Details of the Target

General Information of Target

Target ID LDTP13970
Target Name Splicing factor 3B subunit 6 (SF3B6)
Gene Name SF3B6
Gene ID 51639
Synonyms
SAP14; SF3B14; SF3B14A; Splicing factor 3B subunit 6; Pre-mRNA branch site protein p14; SF3b 14 kDa subunit; SF3B14a; Spliceosome-associated protein, 14-kDa; Splicing factor 3b, subunit 6, 14kDa
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCT
LEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHK
TVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAE
DLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS
Target Bioclass
Other
Family
SF3B6 family
Subcellular location
Nucleus
Function
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B6 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Within the 17S U2 SnRNP complex, SF3B6 directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. SF3B6 stabilizes the intron branch site-U2 snRNA duplex, thereby promoting-binding of introns with poor sequence complementarity. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs.
Uniprot ID
Q9Y3B4
Ensemble ID
ENST00000233468.5
HGNC ID
HGNC:30096

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y61(18.07)  LDD0257  [2]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [3]
STPyne
 Probe Info  		K41(8.01)  LDD0277  [4]
BTD
 Probe Info  		C83(0.66); C74(1.14)  LDD2092  [5]
AHL-Pu-1
 Probe Info  		C83(2.36); C74(2.76)  LDD0169  [6]
HHS-475
 Probe Info  		Y117(0.79)  LDD0264  [7]
HHS-465
 Probe Info  		Y117(7.58)  LDD2237  [8]
DBIA
 Probe Info  		C74(0.85); C83(0.85)  LDD0532  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C83(0.00); C74(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C83(0.00); C74(0.00)  LDD0037  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
aHNE
 Probe Info  		N.A.  LDD0001  [15]
1d-yne
 Probe Info  		N.A.  LDD0356  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
ENE
 Probe Info  		N.A.  LDD0006  [15]
IPM
 Probe Info  		N.A.  LDD0005  [15]
NHS
 Probe Info  		N.A.  LDD0010  [15]
SF
 Probe Info  		N.A.  LDD0028  [18]
TFBX
 Probe Info  		N.A.  LDD0148  [19]
VSF
 Probe Info  		N.A.  LDD0007  [15]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		C74(0.00); C83(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		C74(0.00); C83(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		C74(0.00); C83(0.00)  LDD0218  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]
AOyne
 Probe Info  		15.00  LDD0443  [23]
NAIA_5
 Probe Info  		C83(0.00); C74(0.00)  LDD2223  [14]
HHS-482
 Probe Info  		Y117(1.27)  LDD2239  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C74(0.37)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C74(0.69)  LDD2112  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C83(1.20)  LDD2152  [5]
 LDCM0025  4SU-RNA DM93 C74(2.25)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C83(2.36); C74(2.76)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C74(0.79); C83(1.04)  LDD0812  [9]
 LDCM0215  AC10 HCT 116 C74(0.85); C83(0.85)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C74(0.34); C83(0.73)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C74(0.33); C83(0.70)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C74(0.23); C83(0.65)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C74(0.24); C83(0.60)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C74(0.24); C83(0.65)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C74(0.24); C83(0.60)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C74(0.24); C83(0.60)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C74(0.18); C83(0.68)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C74(0.37); C83(0.62)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C74(0.54); C83(0.62)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C74(0.56); C83(0.56)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C74(0.49); C83(0.59)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C74(0.42); C83(0.63)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C74(0.27); C83(0.84)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C74(0.75); C83(0.85)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C74(0.71); C83(0.81)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C74(0.72); C83(0.81)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C74(0.67); C83(0.76)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C74(0.69); C83(0.77)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C74(0.99); C83(1.01)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C74(0.71); C83(0.87)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C74(0.73); C83(0.73)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C74(0.65); C83(0.79)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C74(1.25); C83(1.26)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C74(0.76); C83(0.89)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C74(1.10); C83(1.05)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C74(1.26); C83(1.20)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C74(0.86); C83(0.95)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