Details of the Target

General Information of Target

Target ID LDTP14502
Target Name Surfeit locus protein 6 (SURF6)
Gene Name SURF6
Gene ID 6838
Synonyms
SURF-6; Surfeit locus protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLAAANAEFCFNLFREMDDNQGNGNVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHV
NTASGYGNSSNSQSGLQSQLKRVFSDINASHKDYDLSIVNGLFAEKVYGFHKDYIECAEK
LYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGK
WQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNLSVIEDPSMKILELRYNGGINMYVL
LPENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRALGLKDIF
DESKADLSGIASGGRLYISRMMHKSYIEVTEEGTEATAATGSNIVEKQLPQSTLFRADHP
FLFVIRKDDIILFSGKVSCP
Target Bioclass
Other
Family
SURF6 family
Subcellular location
Nucleus, nucleoplasm
Function Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly.
Uniprot ID
O75683
Ensemble ID
ENST00000372022.6
HGNC ID
HGNC:11478

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K124(0.69)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
BTD
 Probe Info  		C19(1.09)  LDD2089  [3]
AHL-Pu-1
 Probe Info  		C189(2.79)  LDD0168  [4]
DBIA
 Probe Info  		C19(1.03)  LDD0078  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C189(0.00); C19(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		C19(0.00); C189(0.00)  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
aHNE
 Probe Info  		C189(0.00); C19(0.00)  LDD0001  [12]
1d-yne
 Probe Info  		N.A.  LDD0356  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		C189(0.00); C19(0.00)  LDD0006  [12]
IPM
 Probe Info  		C189(0.00); C19(0.00)  LDD0005  [12]
VSF
 Probe Info  		C189(0.00); C19(0.00)  LDD0007  [12]
YN-1
 Probe Info  		N.A.  LDD0447  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		C189(0.00); C19(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		6.20  LDD0443  [19]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C19(0.42)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C19(0.83); C189(0.95)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C19(0.48)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C19(0.93)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C19(1.93)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C19(1.86)  LDD2152  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C19(0.94)  LDD2131  [3]
 LDCM0025  4SU-RNA HEK-293T C189(2.79)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C189(7.00)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C19(1.05); C189(1.07)  LDD1507  [20]
 LDCM0215  AC10 HCT 116 C19(1.00)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C19(1.01)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C19(0.96)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C19(0.85)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C19(1.27)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C19(1.19)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C19(1.31)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C19(1.66)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C19(1.44)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C19(0.89)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C19(0.72)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C19(1.20)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C19(0.90)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C19(0.99)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C19(1.12)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C19(0.77)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C19(1.07)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C19(1.05)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C19(0.90)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C19(0.80)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C19(1.05)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C19(0.82)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C19(0.80)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C19(0.86)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C19(0.59)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C19(0.70)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C19(0.73)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C19(0.63)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C19(0.63)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C19(0.60)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C19(0.59)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C19(0.84)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C19(0.74)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C19(0.78)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C19(0.63)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C19(0.54)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C19(0.61)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C19(0.79)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C19(0.69)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C19(0.67)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C19(0.57)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C19(0.63)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C19(0.69)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C19(0.95)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C19(0.67)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C19(0.67)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C19(0.50)  LDD0579  [5]
 LDCM0270  AC15 HCT 116 C19(0.70)  LDD0587  [5]
 LDCM0276  AC17 HEK-293T C19(0.92); C189(1.13)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C19(1.00); C189(1.23)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C19(0.99); C189(1.17)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C19(1.06); C189(1.45)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C19(1.04); C189(1.17)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C19(0.97); C189(1.23)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C19(0.92); C189(1.12)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C19(0.82); C189(1.14)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C19(0.99); C189(1.00)  LDD1523  [20]
 LDCM0285  AC25 PaTu 8988t C189(1.19)  LDD1164  [5]
 LDCM0286  AC26 PaTu 8988t C189(1.07)  LDD1165  [5]
 LDCM0287  AC27 PaTu 8988t C189(1.26)  LDD1166  [5]
 LDCM0288  AC28 PaTu 8988t C189(1.90)  LDD1167  [5]
 LDCM0289  AC29 PaTu 8988t C189(1.27)  LDD1168  [5]
 LDCM0290  AC3 HEK-293T C19(1.01); C189(1.44)  LDD1529  [20]
 LDCM0291  AC30 PaTu 8988t C189(1.26)  LDD1170  [5]
 LDCM0292  AC31 PaTu 8988t C189(1.22)  LDD1171  [5]
 LDCM0293  AC32 PaTu 8988t C189(1.16)  LDD1172  [5]
 LDCM0294  AC33 PaTu 8988t C189(1.46)  LDD1173  [5]
 LDCM0295  AC34 PaTu 8988t C189(1.12)  LDD1174  [5]
 LDCM0296  AC35 PaTu 8988t C189(1.06)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C189(1.47)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C189(1.32)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C189(1.37)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C189(1.35)  LDD1179  [5]
 LDCM0301  AC4 HEK-293T C19(1.02); C189(1.17)  LDD1540  [20]
 LDCM0302  AC40 PaTu 8988t C189(1.45)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C189(1.13)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C189(1.07)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C189(1.02)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C189(1.68)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C189(1.24)  LDD1186  [5]
 LDCM0308  AC46 HEK-293T C19(0.97); C189(1.16)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C19(0.90); C189(1.08)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C19(0.98); C189(0.99)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C19(0.97); C189(1.10)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C19(0.94); C189(1.14)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C19(0.99); C189(1.30)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C19(0.94); C189(1.15)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C19(1.00); C189(1.13)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C19(0.89); C189(1.22)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C19(0.92); C189(1.11)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C19(0.86); C189(1.13)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C19(0.95); C189(1.00)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C19(1.01); C189(1.11)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C19(1.02); C189(1.36)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C19(0.94); C189(1.19)  LDD1561  [20]
