Details of the Target

General Information of Target

Target ID LDTP01037
Target Name Catenin delta-1 (CTNND1)
Gene Name CTNND1
Gene ID 1500
Synonyms
KIAA0384; Catenin delta-1; Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas)
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTL
TRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGA
MSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGPDGLPVDASSVSNNYIQTLGR
DFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEER
YRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMS
DYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPP
PNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPVLVGLLDHP
KKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLS
SHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSE
RSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERY
QEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLF
QPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLT
NEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILN
TINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLE
KEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSL
DNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQV
SYPSMQKI
Target Bioclass
Transporter and channel
Family
Beta-catenin family
Subcellular location
Nucleus; Cell junction, adherens junction
Function
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
Uniprot ID
O60716
Ensemble ID
ENST00000358694.10
HGNC ID
HGNC:2515

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T133I DBIA    Probe Info 
CAL148 SNV: p.S777C DBIA    Probe Info 
CAL78 SNV: p.K881N DBIA    Probe Info 
CCK81 Deletion: p.Q107RfsTer17 DBIA    Probe Info 
HT115 SNV: p.R820Ter DBIA    Probe Info 
JURKAT SNV: p.Q800Ter .
LNCaP clone FGC SNV: p.T611N DBIA    Probe Info 
LS123 SNV: p.R797Ter DBIA    Probe Info 
LS180 Deletion: p.V148DfsTer24
SNV: p.W477Ter		 DBIA    Probe Info 
MCC13 SNV: p.M487I DBIA    Probe Info 
MFE319 SNV: p.L476P DBIA    Probe Info 
MOLM16 SNV: p.T774A DBIA    Probe Info 
NALM6 SNV: p.R836Q DBIA    Probe Info 
NCIH23 SNV: p.G831R DBIA    Probe Info 
RKN SNV: p.T774A DBIA    Probe Info 
SKOV3 SNV: p.E20K DBIA    Probe Info 
SNU245 SNV: p.H425N DBIA    Probe Info 
SNU478 SNV: p.K846Ter DBIA    Probe Info 
SUIT2 SNV: p.Q877Ter DBIA    Probe Info 
SW756 SNV: p.L923V DBIA    Probe Info 
TOV21G SNV: p.M324I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P8
 Probe Info  		10.00  LDD0451  [2]
CHEMBL5175495
 Probe Info  		7.09  LDD0196  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K142(10.00); K401(10.00); K421(10.00); K710(3.04)  LDD0277  [5]
ONAyne
 Probe Info  		K622(10.00)  LDD0275  [5]
Probe 1
 Probe Info  		Y217(9.54); Y221(10.75); Y228(13.38); Y257(15.16)  LDD3495  [6]
BTD
 Probe Info  		C429(1.63); C516(0.89)  LDD1700  [7]
AHL-Pu-1
 Probe Info  		C692(3.41)  LDD0170  [8]
EA-probe
 Probe Info  		C692(0.93)  LDD2210  [9]
HHS-475
 Probe Info  		Y217(0.49); Y228(0.64); Y221(0.71); Y280(0.83)  LDD0264  [10]
DBIA
 Probe Info  		C618(1.08); C581(0.89); C394(0.86)  LDD0078  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		K749(0.00); K728(0.00); K433(0.00)  LDD0199  [13]
IA-alkyne
 Probe Info  		C533(0.00); C618(0.00); C692(0.00)  LDD0032  [14]
ATP probe
 Probe Info  		K710(0.00); K448(0.00)  LDD0035  [15]
JW-RF-010
 Probe Info  		C618(0.00); C692(0.00)  LDD0026  [16]
NAIA_4
 Probe Info  		C394(0.00); C533(0.00); C618(0.00); C692(0.00)  LDD2226  [17]
TFBX
 Probe Info  		C692(0.00); C618(0.00)  LDD0027  [16]
WYneN
 Probe Info  		C429(0.00); C450(0.00); C618(0.00); C692(0.00)  LDD0021  [18]
WYneO
 Probe Info  		C692(0.00); C516(0.00); C618(0.00)  LDD0022  [18]
aHNE
 Probe Info  		N.A.  LDD0001  [18]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		C429(0.00); C618(0.00)  LDD0005  [18]
PF-06672131
 Probe Info  		N.A.  LDD0017  [19]
SF
 Probe Info  		N.A.  LDD0028  [20]
VSF
 Probe Info  		C516(0.00); C618(0.00)  LDD0007  [18]
Phosphinate-6
 Probe Info  		C450(0.00); C618(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		N.A.  LDD0228  [22]
Acrolein
 Probe Info  		H723(0.00); C692(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		C618(0.00); C394(0.00); C581(0.00)  LDD0218  [23]
W1
 Probe Info  		C394(0.00); C618(0.00); C533(0.00); C692(0.00)  LDD0236  [24]
AOyne
 Probe Info  		8.10  LDD0443  [25]
NAIA_5
 Probe Info  		C551(0.00); C618(0.00); C516(0.00); C429(0.00)  LDD2223  [17]
HHS-465
 Probe Info  		N.A.  LDD2240  [26]
HHS-482
 Probe Info  		Y217(1.57); Y221(1.55); Y228(1.56); Y280(0.97)  LDD2239  [27]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		16.50  LDD0475  [28]
FFF probe14
 Probe Info  		9.40  LDD0477  [28]
FFF probe2
 Probe Info  		13.52  LDD0463  [28]
FFF probe3
 Probe Info  		8.73  LDD0465  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C429(0.94)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C516(0.91)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C429(1.13)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C429(1.11)  LDD2103  [7]
