Details of the Target

General Information of Target

Target ID LDTP13344
Target Name Tyrosine-protein kinase BAZ1B (BAZ1B)
Gene Name BAZ1B
Gene ID 9031
Synonyms
WBSC10; WBSCR10; WBSCR9; WSTF; Tyrosine-protein kinase BAZ1B; EC 2.7.10.2; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEMEANDHFNFTGLPPAPAASGLKPSPSSGEGLYTNGSPMNFPQQGKSLNGDVNVNGLST
VSHTTTSGILNSAPHSSSTSHLHHPSVAYDCLWNYSQYPSANPGSNLKDPPLLSQFSGGQ
YPLNGILGGSRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMP
NGPPSFFTSPQTSPMLGSSIQTFAPSQEVGSGIHPDEAAEKEMTSVVAENGTGLVGSLEL
EEEQPELKMCGYNGSVPSVESLHQEVSVLVPDPTVSCLDDPSHLPDQLEDTPILSEDSLE
PFNSLAPEPVSGGLYGIDDTELMGAEDKLPLEDSPVISALDCPSLNNATAFSLLADDSQT
STSIFASPTSPPVLGESVLQDNSFDLNNGSDAEQEEMETQSSDFPPSLTQPAPDQSSTIQ
LHPATSPAVSPTTSPAVSLVVSPAASPEISPEVCPAASTVVSPAVFSVVSPASSAVLPAV
SLEVPLTASVTSPKASPVTSPAAAFPTASPANKDVSSFLETTADVEEITGEGLTASGSGD
VMRRRIATPEEVRLPLQHGWRREVRIKKGSHRWQGETWYYGPCGKRMKQFPEVIKYLSRN
VVHSVRREHFSFSPRMPVGDFFEERDTPEGLQWVQLSAEEIPSRIQAITGKRGRPRNTEK
AKTKEVPKVKRGRGRPPKVKITELLNKTDNRPLKKLEAQETLNEEDKAKIAKSKKKMRQK
VQRGECQTTIQGQARNKRKQETKSLKQKEAKKKSKAEKEKGKTKQEKLKEKVKREKKEKV
KMKEKEEVTKAKPACKADKTLATQRRLEERQRQQMILEEMKKPTEDMCLTDHQPLPDFSR
VPGLTLPSGAFSDCLTIVEFLHSFGKVLGFDPAKDVPSLGVLQEGLLCQGDSLGEVQDLL
VRLLKAALHDPGFPSYCQSLKILGEKVSEIPLTRDNVSEILRCFLMAYGVEPALCDRLRT
QPFQAQPPQQKAAVLAFLVHELNGSTLIINEIDKTLESMSSYRKNKWIVEGRLRRLKTVL
AKRTGRSEVEMEGPEECLGRRRSSRIMEETSGMEEEEEEESIAAVPGRRGRRDGEVDATA
SSIPELERQIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRRRYWVLPYLAGIFVEGTE
GNLVPEEVIKKETDSLKVAAHASLNPALFSMKMELAGSNTTASSPARARGRPRKTKPGSM
QPRHLKSPVRGQDSEQPQAQLQPEAQLHAPAQPQPQLQLQLQSHKGFLEQEGSPLSLGQS
QHDLSQSAFLSWLSQTQSHSSLLSSSVLTPDSSPGKLDPAPSQPPEEPEPDEAESSPDPQ
ALWFNISAQMPCNAAPTPPPAVSEDQPTPSPQQLASSKPMNRPSAANPCSPVQFSSTPLA
GLAPKRRAGDPGEMPQSPTGLGQPKRRGRPPSKFFKQMEQRYLTQLTAQPVPPEMCSGWW
WIRDPEMLDAMLKALHPRGIREKALHKHLNKHRDFLQEVCLRPSADPIFEPRQLPAFQEG
IMSWSPKEKTYETDLAVLQWVEELEQRVIMSDLQIRGWTCPSPDSTREDLAYCEHLSDSQ
EDITWRGRGREGLAPQRKTTNPLDLAVMRLAALEQNVERRYLREPLWPTHEVVLEKALLS
TPNGAPEGTTTEISYEITPRIRVWRQTLERCRSAAQVCLCLGQLERSIAWEKSVNKVTCL
VCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCTVCLAQQVEGEFTQKPGFPK
RGQKRKSGYSLNFSEGDGRRRRVLLRGRESPAAGPRYSEEGLSPSKRRRLSMRNHHSDLT
FCEIILMEMESHDAAWPFLEPVNPRLVSGYRRIIKNPMDFSTMRERLLRGGYTSSEEFAA
DALLVFDNCQTFNEDDSEVGKAGHIMRRFFESRWEEFYQGKQANL
Target Bioclass
Enzyme
Family
WAL family, BAZ1B subfamily
Subcellular location
Nucleus
Function
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication.
