Details of the Target

General Information of Target

Target ID LDTP06456
Target Name NGFI-A-binding protein 2 (NAB2)
Gene Name NAB2
Gene ID 4665
Synonyms
MADER; NGFI-A-binding protein 2; EGR-1-binding protein 2; Melanoma-associated delayed early response protein; Protein MADER
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHRAPSPTAEQPPGGGDSARRTLQPRLKPSARAMALPRTLGELQLYRVLQRANLLSYYET
FIQQGGDDVQQLCEAGEEEFLEIMALVGMATKPLHVRRLQKALREWATNPGLFSQPVPAV
PVSSIPLFKISETAGTRKGSMSNGHGSPGEKAGSARSFSPKSPLELGEKLSPLPGGPGAG
DPRIWPGRSTPESDVGAGGEEEAGSPPFSPPAGGGVPEGTGAGGLAAGGTGGGPDRLEPE
MVRMVVESVERIFRSFPRGDAGEVTSLLKLNKKLARSVGHIFEMDDNDSQKEEEIRKYSI
IYGRFDSKRREGKQLSLHELTINEAAAQFCMRDNTLLLRRVELFSLSRQVARESTYLSSL
KGSRLHPEELGGPPLKKLKQEVGEQSHPEIQQPPPGPESYVPPYRPSLEEDSASLSGESL
DGHLQAVGSCPRLTPPPADLPLALPAHGLWSRHILQQTLMDEGLRLARLVSHDRVGRLSP
CVPAKPPLAEFEEGLLDRCPAPGPHPALVEGRRSSVKVEAEASRQ
Target Bioclass
Other
Family
NAB family
Subcellular location
Nucleus
Function Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.
Uniprot ID
Q15742
Ensemble ID
ENST00000300131.8
HGNC ID
HGNC:7627