C74(0.97); C83(0.88)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C74(0.73); C83(0.79)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C74(0.69); C83(1.16)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C74(0.55); C83(0.96)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C74(1.35); C83(1.46)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C74(0.62); C83(1.05)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C74(1.28); C83(1.33)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C74(0.73); C83(1.07)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C74(0.95); C83(1.25)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C74(1.47); C83(1.50)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C74(0.84); C83(1.06)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C74(0.74); C83(1.07)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C74(0.66); C83(1.23)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C74(0.82); C83(1.02)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C74(0.92); C83(0.92)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C74(1.04); C83(1.53)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C74(0.78); C83(1.06)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C74(1.43); C83(1.40)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C74(0.60); C83(0.69)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C83(0.62); C74(0.71)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C74(0.73); C83(0.76)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C74(0.50); C83(0.83)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C74(0.84); C83(1.24)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C74(0.62); C83(0.65)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C74(0.58); C83(0.66)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C74(0.62); C83(0.62)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C74(0.83); C83(2.30)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C74(0.73); C83(1.15)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C74(0.59); C83(1.31)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C74(0.39); C83(0.88)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C74(0.56); C83(0.84)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C74(0.50); C83(2.22)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C74(0.75); C83(1.69)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C74(0.52); C83(0.89)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C74(0.51); C83(0.79)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C74(0.51); C83(0.72)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C74(0.47); C83(0.61)  LDD0595  [9]
 LDCM0279  AC2 HEK-293T C74(0.62); C83(0.76)  LDD0877  [9]
 LDCM0280  AC20 HCT 116 C74(0.44); C83(0.86)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C74(0.46); C83(0.71)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C74(0.45); C83(0.67)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C74(0.38); C83(0.74)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C74(0.43); C83(0.68)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C74(0.78); C83(0.78)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C74(1.10); C83(1.10)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C74(1.00); C83(1.00)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C74(0.96); C83(0.96)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C74(0.99); C83(0.99)  LDD0606  [9]
 LDCM0290  AC3 HEK-293T C74(0.92); C83(0.98)  LDD0888  [9]
 LDCM0291  AC30 HCT 116 C74(1.13); C83(1.13)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C74(1.11); C83(1.11)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C74(0.96); C83(0.96)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C74(0.99); C83(0.99)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C74(0.88); C83(0.88)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C74(1.32); C83(1.32)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C74(0.83); C83(0.83)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C74(1.38); C83(1.38)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C74(0.95); C83(0.95)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C74(1.23); C83(1.23)  LDD0617  [9]
 LDCM0301  AC4 HEK-293T C74(1.00); C83(1.00)  LDD0899  [9]
 LDCM0302  AC40 HCT 116 C74(1.06); C83(1.06)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C74(0.76); C83(0.76)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C74(0.74); C83(0.74)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C74(0.34); C83(0.34)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C74(1.53); C83(1.53)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C74(1.50); C83(1.50)  LDD0624  [9]
 LDCM0308  AC46 HEK-293T C74(1.00); C83(0.99)  LDD0906  [9]
 LDCM0309  AC47 HEK-293T C74(0.99); C83(1.00)  LDD0907  [9]
 LDCM0310  AC48 HEK-293T C74(0.93); C83(0.94)  LDD0908  [9]
 LDCM0311  AC49 HEK-293T C74(1.06); C83(1.03)  LDD0909  [9]
 LDCM0312  AC5 HEK-293T C74(1.65); C83(1.26)  LDD0910  [9]
 LDCM0313  AC50 HEK-293T C74(0.99); C83(0.96)  LDD0911  [9]
 LDCM0314  AC51 HEK-293T C74(1.02); C83(0.93)  LDD0912  [9]
