Details of the Target

General Information of Target

Target ID LDTP05417
Target Name Transcription factor p65 (RELA)
Gene Name RELA
Gene ID 5970
Synonyms
NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPT
IKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQC
VKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLS
HPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFS
QADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEE
KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINY
DEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQA
VAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQ
GIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADM
DFSALLSQISS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The inhibitory effect of I-kappa-B on NF-kappa-B through retention in the cytoplasm is exerted primarily through the interaction with RELA. RELA shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Beside its activity as a direct transcriptional activator, it is also able to modulate promoters accessibility to transcription factors and thereby indirectly regulate gene expression. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells. The NF-kappa-B homodimeric RELA-RELA complex appears to be involved in invasin-mediated activation of IL-8 expression. Key transcription factor regulating the IFN response during SARS-CoV-2 infection.
Uniprot ID
Q04206
Ensemble ID
ENST00000308639.13
HGNC ID
HGNC:9955
ChEMBL ID
CHEMBL5533

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.D243Y .
IGR1 Substitution: p.P182L DBIA    Probe Info 
MCC13 Deletion: p.D167TfsTer33 DBIA    Probe Info 
MFE319 SNV: p.Y152H .
SNGM SNV: p.P182S; p.P189H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
ONAyne
 Probe Info  		K195(1.22)  LDD0274  [3]
STPyne
 Probe Info  		K122(4.48); K310(7.14); K62(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y66(50.56); Y152(20.56); Y257(10.72)  LDD3495  [4]
BTD
 Probe Info  		C38(0.95)  LDD2107  [5]
Sulforaphane-probe2
 Probe Info  		1.82  LDD0160  [6]
AHL-Pu-1
 Probe Info  		C105(2.50)  LDD0169  [7]
DBIA
 Probe Info  		C105(1.01)  LDD0078  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C105(0.00); C160(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C120(0.00); C109(0.00); C105(0.00); C160(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C105(0.00); C160(0.00)  LDD0037  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
aHNE
 Probe Info  		N.A.  LDD0001  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
IPM
 Probe Info  		C38(0.00); C105(0.00)  LDD0147  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Phosphinate-6
 Probe Info  		C38(0.00); C105(0.00)  LDD0018  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Methacrolein
 Probe Info  		C206(0.00); C216(0.00)  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		8.80  LDD0443  [19]
NAIA_5
 Probe Info  		C38(0.00); C120(0.00); C109(0.00)  LDD2223  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C105(2.50)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C105(1.02); C109(1.09); C120(1.16); C160(1.34)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C105(1.21); C109(1.11); C120(1.17); C160(1.14)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C105(1.08); C109(0.75); C120(0.68); C206(0.71)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C105(0.91); C109(0.88); C120(0.76); C206(0.65)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C105(1.11); C109(0.80); C120(0.78); C206(0.67)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C105(1.28); C109(0.69); C120(0.61); C206(0.55)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C105(1.15); C109(0.77); C120(0.78); C206(0.76)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C105(1.42); C109(0.73); C120(0.63); C206(0.57)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C105(1.24); C109(0.71); C120(0.64); C206(0.68)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C105(1.10); C109(0.83); C120(0.66); C206(0.63)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C105(1.09); C109(0.73); C120(0.75); C206(0.77)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C105(1.04); C109(0.73); C120(0.90); C206(0.79)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C105(1.50); C109(1.06); C120(1.14); C160(1.13)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C105(1.00); C109(0.76); C120(0.80); C206(0.63)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C105(0.96); C109(0.69); C120(0.76); C206(0.68)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C105(1.13); C109(0.73); C120(0.69); C206(0.59)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C105(0.98); C109(1.25); C120(1.38); C160(0.84)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C105(1.20); C109(1.02); C120(0.95); C160(0.72)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C105(1.31); C109(1.03); C120(0.99); C160(0.54)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C105(1.54); C109(1.01); C120(0.87); C160(0.56)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C105(1.52); C109(1.11); C120(0.91); C160(0.86)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C105(1.09); C109(1.03); C120(1.13); C160(0.96)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C105(1.29); C109(1.05); C120(0.90); C160(0.77)