Details of the Target

General Information of Target

Target ID LDTP02774
Target Name Phosphoglycerate mutase 2 (PGAM2)
Gene Name PGAM2
Gene ID 5224
Synonyms
PGAMM; Phosphoglycerate mutase 2; EC 5.4.2.11; EC 5.4.2.4; BPG-dependent PGAM 2; Muscle-specific phosphoglycerate mutase; Phosphoglycerate mutase isozyme M; PGAM-M
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
IPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKR
VLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVR
KAMEAVAAQGKAK
Target Bioclass
Enzyme
Family
Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
Function Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Uniprot ID
P15259
Ensemble ID
ENST00000297283.4
HGNC ID
HGNC:8889

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P3
 Probe Info  		1.54  LDD0454  [1]
P8
 Probe Info  		5.31  LDD0455  [1]
TH211
 Probe Info  		Y92(15.20)  LDD0260  [2]
AZ-9
 Probe Info  		E244(0.99)  LDD2208  [3]
Probe 1
 Probe Info  		Y92(15.15)  LDD3495  [4]
DBIA
 Probe Info  		C55(1.04); C153(1.20)  LDD3377  [5]
HHS-475
 Probe Info  		Y92(0.97)  LDD0264  [6]
HHS-465
 Probe Info  		Y92(10.00)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
MPP-AC
 Probe Info  		N.A.  LDD0428  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H186(0.00); H91(0.00)  LDD0222  [8]
 LDCM0116  HHS-0101 DM93 Y92(0.97)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y92(0.90)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y92(0.89)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y92(1.06)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y92(1.18)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 BRX211 C153(1.30)  LDD2268  [5]
 LDCM0023  KB03 BRX211 C153(1.96)  LDD2685  [5]
 LDCM0024  KB05 OPM-2 C55(1.04); C153(1.20)  LDD3377  [5]
 LDCM0109  NEM HeLa H91(0.00); H186(0.00)  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) AAA ATPase family Q9BW62
Bisphosphoglycerate mutase (BPGM) Phosphoglycerate mutase family P07738
Phosphoglycerate mutase 2 (PGAM2) Phosphoglycerate mutase family P15259
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) Dynein light intermediate chain family Q9Y6G9
Clavesin-2 (CLVS2) . Q5SYC1

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-phospho-d-glyceric Acid Small molecular drug DB04510
Benzene Hexacarboxylic Acid . DB01681

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.