Details of the Target

General Information of Target

Target ID LDTP06176
Target Name Mediator of DNA damage checkpoint protein 1 (MDC1)
Gene Name MDC1
Gene ID 9656
Synonyms
KIAA0170; NFBD1; Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDTQAIDWDVEEEEETEQSSESLRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNVVGRMP
DCSVALPFPSISKQHAEIEILAWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQEL
ILFADLLCQYHRLDVSLPFVSRGPLTVEETPRVQGETQPQRLLLAEDSEEEVDFLSERRM
VKKSRTTSSSVIVPESDEEGHSPVLGGLGPPFAFNLNSDTDVEEGQQPATEEASSAARRG
ATVEAKQSEAEVVTEIQLEKDQPLVKERDNDTKVKRGAGNGVVPAGVILERSQPPGEDSD
TDVDDDSRPPGRPAEVHLERAQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRG
PGAPGLAHLQESQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLK
ESQPAIWNRDAEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREAVLKDHTKIRAL
VRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKK
HQVSVEGTNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETDAEEGTSLTASVVADVRKSQL
PAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQ
PQREGAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPTQ
AFMLTPPQELGPSHCSFQTTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLS
PPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERETEKLLP
ERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVEIETSEEI
QEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEPEGGSQDQKG
QASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRI
RAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRK
TRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPK
PTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTRGRKSRSSVKTPE
TVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTDQPV
TSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVK
TPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPSTSTE
QPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQATRGRTNRS
SVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASA
STDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRT
NRSSVKTPESIVPIAPELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPH
PTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQ
SKTLRSSTVRAMPVPTTPEFQSPVTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHK
PCSAPLEPKSQASRNQRWGAVRAAESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFT
PELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPK
PGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERAVLALGGSLAGSA
AEASHLVTDRIRRTVKFLCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVTDPEQEKNFG
FSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVI
TCPQDFPHCSIPLRVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSST
Target Bioclass
Other
Subcellular location
Nucleus
Function
Histone reader protein required for checkpoint-mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. Specifically recognizes and binds histone H2AX phosphorylated at 'Ser-139', a marker of DNA damage, serving as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage sites. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53/p53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1. Required for chromosomal stability during mitosis by promoting recruitment of TOPBP1 to DNA double strand breaks (DSBs): TOPBP1 forms filamentous assemblies that bridge MDC1 and tether broken chromosomes during mitosis.
Uniprot ID
Q14676
Ensemble ID
ENST00000376406.8
HGNC ID
HGNC:21163

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.I2051T DBIA    Probe Info 
CAL148 SNV: p.D502N DBIA    Probe Info 
CAMA1 SNV: p.S1583C DBIA    Probe Info 
CCK81 Deletion: p.E468del DBIA    Probe Info 
CMK SNV: p.R161G DBIA    Probe Info 
DETROIT562 Deletion: p.N644PfsTer41 DBIA    Probe Info 
DOTC24510 SNV: p.Q1185H DBIA    Probe Info 
HCC44 SNV: p.S763F DBIA    Probe Info 
HSC3 SNV: p.R308M DBIA    Probe Info 
HT115 SNV: p.S1594Y DBIA    Probe Info 
IGR1 Insertion: p.S1915KfsTer15 DBIA    Probe Info 
IGROV1 SNV: p.T1109A DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.V31A DBIA    Probe Info 
JHH7 SNV: p.G42E .
