Details of the Target

General Information of Target

Target ID LDTP02656
Target Name Ribonuclease inhibitor (RNH1)
Gene Name RNH1
Gene ID 6050
Synonyms
PRI; RNH; Ribonuclease inhibitor; Placental ribonuclease inhibitor; Placental RNase inhibitor; Ribonuclease/angiogenin inhibitor 1; RAI
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
Uniprot ID
P13489
Ensemble ID
ENST00000354420.7
HGNC ID
HGNC:10074

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.10  LDD0402  [1]
A-EBA
 Probe Info  		5.08  LDD0215  [2]
CY-1
 Probe Info  		6.19  LDD0243  [3]
N1
 Probe Info  		2.54  LDD0242  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
Nap-2
 Probe Info  		N.A.  LDD0435  [5]
ONAyne
 Probe Info  		K46(1.02)  LDD0274  [6]
STPyne
 Probe Info  		K226(10.00); K46(1.67); K86(10.00)  LDD0277  [6]
AZ-9
 Probe Info  		E288(0.80)  LDD2208  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
THZ1-DTB
 Probe Info  		C96(1.03)  LDD0460  [8]
BTD
 Probe Info  		C191(1.99)  LDD1700  [9]
AHL-Pu-1
 Probe Info  		C248(6.46)  LDD0168  [10]
DBIA
 Probe Info  		C220(0.95); C96(0.93); C102(0.93); C95(0.93)  LDD0078  [11]
5E-2FA
 Probe Info  		H253(0.00); H332(0.00); H74(0.00); H398(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C220(0.00); C199(0.00); C362(0.00); C409(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C220(0.00); C305(0.00); C95(0.00); C248(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C199(0.00); C38(0.00); C248(0.00); C75(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C45(0.00); C220(0.00); C199(0.00); C362(0.00)  LDD0037  [14]
NAIA_4
 Probe Info  		C30(0.00); C142(0.00); C248(0.00); C362(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C38(0.00); C85(0.00); C45(0.00); C75(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C216(0.00); C209(0.00)  LDD0021  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
Compound 10
 Probe Info  		C199(0.00); C220(0.00); C248(0.00); C362(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		C248(0.00); C75(0.00)  LDD2213  [20]
IPM
 Probe Info  		N.A.  LDD0005  [19]
PF-06672131
 Probe Info  		C220(0.00); C362(0.00)  LDD0152  [21]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C75(0.00); C85(0.00); C409(0.00)  LDD0018  [22]
Acrolein
 Probe Info  		C75(0.00); C30(0.00); C38(0.00); C209(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C209(0.00); C362(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		C38(0.00); C209(0.00); C216(0.00); C85(0.00)  LDD0218  [23]
W1
 Probe Info  		C30(0.00); C38(0.00); C248(0.00); C199(0.00)  LDD0236  [24]
AOyne
 Probe Info  		9.20  LDD0443  [25]
NAIA_5
 Probe Info  		C248(0.00); C45(0.00); C220(0.00); C409(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C182
 Probe Info  		5.90  LDD1860  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C220(0.55); C191(0.71); C248(0.82)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C38(1.12); C220(0.49); C199(1.08); C248(0.99)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C38(0.92); C220(0.79); C199(0.78)  LDD2095  [9]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C199(0.94); C191(0.99)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C38(0.67); C220(1.03); C191(0.87); C277(0.91)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C38(1.66); C277(0.81)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C199(0.51); C191(0.62); C85(1.04)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C199(0.61); C191(0.91)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C248(6.46)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C248(3.81); C75(2.98); C409(2.58)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C209(0.70); C216(0.68); C102(0.44); C191(1.02)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C209(0.96); C216(1.11); C102(0.73); C191(1.06)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C209(1.11); C216(1.49); C102(0.65); C191(0.79)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C209(0.91); C216(0.93); C102(0.74); C191(0.64)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C209(1.07); C216(1.10); C102(0.92); C191(0.65)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C209(0.95); C216(0.98); C102(0.63); C191(0.61)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C209(1.12); C216(1.21); C102(0.72); C191(0.65)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C209(1.12); C216(1.15); C102(0.77); C191(0.61)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C209(1.28); C216(1.21); C102(0.73); C191(0.68)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C209(1.27); C216(1.35); C102(0.74); C191(0.98)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C209(1.20); C216(1.15); C102(0.84); C191(0.85)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C209(1.26); C216(1.22); C102(0.88); C191(0.78)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C209(0.97); C216(1.01); C102(0.70); C191(0.79)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C209(1.08); C216(1.10); C102(0.83); C191(0.77)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C209(1.03); C216(1.02); C102(0.94); C191(0.79)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C209(1.01); C216(1.04); C102(0.86); C191(0.85)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C152(0.81); C159(0.81); C209(0.91); C216(1.13)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C152(0.51); C159(0.51); C209(1.05); C216(0.96)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C152(0.43); C159(0.43); C209(1.01); C216(0.97)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C152(0.40); C159(0.40); C209(1.03); C216(0.94)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C152(0.63); C159(0.63); C209(0.81); C216(0.73)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