Uniprot ID
Q9UIG0
Ensemble ID
ENST00000339594.9
HGNC ID
HGNC:961
ChEMBL ID
CHEMBL3588730

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T605M DBIA    Probe Info 
AN3CA SNV: p.A97T DBIA    Probe Info 
CALU1 SNV: p.H1424D DBIA    Probe Info 
CCK81 SNV: p.E736D DBIA    Probe Info 
EFO27 SNV: p.R1359C DBIA    Probe Info 
HCC1395 SNV: p.S916Ter DBIA    Probe Info 
HGC27 SNV: p.E1349Q DBIA    Probe Info 
HT115 SNV: p.N960T DBIA    Probe Info 
IGROV1 SNV: p.L662I DBIA    Probe Info 
IM95 SNV: p.T460A DBIA    Probe Info 
JHH7 SNV: p.E575A .
JURKAT SNV: p.R755W Compound 10    Probe Info 
LNCaP clone FGC SNV: p.S1259N DBIA    Probe Info 
LS180 SNV: p.L683S DBIA    Probe Info 
MFE319 SNV: p.A264V DBIA    Probe Info 
MOLT4 SNV: p.M538I IA-alkyne    Probe Info 
NB4 SNV: p.V1356M .
ONS76 SNV: p.A1082V DBIA    Probe Info 
OVK18 SNV: p.R504H DBIA    Probe Info 
PC9 SNV: p.H1033Y .
RL952 SNV: p.R579W DBIA    Probe Info 
SNU1196 SNV: p.Y222Ter DBIA    Probe Info 
SNU478 SNV: p.A480T DBIA    Probe Info 
SW1271 SNV: p.D609N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.03  LDD0402  [1]
STPyne
 Probe Info  		K1037(4.81); K231(2.97); K501(1.18); K853(10.00)  LDD0277  [2]
BTD
 Probe Info  		C497(2.11)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C994(3.81)  LDD0168  [4]
DBIA
 Probe Info  		C1202(1.28); C1205(1.28); C1420(1.07); C497(1.05)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1006(0.00); C1420(0.00); C1045(0.00); C1175(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C1420(0.00); C120(0.00)  LDD0032  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C953(0.00); C1006(0.00); C1420(0.00); C1045(0.00)  LDD0037  [6]
JW-RF-010
 Probe Info  		C120(0.00); C497(0.00)  LDD0026  [9]
TFBX
 Probe Info  		C1096(0.00); C497(0.00); C1420(0.00); C1435(0.00)  LDD0027  [9]
WYneN
 Probe Info  		C953(0.00); C156(0.00); C1045(0.00)  LDD0021  [10]
aHNE
 Probe Info  		N.A.  LDD0001  [10]
Compound 10
 Probe Info  		C1045(0.00); C1420(0.00); C953(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
ENE
 Probe Info  		N.A.  LDD0006  [10]
IPM
 Probe Info  		C497(0.00); C953(0.00)  LDD0005  [10]
PPMS
 Probe Info  		N.A.  LDD0008  [10]
SF
 Probe Info  		N.A.  LDD0028  [12]
VSF
 Probe Info  		C156(0.00); C953(0.00)  LDD0007  [10]
YN-1
 Probe Info  		N.A.  LDD0446  [13]
Phosphinate-6
 Probe Info  		C338(0.00); C156(0.00)  LDD0018  [14]
1c-yne
 Probe Info  		K297(0.00); K231(0.00)  LDD0228  [15]
1d-yne
 Probe Info  		K14(0.00); K231(0.00)  LDD0357  [15]
Acrolein
 Probe Info  		C953(0.00); C753(0.00); C1006(0.00); C156(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C156(0.00); C497(0.00); C953(0.00); C1435(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C156(0.00); C953(0.00); C753(0.00); C497(0.00)  LDD0218  [16]
W1
 Probe Info  		C1045(0.00); C953(0.00); C156(0.00)  LDD0236  [17]
NAIA_5
 Probe Info  		C52(0.00); C1096(0.00); C1045(0.00); C1187(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		18.55  LDD0475  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
FFF probe6
 Probe Info  		7.10  LDD0467  [19]
STS-1
 Probe Info  		N.A.  LDD0136  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C156(1.17); C1435(0.76)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C156(0.95); C1435(0.97)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C497(0.76); C1428(1.02); C1435(1.25); C753(1.08)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1428(1.61)  LDD2152  [3]
 LDCM0025  4SU-RNA HEK-293T C994(3.81)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C994(2.67)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C1202(1.03); C1205(1.08); C1045(0.98); C120(1.09)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C1202(1.02); C1205(1.02); C1045(1.06); C1175(0.92)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C1202(0.69); C1205(0.74); C1045(0.71); C1213(0.39)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C1202(0.72); C1205(0.81); C1045(0.75); C1213(0.62)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C1202(0.87); C1205(0.92); C1045(0.78); C1213(1.03)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C1202(0.79); C1205(0.88); C1045(0.69); C1213(0.68)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C1202(0.76); C1205(0.81); C1045(0.76); C1213(0.68)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C1202(0.81); C1205(0.88); C1045(0.73); C1213(0.89)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C1202(0.83); C1205(0.87); C1045(0.69); C1213(0.48)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C1202(0.79); C1205(0.83); C1045(0.75); C1213(0.62)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C1202(0.63); C1205(0.68); C1045(0.76); C1213(0.37)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C1202(0.77); C1205(0.77); C1045(0.72); C1213(0.76)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C1202(1.08); C1205(1.08); C1045(1.03); C1175(0.87)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C1202(0.84); C1205(0.86); C1045(0.74); C1213(0.67)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C1202(0.86); C1205(0.88); C1045(0.64); C1213(0.72)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C1202(0.90); C1205(0.92); C1045