 LDCM0323  AC6 HCT 116 C19(1.20)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C19(1.01); C189(1.21)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C19(0.98); C189(1.18)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C19(1.03); C189(1.10)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C19(0.86); C189(1.08)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C19(1.05); C189(1.05)  LDD1567  [20]
 LDCM0332  AC68 PaTu 8988t C189(0.68)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C189(0.89)  LDD1212  [5]
 LDCM0334  AC7 HCT 116 C19(1.01)  LDD0651  [5]
 LDCM0335  AC70 PaTu 8988t C189(0.87)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C189(0.78)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C189(0.67)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C189(0.75)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C189(0.76)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C189(0.96)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C189(0.80)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C189(0.69)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C189(0.83)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C189(0.82)  LDD1223  [5]
 LDCM0345  AC8 HCT 116 C19(0.99)  LDD0662  [5]
 LDCM0346  AC80 PaTu 8988t C189(0.64)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C189(0.73)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C189(0.68)  LDD1227  [5]
 LDCM0349  AC83 HCT 116 C19(1.73)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C19(1.46)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C19(1.02)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C19(1.06)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C19(1.11)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C19(1.27)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C19(1.61)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C19(0.91)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C19(1.89)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C19(1.97)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C19(1.16)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C19(1.23)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C19(1.58)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C19(1.60)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C19(1.81)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C19(2.57)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C19(0.90)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C189(0.42)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C19(0.99)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C19(1.29)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C19(0.88)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 12.26  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C19(1.03)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C19(0.42)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa C189(0.00); C19(0.00); H21(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C19(1.31); C19(0.81)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C19(0.84); C189(0.97)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C19(0.88); C189(0.96)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C19(0.93); C189(1.15)  LDD1573  [20]
 LDCM0370  CL101 HCT 116 C19(0.88)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C19(0.82)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C19(0.82)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C19(0.82)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C19(0.92); C189(0.82)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C19(0.97); C189(0.85)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C19(0.91); C189(1.30)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C19(0.99); C189(0.85)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C19(0.95); C189(0.81)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C19(0.75); C189(0.85)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C19(0.93); C189(0.89)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C19(0.95); C189(1.39)  LDD1585  [20]
 LDCM0382  CL112 PaTu 8988t C189(1.23)  LDD1261  [5]
 LDCM0383  CL113 PaTu 8988t C189(0.87)  LDD1262  [5]
 LDCM0384  CL114 PaTu 8988t C189(1.42)  LDD1263  [5]
 LDCM0385  CL115 PaTu 8988t C189(1.20)  LDD1264  [5]
 LDCM0386  CL116 PaTu 8988t C189(1.23)  LDD1265  [5]
 LDCM0387  CL117 PaTu 8988t C189(1.03)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C189(1.14)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C189(1.15)  LDD1268  [5]
 LDCM0390  CL12 HEK-293T C19(0.85); C189(0.75)  LDD1594  [20]
 LDCM0391  CL120 PaTu 8988t C189(1.38)  LDD1270  [5]
 LDCM0392  CL121 HEK-293T C19(0.95); C189(0.84)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C19(0.96); C189(0.80)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C19(0.84); C189(1.24)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C19(0.99); C189(0.98)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C19(0.93); C189(0.91)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C19(1.05); C189(0.91)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C19(0.94); C189(1.40)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C19(1.01); C189(0.93)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C19(1.00); C189(0.89)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C19(0.95); C189(0.76)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C19(0.80); C189(1.37)  LDD1606  [20]
 LDCM0403  CL16 HCT 116 C19(1.33)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C19(0.77)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C19(0.81)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C19(0.74)  LDD0723  [5]
 LDCM0407  CL2 HEK-293T C19(1.02); C189(1.07)  LDD1611  [20]
 LDCM0408  CL20 HCT 116 C19(0.72)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C19(0.69)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C19(0.76)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C19(1.38)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C19(0.92)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C19(0.95)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C19(1.69)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C19(0.82)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C19(0.92)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C19(0.67)  LDD0734  [5]
 LDCM0418  CL3 HEK-293T C19(0.81); C189(1.55)  LDD1622  [20]
 LDCM0419  CL30 HCT 116 C19(0.86)  LDD0736  [5]
 LDCM0420  CL31 PaTu 8988t C189(1.09)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C189(0.93)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C189(1.23)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C189(1.30)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C189(1.01)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C189(2.55)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C189(1.29)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C189(1.22)  LDD1307  [5]
 LDCM0429  CL4 HEK-293T C19(0.93); C189(1.02)  LDD1633  [20]
 LDCM0430  CL40 PaTu 8988t C189(1.21)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C189(1.23)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C189(1.21)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C189(1.24)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C189(1.62)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C189(1.67)  LDD1314  [5]