 LDCM0315  AC52 HEK-293T C74(0.88); C83(0.83)  LDD0913  [9]
 LDCM0316  AC53 HEK-293T C74(0.90); C83(0.94)  LDD0914  [9]
 LDCM0317  AC54 HEK-293T C74(1.00); C83(0.90)  LDD0915  [9]
 LDCM0318  AC55 HEK-293T C74(0.79); C83(0.83)  LDD0916  [9]
 LDCM0319  AC56 HEK-293T C74(0.96); C83(0.96)  LDD0917  [9]
 LDCM0320  AC57 HCT 116 C74(1.00); C83(1.00)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C74(0.79); C83(0.79)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C74(0.96); C83(0.96)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C74(0.61); C83(0.61)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C74(0.97); C83(0.97)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C74(0.93); C83(0.93)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C74(0.67); C83(0.67)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C74(0.74); C83(0.74)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C74(0.76); C83(0.76)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C74(0.80); C83(0.80)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C74(0.81); C83(0.81)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C74(0.69); C83(0.69)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C74(1.63); C83(1.63)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C74(1.28); C83(1.28)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C74(0.81); C83(0.81)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C74(1.07); C83(1.07)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C74(1.42); C83(1.42)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C74(1.00); C83(1.00)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C74(0.96); C83(0.96)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C74(1.87); C83(1.87)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C74(0.93); C83(0.93)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C74(1.50); C83(1.50)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C74(1.05); C83(1.05)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C74(1.52); C83(1.52)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C74(0.99); C83(0.99)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C74(0.69); C83(0.69)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C74(1.81); C83(1.81)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C74(1.62); C83(1.62)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C74(1.30); C83(1.30)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C74(0.71); C83(0.71)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C74(0.89); C83(0.89)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C74(0.77); C83(0.77)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C74(0.79); C83(0.79)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C74(1.03); C83(1.03)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C74(0.89); C83(0.89)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C74(0.79); C83(0.79)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C74(0.78); C83(0.78)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C74(0.76); C83(0.76)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C74(0.65); C83(0.65)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C74(0.90); C83(0.90)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C74(0.94); C83(0.94)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C74(0.80); C83(0.80)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C74(1.04); C83(1.04)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C74(0.69); C83(0.69)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C74(0.15); C83(0.58)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C74(0.32); C83(0.60)  LDD0683  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C74(0.44)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C74(0.94); C83(0.94)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C74(0.84); C83(0.84)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C74(0.57); C83(0.57)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C74(0.00); C83(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C74(0.42)  LDD2227  [14]
 LDCM0367  CL1 PaTu 8988t C83(1.11)  LDD1246  [9]
 LDCM0368  CL10 PaTu 8988t C83(1.30)  LDD1247  [9]
 LDCM0369  CL100 HEK-293T C74(1.10); C83(1.06)  LDD0967  [9]
 LDCM0370  CL101 HCT 116 C74(0.64); C83(0.64)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C74(0.94); C83(0.94)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C74(0.92); C83(0.92)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C74(0.97); C83(0.97)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C74(0.39); C83(0.63)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C74(0.41); C83(0.67)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C74(0.43); C83(0.74)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C74(0.39); C83(0.66)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C74(0.41); C83(0.68)  LDD0695  [9]
 LDCM0379  CL11 PaTu 8988t C83(1.04)  LDD1258  [9]