(0.70); C1213(0.73)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C1202(1.09); C1205(1.09); C1006(0.95); C1045(1.17)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C1202(1.15); C1205(1.17); C1006(0.85); C1045(1.35)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C1202(1.14); C1205(1.16); C1006(0.84); C1045(1.15)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C1202(1.03); C1205(1.07); C1006(0.78); C1045(1.16)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C1202(1.09); C1205(1.12); C1006(0.79); C1045(1.18)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C1202(1.13); C1205(1.17); C1006(1.02); C1045(1.19)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C1202(1.09); C1205(1.13); C1006(0.96); C1045(1.30)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C1202(1.18); C1205(1.18); C1045(0.96); C1175(0.99)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C1202(1.07); C1205(1.09); C1006(0.83); C1045(1.14)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C1202(1.12); C1205(1.17); C1006(0.79); C1045(1.28)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C1202(1.18); C1205(1.24); C1006(1.01); C1045(1.04)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C1202(1.04); C1205(1.11); C1006(1.09); C1045(1.32)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C1202(1.08); C1205(1.11); C1006(0.80); C1045(1.42)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C1202(1.08); C1205(1.06); C1006(0.94); C1045(1.42)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C1202(1.12); C1205(1.12); C1006(0.90); C1045(1.16)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C1202(1.07); C1205(1.07); C1006(0.81); C1045(1.20)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C1202(0.81); C1205(0.81); C1045(1.31); C1228(1.28)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C1202(0.63); C1205(0.63); C1045(1.21); C1228(1.35)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C1202(0.70); C1205(0.70); C1045(1.32); C1228(1.20)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C1202(0.61); C1205(0.61); C1045(0.96); C1228(1.82)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C1202(0.65); C1205(0.65); C1045(1.18); C1228(1.15)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C1202(0.73); C1205(0.73); C1045(0.99); C1228(1.24)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C1202(0.66); C1205(0.66); C1045(1.11); C1228(1.36)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C1202(0.71); C1205(0.71); C1045(1.10); C1228(1.43)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C1202(0.68); C1205(0.68); C1045(1.19); C1228(0.95)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C1202(0.69); C1205(0.69); C1045(1.14); C1228(1.17)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C1202(0.72); C1205(0.72); C1045(0.99); C1228(1.42)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C1202(0.66); C1205(0.66); C1045(1.27); C1228(1.17)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C1202(1.14); C1205(1.14); C1045(1.10); C1175(1.11)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C1202(0.69); C1205(0.69); C1045(1.10); C1228(1.30)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C1202(0.66); C1205(0.66); C1045(1.26); C1228(1.48)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C1202(0.74); C1205(0.74); C1045(1.28); C1228(1.22)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C1202(1.01); C1205(1.02); C1006(0.90); C1045(0.88)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C753(0.74); C1006(0.75); C1213(0.87); C1228(0.87)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C753(0.69); C1228(0.73); C1231(0.73); C1213(0.76)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C753(0.83); C1213(0.91); C1006(0.97); C1045(0.99)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C753(0.77); C1228(0.79); C1231(0.79); C1045(0.88)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C753(0.75); C1213(0.80); C1228(0.83); C1231(0.83)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C753(0.72); C1045(0.87); C994(0.90); C1228(0.92)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C120(0.51); C1393(0.71); C1428(0.82); C1175(0.85)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C1228(0.57); C1231(0.57); C1006(0.78); C753(0.78)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C753(0.82); C1006(0.84); C1393(0.89); C1045(0.89)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1228(0.77); C1231(0.77); C753(0.78); C1006(0.89)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1228(0.68); C1231(0.68); C753(0.70); C1213(0.91)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C1202(1.16); C1205(1.15); C1006(0.98); C1045(0.91)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C1202(1.27); C1205(1.26); C1006(1.10); C1045(0.95)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C1202(1.23); C1205(1.21); C1006(1.10); C1045(1.06)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C1202(1.29); C1205(1.27); C1006(0.94); C1045(0.89)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C120(0.67); C1202(0.81); C1205(0.81); C1435(0.83)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C1393(0.33); C120(0.34); C1435(0.53); C1228(0.66)