C152(0.45); C159(0.45); C209(1.00); C216(1.09)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C152(0.40); C159(0.40); C209(0.88); C216(1.03)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C209(1.00); C216(1.13); C102(0.82); C191(0.84)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C152(0.57); C159(0.57); C209(0.93); C216(0.95)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C152(0.39); C159(0.39); C209(0.98); C216(1.11)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C152(0.28); C159(0.28); C209(1.19); C216(1.11)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C152(0.28); C159(0.28); C209(1.30); C216(1.13)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C152(1.01); C159(1.01); C209(1.01); C216(0.98)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C152(0.57); C159(0.57); C209(1.02); C216(1.58)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C152(0.62); C159(0.62); C209(1.23); C216(1.34)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C152(0.46); C159(0.46); C209(1.19); C216(1.14)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C209(0.95); C216(1.05); C102(0.91); C191(1.21)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C209(1.97); C216(1.98); C102(1.29); C191(0.98)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C209(0.80); C216(0.83); C102(0.84); C191(0.80)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C209(1.61); C216(1.67); C102(1.49); C191(0.98)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C209(0.95); C216(0.95); C102(0.91); C191(0.91)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C209(0.78); C216(0.78); C102(0.74); C191(0.91)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C209(0.86); C216(0.84); C102(0.90); C191(0.93)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C209(0.81); C216(0.82); C102(0.97); C191(0.94)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C209(0.89); C216(0.92); C102(0.94); C191(0.93)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C209(1.06); C216(1.06); C102(1.04); C191(0.99)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C209(0.89); C216(0.93); C102(0.91); C191(0.97)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C209(0.83); C216(0.83); C102(1.00); C191(0.85)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C209(0.83); C216(0.90); C102(0.55); C191(0.76)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C209(0.89); C216(0.84); C102(0.90); C191(0.84)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C209(0.85); C216(0.84); C102(0.88); C191(0.87)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C209(0.82); C216(0.82); C102(0.79); C191(0.86)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C209(0.97); C216(1.05); C277(0.65); C96(0.67)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C96(0.35); C277(0.40); C305(0.44); C313(0.44)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C96(0.47); C277(0.52); C380(0.62); C387(0.62)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C96(0.21); C305(0.24); C313(0.24); C266(0.34)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C96(0.31); C305(0.40); C313(0.40); C266(0.46)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C96(0.23); C305(0.32); C313(0.32); C266(0.39)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C96(0.22); C305(0.31); C313(0.31); C266(0.37)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C266(0.52); C380(0.52); C387(0.52); C30(0.55)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C305(0.51); C313(0.51); C96(0.53); C277(0.60)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C96(0.58); C380(0.63); C387(0.63); C277(0.65)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C96(0.28); C305(0.38); C313(0.38); C277(0.42)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C96(0.21); C305(0.26); C313(0.26); C277(0.32)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C209(1.02); C216(1.02); C102(0.84); C191(0.65)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C209(0.79); C216(0.90); C102(0.90); C191(0.52)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C209(0.84); C216(1.23); C102(0.97); C191(0.70)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C209(0.94); C216(0.98); C102(1.05); C191(0.61)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C277(0.79); C75(1.00); C220(1.04); C85(1.06)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C30(0.65); C216(0.72); C38(0.74); C191(0.75)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C277(0.85); C38(1.05); C191(1.06); C220(1.11)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C305(0.36); C313(0.36); C266(0.49); C409(0.55)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C277(0.93); C75(0.93); C216(1.03); C191(1.08)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C277(0.74); C75(0.97); C191(1.00); C38(1.02)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C277(0.85); C191(1.12); C216(1.12); C220(1.13)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C277(0.75); C191(0.97); C273(1.01); C38(1.01)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C277(0.62); C220(1.07); C191(1.18); C216(1.23)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C152(0.54); C159(0.54); C96(0.73); C380(0.78)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C380(0.43); C387(0.43); C152(0.45); C159(0.45)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C152(0.42); C159(0.42); C380(0.59); C387(0.59)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C152(0.52); C159(0.52); C380(0.59); C387(0.59)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C152(0.42); C159(0.42); C380(0.58); C387(0.58)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C305(0.40); C313(0.40); C266(0.51); C102(0.58)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