 LDCM0380  CL110 HCT 116 C74(0.34); C83(0.79)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C74(0.41); C83(0.90)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C74(1.23); C83(1.23)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C74(0.77); C83(0.77)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C74(0.80); C83(0.80)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C74(1.17); C83(1.17)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C74(0.94); C83(0.94)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C74(0.79); C83(0.79)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C74(0.67); C83(0.67)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C74(0.46); C83(0.46)  LDD0706  [9]
 LDCM0390  CL12 PaTu 8988t C83(1.74)  LDD1269  [9]
 LDCM0391  CL120 HCT 116 C74(0.49); C83(0.49)  LDD0708  [9]
 LDCM0392  CL121 HEK-293T C74(0.90); C83(0.93)  LDD0990  [9]
 LDCM0393  CL122 HEK-293T C74(0.88); C83(0.87)  LDD0991  [9]
 LDCM0394  CL123 HEK-293T C74(0.98); C83(0.97)  LDD0992  [9]
 LDCM0395  CL124 HEK-293T C74(1.00); C83(0.94)  LDD0993  [9]
 LDCM0396  CL125 HCT 116 C74(0.93); C83(0.93)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C74(0.84); C83(0.84)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C74(0.84); C83(0.84)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C74(0.79); C83(0.79)  LDD0716  [9]
 LDCM0400  CL13 PaTu 8988t C83(1.61)  LDD1279  [9]
 LDCM0401  CL14 PaTu 8988t C83(1.30)  LDD1280  [9]
 LDCM0402  CL15 PaTu 8988t C83(0.97)  LDD1281  [9]
 LDCM0403  CL16 PaTu 8988t C74(0.59); C83(0.59)  LDD1282  [9]
 LDCM0404  CL17 HCT 116 C74(0.72); C83(0.72)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C74(0.90); C83(0.90)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C74(0.88); C83(0.88)  LDD0723  [9]
 LDCM0407  CL2 PaTu 8988t C83(1.00)  LDD1286  [9]
 LDCM0408  CL20 HCT 116 C74(0.69); C83(0.69)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C74(0.73); C83(0.73)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C74(1.24); C83(1.24)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C74(0.65); C83(0.65)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C74(0.97); C83(0.97)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C74(0.73); C83(0.73)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C74(0.96); C83(0.96)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C74(0.93); C83(0.93)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C74(0.75); C83(0.75)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C74(0.81); C83(0.81)  LDD0734  [9]
 LDCM0418  CL3 PaTu 8988t C83(1.25)  LDD1297  [9]
 LDCM0419  CL30 HCT 116 C74(1.24); C83(1.24)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C74(0.90); C83(0.87)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C74(0.78); C83(0.71)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C74(0.88); C83(0.83)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C74(0.84); C83(0.87)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C74(0.70); C83(0.89)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C74(0.72); C83(0.83)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C74(0.68); C83(0.92)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C74(0.73); C83(0.85)  LDD0745  [9]
 LDCM0429  CL4 PaTu 8988t C83(1.41)  LDD1308  [9]
 LDCM0430  CL40 HCT 116 C74(0.66); C83(0.82)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C74(0.71); C83(0.73)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C74(0.78); C83(0.80)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C74(0.84); C83(0.74)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C74(0.72); C83(0.73)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C74(0.82); C83(0.72)  LDD0752  [9]
 LDCM0436  CL46 HEK-293T C83(1.04)  LDD1034  [9]
 LDCM0437  CL47 HEK-293T C83(0.97)  LDD1035  [9]
 LDCM0438  CL48 HEK-293T C83(0.87)  LDD1036  [9]
 LDCM0439  CL49 HEK-293T C83(1.00)  LDD1037  [9]
 LDCM0440  CL5 PaTu 8988t C83(1.62)  LDD1319  [9]
 LDCM0441  CL50 HEK-293T C83(1.09)  LDD1039  [9]
 LDCM0442  CL51 HEK-293T C83(0.96)  LDD1040  [9]
 LDCM0443  CL52 HEK-293T C83(1.06)  LDD1041  [9]
 LDCM0444  CL53 HEK-293T C83(1.04)  LDD1042  [9]
 LDCM0445  CL54 HEK-293T C83(1.06)  LDD1043  [9]
 LDCM0446  CL55 HEK-293T C83(1.03)  LDD1044  [9]
 LDCM0447  CL56 HEK-293T C83(0.92)  LDD1045  [9]
 LDCM0448  CL57 HEK-293T C83(1.00)  LDD1046  [9]
 LDCM0449  CL58 HEK-293T C83(0.91)  LDD1047  [9]
 LDCM0450  CL59 HEK-293T C83(0.98)  LDD1048  [9]
 LDCM0451  CL6 PaTu 8988t C83(0.91)  LDD1330  [9]
 LDCM0452  CL60 HEK-293T C83(1.17)  LDD1050  [9]
 LDCM0453  CL61 HCT 116 C74(0.96); C83(0.91)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C74(1.20); C83(0.90)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C74(0.74); C83(0.78)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C74(1.08); C83(0.85)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C74(1.06); C83(0.96)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C74(0.88); C83(0.76)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C74(0.97); C83(0.90)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C74(0.81); C83(1.00)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C74(0.92); C83(0.91)  LDD0778  [9]
 LDCM0462  CL7 PaTu 8988t C83(1.22)  LDD1341  [9]