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C120(0.58); C1393(0.63); C1428(0.71); C1435(0.72)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C1213(0.74); C338(0.80); C1202(0.82); C1428(0.89)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C120(0.66); C1428(0.73); C1435(0.77); C753(0.85)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C1393(0.59); C1435(0.60); C120(0.63); C1395(0.73)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1435(0.74); C120(0.77); C1428(0.82); C1228(0.84)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C1428(0.62); C120(0.68); C1006(0.80); C1228(0.80)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1435(0.71); C1428(0.78); C120(0.79); C1202(0.80)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C1435(0.72); C994(0.72); C1395(0.73); C1428(0.75)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C1435(0.62); C1428(0.65); C1393(0.73); C753(0.74)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C1428(0.56); C1435(0.56); C1393(0.70); C753(0.79)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C1435(0.53); C1393(0.64); C1395(0.66); C1428(0.66)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1428(0.63); C1395(0.64); C1393(0.64); C1435(0.66)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C338(0.66); C1213(0.67); C156(0.82); C1428(0.86)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1428(0.58); C1435(0.62); C1393(0.71); C994(0.71)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C1435(0.60); C1428(0.65); C1393(0.66); C1395(0.77)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1435(0.48); C1428(0.54); C1393(0.63); C753(0.70)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1428(0.47); C1435(0.52); C1393(0.53); C1395(0.56)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1435(0.50); C1393(0.54); C1428(0.55); C753(0.69)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C156(0.70); C1395(0.72); C1006(0.83); C1393(0.83)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C156(0.71); C1006(0.89); C1395(0.89); C1202(0.90)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C156(0.68); C1435(0.83); C1395(0.89); C994(0.90)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C1395(0.88); C1393(0.88); C156(0.89); C753(0.92)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1435(0.90); C1395(0.97); C1175(1.00); C753(1.00)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C120(0.69); C1213(0.71); C338(0.82); C1428(0.84)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C156(0.81); C753(0.86); C1435(0.92); C120(0.92)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C1435(0.87); C1428(0.89); C1175(0.93); C1006(0.94)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1395(0.86); C1435(0.86); C1393(0.92); C120(0.94)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C1395(0.86); C1435(0.91); C156(0.93); C1428(0.94)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C1395(0.83); C1435(0.93); C953(0.98); C1428(0.99)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1435(0.84); C1395(0.90); C120(0.98); C753(0.98)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C753(0.79); C994(0.84); C1202(0.93); C1205(0.93)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C753(0.83); C497(0.88); C994(0.89); C120(0.90)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C497(0.85); C753(1.04); C338(1.06); C994(1.06)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C497(0.80); C753(0.81); C994(0.88); C120(0.95)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C120(0.65); C338(0.71); C1213(0.78); C1202(0.84)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C753(0.77); C994(0.86); C120(0.91); C497(1.02)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C994(0.86); C156(0.89); C753(0.92); C1045(0.97)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C994(0.74); C753(0.87); C120(0.90); C1006(0.93)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C994(0.82); C120(0.85); C753(0.89); C1428(0.92)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C994(0.79); C120(0.85); C753(0.89); C1395(0.92)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C753(0.91); C120(0.92); C497(0.95); C1202(1.01)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C753(0.86); C497(0.88); C994(1.03); C120(1.14)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1393(0.56); C1435(0.72); C1228(0.73); C1231(0.73)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1393(0.61); C1435(0.75); C1395(0.85); C1202(0.86)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C1435(0.72); C1393(0.76); C1228(0.78); C1231(0.78)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C120(0.49); C1428(0.87); C994(0.90); C1175(0.92)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1228(0.75); C1231(0.75); C1435(0.79); C1393(0.79)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1393(0.80); C1228(0.92); C1231(0.92); C1045(0.93)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1435(0.71); C1393(0.77); C1428(0.93); C1202(0.94)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C1393(0.65); C1435(0.79); C1428(0.89); C1228(0.90)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C1393(0.71); C1228(0.78); C1231(0.78); C1435(0.86)