C152(0.38); C159(0.38); C380(0.48); C387(0.48)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C380(0.24); C387(0.24); C152(0.29); C159(0.29)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C152(0.29); C159(0.29); C380(0.29); C387(0.29)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C152(0.39); C159(0.39); C380(0.47); C387(0.47)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C152(0.32); C159(0.32); C380(0.38); C387(0.38)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C409(0.81); C30(0.99); C152(1.06); C159(1.06)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C152(0.63); C159(0.63); C266(0.77); C409(0.82)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C152(0.61); C159(0.61); C266(0.87); C277(0.88)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C152(0.78); C159(0.78); C191(0.83); C277(0.91)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C152(0.43); C159(0.43); C266(0.70); C30(0.80)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C305(0.29); C313(0.29); C266(0.42); C95(0.46)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C152(0.61); C159(0.61); C30(0.88); C216(0.91)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C152(0.52); C159(0.52); C409(0.79); C266(0.79)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C152(0.50); C159(0.50); C30(0.78); C409(0.87)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C152(0.37); C159(0.37); C266(0.56); C30(0.62)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C152(0.47); C159(0.47); C30(0.77); C409(0.80)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C152(0.54); C159(0.54); C266(0.73); C30(0.77)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C152(0.47); C159(0.47); C266(0.78); C209(0.82)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C152(0.62); C159(0.62); C209(0.80); C266(0.89)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C152(0.27); C159(0.27); C266(0.32); C30(0.50)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C152(0.47); C159(0.47); C266(0.65); C191(0.74)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C305(0.23); C313(0.23); C266(0.36); C95(0.46)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C152(0.65); C159(0.65); C266(0.67); C191(0.76)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C266(0.83); C30(0.87); C409(0.96); C191(1.06)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C152(0.77); C159(0.77); C409(0.96); C266(0.97)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C266(0.66); C152(0.75); C159(0.75); C30(0.78)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C152(0.53); C159(0.53); C409(0.76); C191(0.78)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C152(0.53); C159(0.53); C266(0.64); C191(0.84)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C152(0.46); C159(0.46); C266(0.60); C191(0.69)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C96(0.55); C266(0.58); C216(0.59); C95(0.61)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C96(0.58); C85(0.58); C216(0.58); C95(0.60)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C96(0.58); C216(0.60); C102(0.63); C85(0.64)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C266(0.55); C380(0.58); C387(0.58); C95(0.60)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C96(0.44); C216(0.44); C95(0.47); C85(0.48)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C85(0.42); C96(0.43); C95(0.45); C216(0.47)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C96(0.55); C95(0.58); C266(0.60); C216(0.61)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C85(0.54); C95(0.55); C96(0.58); C102(0.59)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C96(0.50); C216(0.51); C85(0.53); C95(0.56)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C85(0.45); C96(0.47); C216(0.48); C266(0.52)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C85(0.44); C96(0.50); C95(0.52); C102(0.53)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C85(0.38); C96(0.43); C191(0.43); C216(0.43)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C152(0.27); C159(0.27); C30(0.66); C273(0.68)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C152(0.28); C159(0.28); C30(0.57); C273(0.68)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C380(0.48); C387(0.48); C409(0.48); C30(0.56)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C152(0.24); C159(0.24); C30(0.55); C96(0.63)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C152(0.32); C159(0.32); C96(0.68); C30(0.76)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C152(0.47); C159(0.47); C96(0.68); C95(0.80)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C152(0.21); C159(0.21); C96(0.57); C30(0.59)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C152(0.15); C159(0.15); C30(0.48); C96(0.57)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C152(0.20); C159(0.20); C30(0.52); C273(0.55)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C152(0.38); C159(0.38); C96(0.77); C30(0.84)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C152(0.36); C159(0.36); C362(0.71); C96(0.78)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C152(0.26); C159(0.26); C96(0.58); C30(0.61)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C152(0.45); C159(0.45); C96(0.80); C362(0.81)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C30(0.56); C380(0.56); C387(0.56); C266(0.59)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C152(0.56); C159(0.56); C96(0.75); C362(0.78)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C152(0.35); C159(0.35); C409(0.53); C96(0.65)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C152(0.14); C159(0.14); C30(0.44); C273(0.54)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C305(0.51); C313(0.51