JURKAT Insertion: p.G680WfsTer6
SNV: p.E841K;p.M1692I;p.A1794V		 Compound 10    Probe Info 
KMCH1 SNV: p.K183Ter; p.Q843R; p.T1589N DBIA    Probe Info 
MDST8 SNV: p.P1052S DBIA    Probe Info 
MFE319 Deletion: p.N877MfsTer14 DBIA    Probe Info 
MOLT4 SNV: p.S23F; p.S402N; p.D2045N IA-alkyne    Probe Info 
P31FUJ SNV: p.E2D DBIA    Probe Info 
SAOS2 SNV: p.R359G DBIA    Probe Info 
SHP77 SNV: p.E14Ter DBIA    Probe Info 
SKMEL30 SNV: p.P1105R DBIA    Probe Info 
TE4 SNV: p.T1183I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.51  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K476(1.35)  LDD0277  [3]
BTD
 Probe Info  		C1939(0.54)  LDD2109  [4]
MCL-4
 Probe Info  		1.50  LDD0049  [5]
AHL-Pu-1
 Probe Info  		C928(2.11); C26(3.11); C1742(2.15); C1037(2.20)  LDD0169  [6]
DBIA
 Probe Info  		C26(1.03)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C26(0.00); C92(0.00); C128(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C1742(0.00); C2042(0.00)  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C26(0.00); C128(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		C26(0.00); C1742(0.00)  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
aHNE
 Probe Info  		N.A.  LDD0001  [11]
Compound 10
 Probe Info  		C1742(0.00); C26(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C1742(0.00); C26(0.00)  LDD2213  [12]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
NPM
 Probe Info  		N.A.  LDD0016  [11]
VSF
 Probe Info  		C26(0.00); C1720(0.00); C1037(0.00); C1742(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C1009(0.00); C1742(0.00); C1037(0.00); C26(0.00)  LDD0018  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
NAIA_5
 Probe Info  		C92(0.00); C62(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		13.26  LDD0464  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1939(0.50)  LDD2117  [4]
 LDCM0025  4SU-RNA DM93 C928(2.48); C1742(8.55)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C928(2.11); C26(3.11); C1742(2.15); C1037(2.20)  LDD0169  [6]
 LDCM0561  Abegg_cp(-)-10 HeLa C2042(2.03)  LDD0312  [10]
 LDCM0214  AC1 HCT 116 C1939(1.23); C26(0.80)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C1939(1.24)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C1939(0.90); C26(1.18)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C1939(0.98); C26(1.07)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C1939(0.88); C26(1.00)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C1939(0.90); C26(1.09)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C1939(0.79); C26(0.98)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C1939(0.74); C26(1.04)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C1939(0.90); C26(1.05)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C1939(0.93); C26(1.00)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C1939(0.98); C26(1.02)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C1939(0.84); C26(0.87)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C1939(1.27)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C1939(0.85); C26(0.99)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C1939(0.87); C26(1.21)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C1939(0.80); C26(1.00)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C1939(1.03); C2020(0.94); C2021(0.94); C26(1.16)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C1939(1.03); C2020(1.37); C2021(1.37); C26(1.04)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C1939(1.05); C2020(1.04); C2021(1.04); C26(1.00)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C1939(1.00); C2020(0.93); C2021(0.93); C26(1.31)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C1939(0.99); C2020(1.45); C2021(1.45); C26(1.13)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C1939(0.95); C2020(1.29); C2021(1.29); C26(0.87)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C1939(0.96); C2020(1.10); C2021(1.10); C26(1.10)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C1939(1.18)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C1939(1.51); C2020(1.28); C2021(1.28); C26(0.92)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C1939(0.95); C2020(1.20); C2021(1.20); C26(0.90)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C1939(0.77); C2020(0.80); C2021(0.80); C26(0.96)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C1939(0.86); C2020(0.98); C2021(0.98); C26(0.87)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C1939(1.13); C2020(1.07); C2021(1.07); C26(0.82)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C1939(1.02); C2020(1.03); C2021(1.03); C26(0.85)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C1939(0.97); C2020(1.16); C2021(1.16); C26(0.77)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C1939(0.89); C2020(1.09); C2021(1.09); C26(0.85)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C1939(1.43)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1939(1.27)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1939(1.25)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1939(1.17)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1939(1.40)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1939(1.19)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1939(1.18)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1939(1.19)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1939(1.27)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1939(1.09)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1939(1.13)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1939(1.16)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C1939(1.17)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1939(1.15)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1939(1.29)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1939(1.19)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C1939(0.68); C26(1.08)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C1939(0.80); C26(0.98)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C1939(0.98); C26(1.04)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C1939(0.88); C26(1.10)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C1939(0.82); C26(0.87)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C1939(0.85); C26(1.12)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C1939(0.70); C26(1.19)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C1939(0.95)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C1939(0.79); C26(0.93)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C1939(0.84); C26(0.97)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C1939(0.79); C26(1.02)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C1939(0.74); C26(1.50)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1939(0.90); C26(0.99)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1939(0.75); C26(1.20)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1939(0.77); C26(0.99)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