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C1228(0.56); C1231(0.56); C1202(0.79); C1205(0.79)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1393(0.64); C1228(0.67); C1231(0.67); C1202(0.76)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1228(0.41); C1231(0.41); C1393(0.75); C1435(0.87)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1228(0.83); C1231(0.83); C1202(0.87); C1205(0.87)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1395(0.78); C1393(0.79); C1420(0.85); C156(0.86)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C120(0.66); C1228(0.78); C1231(0.78); C1393(0.79)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C1202(0.84); C1205(0.84); C1428(0.85); C1228(0.92)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1420(0.72); C156(0.86); C1202(0.86); C1205(0.86)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C1228(0.82); C1231(0.82); C1428(0.82); C1395(0.84)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C1428(0.85); C1228(0.89); C1231(0.89); C753(0.90)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1420(0.85); C156(0.90); C1428(0.92); C1228(0.95)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1428(0.82); C753(0.91); C1420(0.96); C156(1.00)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1428(0.76); C1202(0.85); C1205(0.85); C1228(0.87)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1428(0.77); C156(0.89); C753(0.94); C1420(0.99)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C1228(0.69); C1231(0.69); C1428(0.81); C156(0.94)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C1202(0.84); C1205(0.84); C1228(0.86); C1231(0.86)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C1393(0.53); C120(0.56); C994(0.89); C1175(0.92)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C1420(0.86); C1395(0.86); C1228(0.88); C1231(0.88)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C156(0.82); C1202(0.86); C1205(0.86); C753(0.89)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1420(0.82); C753(0.88); C1228(0.93); C1231(0.93)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C1393(0.71); C1428(0.73); C753(0.77); C994(1.01)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C1393(0.71); C1428(0.72); C1228(0.73); C1231(0.74)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1231(0.57); C1228(0.63); C1428(0.67); C753(0.72)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C1428(0.64); C1393(0.70); C753(0.86); C1228(0.91)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1228(0.75); C1393(0.82); C1428(0.82); C1231(0.83)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C994(0.50); C1393(0.65); C1428(0.65); C753(0.69)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C1428(0.65); C753(0.77); C1045(0.91); C1202(0.99)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C1393(0.82); C1428(0.86); C953(0.88); C1228(0.88)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C1428(0.67); C753(0.71); C1393(0.92); C1228(1.00)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C1428(0.59); C753(0.67); C1393(0.70); C1231(0.90)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1428(0.66); C1393(0.68); C753(0.71); C1228(0.74)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C1428(0.68); C1228(0.70); C753(0.70); C1231(0.78)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C1045(0.82); C1428(0.97); C953(0.98); C1393(1.03)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C1428(0.63); C994(0.78); C753(0.83); C1202(1.00)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C1428(0.66); C753(0.70); C1393(0.75); C1228(0.76)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C1435(0.42); C1213(0.51); C753(0.60); C1228(0.65)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C1435(0.48); C1228(0.60); C1231(0.60); C1213(0.63)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C1202(1.06); C1205(1.06); C1045(1.04); C1175(0.95)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C120(0.66); C1228(0.85); C1231(0.85); C1175(0.99)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C120(0.34); C1393(0.76); C1428(0.92); C994(1.01)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 14.47  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1202(1.28); C1205(1.28); C1420(1.07); C497(1.05)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa C156(0.00); C1006(0.00); K163(0.00); C1435(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C156(1.83); C156(0.94); C156(0.93); C156(0.73)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C156(0.79); C1228(0.82); C1231(0.82); C1420(0.88)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C953(0.79); C753(0.87); C994(0.91); C497(0.99)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C120(0.72); C1428(0.76); C1395(0.83); C1393(0.88)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C120(0.49); C1428(0.77); C1393(0.81); C1175(0.90)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C120(0.69); C338(0.88); C1428(0.90); C953(0.96)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C120(0.62); C1428(0.85); C1045(0.94); C1175(0.95)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C120(0.64); C1393(0.92); C1175(0.94); C338(0.98)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