); C266(0.65); C216(0.71)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C305(0.49); C313(0.49); C152(0.54); C159(0.54)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C305(0.46); C313(0.46); C266(0.55); C152(0.65)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C209(0.82); C305(0.83); C313(0.83); C216(0.87)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C305(0.65); C313(0.65); C216(0.71); C266(0.85)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C216(0.99); C191(1.00); C220(1.07); C102(1.10)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C305(0.66); C313(0.66); C216(0.66); C209(0.84)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C209(1.05); C220(1.13); C191(1.16); C199(1.33)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C305(0.66); C313(0.66); C216(0.81); C273(0.91)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C305(0.87); C313(0.87); C216(0.89); C277(1.00)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C216(0.86); C305(0.88); C313(0.88); C191(0.96)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C305(0.70); C313(0.70); C266(0.77); C362(0.90)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C305(0.35); C313(0.35); C266(0.42); C30(0.65)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C305(0.64); C313(0.64); C216(0.71); C266(0.73)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C216(0.80); C305(0.82); C313(0.82); C209(0.90)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C266(0.14); C38(0.27); C30(0.31); C305(0.36)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C266(0.57); C38(0.63); C96(0.66); C30(0.69)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C38(0.74); C199(0.47); C191(0.40); C362(0.49)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C38(0.94); C220(0.70); C199(0.79); C191(0.91)  LDD2113  [9]
 LDCM0248  AKOS034007472 HCT 116 C209(0.89); C216(1.00); C102(0.88); C191(1.00)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C30(0.54); C266(0.54); C95(0.61); C102(0.65)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C266(0.40); C380(0.45); C387(0.45); C30(0.50)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.63  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C220(0.95); C96(0.93); C102(0.93); C95(0.93)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C191(0.52); C248(1.11)  LDD2091  [9]
 LDCM0630  CCW28-3 231MFP C409(1.44); C75(1.33); C95(1.26); C248(0.22)  LDD2214  [28]
 LDCM0108  Chloroacetamide HeLa C362(0.00); C38(0.00); C248(0.00); C191(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C220(20.00); C266(20.00); C45(1.22); C248(1.11)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C75(0.72); C85(0.72); C96(0.78); C95(0.84)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C380(0.29); C387(0.29); C266(0.32); C152(0.42)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C305(0.29); C313(0.29); C266(0.46); C38(0.54)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C380(0.45); C387(0.45); C266(0.45); C30(0.51)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C30(0.56); C409(0.57); C266(0.63); C380(0.65)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C30(0.58); C266(0.67); C277(0.72); C380(0.74)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C277(0.58); C266(0.67); C30(0.69); C85(0.73)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C216(0.67); C191(0.76); C75(0.76); C38(0.77)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C266(0.32); C380(0.42); C387(0.42); C152(0.43)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C30(0.72); C266(0.72); C216(0.77); C380(0.78)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C30(0.66); C380(0.71); C387(0.71); C216(0.71)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C216(0.78); C38(0.81); C75(0.83); C191(0.86)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C380(0.30); C387(0.30); C152(0.35); C159(0.35)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C216(0.74); C266(0.76); C191(0.78); C38(0.79)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C191(0.83); C277(0.83); C216(0.84); C38(0.89)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C152(0.47); C159(0.47); C380(0.50); C387(0.50)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C152(0.38); C159(0.38); C380(0.55); C387(0.55)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C380(0.43); C387(0.43); C152(0.43); C159(0.43)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C380(0.39); C387(0.39); C152(0.44); C159(0.44)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C152(0.25); C159(0.25); C380(0.33); C387(0.33)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C152(0.41); C159(0.41); C266(0.64); C191(0.67)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C152(0.59); C159(0.59); C30(0.77); C216(0.90)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C152(0.74); C159(0.74); C30(0.92); C409(0.98)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C380(0.44); C387(0.44); C266(0.48); C152(0.68)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C152(0.63); C159(0.63); C409(0.89); C75(0.93)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C409(0.43); C209(0.63); C273(0.66); C216(0.76)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C152(0.28); C159(0.28); C266(0.43); C191(0.60)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C266(0.67); C191(0.70); C152(0.72); C159(0.72)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C152(0.56); C159(0.56); C266(0.66); C191(0.74)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C96(0.63); C102(0.72); C266(0.73); C216(0.78)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C96(0.63); C266(0.63); C38(0.65); C273(0.66)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C96(0.60); C266(0.63); C216