1939(0.84); C26(1.25)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C1939(0.98)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C1939(1.06)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C1939(0.81)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C1939(1.14); C26(1.17)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C1939(0.74)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C1939(0.83)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C1939(0.99)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C1939(0.87)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C1939(0.95)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C26(1.25); C1939(1.33)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C1939(1.14); C26(1.28)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C26(1.14); C1939(1.16)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C26(1.09); C1939(1.23)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C1939(1.39); C26(1.50)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C26(1.07); C1939(1.32)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C1939(0.95); C26(1.50)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C1939(1.26); C26(1.51)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C26(1.47); C1939(1.55)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C26(1.18); C1939(1.20)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C1939(1.14); C26(1.27)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C26(0.78); C1939(0.82)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C1939(0.71); C26(0.97)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1939(0.78); C26(1.21)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C1939(0.85); C26(1.34)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1939(0.78); C26(1.26)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C26(0.94); C1939(1.46)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1939(0.83); C26(1.28)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C1939(0.89); C26(1.04)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C1939(0.83); C26(1.46)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C1939(0.78); C26(1.23)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C1939(0.74); C26(1.23)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1939(0.72); C26(1.34)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C1939(0.82); C26(1.04)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C1939(0.94); C26(1.11)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C1939(1.02); C26(1.68)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C1939(0.81); C26(1.83)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C26(1.12); C1939(1.31)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C1939(0.95); C26(1.65)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C1939(0.79); C26(0.91)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C1939(0.82); C26(1.18)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C1939(0.71); C26(1.38)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C1939(0.86); C26(1.32)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C1939(0.93); C26(1.94)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C1939(0.86); C26(2.73)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C1939(1.10); C26(1.18)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C26(0.92); C1939(1.18)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C1939(1.15); C26(1.29)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1939(1.07)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C26(1.31); C1939(1.32)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C1939(1.03); C26(1.14)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C1939(1.15); C26(1.26)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C1939(0.94); C26(1.24)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C1939(1.20); C26(1.24)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C26(1.09); C1939(1.17)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C1939(1.01); C26(1.13)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C1939(1.14); C26(1.30)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C26(0.79); C1939(1.16)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C26(0.96); C1939(1.02)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C1939(0.96)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C1939(0.93); C26(1.11)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C26(1.02); C1939(1.20)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C26(1.00); C1939(1.48)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C26(0.95); C1939(1.31)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C26(1.12); C1939(1.39)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C1939(0.93); C26(1.34)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C26(1.05); C1939(1.19)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C26(0.86); C1939(0.97)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C1939(1.01); C26(1.19)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C26(0.99); C1939(1.03)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C1939(1.10)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C26(1.19); C1939(1.28)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C1939(1.03); C26(1.06)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C26(1.17); C1939(1.25)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C1939(1.13); C26(1.59)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C1939(1.10); C26(1.31)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C1939(1.09); C26(1.40)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C1939(1.15); C26(1.26)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C26(0.98); C1939(1.11)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C1939(0.89); C26(0.99)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C1939(1.09); C26(1.33)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C1939(1.07); C26(1.13)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C1939(1.27); C26(1.58)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C1939(1.21); C26(1.55)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C1939(0.97); C26(1.03)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C1939(0.98); C26(1.29)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1939(1.11); C26(1.12)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C1939(0.97); C26(1.49)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C1939(1.02); C26(1.30)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C1939(0.90); C26(0.95)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C1939(0.80); C26(0.94)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C1939(0.96)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C1939(1.03)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C1939(1.05)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C26(1.03)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