C120(0.47); C1393(0.51); C1435(0.59); C1428(0.60)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C120(0.38); C1393(0.56); C1435(0.69); C1228(0.70)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C120(0.34); C1393(0.46); C1435(0.62); C1395(0.70)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C120(0.33); C1393(0.47); C1228(0.62); C1231(0.62)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C120(0.48); C1393(0.48); C1435(0.61); C1428(0.63)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C1228(0.82); C1231(0.82); C753(0.88); C497(0.99)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C120(0.36); C1393(0.46); C1435(0.53); C1428(0.63)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C1393(0.49); C120(0.57); C1228(0.64); C1231(0.64)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1395(0.65); C1393(0.72); C1435(0.81); C753(0.84)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1435(0.49); C1428(0.54); C1393(0.56); C1395(0.57)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1393(0.49); C1435(0.60); C1395(0.63); C1428(0.64)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C1395(0.55); C1435(0.56); C1428(0.60); C1393(0.62)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1393(0.52); C1395(0.64); C1428(0.66); C1435(0.68)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C753(0.88); C1395(0.92); C497(1.04); C1393(1.14)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C1395(0.78); C1393(0.81); C1202(0.83); C1435(0.87)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C1435(0.89); C1428(0.90); C1175(0.93); C1006(0.96)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C953(0.90); C497(0.94); C1175(1.04); C994(1.14)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C1435(0.85); C156(0.88); C1428(0.89); C1175(0.94)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C994(0.72); C1045(0.78); C120(0.84); C753(0.91)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C497(0.89); C994(0.91); C1202(0.95); C1205(0.95)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C120(0.78); C994(0.80); C1202(0.81); C1205(0.81)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C497(0.76); C753(0.84); C994(0.86); C120(0.95)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1393(0.90); C338(0.91); C1202(0.95); C1205(0.95)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1435(0.69); C1393(0.71); C1395(0.82); C994(0.90)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C1393(0.63); C1228(0.67); C1231(0.67); C1395(0.81)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C1393(0.69); C1435(0.75); C1395(0.82); C338(0.94)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C953(0.79); C1228(0.96); C1231(0.96); C497(0.97)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C953(0.86); C156(0.89); C497(0.94); C1228(0.94)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C953(0.84); C1228(0.87); C1231(0.87); C1395(0.90)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C994(0.86); C1428(1.02); C1420(1.03); C338(1.08)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C994(0.88); C1428(0.95); C156(0.97); C1228(0.98)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C1045(0.80); C1228(0.99); C1231(0.99); C953(1.01)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1045(0.78); C994(0.89); C1428(0.96); C953(0.97)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C156(0.83); C753(0.85); C1045(0.88); C1228(0.89)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1428(0.75); C994(0.85); C1045(0.88); C753(0.89)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1428(0.78); C1228(0.78); C1231(0.78); C753(0.91)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1228(0.84); C1231(0.84); C753(0.94); C953(0.98)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C1428(0.68); C994(0.81); C1045(0.92); C753(0.95)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1428(0.86); C953(0.96); C994(0.98); C753(0.98)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C1202(1.37); C1205(1.37); C1045(0.96); C1228(1.39)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C1202(1.31); C1205(1.31); C1045(1.00); C1228(1.00)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C1202(1.35); C1205(1.35); C1045(0.96); C1228(1.63)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C1202(1.38); C1205(1.38); C1045(0.85); C1228(1.70)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C1202(1.23); C1205(1.23); C1045(0.99); C1228(1.77)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C1202(1.07); C1205(1.07); C1045(0.91); C1175(1.01)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C1202(1.31); C1205(1.31); C1045(1.04); C1228(1.36)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C1202(0.73); C1205(0.73); C1045(1.04); C1175(0.88)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C1202(0.96); C1205(0.96); C1045(1.23); C1175(1.32)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C1202(0.80); C1205(0.80); C1045(1.60); C1175(0.92)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C1202(0.71); C1205(0.71); C1045(1.27); C1175(1.19)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C1202(0.81); C1205(0.81); C1045(1.09); C1175(0.93)