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C105(1.12); C109(0.97); C120(1.12); C160(1.09)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C105(1.19); C109(1.08); C120(1.39); C160(0.68)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C105(1.09); C109(1.19); C120(0.94); C160(1.05)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C105(1.44); C109(1.02); C120(0.93); C160(1.03)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C105(1.21); C109(1.03); C120(1.06); C160(1.13)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C105(1.03); C109(1.20); C120(0.89); C160(0.88)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C105(1.41); C109(1.03); C120(0.94); C160(0.91)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C105(1.51); C109(0.96); C120(0.98); C160(0.61)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C105(1.42); C109(1.02); C120(0.96); C160(0.62)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C105(1.51); C109(0.80); C120(0.80); C160(0.78)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C105(1.01); C109(1.15); C120(1.15); C160(1.48)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C105(1.40); C109(0.79); C120(0.79); C160(0.87)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C105(1.05); C109(1.12); C120(1.12); C160(1.29)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C105(1.27); C109(0.98); C120(0.98); C160(1.42)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C105(1.57); C109(0.85); C120(0.85); C160(1.02)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C105(1.57); C109(0.58); C120(0.58); C160(0.96)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C105(1.50); C109(0.66); C120(0.66); C160(0.88)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C105(1.26); C109(0.76); C120(0.76); C160(1.02)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C105(1.38); C109(0.88); C120(0.88); C160(1.26)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C105(1.78); C109(0.54); C120(0.54); C160(1.21)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C105(1.62); C109(0.65); C120(0.65); C160(1.17)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C105(1.22); C109(1.14); C120(1.33); C160(1.21)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C105(1.79); C109(0.43); C120(0.43); C160(0.94)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C105(1.56); C109(0.59); C120(0.59); C160(1.22)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C105(1.23); C109(1.34); C120(1.34); C160(1.88)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C206(0.84); C216(0.84); C120(0.90); C109(0.94)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C160(0.43); C109(0.58); C120(0.66); C216(0.70)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C160(0.73); C109(0.76); C120(0.80); C206(0.81)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C109(0.74); C160(0.74); C120(0.76); C206(0.80)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C160(0.44); C109(0.49); C120(0.61); C216(0.76)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C160(0.33); C109(0.51); C120(0.60); C206(0.80)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C160(0.45); C109(0.55); C120(0.63); C206(0.76)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C206(0.94); C216(0.95); C109(1.08); C160(1.11)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C206(0.78); C216(0.78); C160(0.83); C120(0.84)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C120(0.82); C160(0.83); C206(0.83); C109(0.84)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C160(0.39); C109(0.58); C120(0.59); C206(0.77)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C160(0.36); C120(0.62); C109(0.63); C206(0.83)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C105(1.54); C109(0.61); C120(0.69); C160(0.53)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C105(2.05); C109(0.65); C120(0.69); C160(0.54)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C105(1.19); C109(0.89); C120(0.98); C160(0.90)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C105(1.19); C109(0.93); C120(1.02); C160(0.84)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C109(0.88); C206(0.88); C216(0.88); C120(0.90)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C206(0.58); C216(0.58); C109(0.66); C120(0.67)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C206(0.81); C216(0.81); C120(0.85); C109(0.88)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C120(0.86); C109(0.94); C206(0.99); C216(0.99)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C109(0.81); C206(0.84); C216(0.84); C120(0.84)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C109(0.80); C206(0.81); C216(0.81); C120(0.81)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C206(0.85); C216(0.85); C109(1.02); C105(1.03)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C206(0.71); C216(0.71); C120(0.92); C109(0.93)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C206(0.80); C216(0.80); C120(0.92); C109(0.96)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C109(0.85); C216(0.87); C206(0.88); C120(0.89)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C109(0.71); C216(0.74); C120(0.78); C206(0.81)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C109(0.64); C120(0.73); C216(0.79); C206(0.86)