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C499(1.88)  LDD3311  [1]
AHL-Pu-1
 Probe Info  		C499(2.54)  LDD0168  [2]
EA-probe
 Probe Info  		N.A.  LDD0440  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
aHNE
 Probe Info  		N.A.  LDD0001  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
NPM
 Probe Info  		N.A.  LDD0016  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C499(2.54)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C499(9.77)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C499(1.07)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C499(1.08)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C499(1.16)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C499(1.12)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C499(1.05)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C499(1.16)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C499(1.12)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C499(1.06)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C499(1.09)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C499(1.00)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C499(1.05)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C499(1.03)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C499(0.98)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C499(1.19)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C499(1.15)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C499(1.09)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C499(1.01)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C499(0.97)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C499(0.99)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C499(1.03)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C499(1.03)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C499(1.05)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C499(1.02)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C499(1.10)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C499(1.17)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C499(1.16)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C499(1.17)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C499(1.10)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C499(1.08)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C499(1.04)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C499(1.12)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C499(0.98)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C499(1.04)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C499(1.16)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C499(1.09)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C499(1.23)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C499(1.05)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C499(1.09)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C499(1.07)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C499(1.12)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C499(1.10)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C499(1.10)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C499(1.00)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C499(1.02)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C499(1.17)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C499(1.01)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C499(1.01)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C499(1.01)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C499(1.19)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C499(1.06)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C499(1.09)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C499(1.11)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C499(1.00)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C499(0.96)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C499(0.96)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C499(0.99)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C499(0.97)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C499(1.10)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C499(1.07)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C499(1.02)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C499(1.05)  LDD1569  [8]
 LDCM0248  AKOS034007472 HEK-293T C499(1.01)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C499(1.17)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C499(1.10)  LDD1514  [8]
 LDCM0367  CL1 HEK-293T C499(0.89)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C499(0.93)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C499(1.16)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C499(0.94)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C499(0.99)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C499(1.01)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C499(1.05)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C499(0.92)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C499(0.94)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C499(0.96)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C499(1.10)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C499(0.93)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C499(1.05)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C499(1.07)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C499(0.87)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C499(1.11)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C499(0.96)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C499(1.12)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C499(0.93)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C499(1.07)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C499(1.10)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C499(1.10)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C499(1.05)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C499(1.00)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C499(1.21)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C499(0.99)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C499(1.09)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C499(1.00)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C499(1.12)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C499(0.96)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C499(1.10)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C499(0.99)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C499(1.11)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C499(1.12)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C499(1.06)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C499(1.04)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C499(1.19)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C499(1.02)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C499(1.04)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C499(1.21)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C499(0.95)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C499(1.02)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C499(1.01)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C499(1.05)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C499(1.03)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C499(1.00)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C499(0.87)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C499(1.09)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C499(0.94)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C499(1.11)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C499(1.08)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C499(0.92)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C499(1.08)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C499(1.10)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C499(1.01)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C499(0.87)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C499(0.94)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C499(0.95)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C499(1.03)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C499(0.97)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C499(0.98)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C499(1.12)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C499(1.12)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C499(1.08)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C499(1.02)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C499(1.03)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C499(0.95)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C499(1.08)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C499(0.95)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C499(1.02)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C499(1.08)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C499(1.02)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C499(1.02)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C499(1.17)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C499(1.17)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C499(1.17)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C499(1.06)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C499(1.14)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C499(1.08)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C499(1.07)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C499(1.03)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C499(1.12)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C499(1.01)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C499(1.13)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C499(0.95)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C499(1.11)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C499(1.01)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C499(1.07)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C499(1.12)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C499(1.12)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C499(1.16)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C499(1.01)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C499(1.04)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C499(1.08)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C499(0.97)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C499(1.07)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C499(1.07)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C499(0.96)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C499(1.05)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C499(1.11)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C499(0.98)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C499(0.95)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C499(1.07)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C499(0.89)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C499(0.99)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C499(1.00)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C499(0.94)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C499(0.99)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C499(1.07)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C499(0.87)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C499(1.12)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C499(0.92)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C499(1.12)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C499(1.14)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C499(0.93)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C499(1.08)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C499(1.10)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C499(1.02)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C499(1.19)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C499(0.99)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C499(1.07)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C499(0.98)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C499(0.93)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C499(1.08)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C499(0.96)  LDD1697  [8]
 LDCM0634  CY-0357 Hep-G2 C499(1.15)  LDD2228  [5]
 LDCM0495  E2913 HEK-293T C499(1.09)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C499(1.18)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [3]
 LDCM0468  Fragment33 HEK-293T C499(0.95)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C499(1.09)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C499(1.01)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C499(1.04)  LDD1497  [8]
 LDCM0024  KB05 G361 C499(1.88)  LDD3311  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Replication factor C subunit 5 (RFC5) Activator 1 small subunits family P40937
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2) PHOSPHO family Q8TCD6
DNA replication licensing factor MCM7 (MCM7) MCM family P33993
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHB4
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Caspase-6 (CASP6) Peptidase C14A family P55212
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Developmentally-regulated GTP-binding protein 2 (DRG2) OBG GTPase family P55039
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) . O60568
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
PHD finger protein 1 (PHF1) Polycomblike family O43189
Homeobox protein TGIF2LY (TGIF2LY) TALE/TGIF homeobox family Q8IUE0
Other
Click To Hide/Show 37 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Enhancer of filamentation 1 (NEDD9) CAS family Q14511
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Protein FAM9A (FAM9A) FAM9 family Q8IZU1
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein DGCR6L (DGCR6L) Gonadal family Q9BY27
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) JAKMIP family Q96AA8
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
Small ubiquitin-related modifier 5 (SUMO1P1) Ubiquitin family G2XKQ0
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Chromobox protein homolog 8 (CBX8) . Q9HC52
Elongin-A (ELOA) . Q14241
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Heat shock factor 2-binding protein (HSF2BP) . O75031
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Microspherule protein 1 (MCRS1) . Q96EZ8
Mortality factor 4-like protein 1 (MORF4L1) . Q9UBU8
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Protein FAM200C (FAM200C) . Q8IZ13
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
Transcription elongation factor A N-terminal and central domain-containing protein (TCEANC) . Q8N8B7
Vinexin (SORBS3) . O60504
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761