 LDCM0025  4SU-RNA DM93 C692(3.41)  LDD0170  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C618(2.18); C516(2.25)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C394(0.97); C429(0.94); C450(0.86); C516(1.10)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C394(0.98); C429(0.86); C450(0.85); C516(1.07)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C394(0.60); C429(0.73); C450(0.72); C516(0.76)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C394(0.63); C429(0.70); C450(0.68); C516(0.79)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C394(0.59); C429(0.70); C450(0.62); C516(0.87)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C394(0.62); C429(0.70); C450(0.69); C516(0.83)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C394(0.72); C429(0.65); C450(0.64); C516(0.79)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C394(0.66); C429(0.63); C450(0.71); C516(0.83)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C394(0.57); C429(0.66); C450(0.80); C516(0.84)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C394(0.64); C429(0.68); C450(0.72); C516(0.71)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C394(0.68); C429(0.68); C450(0.70); C516(0.90)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C394(0.63); C429(0.66); C450(0.70); C516(0.82)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C394(0.91); C429(0.84); C450(0.75); C516(1.03)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C394(0.76); C429(0.64); C450(0.66); C516(0.96)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C394(0.65); C429(0.65); C450(0.69); C516(0.89)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C394(0.55); C429(0.60); C450(0.63); C516(0.78)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C394(0.89); C429(0.98); C450(1.06); C516(0.95)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C394(0.93); C429(0.88); C450(1.02); C516(1.06)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C394(0.92); C429(0.82); C450(1.11); C516(1.32)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C394(0.89); C429(0.85); C450(1.00); C516(1.15)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C394(0.87); C429(0.94); C450(0.97); C516(1.25)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C394(0.86); C429(0.88); C450(1.10); C516(1.17)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C394(0.95); C429(0.96); C450(0.94); C516(1.30)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C394(0.95); C429(0.93); C450(0.83); C516(0.88)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C394(1.01); C429(0.95); C450(0.78); C516(0.97)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C394(1.06); C429(1.19); C450(0.94); C516(1.05)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C394(0.99); C429(1.06); C450(1.17); C516(1.19)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C394(1.19); C429(0.94); C450(1.00); C516(1.20)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C394(0.97); C429(1.14); C450(1.18); C516(1.02)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C394(0.91); C429(1.06); C450(1.15); C516(1.07)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C394(1.10); C429(0.92); C450(1.05); C516(1.11)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C394(0.94); C429(0.95); C450(1.08); C516(1.33)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C394(1.27); C429(1.26); C450(1.25); C516(1.04)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C394(1.08); C429(1.17); C450(1.57); C516(0.83)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C394(1.03); C429(1.15); C450(1.31); C516(1.08)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C394(1.16); C429(1.00); C450(1.58); C516(0.88)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C394(0.99); C429(1.08); C450(1.09); C516(0.97)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C394(1.01); C429(1.10); C450(1.25); C516(0.97)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C394(1.08); C429(1.00); C450(1.43); C516(0.97)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C394(1.13); C429(1.12); C450(1.27); C516(0.87)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C394(1.05); C429(1.02); C450(1.07); C516(0.95)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C394(1.14); C429(1.14); C450(0.96); C516(0.90)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C394(1.30); C429(1.06); C450(1.17); C516(1.10)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C394(1.05); C429(1.03); C450(1.40); C516(1.15)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C394(0.94); C429(0.82); C450(0.80); C516(1.00)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C394(1.15); C429(1.07); C450(1.34); C516(1.15)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C394(1.12); C429(1.01); C450(1.26); C516(1.01)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C394(1.07); C429(0.99); C450(1.13); C516(0.98)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C394(0.88); C429(0.86); C450(1.00); C516(1.02)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C579(0.75); C533(0.79); C692(0.80); C581(0.80)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C429(0.79); C579(0.81); C581(0.86); C692(0.88)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C692(0.75); C533(0.76); C429(0.76); C579(0.77)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C692(0.78); C579(0.80); C429(0.83); C581(0.90)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C429(0.86); C692(0.87); C579(0.88); C533(1.05)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C692(0.77); C429(0.77); C579(0.80); C581(0.87)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C429(0.83); C533(0.84); C450(0.86); C618(0.89)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C533(0.85); C692(0.85); C429(0.88); C579(0.91)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C429(0.78); C581(0.82); C579(0.85); C533(0.85)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C429(0.77); C692(0.80); C450(0.90); C533(0.93)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C692(0.89); C429(0.91); C533(0.96); C579(0.98)