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C109(0.61); C120(0.68); C216(0.78); C206(0.87)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C109(0.69); C216(0.76); C120(0.79); C206(0.79)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C109(0.90); C120(0.95); C206(1.11); C216(1.11)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C109(0.64); C206(0.71); C216(0.71); C120(0.72)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C109(0.77); C216(0.77); C206(0.83); C120(0.89)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C109(0.49); C120(0.55); C216(0.62); C206(0.70)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C109(0.66); C120(0.68); C216(0.70); C206(0.77)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C109(0.50); C120(0.54); C216(0.62); C206(0.73)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C105(0.87); C206(1.05); C216(1.09); C160(1.17)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C105(0.82); C206(1.08); C216(1.16); C109(1.21)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C105(0.89); C206(1.04); C109(1.18); C120(1.19)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C105(0.98); C206(0.99); C216(1.01); C109(1.06)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C109(0.89); C120(0.94); C206(1.13); C160(1.13)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C120(0.79); C109(0.81); C206(0.96); C216(0.96)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C109(0.79); C120(0.80); C206(0.90); C160(0.94)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C206(0.98); C105(1.01); C216(1.06); C120(1.13)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C120(0.78); C109(0.80); C206(0.89); C216(0.95)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C120(1.05); C109(1.12); C105(1.12); C206(1.14)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C120(0.88); C109(0.92); C206(0.97); C216(1.03)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C120(0.82); C109(0.82); C206(0.88); C216(0.98)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C216(0.94); C206(0.98); C109(1.02); C120(1.07)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C216(0.91); C206(0.95); C109(0.97); C120(1.06)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C109(1.22); C105(1.27); C120(1.34); C206(1.40)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C160(0.70); C120(0.77); C109(0.77); C216(0.94)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C109(0.82); C105(0.93); C120(0.95); C206(0.97)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C160(0.70); C109(0.73); C120(0.84); C216(0.96)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C105(0.99); C216(1.03); C206(1.05); C120(1.23)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C109(0.89); C216(0.94); C160(0.97); C206(0.97)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C120(0.78); C160(0.81); C109(0.86); C216(0.87)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C109(0.78); C160(0.81); C216(0.91); C120(0.91)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C120(0.80); C160(0.84); C216(0.89); C109(0.91)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C109(0.79); C120(0.81); C160(0.82); C216(1.07)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C109(0.56); C120(0.63); C160(0.71); C206(1.11)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C120(0.53); C109(0.57); C160(0.75); C206(0.85)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C109(0.46); C120(0.50); C160(0.58); C206(0.87)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C120(0.78); C206(0.88); C216(0.89); C109(0.91)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C109(0.75); C120(0.84); C160(0.87); C206(1.04)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C109(0.93); C120(1.00); C105(1.27); C160(1.40)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C109(0.50); C160(0.57); C120(0.60); C206(0.80)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C109(0.63); C120(0.75); C160(0.80); C206(0.84)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C109(0.53); C160(0.60); C120(0.76); C206(0.80)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C109(0.49); C120(0.51); C160(0.83); C206(1.04)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C120(0.54); C109(0.56); C206(0.92); C216(0.92)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C109(0.45); C120(0.54); C160(0.58); C206(0.83)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C109(0.88); C160(0.90); C105(0.94); C206(0.95)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C109(0.72); C120(0.90); C160(0.93); C206(0.94)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C206(0.88); C216(0.92); C120(0.98); C109(1.05)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C160(0.54); C109(0.61); C120(0.92); C206(0.95)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C109(0.97); C105(1.00); C206(1.07); C216(1.07)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C109(0.71); C160(0.74); C206(0.93); C216(0.93)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C109(0.63); C160(0.67); C120(0.95); C206(1.04)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C160(0.68); C109(0.69); C206(1.01); C216(1.01)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C109(0.65); C160(0.76); C120(1.01); C206(1.15)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