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C1202(0.71); C1205(0.71); C1045(1.03); C1175(0.88)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C1202(0.73); C1205(0.73); C1045(1.19); C1175(0.92)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C1202(0.78); C1205(0.78); C1045(1.14); C1175(0.86)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C1202(1.05); C1205(1.05); C1045(1.07); C1175(0.97)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C1202(0.95); C1205(0.95); C1045(1.20); C1175(0.84)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C1202(0.69); C1205(0.69); C1045(1.08); C1175(0.90)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C1202(0.96); C1205(0.96); C1045(1.29); C1175(1.04)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C1202(0.75); C1205(0.75); C1045(1.20); C1175(1.05)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C1202(0.83); C1205(0.83); C1045(1.43); C1175(1.01)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C1202(0.91); C1205(0.91); C1045(1.45); C1175(0.99)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C1202(0.99); C1205(0.97); C1045(0.93); C1228(0.65)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C1202(0.90); C1205(0.93); C1045(0.85); C1228(0.78)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C1202(1.01); C1205(1.01); C1045(0.83); C1228(0.84)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C1202(0.80); C1205(0.80); C1045(0.89); C1228(0.87)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C1202(1.10); C1205(1.10); C1045(1.02); C1175(1.10)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C1202(0.84); C1205(0.86); C1045(0.83); C1228(0.64)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C1202(1.00); C1205(1.01); C1045(0.81); C1228(0.81)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C1202(1.08); C1205(1.11); C1045(0.69); C1228(0.77)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C1202(0.86); C1205(0.86); C1045(0.83); C1228(0.63)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C1202(0.98); C1205(0.98); C1045(0.81); C1228(0.94)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C1202(0.94); C1205(0.96); C1045(0.77); C1228(1.15)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C1202(1.08); C1205(1.09); C1045(0.82); C1228(1.00)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C1202(0.90); C1205(0.89); C1045(0.80); C1228(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C1202(0.95); C1205(0.96); C1045(0.88); C1228(1.24)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C1202(1.01); C1205(1.00); C1045(0.85); C1228(1.04)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C1202(1.13); C1205(1.13); C1045(0.97); C1175(1.16)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C1202(0.94); C1205(0.91); C1045(0.80); C1228(1.01)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C1202(0.85); C1205(0.85); C1045(1.12); C120(0.92)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C1202(0.85); C1205(0.85); C1045(1.37); C120(0.88)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C1202(0.96); C1205(0.96); C1045(1.01); C120(0.74)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C1202(0.86); C1205(0.86); C1045(1.18); C120(0.46)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C1202(0.85); C1205(0.85); C1045(1.13); C120(0.77)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C1202(0.98); C1205(0.98); C1045(1.12); C120(0.45)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C1202(0.88); C1205(0.88); C1045(1.43); C120(0.43)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C1202(1.14); C1205(1.14); C1045(1.31); C120(0.71)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C1202(1.36); C1205(1.36); C1045(1.34); C120(1.56)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C1202(1.16); C1205(1.16); C1045(1.18); C1175(1.20)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C1202(1.06); C1205(1.06); C1045(1.32); C120(0.85)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C1202(0.88); C1205(0.88); C1045(1.30); C120(0.58)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C1202(0.94); C1205(0.94); C1045(1.31); C120(0.90)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C1202(0.76); C1205(0.76); C1045(1.04); C120(0.57)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C1202(0.94); C1205(0.94); C1045(1.22); C120(0.52)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C1202(0.99); C1205(0.99); C1045(1.26); C1175(1.06)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C1202(0.92); C1205(0.92); C1045(1.16); C1175(0.89)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C1202(0.99); C1205(0.99); C1045(0.94); C1175(0.93)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C1202(0.89); C1205(0.89); C1045(1.17); C1175(0.89)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C1202(0.91); C1205(0.91); C1045(1.07); C1175(0.99)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C1202(1.12); C1205(1.12); C1045(1.74); C1175(1.33)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C1202(0.81); C1205(0.81); C1045(1.17); C1175(1.01)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C1202(0.97); C1205(0.97); C1045(1.41); C1175(1.13)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