 LDCM0463  CL70 HCT 116 C74(0.73); C83(0.84)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C74(1.00); C83(1.11)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C74(0.84); C83(0.99)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C74(0.74); C83(0.93)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C74(0.75); C83(0.88)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C83(1.26)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C83(1.15)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C83(1.08)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C83(1.39)  LDD0789  [9]
 LDCM0473  CL8 PaTu 8988t C83(1.42)  LDD1352  [9]
 LDCM0474  CL80 HCT 116 C83(1.43)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C83(0.99)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C83(1.35)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C83(1.06)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C83(1.02)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C83(1.48)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C83(1.38)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C83(1.32)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C83(1.35)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C83(1.28)  LDD0800  [9]
 LDCM0484  CL9 PaTu 8988t C83(1.28)  LDD1363  [9]
 LDCM0485  CL90 HCT 116 C83(1.33)  LDD0802  [9]
 LDCM0486  CL91 HEK-293T C74(0.76); C83(0.98)  LDD1084  [9]
 LDCM0487  CL92 HEK-293T C74(0.63); C83(0.83)  LDD1085  [9]
 LDCM0488  CL93 HEK-293T C74(0.70); C83(0.79)  LDD1086  [9]
 LDCM0489  CL94 HEK-293T C74(0.78); C83(0.95)  LDD1087  [9]
 LDCM0490  CL95 HEK-293T C74(0.75); C83(0.83)  LDD1088  [9]
 LDCM0491  CL96 HEK-293T C74(1.00); C83(0.97)  LDD1089  [9]
 LDCM0492  CL97 HEK-293T C74(0.81); C83(0.84)  LDD1090  [9]
 LDCM0493  CL98 HEK-293T C74(0.71); C83(0.91)  LDD1091  [9]
 LDCM0494  CL99 HEK-293T C74(0.82); C83(0.90)  LDD1092  [9]
 LDCM0495  E2913 HEK-293T C74(1.13); C83(0.77)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C83(1.72); C74(1.23)  LDD1702  [5]
 LDCM0625  F8 Ramos 1.42  LDD2187  [25]
 LDCM0572  Fragment10 Ramos 1.10  LDD2189  [25]
 LDCM0573  Fragment11 Ramos 20.00  LDD2190  [25]
 LDCM0574  Fragment12 Ramos 0.84  LDD2191  [25]
 LDCM0575  Fragment13 Ramos 2.10  LDD2192  [25]
 LDCM0576  Fragment14 Ramos 1.03  LDD2193  [25]
 LDCM0579  Fragment20 Ramos 0.88  LDD2194  [25]
 LDCM0580  Fragment21 Ramos 1.27  LDD2195  [25]
 LDCM0582  Fragment23 Ramos 2.05  LDD2196  [25]
 LDCM0578  Fragment27 Ramos 1.11  LDD2197  [25]
 LDCM0586  Fragment28 Ramos 1.15  LDD2198  [25]
 LDCM0588  Fragment30 Ramos 1.26  LDD2199  [25]
 LDCM0590  Fragment32 Ramos 1.20  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C74(0.73); C83(0.78)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos 0.93  LDD2203  [25]
 LDCM0566  Fragment4 Ramos 1.13  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C74(0.74); C83(0.99)  LDD0744  [9]
 LDCM0569  Fragment7 Ramos 0.74  LDD2186  [25]
 LDCM0571  Fragment9 Ramos 0.84  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y117(0.79)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y117(0.87)  LDD0265  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C74(0.96); C83(1.12); C74(0.97); C83(0.97)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C74(0.82); C83(1.02); C74(0.99); C83(0.99)  LDD1497  [24]
 LDCM0024  KB05 HEK-293T C74(0.94); C83(1.16); C74(0.95); C83(0.95)  LDD1502  [24]
 LDCM0109  NEM HeLa N.A.  LDD0224  [21]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C83(0.66); C74(1.14)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C83(0.99); C74(2.18)  LDD2094  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C74(1.06)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C83(2.00); C74(1.76)  LDD2098  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C74(0.44)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C83(2.80); C74(2.38)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C74(0.90)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C74(0.48)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C74(0.79)  LDD2109  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C74(0.44)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C74(0.39)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C74(0.37)  LDD2116  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C74(1.57)  LDD2119  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C74(0.31)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C74(0.29)  LDD2123  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C74(1.06)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C83(0.72)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C74(0.76)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C83(0.64); C74(0.55)  LDD2134  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C74(0.64)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C74(0.80)  LDD2143  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C74(2.58)  LDD2145  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C74(0.36)  LDD2148  [5]
 LDCM0131  RA190 MM1.R C83(1.07)  LDD0304  [26]

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.