(0.66); C95(0.68)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C96(0.60); C102(0.66); C95(0.69); C266(0.70)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C266(0.26); C380(0.30); C387(0.30); C152(0.38)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C75(0.60); C85(0.60); C266(0.61); C380(0.61)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C266(0.22); C380(0.27); C387(0.27); C152(0.34)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C380(0.50); C387(0.50); C266(0.63); C209(0.67)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C380(0.32); C387(0.32); C266(0.34); C152(0.46)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C266(0.19); C380(0.21); C387(0.21); C152(0.33)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C380(0.27); C387(0.27); C266(0.31); C152(0.58)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C75(0.66); C85(0.66); C380(0.72); C387(0.72)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C380(0.57); C387(0.57); C266(0.58); C216(0.67)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C380(0.33); C387(0.33); C266(0.35); C38(0.54)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C380(0.25); C387(0.25); C266(0.37); C152(0.47)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C362(0.78); C266(0.78); C85(0.82); C273(0.86)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C216(0.64); C209(0.64); C152(1.03); C159(1.03)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C152(0.67); C159(0.67); C209(0.65); C216(0.66)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C152(0.96); C159(0.96); C209(0.70); C216(0.78)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C152(0.92); C159(0.92); C209(0.84); C216(0.70)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C152(0.65); C159(0.65); C209(0.60); C216(0.65)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C152(0.58); C159(0.58); C209(0.57); C216(0.57)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C152(0.99); C159(0.99); C209(1.05); C216(1.18)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C152(0.75); C159(0.75); C209(0.88); C216(0.87)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C209(1.14); C216(1.11); C102(0.78); C191(0.97)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C209(0.92); C216(0.90); C102(0.50); C191(0.93)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C209(0.89); C216(0.92); C102(0.60); C191(0.87)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C209(0.90); C216(0.87); C102(0.70); C191(0.85)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C209(0.86); C216(0.89); C102(0.76); C191(0.91)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C209(0.93); C216(0.87); C102(0.88); C191(0.92)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C209(0.94); C216(0.94); C102(0.83); C191(0.92)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C209(1.14); C216(1.21); C102(0.83); C191(1.10)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C152(1.32); C159(1.32); C209(0.80); C216(0.84)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C209(1.11); C216(1.14); C102(0.90); C191(0.99)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C209(1.01); C216(0.96); C102(0.86); C191(0.87)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C209(1.05); C216(1.05); C102(0.66); C191(1.04)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C209(1.15); C216(1.21); C102(0.77); C191(1.08)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C209(1.13); C216(1.11); C102(0.67); C191(1.05)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C209(1.10); C216(1.00); C102(0.64); C191(0.95)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C152(2.56); C159(2.56); C209(2.04); C216(2.05)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C152(2.35); C159(2.35); C209(2.59); C216(2.63)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C152(4.55); C159(4.55); C209(2.86); C216(2.91)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C152(2.61); C159(2.61); C209(1.98); C216(1.99)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C152(0.75); C159(0.75); C209(1.36); C216(1.18)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C152(1.90); C159(1.90); C209(2.50); C216(2.52)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C152(1.74); C159(1.74); C209(2.76); C216(2.75)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C152(1.23); C159(1.23); C209(2.02); C216(2.04)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C152(3.44); C159(3.44); C209(2.55); C216(2.54)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C152(4.86); C159(4.86); C209(2.41); C216(2.41)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C152(4.04); C159(4.04); C209(4.56); C216(4.52)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C152(1.23); C159(1.23); C209(1.51); C216(1.55)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C152(1.59); C159(1.59); C209(1.97); C216(2.00)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C152(4.52); C159(4.52); C209(2.80); C216(2.79)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C152(2.55); C159(2.55); C209(2.27); C216(2.24)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C152(0.30); C159(0.30); C209(0.60); C216(0.61)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C152(1.86); C159(1.86); C209(1.95); C216(2.03)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C209(1.16); C216(1.26); C102(1.09); C191(0.90)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C209(1.04); C216(1.17); C102(1.03); C191(0.95)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C209(0.88); C216(0.91); C102(0.72); C191(0.83)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C209(1.03); C216(1.12); C102(0.85); C191(0.91)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C209(1.