C1202(0.87); C1205(0.87); C1045(1.63); C1175(1.18)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C1202(0.96); C1205(0.96); C1045(1.64); C1175(1.23)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C1202(0.90); C1205(0.90); C1045(1.16); C1175(0.94)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C1202(0.88); C1205(0.88); C1045(1.16); C1175(0.99)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C1202(0.80); C1205(0.80); C1045(1.18); C1175(0.90)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C1202(0.89); C1205(0.89); C1045(1.17); C1175(1.10)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C1202(1.00); C1205(1.00); C1045(1.83); C1175(1.13)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C1202(1.06); C1205(1.06); C1045(1.00); C1175(0.92)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C1202(0.74); C1205(0.74); C1045(1.56); C1175(1.05)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C1202(0.94); C1205(0.99); C1045(0.97); C120(0.96)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C1202(0.86); C1205(0.93); C1045(0.86); C120(0.95)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C1202(0.97); C1205(1.01); C1045(0.93); C120(0.92)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C1202(0.92); C1205(0.99); C1045(0.97); C120(0.78)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C1202(0.90); C1205(0.98); C1045(0.91); C120(0.73)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C1202(1.01); C1205(1.04); C1045(0.94); C120(0.82)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C1202(0.91); C1205(0.95); C1045(0.91); C120(0.70)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C1202(0.84); C1205(0.91); C1045(1.00); C120(0.72)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C1202(0.90); C1205(0.95); C1045(1.02); C120(0.72)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C953(50.00); C1420(1.02)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C156(1.02); C1428(1.09); C338(1.02); C497(0.88)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1393(1.77); C1395(1.45); C953(1.30); C497(1.25)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C1202(0.89); C1205(0.89); C1045(1.25); C120(0.55)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C1202(1.07); C1205(1.07); C1045(1.19); C1175(1.12)  LDD0744  [5]
 LDCM0107  IAA HeLa C753(0.00); H1033(0.00); H930(0.00); H944(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C994(5.48); C338(2.17); C1045(1.75); C1205(1.61)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C994(8.28); C338(1.36); C1045(2.06); C1205(1.85)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C994(12.09); C338(2.34); C1045(1.93); C1205(1.71)  LDD0082  [5]
 LDCM0109  NEM HeLa H1030(0.00); H94(0.00); H1382(0.00); H1033(0.00)  LDD0223  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1435(1.10)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1428(0.92)  LDD2093  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1435(0.95)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C497(0.88); C1428(1.28); C1435(1.42)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C156(0.85)  LDD2100  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C156(0.63); C1435(0.80)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C156(0.75)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1428(1.15)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C156(0.95); C1435(0.82)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C497(0.78); C1428(1.19); C1435(0.74); C753(0.50)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C156(0.92); C1435(0.78)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C497(0.86)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C156(0.59); C1435(0.51)  LDD2114  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C497(2.12); C1428(1.00)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C497(0.83)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C497(0.94); C1428(0.99); C1435(1.00); C753(1.16)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C156(0.85); C1428(0.90); C753(1.14); C1213(0.66)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C497(0.81); C1428(1.04); C1435(0.82); C753(1.06)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C156(0.87); C497(1.37); C1428(1.58); C1435(1.62)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C497(1.00); C1428(1.13); C1435(1.43)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C497(0.84); C1428(1.04); C1435(1.05); C753(1.18)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C497(2.11)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C497(0.62); C1428(0.85); C1435(0.98)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C156(0.94); C1395(0.38)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C497(2.17); C1428(0.98)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C497(0.90); C1428(0.95); C1435(0.86)  LDD2146  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1435(1.82)  LDD2153  [3]
 LDCM0021  THZ1 HCT 116 C1420(1.03); C953(1.35); C1202(1.13); C1205(1.13)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) SNF2/RAD54 helicase family O60264

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402