2126  [24]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C606(1.25)  LDD2127  [24]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C606(1.05); C493(1.49)  LDD2129  [24]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C606(0.41); C493(0.62)  LDD2134  [24]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C493(1.95)  LDD2135  [24]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C606(1.11)  LDD2136  [24]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C606(1.17); C493(1.33)  LDD2137  [24]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C606(1.11)  LDD1700  [24]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C606(0.77)  LDD2140  [24]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C606(2.20); C493(1.87)  LDD2144  [24]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C606(0.80); C493(1.26)  LDD2146  [24]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C606(1.00)  LDD2149  [24]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C606(0.62)  LDD2150  [24]
 LDCM0627  NUDT7-COV-1 HEK-293T C606(4.38)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C606(0.40)  LDD2207  [27]
 LDCM0131  RA190 MM1.R C49(1.06); C606(0.96)  LDD0304  [28]
 LDCM0021  THZ1 HCT 116 C321(1.84); C606(0.93); C475(1.16); C478(1.16)  LDD2173  [7]
 LDCM0111  W14 Hep-G2 C606(14.50)  LDD0238  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase 1 (PARP1) ARTD/PARP family P09874
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-1 (KPNA2) Importin alpha family P52292
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.