C160(0.64); C109(0.68); C120(0.92); C206(0.96)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C160(0.60); C109(0.70); C206(0.89); C216(0.89)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C206(1.06); C216(1.06); C105(1.13); C109(1.18)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C109(0.88); C206(0.92); C216(0.92); C160(0.94)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C120(0.87); C206(0.89); C216(0.91); C109(0.95)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C160(0.71); C109(0.79); C206(0.95); C216(0.95)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C109(0.89); C206(1.01); C216(1.01); C120(1.11)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C160(0.68); C109(0.75); C120(1.09); C206(1.18)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C160(0.42); C109(0.47); C120(0.50); C216(0.66)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C160(0.47); C120(0.55); C109(0.56); C216(0.67)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C206(0.71); C216(0.72); C109(0.74); C120(0.74)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C216(0.63); C160(0.66); C206(0.66); C109(0.69)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C120(0.88); C216(0.89); C206(0.91); C160(0.96)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C120(0.65); C109(0.65); C206(0.66); C216(0.66)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C160(0.52); C120(0.57); C109(0.58); C216(0.73)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C206(0.84); C216(0.87); C120(0.96); C109(1.15)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C160(0.40); C109(0.49); C120(0.57); C216(0.69)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C160(0.40); C109(0.47); C120(0.52); C206(0.64)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C160(0.64); C120(0.64); C206(0.68); C109(0.69)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C160(0.73); C216(0.75); C206(0.77); C109(0.77)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C206(1.04); C120(1.05); C216(1.05); C105(1.16)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C160(0.62); C109(0.66); C120(0.70); C206(0.74)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C160(0.41); C120(0.47); C109(0.49); C216(0.64)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C120(0.63); C206(0.65); C109(0.70); C216(0.72)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C206(0.71); C120(0.74); C216(0.77); C109(0.79)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C105(1.20); C109(1.11); C120(1.23); C160(1.26)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C206(0.94); C216(0.96); C105(1.14); C160(1.14)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C120(0.71); C206(0.83); C160(0.85); C216(0.88)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.81  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C105(1.01)  LDD0078  [8]
 LDCM0630  CCW28-3 231MFP C105(0.11)  LDD2214  [20]
 LDCM0108  Chloroacetamide HeLa C38(0.00); C216(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C109(0.53)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C105(0.90); C120(0.94); C216(0.96); C206(0.99)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C120(0.65); C109(0.72); C206(0.98); C216(1.00)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C109(0.81); C120(0.85); C206(0.92); C216(0.92)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C206(0.82); C216(0.86); C120(0.90); C109(0.94)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C206(1.00); C105(1.01); C120(1.03); C160(1.05)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C109(0.97); C206(0.99); C216(1.04); C120(1.06)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C206(0.90); C216(0.91); C160(1.13); C105(1.16)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C120(0.68); C206(0.69); C216(0.69); C109(0.71)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C109(0.70); C120(0.71); C206(0.74); C216(0.74)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C206(0.68); C216(0.68); C109(0.69); C120(0.71)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C109(0.54); C120(0.56); C206(0.79); C216(0.79)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C120(0.80); C109(0.85); C206(0.88); C216(0.88)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C120(0.61); C109(0.66); C160(0.86); C206(1.00)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C120(0.72); C206(0.74); C216(0.74); C109(0.80)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C206(0.68); C216(0.68); C120(0.72); C109(0.85)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C109(0.78); C120(0.79); C216(0.85); C206(0.88)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C109(0.55); C120(0.58); C216(0.62); C206(0.69)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C216(0.59); C109(0.69); C206(0.70); C120(0.75)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C109(0.67); C216(0.68); C120(0.73); C206(0.74)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C109(0.69); C120(0.74); C216(0.81); C206(0.88)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C120(0.62); C109(0.64); C160(0.90); C206(1.05)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C206(0.90); C109(0.93); C216(0.94); C120(0.98)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C109(0.85); C120(0.87); C206(0.91); C160(0.97)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C120(0.60); C109(0.63); C160(0.98); C216(1.13)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C206(0.98); C105(1.03); C160(1.04); C216(1.05)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C160(0.90); C105(1.06); C120(1.18); C109(1.23)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C216(0.92); C206(0.95); C160(1.01); C109(1.02)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C120(0.73); C160(0.74); C109(0.75); C216(0.83)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C109(0.72); C160(0.72); C120(0.74); C216(0.98)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C120(0.89); C109(0.90); C206(1.14); C216(1.14)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C206(0.78); C216(0.78); C120(0.80); C109(0.83)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C206(0.80); C216(0.80); C109(0.85); C120(0.88)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C109(0.52); C120(0.54); C160(0.63); C206(0.89)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C120(0.80); C109(0.83); C160(0.98); C206(1.06)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C120(0.86); C109(0.91); C216(1.01); C206(1.02)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C120(0.96); C109(0.97); C216(1.07); C206(1.07)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C206(0.97); C216(1.00); C120(1.06); C109(1.12)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C206(0.91); C216(0.95); C120(0.98); C109(0.98)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C105(1.09); C120(1.19); C109(1.22); C206(1.49)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C120(0.94); C109(0.98); C206(0.99); C216(1.00)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C216(0.98); C105(0.99); C206(0.99); C120(1.07)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C120(0.68); C109(0.73); C206(0.96); C216(0.98)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C120(0.53); C109(0.63); C206(0.87); C216(0.92)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C120(0.70); C109(0.72); C206(1.07); C216(1.14)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C120(0.78); C109(0.80); C206(0.93); C216(0.95)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C105(1.38); C109(0.73); C120(0.67); C206(1.01)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C105(1.58); C109(0.66); C120(0.67); C206(0.93)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C105(1.29); C109(0.84); C120(0.73); C206(1.04)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C105(1.38); C109(0.91); C120(0.88); C206(1.13)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C105(1.29); C109(0.86); C120(0.75); C206(0.96)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C105(1.26); C109(0.85); C120(0.82); C206(1.07)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C105(1.17); C109(0.98); C120(0.95); C160(1.88)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C105(1.00); C109(1.08); C120(1.08); C206(1.13)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C105(1.15); C109(0.85); C120(0.68); C160(0.93)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C105(1.27); C109(1.02); C120(0.93); C160(1.28)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C105(1.39); C109(0.91); C120(0.69); C160(0.92)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C105(1.69); C109(0.91); C120(0.39); C160(0.74)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C105(1.63); C109(0.85); C120(0.40); C160(0.72)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C105(1.65); C109(0.85); C120(0.43); C160(0.72)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C105(1.66); C109(0.77); C120(0.35); C160(0.67)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C105(1.94); C109(0.77); C120(0.36); C160(0.69)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C105(0.99); C109(0.98); C120(1.02); C160(1.12)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C105(1.59); C109(0.75); C120(0.43); C160(0.75)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C105(1.38); C109(0.85); C120(0.49); C160(0.80)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C105(2.18); C109(0.83); C120(0.38); C160(0.70)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C105(1.70); C109(0.82); C120(0.39); C160(0.75)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C105(1.60); C109(0.77); C120(0.58); C160(0.82)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C105(1.80); C109(0.85); C120(0.45); C160(0.76)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C105(1.00); C109(0.98); C120(1.19); C206(0.93)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C105(0.71); C109(0.97); C120(1.04); C206(1.01)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C105(0.85); C109(0.97); C120(1.16); C206(1.02)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C105(1.05); C109(0.91); C120(0.93); C206(1.02)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C105(1.03); C109(0.97); C120(0.97); C160(0.94)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C105(0.94); C109(0.89); C120(1.00); C206(1.11)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C105(0.89); C109(0.93); C120(1.04); C206(1.13)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C105(0.81); C109(0.92); C120(1.