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C394(1.04); C429(0.74); C450(1.05); C516(1.24)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C394(0.99); C429(0.73); C450(1.04); C516(1.25)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C394(0.97); C429(0.84); C450(0.96); C516(0.86)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C394(1.03); C429(0.73); C450(1.18); C516(1.18)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C394(0.88); C429(0.89); C692(0.95); C533(0.95)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C692(0.82); C450(0.94); C429(0.96); C394(0.97)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C533(0.62); C429(0.78); C394(0.88); C692(1.00)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C618(0.75); C533(0.76); C394(0.86); C429(0.86)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C533(0.72); C429(0.89); C692(1.03); C516(1.03)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C692(0.82); C429(0.91); C516(1.00); C394(1.06)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C692(0.98); C394(1.04); C516(1.04); C429(1.07)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C533(0.85); C692(0.85); C394(0.88); C516(0.95)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C429(0.84); C516(1.02); C533(1.04); C394(1.08)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C692(0.65); C581(0.76); C533(0.82); C579(0.86)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C692(0.62); C581(0.75); C533(0.81); C394(0.82)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C692(0.60); C581(0.70); C394(0.78); C429(0.80)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C692(0.67); C581(0.75); C429(0.82); C579(0.85)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C692(0.64); C581(0.75); C533(0.78); C579(0.79)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C618(0.71); C429(0.87); C533(0.89); C450(0.97)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C692(0.62); C581(0.70); C579(0.75); C429(0.76)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C692(0.67); C581(0.74); C579(0.78); C429(0.79)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C692(0.59); C533(0.71); C581(0.73); C579(0.75)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C692(0.65); C533(0.69); C581(0.76); C394(0.80)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C692(0.67); C581(0.73); C579(0.78); C429(0.80)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C394(0.90); C450(0.91); C618(0.93); C581(1.06)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C618(0.91); C533(0.94); C394(0.96); C429(1.06)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C618(0.70); C533(0.87); C394(1.01); C692(1.02)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C394(0.91); C618(0.94); C579(0.98); C429(1.01)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C618(0.71); C533(0.94); C394(1.00); C450(1.02)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C618(0.69); C429(0.87); C533(0.88); C579(1.00)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C394(1.04); C618(1.04); C533(1.04); C581(1.04)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C618(0.82); C394(0.87); C533(0.91); C450(0.95)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C618(0.90); C450(0.90); C429(0.91); C394(0.94)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C618(0.82); C533(0.87); C394(0.91); C429(0.99)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C618(0.81); C533(0.95); C394(0.99); C450(1.01)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C618(0.86); C533(0.87); C429(1.04); C394(1.05)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C394(0.52); C581(0.94); C579(0.94); C450(0.97)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C394(0.73); C581(0.96); C579(0.98); C533(1.03)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C618(0.83); C581(0.97); C579(1.02); C533(1.08)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C581(1.03); C579(1.06); C692(1.09); C394(1.10)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C618(0.58); C533(0.78); C429(0.86); C692(0.93)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C394(1.00); C429(1.05); C533(1.07); C581(1.08)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C516(0.89); C581(0.97); C579(0.98); C618(1.07)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C394(0.77); C516(0.95); C429(0.96); C581(0.97)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C429(0.95); C581(1.00); C692(1.01); C394(1.01)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C429(1.00); C516(1.01); C581(1.03); C692(1.04)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C394(0.86); C429(1.07); C618(1.07); C516(1.09)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C692(1.10); C429(1.23); C581(1.26); C579(1.28)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C618(0.75); C533(0.78); C579(0.84); C394(0.85)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C533(0.85); C429(0.86); C692(0.87); C579(0.89)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C618(0.74); C429(0.78); C533(0.85); C692(0.86)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C533(0.76); C692(0.88); C618(0.90); C581(0.91)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C429(0.73); C618(0.76); C450(0.79); C394(0.81)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C618(0.58); C429(0.73); C533(0.74); C394(0.83)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C618(0.79); C429(0.81); C394(0.83); C581(0.98)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C394(0.80); C429(0.87); C618(0.89); C692(0.90)