 LDCM0436  CL46 HCT 116 C19(0.93)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C19(0.92)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C19(0.81)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C19(0.69)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C19(0.87); C189(1.21)  LDD1644  [20]
 LDCM0441  CL50 HCT 116 C19(0.94)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C19(0.84)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C19(1.10)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C19(1.65)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C19(1.12)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C19(0.92)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C19(0.90)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C19(0.91)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C19(0.91)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C19(0.78)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C19(0.92); C189(1.15)  LDD1654  [20]
 LDCM0452  CL60 HCT 116 C19(0.86)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C19(0.91)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C19(1.10)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C19(1.11)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C19(0.85)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C19(0.96)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C19(1.03)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C19(1.03)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C19(0.87)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C19(1.08)  LDD0778  [5]
 LDCM0462  CL7 HEK-293T C19(0.95); C189(1.09)  LDD1665  [20]
 LDCM0463  CL70 HCT 116 C19(0.97)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C19(1.02)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C19(0.85)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C19(0.89)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C19(1.08)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C19(0.86)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C19(0.90)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C19(0.99)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C19(0.89)  LDD0789  [5]
 LDCM0473  CL8 HEK-293T C19(0.79); C189(0.77)  LDD1676  [20]
 LDCM0474  CL80 HCT 116 C19(0.95)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C19(0.88)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C19(0.79)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C19(0.82)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C19(0.87)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C19(0.91)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C19(0.91)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C19(0.86)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C19(0.77)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C19(0.81)  LDD0800  [5]
 LDCM0484  CL9 HEK-293T C19(0.79); C189(0.85)  LDD1687  [20]
 LDCM0485  CL90 HCT 116 C19(0.77)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C19(0.93); C189(1.12)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C19(0.93); C189(1.12)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C19(0.88); C189(0.84)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C19(0.87); C189(0.82)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C19(0.79); C189(0.67)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C19(0.92); C189(0.67)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C19(0.93); C189(0.87)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C19(1.03); C189(0.81)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C19(1.01); C189(1.26)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C19(0.95); C189(1.37)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C189(1.06); C19(0.94)  LDD1702  [3]
 LDCM0625  F8 Ramos C19(1.61)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C19(1.17)  LDD2189  [21]
 LDCM0574  Fragment12 Ramos C19(0.72)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C19(0.61)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C19(0.54)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C19(0.87)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C19(0.75)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C19(1.17)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C19(1.02)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C19(0.49)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C19(1.25)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C19(0.90)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C19(1.80)  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C19(0.95)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C19(0.96)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C19(0.78)  LDD2184  [21]
 LDCM0427  Fragment51 PaTu 8988t C189(1.44)  LDD1306  [5]
 LDCM0610  Fragment52 Ramos C19(1.01)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C19(1.39)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C19(0.82)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C19(0.72)  LDD2188  [21]
 LDCM0015  HNE MDA-MB-231 C19(0.93)  LDD0346  [21]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C19(1.67)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C19(0.86)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C19(1.57)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C19(0.93)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C19(1.09)  LDD2089  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C189(0.90)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C19(1.02)  LDD2092  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C19(1.15)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C189(1.05)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C189(0.88)  LDD2098  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C19(0.50); C189(1.02)  LDD2100  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C19(0.64); C189(0.86)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C19(0.54); C189(0.71)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C19(1.33)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C19(1.16); C189(0.86)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C19(1.24)  LDD2109  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C19(0.55)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C19(0.52)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C19(1.04)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C19(0.74); C189(1.52)  LDD2118  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C189(1.10)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C189(1.59)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C19(1.09)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C189(0.83)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C19(1.25); C189(1.02)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C19(1.03)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C19(0.94)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C19(0.66); C189(0.94)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C19(1.17)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C19(0.89)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C19(1.01)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C19(1.43); C189(1.15)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C19(1.09)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C19(1.34)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C19(0.85); C189(1.07)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C19(0.80); C189(1.19)  LDD2143  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C19(0.57)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C19(0.44)  LDD2150  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C19(2.71)  LDD2206  [22]
 LDCM0131  RA190 MM1.R C189(1.16)  LDD0304  [23]
 LDCM0021  THZ1 HCT 116 C19(0.95)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large ribosomal subunit protein eL22 (RPL22) Eukaryotic ribosomal protein eL22 family P35268
Protein FAM9B (FAM9B) FAM9 family Q8IZU0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.