20); C216(1.29); C102(0.95); C191(1.04)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C209(1.02); C216(1.08); C102(0.76); C191(0.91)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C209(1.25); C216(1.28); C102(0.91); C191(1.01)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C209(1.25); C216(1.23); C102(0.70); C191(0.98)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C209(1.09); C216(1.15); C102(0.64); C191(0.91)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C152(0.51); C159(0.51); C209(0.68); C216(0.67)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C209(1.15); C216(1.29); C102(0.74); C191(0.99)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C209(1.40); C216(1.45); C102(0.97); C191(1.05)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C209(1.38); C216(1.54); C102(1.25); C191(1.20)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C209(1.27); C216(1.35); C102(0.97); C191(1.16)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C209(1.49); C216(1.59); C102(0.92); C191(1.24)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C209(0.85); C216(0.78); C102(0.55); C191(1.05)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C209(0.88); C216(1.04); C102(0.69); C191(0.94)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C209(1.09); C216(1.01); C102(0.80); C191(0.97)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C209(0.97); C216(0.90); C102(0.74); C191(1.11)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C152(0.51); C159(0.51); C209(0.72); C216(0.76)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C209(0.78); C216(0.70); C102(0.59); C191(1.17)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C209(1.18); C216(1.13); C102(0.86); C191(1.25)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C209(0.97); C216(0.87); C102(0.58); C191(1.19)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C209(0.87); C216(0.73); C102(0.53); C191(1.02)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C209(0.76); C216(0.65); C102(0.52); C191(0.96)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C209(1.02); C216(1.00); C102(0.69); C191(0.99)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C209(1.01); C216(1.06); C102(0.77); C191(0.96)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C209(1.04); C216(0.96); C102(0.67); C191(1.06)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C209(1.11); C216(0.85); C102(0.68); C191(1.07)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C209(1.04); C216(0.92); C102(0.57); C191(1.01)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C152(0.77); C159(0.77); C209(0.96); C216(1.16)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C209(1.25); C216(1.38); C102(0.88); C191(0.96)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C209(0.77); C216(0.74); C102(0.60); C191(0.84)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C209(0.80); C216(0.78); C102(0.69); C191(1.07)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C209(1.02); C216(0.91); C102(0.62); C191(1.21)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C209(0.82); C216(0.65); C102(0.55); C191(0.84)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C209(0.64); C216(0.72); C102(0.56); C191(0.93)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C209(0.79); C216(0.72); C102(0.55); C191(0.83)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C209(0.67); C216(0.63); C102(0.57); C191(0.84)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C209(0.57); C216(0.57); C102(0.53); C191(0.86)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C209(0.63); C216(0.66); C102(0.55); C191(0.90)  LDD0811  [11]
 LDCM0634  CY-0357 Hep-G2 C220(3.35); C409(2.99); C45(1.41); C12(1.14)  LDD2228  [17]
 LDCM0495  E2913 HEK-293T C38(1.06); C191(0.98); C199(0.82); C220(0.91)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C199(2.34); C75(1.22); C220(1.20); C85(1.05)  LDD1702  [9]
 LDCM0625  F8 Ramos C362(0.71); C45(0.89); C38(1.28); C248(0.82)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C362(0.52); C38(0.59); C248(0.53); 0.92  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C362(1.86); C45(0.55); C38(0.22); 3.18  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C362(0.62); C38(0.63); C248(0.57); 1.11  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C362(1.11); C38(0.89); C248(1.18); 1.20  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C362(1.23); C45(0.49); C248(0.94); C75(1.21)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C362(0.50); C38(0.50); C248(0.44); 0.77  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C362(0.95); C38(1.02); C248(0.99); 1.12  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C362(0.14); C38(0.21); C248(0.19); 0.25  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C362(1.02); C38(0.89); C248(1.07); C409(0.16)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C362(0.61); C45(0.60); C38(0.63); C248(0.99)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C362(1.15); C38(0.86); C248(1.07); 1.24  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C362(1.12); C38(0.77); C248(1.39); 1.03  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C362(0.52); C38(0.48); C248(0.53); 0.90  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C209(1.06); C216(1.17); C102(0.92); C191(0.90)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C362(0.82); C38(0.76); C248(0.80); 0.57  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C362(0.64); C45(0.95); C38(0.70); C248(0.75)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C209(1.02); C216(1.09); C102(0.84); C191(1.21)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C362(1.35); C38(0.92); C248(1.15); C409(0.38)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C362(1.19); C38(1.04); C248(1.09); 1.28  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C362(0.50); C45(0.82); C38(0.44); C248(0.59)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C362(0.46); C38(0.48); C248(0.42); 0.94  LDD2188  [30]