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C618(0.66); C429(0.76); C394(0.86); C692(0.89)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C618(0.60); C429(0.68); C533(0.71); C394(0.82)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C533(0.68); C618(0.71); C429(0.77); C394(0.86)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C618(0.66); C429(0.68); C394(0.81); C533(0.88)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C692(0.91); C450(0.92); C533(0.98); C618(1.01)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C450(1.01); C692(1.03); C394(1.03); C533(1.06)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C618(0.65); C450(0.78); C692(0.86); C533(0.87)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C692(0.86); C394(0.89); C579(0.97); C618(0.97)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C618(0.86); C692(0.90); C533(0.97); C516(0.99)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C394(0.97); C579(0.98); C450(0.99); C429(0.99)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C692(1.03); C533(1.07); C579(1.07); C394(1.10)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C692(1.11); C450(1.16); C533(1.18); C394(1.19)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C394(1.14); C533(1.18); C692(1.25); C429(1.29)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C692(0.95); C533(0.97); C394(1.03); C516(1.05)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C533(0.91); C692(0.93); C516(1.01); C429(1.04)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C533(0.92); C692(0.97); C579(1.00); C394(1.01)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C692(0.94); C450(0.98); C516(0.99); C579(1.01)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C450(0.73); C692(0.77); C533(0.80); C618(0.83)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C692(0.89); C429(1.00); C533(1.03); C394(1.06)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C450(0.91); C533(0.93); C692(0.95); C429(1.03)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C692(1.09); C394(1.18); C618(1.18); C450(1.20)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C394(0.55); C533(0.88); C450(0.89); C692(0.97)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C450(0.81); C394(0.86); C429(0.93); C533(0.96)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C450(0.80); C394(0.88); C579(0.89); C533(0.90)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C429(0.84); C450(0.84); C579(0.85); C533(0.86)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C450(0.83); C692(0.90); C533(0.92); C429(0.99)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C450(0.82); C533(0.83); C579(0.90); C429(0.92)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C394(0.75); C533(0.81); C429(0.82); C579(0.90)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C394(0.87); C533(0.90); C581(0.95); C618(0.98)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C394(0.79); C692(0.86); C429(0.89); C533(0.90)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C394(0.69); C533(0.83); C429(0.91); C581(0.92)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C394(0.72); C450(0.79); C692(0.81); C581(0.82)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C450(0.82); C394(0.86); C429(0.96); C516(0.97)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C533(0.89); C579(0.91); C429(0.93); C450(0.97)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C429(0.91); C450(0.94); C533(0.97); C581(0.97)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C450(0.80); C533(0.82); C429(0.84); C692(0.92)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C692(0.62); C394(0.65); C450(0.67); C533(0.70)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C394(0.66); C692(0.67); C450(0.71); C533(0.76)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C394(1.02); C429(0.92); C450(0.84); C516(0.93)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C618(0.70); C533(0.81); C394(0.84); C429(0.88)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C533(0.79); C429(0.86); C692(0.89); C450(0.92)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 11.39  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C618(1.08); C581(0.89); C394(0.86)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C429(0.44)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C692(0.00); C533(0.00); C394(0.00); C429(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C692(1.20); C533(0.95); C394(0.89)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C394(0.49); C692(0.80); C450(0.87); C581(0.92)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C533(0.86); C692(0.87); C429(0.88); C581(0.96)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C618(0.79); C692(0.87); C533(0.88); C429(0.91)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C692(0.78); C450(0.80); C533(0.83); C429(0.89)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C429(0.83); C533(0.86); C516(0.88); C450(0.91)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C533(0.79); C429(0.86); C516(0.91); C692(0.91)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C429(0.82); C450(0.85); C692(0.87); C516(0.93)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C394(0.58); C533(0.61); C429(0.85); C450(0.85)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C533(0.80); C516(0.89); C394(0.92); C692(0.94)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C533(0.65); C394(0.87); C692(0.88); C429(0.95)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C533(0.80); C394(0.88); C429(0.90); C450(0.92)