00); C206(1.06)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C105(0.75); C109(0.93); C120(1.10); C206(0.92)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C105(0.54); C109(0.96); C120(1.07); C206(1.16)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C105(0.56); C109(0.94); C120(1.13); C206(1.11)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C105(0.84); C109(0.96); C120(1.00); C206(0.94)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C105(0.89); C109(1.01); C120(1.12); C206(1.10)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C105(0.97); C109(0.93); C120(1.09); C206(1.11)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C105(0.70); C109(0.92); C120(1.03); C206(1.02)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C105(1.22); C109(1.13); C120(1.10); C160(1.43)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C105(0.68); C109(0.96); C120(0.98); C206(1.02)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C105(1.25); C109(0.91); C120(0.94); C206(0.93)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C105(1.16); C109(0.96); C120(0.91); C206(0.87)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C105(1.32); C109(0.87); C120(0.96); C206(0.84)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C105(1.46); C109(0.60); C120(0.74); C206(0.75)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C105(1.18); C109(0.90); C120(0.94); C206(0.93)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C105(2.00); C109(0.43); C120(0.68); C206(0.72)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C105(1.43); C109(0.65); C120(0.80); C206(0.79)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C105(1.36); C109(0.89); C120(1.06); C206(0.93)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C105(1.08); C109(1.66); C120(1.35); C206(1.40)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C105(1.24); C109(0.72); C120(0.76); C160(1.76)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C105(1.09); C109(1.02); C120(1.02); C206(1.00)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C105(1.51); C109(0.79); C120(0.91); C206(0.78)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C105(1.00); C109(1.04); C120(1.05); C206(0.95)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C105(1.10); C109(0.78); C120(0.88); C206(0.80)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C105(1.33); C109(0.77); C120(0.86); C206(0.85)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C105(1.19); C109(1.10); C120(0.95); C160(1.01)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C105(1.35); C109(1.01); C120(0.83); C160(0.87)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C105(1.29); C109(1.07); C120(0.79); C160(0.91)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C105(1.38); C109(1.17); C120(0.68); C160(0.66)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C105(1.87); C109(0.58); C120(0.50); C160(1.19)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C105(1.34); C109(1.35); C120(1.34); C160(1.20)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C105(1.28); C109(0.97); C120(0.78); C160(0.85)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C105(1.04); C109(1.15); C120(0.74); C160(0.69)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C105(1.20); C109(1.06); C120(0.73); C160(0.64)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C105(1.39); C109(1.07); C120(0.62); C160(0.66)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C105(1.42); C109(1.04); C120(0.84); C160(0.88)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C105(1.13); C109(1.09); C120(0.90); C160(0.86)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C105(1.32); C109(0.94); C120(0.62); C160(0.84)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C105(1.14); C109(0.97); C120(0.66); C160(0.65)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C105(1.13); C109(1.24); C120(0.73); C160(0.78)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C105(1.46); C109(0.77); C120(0.73); C160(1.36)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C105(1.29); C109(1.03); C120(0.92); C160(0.68)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C105(1.23); C109(0.96); C120(0.89); C160(1.02)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C105(1.22); C109(0.97); C120(1.01); C160(1.01)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C105(0.97); C109(0.83); C120(0.89); C160(1.20)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C105(1.04); C109(0.78); C120(0.86); C160(0.98)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C105(1.10); C109(0.77); C120(0.72); C160(0.91)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C105(1.18); C109(0.83); C120(0.80); C160(1.02)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C105(1.13); C109(0.81); C120(0.74); C160(0.99)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C105(1.10); C109(0.76); C120(0.73); C160(1.14)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C105(1.09); C109(0.79); C120(0.86); C160(1.25)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C105(1.00); C160(1.06); C109(1.02)  LDD1698  [21]
 LDCM0625  F8 Ramos C105(1.19)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C105(0.85)  LDD2189  [22]