C1939(0.00); H1925(0.00); C2049(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C2020(0.97); C2021(0.97); C1939(1.04); C26(1.04)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C2020(0.83); C2021(0.83); C26(0.93); C1939(1.86)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C26(0.89); C1939(1.17)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C1939(0.91)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1939(1.11)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C1939(1.11)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C1939(1.05)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C1939(0.96)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C1939(1.12)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C1939(0.91)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C1939(1.00)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C1939(0.96)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C2020(0.85); C2021(0.85); C26(1.06); C1939(1.13)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C1939(1.06)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C1939(1.00)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C26(1.08); C1939(1.16)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C1939(0.85); C26(1.37)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C1939(1.04); C26(1.56)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C1939(1.31); C26(1.32)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C1939(1.23); C26(1.44)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1939(0.70); C26(1.55)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C1939(0.79); C26(1.20)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1939(0.90); C26(1.16)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C2020(0.88); C2021(0.88); C26(1.05); C1939(2.53)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C1939(0.85); C26(1.09)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C1939(0.87); C26(1.05)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C1939(0.81); C26(1.47)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C1939(0.88); C26(1.58)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C1939(1.02); C26(1.91)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C1939(1.01); C26(1.17)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C26(1.07); C1939(1.19)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C1939(1.16); C26(1.19)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C1939(1.05); C26(1.06)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C2020(0.82); C2021(0.82); C26(1.04); C1939(3.11)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C2020(0.93); C2021(0.93); C26(0.96); C1939(2.82)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C2020(0.83); C2021(0.83); C26(1.03); C1939(3.67)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C1939(0.85); C2020(1.27); C2021(1.27)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C1939(0.81); C2020(0.89); C2021(0.89)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C2020(0.68); C2021(0.68); C1939(0.85)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C1939(0.83); C2020(0.92); C2021(0.92)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C2020(0.80); C2021(0.80); C26(1.20); C1939(1.23)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1939(0.88); C2020(0.89); C2021(0.89)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C1939(0.82); C2020(0.88); C2021(0.88)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C2020(0.96); C2021(0.96); C1939(1.06)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C2020(0.83); C2021(0.83); C1939(0.94)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C2020(0.76); C2021(0.76); C1939(1.03)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C1939(1.09); C2020(0.98); C2021(0.98)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C1939(0.88); C2020(0.81); C2021(0.81)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C1939(0.97); C2020(0.86); C2021(0.86)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C1939(0.90); C2020(0.88); C2021(0.88)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C1939(0.82); C2020(0.79); C2021(0.79)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C1939(1.23); C2020(0.78); C2021(0.78); C26(1.01)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C1939(0.80); C2020(0.74); C2021(0.74)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C1939(1.05); C26(1.02)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C1939(1.15); C26(0.96)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C1939(1.10); C26(1.16)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C1939(1.17); C26(1.05)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C1939(1.20); C26(1.11)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C1939(1.08); C26(1.02)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C1939(1.91); C26(0.84)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C1939(1.08); C26(1.05)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C1939(1.21); C2020(0.83); C2021(0.83); C26(1.05)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C1939(0.98); C26(1.05)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C1939(0.94); C26(0.94)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C1939(1.09); C26(1.03)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C1939(0.96); C26(1.07)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C1939(1.11); C26(0.95)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C1939(1.38); C26(0.92)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C1939(0.93); C26(0.69)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C1939(0.73); C26(0.70)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C1939(0.73); C26(0.80)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C1939(1.10); C26(0.81)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C1939(1.87); C2020(0.83); C2021(0.83); C26(1.13)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C1939(0.98); C26(1.02)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C1939(0.84); C26(1.04)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C1939(0.78); C26(1.39)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C1939(0.68); C26(0.99)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C1939(0.96); C26(0.76)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C1939(0.82); C26(0.89)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C1939(0.85); C26(1.11)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C1939(0.75); C26(1.02)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C1939(1.16); C26(0.66)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C1939(0.91); C26(0.87)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C1939(1.88); C2020(0.82); C2021(0.82); C26(0.99)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C1939(0.97); C26(0.72)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C1939(1.25); C2020(0.81); C2021(0.81); C26(1.04)