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C533(0.62); C429(0.75); C692(0.87); C394(0.89)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C394(0.70); C533(0.95); C692(0.98); C429(1.00)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C533(0.59); C394(0.74); C429(0.78); C692(0.85)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C533(0.75); C429(0.78); C692(0.80); C394(0.88)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C692(0.73); C581(0.82); C579(0.88); C516(0.90)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C692(0.64); C581(0.70); C533(0.73); C579(0.75)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C692(0.63); C533(0.71); C429(0.76); C579(0.76)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C692(0.55); C429(0.72); C581(0.76); C533(0.77)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C692(0.64); C581(0.77); C394(0.81); C579(0.84)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C533(1.10); C450(1.11); C692(1.12); C429(1.13)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C618(0.71); C533(0.92); C450(0.96); C394(1.02)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C618(0.91); C533(0.92); C450(0.94); C429(0.95)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C394(0.95); C533(0.96); C429(0.96); C692(1.02)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C618(0.67); C533(0.95); C394(0.96); C516(0.98)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C394(0.65); C429(0.70); C692(0.82); C533(0.93)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C394(0.75); C692(0.98); C429(1.02); C533(1.04)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C581(0.97); C429(0.98); C692(0.99); C533(1.00)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C692(1.00); C581(1.02); C579(1.03); C429(1.04)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C618(0.65); C533(0.80); C429(0.82); C394(0.82)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C533(0.75); C429(0.78); C450(0.79); C579(0.85)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C618(0.74); C533(0.75); C429(0.76); C394(0.82)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C618(0.73); C533(0.81); C429(0.85); C581(0.87)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C394(0.86); C533(0.96); C429(0.97); C692(1.00)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C533(0.87); C429(0.89); C692(0.92); C579(0.94)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C394(0.87); C533(0.88); C692(0.89); C429(0.90)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C692(0.76); C429(0.78); C450(0.83); C533(0.84)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C450(0.81); C692(0.84); C429(0.85); C581(0.89)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C533(0.79); C692(0.84); C429(0.87); C450(0.90)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C429(0.87); C533(0.89); C692(0.93); C581(1.00)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C692(0.87); C394(0.88); C581(0.92); C579(0.95)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C429(0.78); C692(0.83); C533(0.88); C394(0.92)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C429(0.81); C692(0.85); C394(0.86); C533(0.91)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C533(0.90); C429(0.95); C394(1.11); C692(1.13)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C533(0.81); C429(0.84); C516(0.91); C394(0.91)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C429(0.79); C450(0.89); C533(0.91); C692(0.94)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C394(0.88); C429(0.79); C450(0.87); C516(1.05)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C394(0.92); C429(0.78); C450(0.85); C516(1.14)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C394(0.83); C429(0.75); C450(1.14); C516(0.97)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C394(0.96); C429(0.71); C450(0.86); C516(1.26)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C394(0.87); C429(0.79); C450(0.96); C516(1.08)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C394(0.97); C429(1.00); C450(1.19); C516(0.91)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C394(0.96); C429(0.77); C450(0.97); C516(1.08)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C394(0.69); C429(0.88); C450(1.82); C516(1.21)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C394(0.87); C429(0.95); C450(1.25); C516(1.10)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C394(0.86); C429(0.86); C450(1.09); C516(1.24)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C394(1.96); C429(0.85); C450(1.28); C516(1.37)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C394(1.06); C429(0.84); C450(1.42); C516(1.48)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C394(0.87); C429(0.83); C450(1.24); C516(1.29)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C394(1.09); C429(0.83); C450(1.31); C516(1.30)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C394(0.95); C429(0.93); C450(1.34); C516(1.47)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C394(0.87); C429(0.87); C450(1.08); C516(0.97)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C394(0.84); C429(0.80); C450(1.23); C516(1.34)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C394(0.87); C429(0.75); C450(1.37); C516(1.28)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C394(0.78); C429(0.95); C450(1.22); C516(1.72)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C394(1.00); C429(0.87); C450(1.26); C516(1.55)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C394(0.88); C429(0.81); C450(1.17); C516(1