 LDCM0574  Fragment12 Ramos C105(0.81)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C105(0.79)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C105(0.57)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C105(0.55)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C105(0.80)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C105(0.75)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C105(0.68)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C105(0.34)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C105(0.77)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C105(0.67)  LDD2200  [22]
 LDCM0468  Fragment33 HCT 116 C105(1.15); C109(0.84); C120(0.93); C206(0.84)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C105(0.60)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C105(0.78)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C105(2.17); C109(0.83); C120(0.40); C160(0.74)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C105(0.62)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C105(0.61)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C105(0.90)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C105(0.60)  LDD2188  [22]
 LDCM0107  IAA HeLa C206(0.00); H181(0.00)  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C105(1.59); C109(1.90); C120(1.90)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C105(1.46); C109(1.66); C120(1.66)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C105(1.69); C109(1.48); C120(1.48)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C38(0.95)  LDD2107  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C38(0.50); C197(0.25)  LDD2116  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C38(0.40)  LDD2122  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C105(15.00)  LDD2207  [23]
 LDCM0131  RA190 MM1.R C105(1.22)  LDD0304  [24]
 LDCM0003  Sulforaphane MDA-MB-231 1.82  LDD0160  [6]
 LDCM0021  THZ1 HCT 116 C105(1.07); C109(1.05); C120(1.05)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EHMT1 (EHMT1) Class V-like SAM-binding methyltransferase superfamily Q9H9B1
Histone-lysine N-methyltransferase, H3 lysine-36 specific (NSD1) Class V-like SAM-binding methyltransferase superfamily Q96L73
Histone-lysine N-methyltransferase SETD7 (SETD7) Histone-lysine methyltransferase family Q8WTS6
ATP-dependent RNA helicase A (DHX9) DEAD box helicase family Q08211
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) Glycosyltransferase 41 family O15294
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Lysine-specific demethylase 2A (KDM2A) JHDM1 histone demethylase family Q9Y2K7
Caspase-6 (CASP6) Peptidase C14A family P55212
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) Phosphatase 2A regulatory subunit A family P30153
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Mitogen-activated protein kinase 10 (MAPK10) CMGC Ser/Thr protein kinase family P53779
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) Ser/Thr protein kinase family O15111
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) Sirtuin family Q8IXJ6
NAD-dependent protein deacylase sirtuin-6 (SIRT6) Sirtuin family Q8N6T7
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) Transglutaminase family P21980
Small ribosomal subunit protein uS3 (RPS3) Universal ribosomal protein uS3 family P23396
ADP-ribose glycohydrolase MACROD1 (MACROD1) . Q9BQ69
CREB-binding protein (CREBBP) . Q92793
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Interferon regulatory factor 5 (IRF5) IRF family Q13568
Krueppel-like factor 6 (KLF6) Krueppel C2H2-type zinc-finger protein family Q99612
NF-kappa-B inhibitor alpha (NFKBIA) NF-kappa-B inhibitor family P25963
NF-kappa-B inhibitor beta (NFKBIB) NF-kappa-B inhibitor family Q15653
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Homeobox protein SIX2 (SIX2) SIX/Sine oculis homeobox family Q9NPC8
Zinc finger protein SNAI1 (SNAI1) Snail C2H2-type zinc-finger protein family O95863
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Nuclear factor NF-kappa-B p105 subunit (NFKB1) . P19838
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Transcription factor p65 (RELA) . Q04206
Transcription factor RelB (RELB) . Q01201
Zinc finger protein Gfi-1 (GFI1) . Q99684
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein AATF (AATF) AATF family Q9NY61
Apoptosis-stimulating of p53 protein 2 (TP53BP2) ASPP family Q13625
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) CDK5RAP3 family Q96JB5
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Programmed cell death protein 4 (PDCD4) PDCD4 family Q53EL6
RNA-binding protein FUS (FUS) RRM TET family P35637
Suppressor of cytokine signaling 1 (SOCS1) SOCS1 family O15524
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Protein UXT (UXT) UXT family Q9UBK9
Gelsolin (GSN) Villin/gelsolin family P06396
Bromodomain-containing protein 4 (BRD4) . O60885
COMM domain-containing protein 1 (COMMD1) . Q8N668
Cysteine-rich protein 2 (CRIP2) . P52943
Rhombotin-2 (LMO2) . P25791
TAR DNA-binding protein 43 (TARDBP) . Q13148
Ubiquilin-1 (UBQLN1) . Q9UMX0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dimethyl Fumarate Small molecular drug DB08908
Glucosamine Small molecular drug DB01296
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sc-236 Small molecular drug DB14059

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.