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C1939(1.43); C2020(1.06); C2021(1.06); C26(0.80)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C1939(1.42); C2020(0.63); C2021(0.63); C26(0.72)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C1939(1.28); C2020(0.79); C2021(0.79); C26(0.85)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C1939(1.19); C2020(0.59); C2021(0.59); C26(0.67)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C1939(1.33); C2020(0.95); C2021(0.95); C26(1.06)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C1939(1.22); C2020(1.07); C2021(1.07); C26(0.66)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C1939(1.16); C2020(0.80); C2021(0.80); C26(0.84)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C1939(1.12); C2020(0.78); C2021(0.78); C26(1.11)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C1939(3.05); C2020(0.97); C2021(0.97); C26(0.96)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C1939(1.15); C2020(0.92); C2021(0.92); C26(0.76)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C1939(1.13); C2020(0.57); C2021(0.57); C26(1.14)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C1939(1.17); C2020(0.80); C2021(0.80); C26(0.89)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C1939(1.23); C2020(0.78); C2021(0.78); C26(0.84)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C1939(1.08); C2020(1.14); C2021(1.14); C26(0.87)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C1939(0.99); C2020(0.51); C2021(0.51); C26(1.28)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C1939(0.98); C2020(0.56); C2021(0.56); C26(1.33)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C1939(1.03); C2020(0.54); C2021(0.54); C26(1.24)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C1939(0.99); C2020(0.62); C2021(0.62); C26(0.96)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C1939(0.75); C2020(1.00); C2021(1.00); C26(1.16)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C1939(1.05); C2020(0.86); C2021(0.86); C26(1.26)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C1939(1.05); C2020(0.82); C2021(0.82); C26(1.16)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C1939(1.16); C2020(0.57); C2021(0.57); C26(1.07)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C1939(1.08); C2020(0.79); C2021(0.79); C26(1.11)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C1939(1.17); C2020(0.73); C2021(0.73); C26(0.99)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C1939(0.97); C2020(0.53); C2021(0.53); C26(1.13)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C1939(1.12); C2020(0.47); C2021(0.47); C26(1.11)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C1939(1.12); C2020(0.56); C2021(0.56); C26(0.94)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C1939(1.09); C2020(0.59); C2021(0.59); C26(1.03)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C1939(1.25); C2020(0.89); C2021(0.89); C26(1.00)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C1939(1.39); C2020(0.94); C2021(0.94); C26(1.25)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C1939(1.05); C2020(0.56); C2021(0.56); C26(1.16)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C1939(1.12); C26(1.45)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C1939(1.12); C26(1.03)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C1939(1.14); C26(0.91)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C1939(1.13); C26(0.75)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C1939(1.16); C26(1.25)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C1939(1.21); C26(1.14)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C1939(1.15); C26(1.08)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C1939(1.17); C26(0.96)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C1939(1.19); C26(0.92)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C26(1.01); C1742(0.98); C1037(1.08); C1939(0.89)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1939(1.77); C1742(1.05); C26(1.01)  LDD1702  [4]
 LDCM0625  F8 Ramos C26(0.98)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C26(0.79)  LDD2189  [19]
 LDCM0574  Fragment12 Ramos C26(0.39)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C26(0.48)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C26(0.73)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C26(0.41)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C26(0.48)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C26(0.47)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C26(0.38)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C26(0.48)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C26(0.44)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C26(0.35)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C26(0.57)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C1939(1.01); C2020(0.70); C2021(0.70); C26(0.88)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C26(0.36)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C26(0.90)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C1939(1.28); C26(1.10)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C26(0.45)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C26(0.57)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C26(0.94)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C26(0.42)  LDD2188  [19]
 LDCM0107  IAA HeLa H1925(0.00); H2048(0.00)  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C26(1.71)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C26(1.11)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C26(1.44)  LDD0082  [7]
 LDCM0006  Micheliolide M9-ENL1 1.50  LDD0049  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1939(0.54)  LDD2109  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1742(0.98); C1939(0.43)  LDD2123  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1742(0.80)  LDD2127  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1939(0.60)  LDD2137  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C1742(1.81)  LDD2147  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1742(0.33)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C26(0.93)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C26(0.66)  LDD2207  [20]
 LDCM0021  THZ1 HCT 116 C26(1.12); C1939(0.94); C2042(1.12); C2049(1.12)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase NSD2 (NSD2) Histone-lysine methyltransferase family O96028
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone H2AX (H2AX) Histone H2A family P16104
DNA repair protein RAD51 homolog 1 (RAD51) RecA family Q06609
Nibrin (NBN) . O60934

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Comprehensive Structure-Activity Profiling of Micheliolide and its Targeted Proteome in Leukemia Cells via Probe-Guided Late-Stage C-H Functionalization. ACS Cent Sci. 2021 May 26;7(5):841-857. doi: 10.1021/acscentsci.0c01624. Epub 2021 Apr 28.
Mass spectrometry data entry: PXD024455
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.