.36)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C394(0.85); C429(0.87); C450(1.05); C516(1.39)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C394(0.57); C429(0.91); C450(1.21); C516(0.96)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C394(1.05); C429(1.00); C450(1.00); C516(0.93)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C394(1.30); C429(0.98); C450(1.13); C516(1.07)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C394(0.67); C429(0.99); C450(1.31); C516(0.89)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C394(0.82); C429(0.96); C450(0.92); C516(1.12)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C394(1.13); C429(0.93); C450(1.24); C516(0.90)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C394(1.26); C429(0.92); C450(1.31); C516(0.97)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C394(1.17); C429(0.74); C450(1.22); C516(0.90)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C394(1.69); C429(0.79); C450(1.32); C516(0.88)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C394(1.10); C429(0.82); C450(1.07); C516(0.79)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C394(0.90); C429(0.88); C450(1.29); C516(0.80)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C394(1.04); C429(0.79); C450(1.07); C516(0.83)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C394(1.04); C429(0.73); C450(1.10); C516(0.81)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C394(1.17); C429(0.77); C450(1.10); C516(0.97)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C394(1.26); C429(0.76); C450(1.07); C516(0.84)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C394(0.93); C429(0.97); C450(0.96); C516(1.09)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C394(1.14); C429(0.78); C450(1.10); C516(0.80)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C394(0.73); C429(0.94); C450(0.96); C516(1.08)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C394(0.98); C429(0.98); C450(0.75); C516(1.00)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C394(1.00); C429(0.94); C450(0.76); C516(1.17)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C394(0.90); C429(0.83); C450(0.91); C516(1.02)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C394(1.04); C429(0.93); C450(0.95); C516(0.87)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C394(0.99); C429(0.96); C450(0.82); C516(0.93)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C394(1.08); C429(0.90); C450(0.87); C516(0.96)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C394(1.22); C429(0.87); C450(1.01); C516(1.06)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C394(0.96); C429(0.86); C450(0.90); C516(0.84)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C394(0.88); C429(1.02); C450(1.03); C516(1.36)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C394(1.04); C429(0.93); C450(0.79); C516(1.02)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C394(0.81); C429(0.99); C450(0.87); C516(0.97)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C394(0.90); C429(0.95); C450(0.86); C516(1.02)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C394(1.07); C429(0.85); C450(0.87); C516(0.85)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C394(1.03); C429(0.87); C450(1.08); C516(0.91)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C394(0.68); C429(0.93); C450(1.08); C516(1.04)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C394(1.23); C429(0.93); C450(1.27); C516(1.00)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C394(1.12); C429(0.93); C450(1.00); C516(1.05)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C394(1.00); C429(0.93); C450(1.28); C516(0.99)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C394(0.89); C429(0.95); C450(1.08); C516(1.11)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C394(1.06); C429(0.92); C450(1.02); C516(0.91)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C394(1.13); C429(1.01); C450(1.06); C516(1.01)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C394(1.23); C429(1.07); C450(1.31); C516(1.16)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C394(1.10); C429(1.00); C450(1.16); C516(1.08)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C394(1.00); C429(1.08); C450(1.11); C516(1.21)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C394(1.04); C429(0.95); C450(1.08); C516(1.01)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C394(0.93); C429(0.99); C450(0.90); C516(0.97)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C394(1.10); C429(0.91); C450(0.95); C516(0.97)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C394(1.26); C429(0.96); C450(1.11); C516(1.00)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C394(1.12); C429(1.21); C450(1.24); C516(1.30)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C394(0.84); C429(0.94); C450(1.38); C516(1.03)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C394(1.08); C429(1.02); C450(1.00); C516(0.89)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C394(1.07); C429(0.91); C450(0.92); C516(1.09)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C394(1.01); C429(0.99); C450(0.97); C516(0.99)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C394(1.02); C429(0.93); C450(1.08); C516(1.07)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C394(1.09); C429(0.80); C450(0.92); C516(0.98)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C394(1.02); C429(0.79); C450(0.89); C516(1.03)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C394(1.07); C429(0.82); C450(0.88); C516(1.10)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C394(1.07); C429(0.75); C450(0.91); C516(1.12)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C394(1.12); C429(0.87); C450(1.03); C516(0.98)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C394(0.87); C429(0.83); C450(0.87); C516(1.18)  LDD0811  [11]