 LDCM0107  IAA HeLa C209(0.00); C95(0.00); C362(0.00); C38(0.00)  LDD0221  [23]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HCT 116 C209(5.69); C216(5.69); C266(1.80); C102(2.71)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C209(12.28); C216(12.28); C266(2.69); C102(4.78)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C209(9.16); C216(9.16); C266(2.45); C102(2.40)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C38(1.05); C220(0.97); C199(0.94)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C38(1.06); C199(0.60); C191(0.68)  LDD2121  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C38(0.77); C362(0.60)  LDD2089  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C38(1.91); C191(1.12); C277(1.02)  LDD2093  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C191(0.10); C248(0.20)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C38(1.18); C191(1.18); C362(0.77)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C220(1.10); C191(0.77); C248(1.15); C85(0.98)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C191(1.08); C277(1.15); C362(1.14); C248(1.09)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C38(1.07); C220(0.58); C191(0.44); C362(0.29)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C38(1.00); C220(0.81); C199(1.00); C191(0.91)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C220(0.54); C248(0.68)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C220(0.97); C199(1.28); C191(1.66); C248(1.37)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C38(2.05)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C38(1.80); C199(0.89); C191(0.96); C362(0.89)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C220(0.50); C199(0.88); C191(0.56); C362(1.06)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C220(0.62); C199(0.73); C191(0.49); C277(0.74)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C38(1.05)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C38(2.05); C191(1.00); C277(1.32); C362(0.95)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C248(0.72)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C191(0.49); C362(0.35); C85(0.74)  LDD2115  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C191(0.36)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C38(1.82); C277(1.92); C362(1.90)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C199(0.76); C191(0.79); C362(1.33); C85(0.96)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C191(0.17)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C38(1.26); C191(0.73); C277(0.80); C362(1.04)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C191(0.09); C248(0.31)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C220(0.95); C191(0.69); C277(0.78); C362(1.04)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C191(0.04); C277(0.60)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C38(0.91); C277(0.87); C362(0.93); C248(0.86)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C191(0.80); C85(0.86)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C38(1.74); C191(1.26); C277(1.12); C362(1.11)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C220(0.59); C277(0.84); C273(1.17)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C220(0.54); C362(0.40); C85(0.92); C75(0.67)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C38(1.40); C191(1.27); C277(1.02); C362(1.54)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C38(0.68); C220(1.26); C191(1.10); C277(1.06)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C220(0.88); C191(0.76); C277(0.75); C362(0.78)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C191(1.99)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C38(2.43); C220(0.80); C199(0.88); C191(0.88)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C38(0.96); C220(0.72); C191(0.61); C248(0.74)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C191(0.77); C85(0.74)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C38(2.59); C220(2.82); C191(3.18); C277(2.30)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C38(1.56); C220(1.01); C191(1.06); C362(0.90)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C199(2.48); C191(1.90)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C220(0.50); C199(0.88); C191(0.43); C362(0.43)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C191(0.13)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C38(0.83); C199(0.47); C191(0.40); C362(0.48)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C362(0.19)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C38(1.23); C199(1.58)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C38(0.71)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C95(0.94); C75(0.26)  LDD2207  [31]
 LDCM0131  RA190 MM1.R C362(1.37); C409(1.13)  LDD0304  [32]
 LDCM0021  THZ1 HeLa S3 C96(1.03)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiogenin (ANG) Pancreatic ribonuclease family P03950
Ribonuclease pancreatic (RNASE1) Pancreatic ribonuclease family P07998
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Wolframin (WFS1) . O76024

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Proteome-Wide Identification of On- and Off-Targets of Bcl-2 Inhibitors in Native Biological Systems by Using Affinity-Based Probes (AfBPs). Chembiochem. 2018 Nov 2;19(21):2312-2320. doi: 10.1002/cbic.201800380. Epub 2018 Oct 18.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
32 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.