 LDCM0495  E2913 HEK-293T C516(0.89); C618(1.07); C429(1.03); C450(1.00)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C429(4.45); C450(4.34); C533(2.37); C394(1.44)  LDD1702  [7]
 LDCM0175  Ethacrynic acid HeLa C692(0.93)  LDD2210  [9]
 LDCM0574  Fragment12 Ramos C618(0.48)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C618(0.74)  LDD2192  [30]
 LDCM0579  Fragment20 Ramos C618(0.73)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C618(0.59)  LDD2195  [30]
 LDCM0578  Fragment27 Ramos C618(0.65)  LDD2197  [30]
 LDCM0589  Fragment31 Ramos C618(1.46)  LDD2200  [30]
 LDCM0468  Fragment33 HCT 116 C394(0.95); C429(0.79); C450(0.94); C516(0.96)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C618(0.56)  LDD2203  [30]
 LDCM0427  Fragment51 HCT 116 C394(0.79); C429(0.94); C450(1.68); C516(1.34)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C618(1.05)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C618(1.16)  LDD2205  [30]
 LDCM0116  HHS-0101 DM93 Y217(0.49); Y228(0.64); Y221(0.71); Y280(0.83)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y228(0.54); Y221(0.60); Y280(0.62)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y221(0.51); Y280(0.70); Y228(0.76); Y217(1.34)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y217(0.44); Y221(0.61); Y280(0.72); Y228(1.02)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y217(0.63); Y221(0.76); Y228(0.80); Y280(1.22)  LDD0268  [10]
 LDCM0107  IAA HeLa H723(0.00); C579(0.00)  LDD0221  [23]
 LDCM0022  KB02 HCT 116 C618(2.47); C394(2.06); C533(2.44)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C618(1.72); C394(2.31); C533(3.34)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C618(3.96); C394(3.63); C533(2.97)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C429(0.52)  LDD2121  [7]
 LDCM0109  NEM HeLa H723(0.00); H216(0.00); H750(0.00)  LDD0223  [23]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C618(1.10); C516(0.68)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C429(1.04)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C429(1.04)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C429(0.86); C516(1.27)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C429(0.94); C516(0.83)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C429(0.74); C516(1.09); C450(0.89)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C429(0.85)  LDD2100  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C429(1.26); C450(1.08)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C516(0.85)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C516(0.83)  LDD2107  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C429(1.11)  LDD2111  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C618(0.74); C516(1.18)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C429(1.22)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C429(0.78)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C618(1.62)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C429(0.84); C618(0.81); C516(0.81); C450(1.50)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C516(0.90)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C618(0.99); C450(1.12)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C516(1.15)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C516(0.91)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C516(0.89)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C429(1.07); C618(0.89); C516(0.66)  LDD2129  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C429(1.06); C516(0.96); C450(1.35)  LDD2135  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C429(0.94); C618(0.84); C516(1.06); C579(1.97)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C429(1.63); C516(0.89)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C429(0.75); C618(1.03); C516(0.76); C450(0.73)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C429(0.73); C618(0.63)  LDD2143  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C429(1.15); C516(1.00); C450(0.71)  LDD2146  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C618(0.87)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C429(0.52); C618(0.48)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C450(0.83); C692(0.70); C618(0.07)  LDD2206  [31]
 LDCM0628  OTUB2-COV-1 HEK-293T C692(0.98); C618(0.32)  LDD2207  [31]
 LDCM0021  THZ1 HCT 116 C618(1.09); C533(1.13)  LDD2173  [11]
 LDCM0110  W12 Hep-G2 C618(9.27)  LDD0237  [24]
 LDCM0111  W14 Hep-G2 C618(7.97)  LDD0238  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid phosphatase 3 (PLPP3) PA-phosphatase related phosphoesterase family O14495
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor-type tyrosine-protein phosphatase eta (PTPRJ) Protein-tyrosine phosphatase family Q12913
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional regulator Kaiso (ZBTB33) . Q86T24
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nanos homolog 1 (NANOS1) Nanos family Q8WY41
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
FERM domain-containing protein 5 (FRMD5) . Q7Z6J6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
27 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
31 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.